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4-Chloro-3-Methylbenzene-1,2-Diamine Hydrochloride
Linshang Chemical
|
HS Code |
137222 |
| Chemical Formula | C7H10ClN2·HCl |
| Molecular Weight | 209.08 |
| Appearance | Solid |
| Color | Typically white to off - white |
| Odor | May have a characteristic amine - like odor |
| Solubility In Water | Soluble to some extent |
| Solubility In Organic Solvents | Soluble in certain polar organic solvents |
| Melting Point | Specific value would require further literature search |
| Pka | Values related to amine groups would be relevant and require specific data sources |
| Stability | Stable under normal storage conditions away from strong oxidizing agents |
As an accredited 4-Chloro-3-Methylbenzene-1,2-Diamine Hydrochloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 4 - chloro - 3 - methylbenzene - 1,2 - diamine Hydrochloride in a sealed plastic bag. |
| Storage | 4 - chloro - 3 - methylbenzene - 1,2 - diamine Hydrochloride should be stored in a cool, dry place, away from direct sunlight and heat sources. Keep it in a tightly - sealed container to prevent moisture absorption and exposure to air, which could lead to degradation. Store it separately from incompatible substances like strong oxidizing agents to avoid potential chemical reactions. |
| Shipping | 4 - chloro - 3 - methylbenzene - 1,2 - diamine Hydrochloride is shipped in sealed, corrosion - resistant containers. Compliance with hazardous chemical shipping regulations ensures safe transportation to prevent spills and environmental or safety risks. |
Competitive 4-Chloro-3-Methylbenzene-1,2-Diamine Hydrochloride prices that fit your budget—flexible terms and customized quotes for every order.
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4-chloro-3-methylbenzene-1, what are the chemical properties of 2-diamine Hydrochloride?
4-Chloro-3-methylbenzene-1,2-diamine hydrochloride, this is an organic compound. Its chemical properties are unique, let me tell you in detail.
First of all, looking at its structure, there are chlorine atoms, methyl groups and two amino groups attached to the benzene ring, and it forms a hydrochloride state. This structure gives it many characteristics. In terms of acidity and alkalinity, due to hydrochloride, hydrogen ions can be dissociated in water, so it is acidic.
In terms of solubility, generally speaking, it can have a certain solubility in polar solvents such as water. Due to the ionic characteristics of hydrochloride, it is easy to interact with water molecules.
Furthermore, its amino group has a certain reactivity. It can participate in many reactions, such as acylation with acid anhydride, acyl chloride, etc., and the hydrogen atom of the amino group is replaced by an acyl group to form the corresponding amide compound.
Chlorine atoms are not "idle", and under appropriate conditions, nucleophilic substitution reactions can occur. For example, when reacting with nucleophilic reagents such as sodium alcohol and sodium phenol, the chlorine atom can be replaced by the corresponding alkoxy group and phenoxy group.
Although the methyl group is relatively stable, it may also be oxidized under certain strong oxidation conditions, such as under the action of strong oxidizing agents, it can be converted into functional groups such as carboxyl groups. The chemical properties of this compound are rich and diverse, and it has important uses in organic synthesis and other fields. It can provide key raw materials and intermediates for the preparation of many organic compounds.
First of all, looking at its structure, there are chlorine atoms, methyl groups and two amino groups attached to the benzene ring, and it forms a hydrochloride state. This structure gives it many characteristics. In terms of acidity and alkalinity, due to hydrochloride, hydrogen ions can be dissociated in water, so it is acidic.
In terms of solubility, generally speaking, it can have a certain solubility in polar solvents such as water. Due to the ionic characteristics of hydrochloride, it is easy to interact with water molecules.
Furthermore, its amino group has a certain reactivity. It can participate in many reactions, such as acylation with acid anhydride, acyl chloride, etc., and the hydrogen atom of the amino group is replaced by an acyl group to form the corresponding amide compound.
Chlorine atoms are not "idle", and under appropriate conditions, nucleophilic substitution reactions can occur. For example, when reacting with nucleophilic reagents such as sodium alcohol and sodium phenol, the chlorine atom can be replaced by the corresponding alkoxy group and phenoxy group.
Although the methyl group is relatively stable, it may also be oxidized under certain strong oxidation conditions, such as under the action of strong oxidizing agents, it can be converted into functional groups such as carboxyl groups. The chemical properties of this compound are rich and diverse, and it has important uses in organic synthesis and other fields. It can provide key raw materials and intermediates for the preparation of many organic compounds.
4-chloro-3-methylbenzene-1, What are the uses of 2-diamine Hydrochloride
4-Chloro-3-methylbenzene-1,2-diamine hydrochloride, an organic compound, is widely used in chemical and scientific research fields.
First, in the synthesis of dyes, this compound is a key intermediate. Through a series of chemical reactions, it can be cleverly combined with other reagents to construct complex dye molecules. Due to the characteristics of benzene ring and amine group, it can endow dyes with unique color and good dyeing properties. It is widely used in textile, printing and dyeing industries to make fabrics show brilliant colors.
Second, it is also of great value in the field of medicinal chemistry. Due to the presence of chlorine atoms, methyl and amine groups in its structure, it provides a unique chemical environment for drug design. Scientists can use this to modify and modify its structure to synthesize compounds with specific pharmacological activities, which is expected to develop new drugs for the treatment of diseases.
Third, in the field of materials science, it can be used as a raw material for the synthesis of functional materials. After special reactions, it can be introduced into polymer materials to impart special properties such as antioxidant and antibacterial properties to the materials, so that it can be used in food packaging, biomedical materials and other fields to improve material properties and application value.
In addition, in organic synthetic chemistry research, 4-chloro-3-methylbenzene-1,2-diamine hydrochloride is often used as a starting material or reaction reagent. Due to its unique structure, it can participate in a variety of organic reactions, such as nucleophilic substitution, coupling reactions, etc., assisting researchers in the synthesis of various complex organic compounds and contributing to the development of organic synthesis methodologies.
First, in the synthesis of dyes, this compound is a key intermediate. Through a series of chemical reactions, it can be cleverly combined with other reagents to construct complex dye molecules. Due to the characteristics of benzene ring and amine group, it can endow dyes with unique color and good dyeing properties. It is widely used in textile, printing and dyeing industries to make fabrics show brilliant colors.
Second, it is also of great value in the field of medicinal chemistry. Due to the presence of chlorine atoms, methyl and amine groups in its structure, it provides a unique chemical environment for drug design. Scientists can use this to modify and modify its structure to synthesize compounds with specific pharmacological activities, which is expected to develop new drugs for the treatment of diseases.
Third, in the field of materials science, it can be used as a raw material for the synthesis of functional materials. After special reactions, it can be introduced into polymer materials to impart special properties such as antioxidant and antibacterial properties to the materials, so that it can be used in food packaging, biomedical materials and other fields to improve material properties and application value.
In addition, in organic synthetic chemistry research, 4-chloro-3-methylbenzene-1,2-diamine hydrochloride is often used as a starting material or reaction reagent. Due to its unique structure, it can participate in a variety of organic reactions, such as nucleophilic substitution, coupling reactions, etc., assisting researchers in the synthesis of various complex organic compounds and contributing to the development of organic synthesis methodologies.
4-chloro-3-methylbenzene-1, what is the synthesis method of 2-diamine Hydrochloride?
To prepare 4-chloro-3-methylbenzene-1,2-diamine hydrochloride, the following method is often followed.
Choose 4-chloro-3-methylphthalonitrile as the starting material. First dissolve 4-chloro-3-methylphthalonitrile in a suitable solvent, such as ethanol, dioxane, etc., to create a reaction environment.
Then, add an appropriate amount of reducing agent, such as lithium aluminum hydride (LiAlH). Lithium aluminum hydride has strong reducing properties. In this reaction, nitrile groups (-CN) can be reduced to amino groups (-NH2O). This step requires careful temperature control. Generally, it starts at a low temperature, such as between 0 ° C and 5 ° C, and then gradually heats up to room temperature or moderate heating to promote a smooth and sufficient reaction. At the time of the reaction, pay close attention to the reaction process, which can be monitored by thin-layer chromatography (TLC). When the raw material point disappears or reaches the expected reaction level, the reaction is stopped.
After the reaction is completed, the excess lithium aluminum hydride and the reaction intermediate are decomposed through the hydrolysis step. Dilute acids, such as dilute hydrochloric acid, are commonly used for hydrolysis, and are slowly added dropwise to control the reaction gently and avoid sudden violent reactions. After this, 4-chloro-3-methylbenzene-1,2-diamine can be obtained.
Finally, dissolve 4-chloro-3-methylbenzene-1,2-diamine in an appropriate amount of organic solvent, such as ether and dichloromethane, slowly introduce hydrogen chloride gas or add a suitable concentration of hydrochloric acid solution to make the amine group a salt, that is, 4-chloro-3-methylbenzene-1,2-diamine hydrochloride. After that, after cooling, crystallization, filtration, drying, etc., a purified product can be obtained.
Or start from 4-chloro-3-methyl o-nitrotoluene. First, by means of a suitable nitrifying agent, such as a mixed acid of concentrated nitric acid and concentrated sulfuric acid, under specific conditions, the methyl ortho-position is introduced into the nitro group to obtain 4-chloro-3-methyl-1,2-dinitrobenzene.
Then, the nitro group is reduced to an amino group using a metal and acid system, such as iron and hydrochloric acid, or under catalytic hydrogenation conditions, such as palladium carbon as a catalyst and hydrogen as a reducing agent, 4-chloro-3-methylbenzene-1,2-diamine can also be obtained. The subsequent salt-forming steps are the same as before, and 4-chloro-3-methylbenzene-1,2-diamine hydrochloride is finally obtained.
Choose 4-chloro-3-methylphthalonitrile as the starting material. First dissolve 4-chloro-3-methylphthalonitrile in a suitable solvent, such as ethanol, dioxane, etc., to create a reaction environment.
Then, add an appropriate amount of reducing agent, such as lithium aluminum hydride (LiAlH). Lithium aluminum hydride has strong reducing properties. In this reaction, nitrile groups (-CN) can be reduced to amino groups (-NH2O). This step requires careful temperature control. Generally, it starts at a low temperature, such as between 0 ° C and 5 ° C, and then gradually heats up to room temperature or moderate heating to promote a smooth and sufficient reaction. At the time of the reaction, pay close attention to the reaction process, which can be monitored by thin-layer chromatography (TLC). When the raw material point disappears or reaches the expected reaction level, the reaction is stopped.
After the reaction is completed, the excess lithium aluminum hydride and the reaction intermediate are decomposed through the hydrolysis step. Dilute acids, such as dilute hydrochloric acid, are commonly used for hydrolysis, and are slowly added dropwise to control the reaction gently and avoid sudden violent reactions. After this, 4-chloro-3-methylbenzene-1,2-diamine can be obtained.
Finally, dissolve 4-chloro-3-methylbenzene-1,2-diamine in an appropriate amount of organic solvent, such as ether and dichloromethane, slowly introduce hydrogen chloride gas or add a suitable concentration of hydrochloric acid solution to make the amine group a salt, that is, 4-chloro-3-methylbenzene-1,2-diamine hydrochloride. After that, after cooling, crystallization, filtration, drying, etc., a purified product can be obtained.
Or start from 4-chloro-3-methyl o-nitrotoluene. First, by means of a suitable nitrifying agent, such as a mixed acid of concentrated nitric acid and concentrated sulfuric acid, under specific conditions, the methyl ortho-position is introduced into the nitro group to obtain 4-chloro-3-methyl-1,2-dinitrobenzene.
Then, the nitro group is reduced to an amino group using a metal and acid system, such as iron and hydrochloric acid, or under catalytic hydrogenation conditions, such as palladium carbon as a catalyst and hydrogen as a reducing agent, 4-chloro-3-methylbenzene-1,2-diamine can also be obtained. The subsequent salt-forming steps are the same as before, and 4-chloro-3-methylbenzene-1,2-diamine hydrochloride is finally obtained.
4-chloro-3-methylbenzene-1, 2-diamine Hydrochloride What to pay attention to when storing
4-Chloro-3-methylbenzene-1,2-diamine hydrochloride is a chemical substance. When storing, many things need to be paid attention to.
First, it concerns the environment. This substance should be stored in a cool, dry and well-ventilated place. Due to high temperature, or its chemical properties change, it accelerates decomposition and deterioration; and excessive humidity, or causes moisture decomposition, which affects its purity and quality. In addition, if the ventilation is poor, if the substance volatilizes some harmful gases, it will accumulate and not disperse, which is unfavorable to the storage environment and poses a safety hazard.
Second, the packaging must be tight. Because of its certain chemical activity, if the packaging is not strict, it is easy to react with oxygen, carbon dioxide and other components in the air. If oxygen or cause oxidation, carbon dioxide or react with it to change its chemical structure, thereby affecting its quality and performance. Therefore, the packaging material also needs to be adapted, and it should be selected to effectively block the intrusion of external substances.
Furthermore, it should be stored in isolation from other chemical substances. 4-chloro-3-methylbenzene-1,2-diamine hydrochloride may react violently with certain oxidants, acids, bases, etc., and even cause explosions, combustion and other hazards. Therefore, when storing, it must be strictly classified according to the nature of chemical substances to avoid mixing.
In addition, the storage area should be clearly marked. Label the name, characteristics, hazards and emergency treatment of the substance. In this way, in the event of an accident, the staff can quickly know the situation and take appropriate response measures to reduce the harm. At the same time, the storage site should also be equipped with corresponding safety facilities and emergency rescue equipment, such as fire extinguishers, eye washers, protective gear, etc., for emergencies.
In short, when 4-chloro-3-methylbenzene-1,2-diamine hydrochloride is stored, the environment, packaging, isolation, labeling and safety facilities should not be ignored, so as to ensure its storage safety and maintain good quality.
First, it concerns the environment. This substance should be stored in a cool, dry and well-ventilated place. Due to high temperature, or its chemical properties change, it accelerates decomposition and deterioration; and excessive humidity, or causes moisture decomposition, which affects its purity and quality. In addition, if the ventilation is poor, if the substance volatilizes some harmful gases, it will accumulate and not disperse, which is unfavorable to the storage environment and poses a safety hazard.
Second, the packaging must be tight. Because of its certain chemical activity, if the packaging is not strict, it is easy to react with oxygen, carbon dioxide and other components in the air. If oxygen or cause oxidation, carbon dioxide or react with it to change its chemical structure, thereby affecting its quality and performance. Therefore, the packaging material also needs to be adapted, and it should be selected to effectively block the intrusion of external substances.
Furthermore, it should be stored in isolation from other chemical substances. 4-chloro-3-methylbenzene-1,2-diamine hydrochloride may react violently with certain oxidants, acids, bases, etc., and even cause explosions, combustion and other hazards. Therefore, when storing, it must be strictly classified according to the nature of chemical substances to avoid mixing.
In addition, the storage area should be clearly marked. Label the name, characteristics, hazards and emergency treatment of the substance. In this way, in the event of an accident, the staff can quickly know the situation and take appropriate response measures to reduce the harm. At the same time, the storage site should also be equipped with corresponding safety facilities and emergency rescue equipment, such as fire extinguishers, eye washers, protective gear, etc., for emergencies.
In short, when 4-chloro-3-methylbenzene-1,2-diamine hydrochloride is stored, the environment, packaging, isolation, labeling and safety facilities should not be ignored, so as to ensure its storage safety and maintain good quality.
4-chloro-3-methylbenzene-1, what is the environmental impact of 2-diamine Hydrochloride
4-Chloro-3-methylbenzene-1,2-diamine hydrochloride, the impact of this substance on the environment cannot be ignored.
Its chemical properties are active. If it accidentally flows into the water body, or the water quality deteriorates. Aquatic organisms depend on water for growth and water quality changes, their survival is worrying. This compound may interfere with the physiological functions of aquatic organisms, affect their reproduction and growth, and cause changes in population numbers.
In the soil environment, if it remains in it, it may change the chemical composition and properties of the soil. Soil microbial communities depend on suitable environments for survival. The intervention of this substance may destroy its ecological balance, affect the nutrient cycle and material transformation of the soil, and then affect plant growth. Plant roots ingest nutrients from the soil, the soil is polluted, plants or stunted, and the yield and quality of agricultural products are also implicated.
And if it evaporates into the atmosphere, it will affect air quality. Humans breathe air, and this harmful substance enters the human body, or damages the respiratory system and other organs, endangering human health. Furthermore, this substance may participate in photochemical reactions in the atmosphere, generating other harmful pollutants and further deteriorating the environment.
Therefore, for 4-chloro-3-methylbenzene-1,2-diamine hydrochloride, care must be taken in the production, use and disposal to prevent it from causing irreparable damage to the environment.
Its chemical properties are active. If it accidentally flows into the water body, or the water quality deteriorates. Aquatic organisms depend on water for growth and water quality changes, their survival is worrying. This compound may interfere with the physiological functions of aquatic organisms, affect their reproduction and growth, and cause changes in population numbers.
In the soil environment, if it remains in it, it may change the chemical composition and properties of the soil. Soil microbial communities depend on suitable environments for survival. The intervention of this substance may destroy its ecological balance, affect the nutrient cycle and material transformation of the soil, and then affect plant growth. Plant roots ingest nutrients from the soil, the soil is polluted, plants or stunted, and the yield and quality of agricultural products are also implicated.
And if it evaporates into the atmosphere, it will affect air quality. Humans breathe air, and this harmful substance enters the human body, or damages the respiratory system and other organs, endangering human health. Furthermore, this substance may participate in photochemical reactions in the atmosphere, generating other harmful pollutants and further deteriorating the environment.
Therefore, for 4-chloro-3-methylbenzene-1,2-diamine hydrochloride, care must be taken in the production, use and disposal to prevent it from causing irreparable damage to the environment.
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