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4-Chloro-3-Methoxybromobenzene
Linshang Chemical
|
HS Code |
300992 |
| Chemical Formula | C7H6BrClO |
| Molar Mass | 221.48 g/mol |
| Appearance | Solid (presumed, typical for aromatic halides) |
| Boiling Point | Estimated around 240 - 260 °C (approximate for similar substituted benzenes) |
| Density | Estimated around 1.6 - 1.8 g/cm³ (for similar halogen - substituted aromatic ethers) |
| Solubility In Water | Insoluble (aromatic halides are generally hydrophobic) |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform, toluene |
| Flash Point | Estimated to be around 100 - 120 °C (approximate for related halogenated aromatic compounds) |
| Odor | Aromatic, likely pungent due to halogens and methoxy group |
As an accredited 4-Chloro-3-Methoxybromobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 4 - chloro - 3 - methoxybromobenzene packaged in a sealed glass bottle. |
| Storage | 4 - chloro - 3 - methoxybromobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly - sealed container, preferably made of corrosion - resistant material, to prevent leakage and exposure to air or moisture, which could potentially cause decomposition or unwanted reactions. |
| Shipping | 4 - chloro - 3 - methoxybromobenzene should be shipped in tightly - sealed, corrosion - resistant containers. Label it clearly as a chemical. Ensure compliance with hazardous material shipping regulations to prevent spills and ensure safe transportation. |
Competitive 4-Chloro-3-Methoxybromobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What is the Chinese name of 4-chloro-3-methoxybromobenzene?
4-Chloro-3-methoxybromobenzene is one of the organic compounds. Its naming follows the rules of organic chemistry naming. Looking at its name, "4-chloro" means that the chlorine atom is at the 4th position of the benzene ring; "3-methoxy" means that the methoxy group is at the 3rd position of the benzene ring; "bromobenzene" means that there is a bromine atom on the epitene ring. This nomenclature allows scholars to know the approximate molecular structure when they see its name, which is of great significance in the study and communication of organic chemistry. There are many organic compounds, and the naming rules are strict. Only by naming according to this rule can various compounds be accurately referred to, so as to facilitate academic research, industrial production and other matters. This 4-chloro-3-methoxybromobenzene, due to its specific combination of atoms and groups, has unique physical and chemical properties and may have specific uses in organic synthesis and other fields.
What are the chemical properties of 4-chloro-3-methoxybromobenzene?
4-Chloro-3-methoxybromobenzene, this is an organic compound with unique chemical properties and a variety of reaction characteristics.
First, the typical properties of halogenated aromatics, in this compound, both bromine and chlorine are halogen atoms, which can undergo nucleophilic substitution reaction. Taking the basic solution of alcohols as an example, the halogen atom can be replaced by the hydroxyl group to form the corresponding phenolic derivatives. In this reaction, the nucleophilic hydroxyl group attacks the carbon atom connected to the halogen atom, and the halogen atom leaves to form a new compound.
Furthermore, the presence of methoxy group also gives it special reactivity. Methoxy group is the power supply group, which can increase the electron cloud density of the benzene ring, causing the benzene ring to be more prone to electrophilic substitution reaction. In terms of bromination reaction, electrophilic reagents tend to attack the ortho and para-position of methoxy groups, and the electron cloud density of the ortho and para-position is relatively higher due to the power supply effect of methoxy groups.
In addition, the carbon atoms connected to the halogen atoms in 4-chloro-3-methoxybromobenzene have certain positive electricity due to the electron-absorbing properties of the halogen atoms, which can participate in metal-organic reactions. For example, it can be made into Grignard reagents by reacting with magnesium. This Grignard reagent is extremely active and can react with many carbonyl compounds to generate various alcohols, which are widely used in the field of organic synthesis.
At the same time, due to the conjugated system of the benzene ring, the compound has certain stability. However, under certain conditions, such as high temperature and strong oxidant action, the benzene ring may also be destroyed, triggering oxidation and other reactions, resulting in compounds containing carboxyl groups and other functional groups. In short, 4-chloro-3-methoxybromobenzene has rich chemical properties and has broad application prospects in organic synthesis and other fields.
First, the typical properties of halogenated aromatics, in this compound, both bromine and chlorine are halogen atoms, which can undergo nucleophilic substitution reaction. Taking the basic solution of alcohols as an example, the halogen atom can be replaced by the hydroxyl group to form the corresponding phenolic derivatives. In this reaction, the nucleophilic hydroxyl group attacks the carbon atom connected to the halogen atom, and the halogen atom leaves to form a new compound.
Furthermore, the presence of methoxy group also gives it special reactivity. Methoxy group is the power supply group, which can increase the electron cloud density of the benzene ring, causing the benzene ring to be more prone to electrophilic substitution reaction. In terms of bromination reaction, electrophilic reagents tend to attack the ortho and para-position of methoxy groups, and the electron cloud density of the ortho and para-position is relatively higher due to the power supply effect of methoxy groups.
In addition, the carbon atoms connected to the halogen atoms in 4-chloro-3-methoxybromobenzene have certain positive electricity due to the electron-absorbing properties of the halogen atoms, which can participate in metal-organic reactions. For example, it can be made into Grignard reagents by reacting with magnesium. This Grignard reagent is extremely active and can react with many carbonyl compounds to generate various alcohols, which are widely used in the field of organic synthesis.
At the same time, due to the conjugated system of the benzene ring, the compound has certain stability. However, under certain conditions, such as high temperature and strong oxidant action, the benzene ring may also be destroyed, triggering oxidation and other reactions, resulting in compounds containing carboxyl groups and other functional groups. In short, 4-chloro-3-methoxybromobenzene has rich chemical properties and has broad application prospects in organic synthesis and other fields.
What are the common uses of 4-chloro-3-methoxybromobenzene?
4-Chloro-3-methoxybromobenzene is an organic compound. There are several common pathways for the preparation of this compound.
One is to use phenolic compounds as starting materials. Taking m-methoxyphenol as an example, it is first brominated with bromine. Because the phenolic hydroxyl group is a strong donator group, it belongs to the ortho-para-site group, and the methoxy group is also a donator group, the two affect together, so that the bromine atom mainly replaces the phenolic hydroxyl ortho-site, and 4-bromo-3-methoxyphenol can be prepared. Then, 4-bromo-3-methoxyphenol reacts with chlorinated reagents, such as phosphorus oxychloride (POCl
), etc. The oxygen atoms in the phenolic hydroxyl group will attack the phosphorus oxychloride atoms. After a series of transformations, the hydroxyl group is replaced by the chlorine atom, and the final product is 4-chloro-3-methoxybromobenzene. This path step is relatively simple, and the starting material intermethoxyphenol is relatively easy to obtain. However, the reaction conditions need to be precisely controlled during the bromination reaction to prevent the formation of polybrominated by-products.
The second is to use halogenated benzene derivatives as raw materials. For example, 3-methoxy-4-nitrobromobenzene is selected, and the nitro group is first reduced. Iron powder, hydrochloric acid and other reduction systems can be used to reduce the nitro group to an amino group to obtain 3-methoxy-4-aminobrobenzene. Then, through the diazotization reaction, 3-methoxy-4-aminobrobenzene is reacted with sodium nitrite and hydrochloric acid at low temperature to form a diazonium salt. Finally, the diazonium salt is reacted with a copper salt such as cuprous chloride, and the diazonium group is replaced by a chlorine atom to achieve the preparation of 4-chloro-3-methoxy bromobenzene. Although there are a few more steps in this path, the reaction selectivity of each step is quite high, which can effectively reduce side reactions. However, the diazotization reaction requires strict control of low temperature conditions, and the operation requirements are relatively strict.
The third is to use anisole as the starting material. First, the bromination reaction of anisole is carried out to generate 4-bromoanisole. Then, chlorine atoms are introduced at specific positions in the phenyl ring by means of Fu-gram alkylation reaction or Fu-gram acylation reaction. For example, 4-chloro-3-methoxybromobenzene can be obtained by the reaction of chlorinated reagents with 4-bromoanisole catalyzed by Lewis acid. After reasonable control of the reaction conditions, the chlorine atom can be substituted to the target position, and then 4-chloro-3-methoxybromobenzene can be obtained. This route has a wide range of raw materials, but the Fu-gram reaction may produce a variety of position isomers, and high-purity products need to be obtained by optimizing the reaction conditions or subsequent separation methods.
In summary, the common pathways for preparing 4-chloro-3-methoxybromobenzene have their own advantages and disadvantages. The actual synthesis needs to be based on the availability of raw materials, reaction conditions, product purity requirements and many other factors, and the appropriate synthesis route
One is to use phenolic compounds as starting materials. Taking m-methoxyphenol as an example, it is first brominated with bromine. Because the phenolic hydroxyl group is a strong donator group, it belongs to the ortho-para-site group, and the methoxy group is also a donator group, the two affect together, so that the bromine atom mainly replaces the phenolic hydroxyl ortho-site, and 4-bromo-3-methoxyphenol can be prepared. Then, 4-bromo-3-methoxyphenol reacts with chlorinated reagents, such as phosphorus oxychloride (POCl
), etc. The oxygen atoms in the phenolic hydroxyl group will attack the phosphorus oxychloride atoms. After a series of transformations, the hydroxyl group is replaced by the chlorine atom, and the final product is 4-chloro-3-methoxybromobenzene. This path step is relatively simple, and the starting material intermethoxyphenol is relatively easy to obtain. However, the reaction conditions need to be precisely controlled during the bromination reaction to prevent the formation of polybrominated by-products.
The second is to use halogenated benzene derivatives as raw materials. For example, 3-methoxy-4-nitrobromobenzene is selected, and the nitro group is first reduced. Iron powder, hydrochloric acid and other reduction systems can be used to reduce the nitro group to an amino group to obtain 3-methoxy-4-aminobrobenzene. Then, through the diazotization reaction, 3-methoxy-4-aminobrobenzene is reacted with sodium nitrite and hydrochloric acid at low temperature to form a diazonium salt. Finally, the diazonium salt is reacted with a copper salt such as cuprous chloride, and the diazonium group is replaced by a chlorine atom to achieve the preparation of 4-chloro-3-methoxy bromobenzene. Although there are a few more steps in this path, the reaction selectivity of each step is quite high, which can effectively reduce side reactions. However, the diazotization reaction requires strict control of low temperature conditions, and the operation requirements are relatively strict.
The third is to use anisole as the starting material. First, the bromination reaction of anisole is carried out to generate 4-bromoanisole. Then, chlorine atoms are introduced at specific positions in the phenyl ring by means of Fu-gram alkylation reaction or Fu-gram acylation reaction. For example, 4-chloro-3-methoxybromobenzene can be obtained by the reaction of chlorinated reagents with 4-bromoanisole catalyzed by Lewis acid. After reasonable control of the reaction conditions, the chlorine atom can be substituted to the target position, and then 4-chloro-3-methoxybromobenzene can be obtained. This route has a wide range of raw materials, but the Fu-gram reaction may produce a variety of position isomers, and high-purity products need to be obtained by optimizing the reaction conditions or subsequent separation methods.
In summary, the common pathways for preparing 4-chloro-3-methoxybromobenzene have their own advantages and disadvantages. The actual synthesis needs to be based on the availability of raw materials, reaction conditions, product purity requirements and many other factors, and the appropriate synthesis route
What are 4-chloro-3-methoxybromobenzene synthesis methods?
The synthesis method of 4-chloro-3-methoxybromobenzene often follows several paths. First, m-methoxyaniline is used as the starting material. First, m-methoxyaniline is diazotized with hydrochloric acid and sodium nitrite at low temperature to obtain a diazonium salt. Then the diazonium salt is co-heated with the hydrochloric acid solution of cuprous chloride, and the Sandmeier reaction is carried out to replace the diazoyl group with a chlorine atom to obtain m-methoxychlorobenzene. Then the m-methoxychlorobenzene is reacted with bromine under the catalysis of an appropriate catalyst such as iron powder. Because the methoxy group is the ortho-and para-site group, the bromine atom will be mainly substituted in the methoxy ortho-site, so 4-chloro-3-methoxybromo
Second, or it can be started with 3-methoxybenzoic acid. First, 3-methoxybenzoic acid is interacted with phosphorus pentachloride to convert its carboxyl group to an acyl chloride group, resulting in 3-methoxybenzoyl chloride. Then the acyl chloride group is reduced to methyl with a reducing agent such as lithium aluminum hydride to obtain 3-methoxytoluene. After that, 3-methoxytoluene is first reacted with bromine under the catalysis of iron powder, and the bromine atom is substituted in the methyl ortho position to obtain 2-bromo-3-methoxytoluene. Then the product is chlorinated with chlorine gas under suitable conditions, chlorine atoms are introduced at suitable positions, and the target product 4-chloro-3-methoxybromobenzene can be obtained through a series of reactions.
Or from 3-methoxyphenol, it can be brominated with a brominating agent such as bromine carbon tetrachloride solution. Because the phenolic hydroxyl group is a strong ortho and para-site group, the bromine atom is preferentially substituted in the phenolic hydroxyl ortho-site to obtain 2-bromo-3-methoxyphenol. Then the product is reacted with halogenated hydrocarbons such as chloromethane under basic conditions, and the oxygen atom of the phenolic hydroxyl group nucleophilically replaces the halogenated atom in the halogenated hydrocarbon to form a methoxy group, and finally 4-chloro-3-methoxybromobenzene is obtained. All methods have advantages and disadvantages, and the actual synthesis needs to be comprehensively weighed according to factors such as the availability of raw materials, the ease of control of reaction conditions and cost.
Second, or it can be started with 3-methoxybenzoic acid. First, 3-methoxybenzoic acid is interacted with phosphorus pentachloride to convert its carboxyl group to an acyl chloride group, resulting in 3-methoxybenzoyl chloride. Then the acyl chloride group is reduced to methyl with a reducing agent such as lithium aluminum hydride to obtain 3-methoxytoluene. After that, 3-methoxytoluene is first reacted with bromine under the catalysis of iron powder, and the bromine atom is substituted in the methyl ortho position to obtain 2-bromo-3-methoxytoluene. Then the product is chlorinated with chlorine gas under suitable conditions, chlorine atoms are introduced at suitable positions, and the target product 4-chloro-3-methoxybromobenzene can be obtained through a series of reactions.
Or from 3-methoxyphenol, it can be brominated with a brominating agent such as bromine carbon tetrachloride solution. Because the phenolic hydroxyl group is a strong ortho and para-site group, the bromine atom is preferentially substituted in the phenolic hydroxyl ortho-site to obtain 2-bromo-3-methoxyphenol. Then the product is reacted with halogenated hydrocarbons such as chloromethane under basic conditions, and the oxygen atom of the phenolic hydroxyl group nucleophilically replaces the halogenated atom in the halogenated hydrocarbon to form a methoxy group, and finally 4-chloro-3-methoxybromobenzene is obtained. All methods have advantages and disadvantages, and the actual synthesis needs to be comprehensively weighed according to factors such as the availability of raw materials, the ease of control of reaction conditions and cost.
4-chloro-3-methoxybromobenzene What are the precautions during storage and transportation?
4-Chloro-3-methoxybromobenzene is an organic compound. When storing and transporting, you must pay attention to the following things:
First, when storing, store it in a cool, dry and well-ventilated place. This is because the compound may be sensitive to heat and moisture, and high temperature and humidity may cause it to deteriorate and damage quality and purity. Therefore, the warehouse temperature should be controlled within a suitable range, and the humidity should also be maintained within a reasonable range, so as to ensure the stability of the material.
Second, because it has a certain chemical activity, it needs to be stored separately from oxidants, acids, bases and other substances when storing. When these substances meet 4-chloro-3-methoxybromobenzene, they can easily cause chemical reactions, or cause serious consequences such as combustion and explosion. Therefore, in the storage layout, it must be strictly separated to prevent accidents.
Third, during transportation, the packaging must be tight and firm. It is necessary to choose packaging materials that meet relevant standards to ensure that the packaging will not be damaged and leaked under bumps, vibrations, etc. Warning labels should be clearly marked on the outside of the package, so that the transporter can clearly understand its characteristics and potential dangers, and pay more attention during operation.
Fourth, the transportation tool must also be clean and dry, without other chemical residues. If the means of transportation are unclean, residual substances or interact with 4-chloro-3-methoxybromobenzene, which will affect the quality of the product. At the same time, avoid high temperature environment during transportation. For example, during the high temperature period in summer, the itinerary should be reasonably arranged to avoid long-term exposure to the sun.
Fifth, whether it is storage or transportation, relevant operators should receive professional training and be familiar with the characteristics, hazards and emergency treatment methods of 4-chloro-3-methoxybromobenzene. In the event of an accident such as leakage, the operator can quickly and properly dispose of it to minimize losses and hazards.
First, when storing, store it in a cool, dry and well-ventilated place. This is because the compound may be sensitive to heat and moisture, and high temperature and humidity may cause it to deteriorate and damage quality and purity. Therefore, the warehouse temperature should be controlled within a suitable range, and the humidity should also be maintained within a reasonable range, so as to ensure the stability of the material.
Second, because it has a certain chemical activity, it needs to be stored separately from oxidants, acids, bases and other substances when storing. When these substances meet 4-chloro-3-methoxybromobenzene, they can easily cause chemical reactions, or cause serious consequences such as combustion and explosion. Therefore, in the storage layout, it must be strictly separated to prevent accidents.
Third, during transportation, the packaging must be tight and firm. It is necessary to choose packaging materials that meet relevant standards to ensure that the packaging will not be damaged and leaked under bumps, vibrations, etc. Warning labels should be clearly marked on the outside of the package, so that the transporter can clearly understand its characteristics and potential dangers, and pay more attention during operation.
Fourth, the transportation tool must also be clean and dry, without other chemical residues. If the means of transportation are unclean, residual substances or interact with 4-chloro-3-methoxybromobenzene, which will affect the quality of the product. At the same time, avoid high temperature environment during transportation. For example, during the high temperature period in summer, the itinerary should be reasonably arranged to avoid long-term exposure to the sun.
Fifth, whether it is storage or transportation, relevant operators should receive professional training and be familiar with the characteristics, hazards and emergency treatment methods of 4-chloro-3-methoxybromobenzene. In the event of an accident such as leakage, the operator can quickly and properly dispose of it to minimize losses and hazards.
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