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4-Chloro-3-Nitrobenzene-1-Sulfonyl Chloride
Linshang Chemical
|
HS Code |
686811 |
| Name | 4-Chloro-3-Nitrobenzene-1-Sulfonyl Chloride |
| Molecular Formula | C6H3Cl2NO4S |
| Molecular Weight | 256.06 g/mol |
| Appearance | Yellow to brown solid |
| Melting Point | 74 - 78 °C |
| Boiling Point | Decomposes |
| Solubility In Water | Reacts with water |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane |
| Density | Approx. 1.78 g/cm³ |
| Flash Point | Non - applicable (decomposes) |
| Purity | Typically available in high purity grades (e.g., 95%+) |
As an accredited 4-Chloro-3-Nitrobenzene-1-Sulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 4 - chloro - 3 - nitrobenzene - 1 - sulfonyl chloride in sealed, corrosion - resistant container. |
| Storage | 4 - chloro - 3 - nitrobenzene - 1 - sulfonyl chloride should be stored in a cool, dry, well - ventilated area, away from heat and ignition sources. Keep it in a tightly closed container, preferably made of corrosion - resistant materials due to its reactive nature. Store it separately from incompatible substances like bases, reducing agents, and water to prevent dangerous reactions. |
| Shipping | 4 - chloro - 3 - nitrobenzene - 1 - sulfonyl chloride is a chemical. It should be shipped in well - sealed, corrosion - resistant containers. Follow strict hazardous materials shipping regulations to ensure safe transport and prevent spills. |
Competitive 4-Chloro-3-Nitrobenzene-1-Sulfonyl Chloride prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 4-Chloro-3-Nitrobenzene-1-Sulfonyl Chloride in China?
As a trusted 4-Chloro-3-Nitrobenzene-1-Sulfonyl Chloride manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 4-Chloro-3-Nitrobenzene-1-Sulfonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 4-chloro-3-nitrobenzene-1-sulfonyl Chloride?
4-Chloro-3-nitrobenzene-1-sulfonyl chloride, which has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. Due to its active chlorine atoms and sulfonyl chloride groups in the molecule, it can participate in a variety of chemical reactions, and many complex organic compounds can be constructed through substitution, condensation and other steps.
In the field of pharmaceutical chemistry, with the help of its chemical activity, it can synthesize drug molecules with specific structures, or it can be used to introduce specific functional groups to improve the physicochemical properties and biological activities of drugs, such as improving drug solubility, stability or targeting.
In the field of materials science, it also has important uses. Polymer materials can be chemically reacted to impart special properties to the material, such as improving the corrosion resistance and thermal stability of the material, or introducing specific functions to meet the needs of special application scenarios.
In dye synthesis, 4-chloro-3-nitrobenzene-1-sulfonyl chloride can be used as an important raw material to participate in the construction of dye molecular structures with specific colors and properties, and to adjust the color light, fastness and other properties of dyes to suit different dyeing processes and application requirements.
In the fine chemical industry, as an important starting material for the synthesis of a variety of fine chemicals, a series of high-value-added products can be derived, which are widely used in coatings, fragrances, additives, and many other fields. It plays a key role in promoting the development of the fine chemical industry.
In the field of pharmaceutical chemistry, with the help of its chemical activity, it can synthesize drug molecules with specific structures, or it can be used to introduce specific functional groups to improve the physicochemical properties and biological activities of drugs, such as improving drug solubility, stability or targeting.
In the field of materials science, it also has important uses. Polymer materials can be chemically reacted to impart special properties to the material, such as improving the corrosion resistance and thermal stability of the material, or introducing specific functions to meet the needs of special application scenarios.
In dye synthesis, 4-chloro-3-nitrobenzene-1-sulfonyl chloride can be used as an important raw material to participate in the construction of dye molecular structures with specific colors and properties, and to adjust the color light, fastness and other properties of dyes to suit different dyeing processes and application requirements.
In the fine chemical industry, as an important starting material for the synthesis of a variety of fine chemicals, a series of high-value-added products can be derived, which are widely used in coatings, fragrances, additives, and many other fields. It plays a key role in promoting the development of the fine chemical industry.
What are the synthesis methods of 4-chloro-3-nitrobenzene-1-sulfonyl Chloride?
The synthesis method of 4-chloro-3-nitrobenzene-1-sulfonyl chloride has been around for a long time. Its methods are diverse and each has its own advantages. The following are the main methods.
One of them can be started from the corresponding aromatic hydrocarbon. First, take a suitable benzene derivative, use a chlorinated reagent, such as chlorine gas, and carry out a chlorination reaction under a suitable catalyst, such as ferric chloride, to introduce chlorine atoms at a specific position in the benzene ring. This process requires temperature control and pressure control to make the reaction proceed smoothly to obtain chlorinated aromatics. After that, a mixed acid (a mixture of nitric acid and sulfuric acid) is used for nitrification to skillfully guide the nitro group into the predetermined position to form 4-chloro-3-nitroaromatics. Finally, 4-chloro-3-nitrobenzene-1-sulfonyl chloride can be obtained by using strong sulfonating reagents, such as fuming sulfuric acid or chlorosulfonic acid, under suitable conditions.
Second, other sulfur-containing compounds are also used as starting materials. For example, a compound containing sulfur and with specific substituents is selected, and the phenyl ring structure is gradually constructed through a series of reactions, and chlorine, nitro and sulfonyl chloride groups are introduced at the same time. This path requires precise control of the conditions of each step of the reaction, such as the choice of reaction solvent, the length of reaction time, and the proportion of reactants. With a slight difference, it is difficult to achieve the expected product.
Furthermore, there is a method that involves the reaction of organometallic reagents. Using the unique activity of organometallic reagents, cross-coupling with halogen-containing, nitro-containing and sulfur-containing related substrates, and multi-step transformation, the synthesis of 4-chloro-3-nitrobenzene-1-sulfonyl chloride is completed. Although this approach is innovative, it requires strict reaction conditions and needs to be operated in special environments such as anhydrous and anaerobic, and organic metal reagents are expensive and costly.
All these synthesis methods have their own advantages and disadvantages. It is necessary to choose carefully according to actual needs, such as product purity, cost, reaction difficulty, etc., in order to synthesize 4-chloro-3-nitrobenzene-1-sulfonyl chloride efficiently and with high quality.
One of them can be started from the corresponding aromatic hydrocarbon. First, take a suitable benzene derivative, use a chlorinated reagent, such as chlorine gas, and carry out a chlorination reaction under a suitable catalyst, such as ferric chloride, to introduce chlorine atoms at a specific position in the benzene ring. This process requires temperature control and pressure control to make the reaction proceed smoothly to obtain chlorinated aromatics. After that, a mixed acid (a mixture of nitric acid and sulfuric acid) is used for nitrification to skillfully guide the nitro group into the predetermined position to form 4-chloro-3-nitroaromatics. Finally, 4-chloro-3-nitrobenzene-1-sulfonyl chloride can be obtained by using strong sulfonating reagents, such as fuming sulfuric acid or chlorosulfonic acid, under suitable conditions.
Second, other sulfur-containing compounds are also used as starting materials. For example, a compound containing sulfur and with specific substituents is selected, and the phenyl ring structure is gradually constructed through a series of reactions, and chlorine, nitro and sulfonyl chloride groups are introduced at the same time. This path requires precise control of the conditions of each step of the reaction, such as the choice of reaction solvent, the length of reaction time, and the proportion of reactants. With a slight difference, it is difficult to achieve the expected product.
Furthermore, there is a method that involves the reaction of organometallic reagents. Using the unique activity of organometallic reagents, cross-coupling with halogen-containing, nitro-containing and sulfur-containing related substrates, and multi-step transformation, the synthesis of 4-chloro-3-nitrobenzene-1-sulfonyl chloride is completed. Although this approach is innovative, it requires strict reaction conditions and needs to be operated in special environments such as anhydrous and anaerobic, and organic metal reagents are expensive and costly.
All these synthesis methods have their own advantages and disadvantages. It is necessary to choose carefully according to actual needs, such as product purity, cost, reaction difficulty, etc., in order to synthesize 4-chloro-3-nitrobenzene-1-sulfonyl chloride efficiently and with high quality.
What are the physical properties of 4-chloro-3-nitrobenzene-1-sulfonyl Chloride?
4-Chloro-3-nitrobenzene-1-sulfonyl chloride is an important compound in organic chemistry. Its physical properties are unique and it has a wide range of uses in scientific research and industry.
Looking at its properties, it is mostly white to light yellow crystalline powder under normal conditions, which is convenient for preliminary identification. The melting point is also a key physical property, which is about a specific temperature range. This property is of great significance to its state control under different reaction conditions. If the temperature is lower than the melting point, it is in a solid state and has a stable structure; if it is close to or higher than the melting point, it gradually melts into a liquid state, and the active level of molecules increases, which is conducive to participating in various chemical reactions.
Furthermore, 4-chloro-3-nitrobenzene-1-sulfonyl chloride has a certain solubility. In organic solvents, such as common aromatic hydrocarbons and halogenated hydrocarbon solvents, it exhibits good solubility. This solubility facilitates its use as a reactant or intermediate in organic synthesis reactions. In the reaction system, it can be evenly dispersed in solvents and fully contacted with other reactants to accelerate the reaction process and improve the reaction efficiency.
In addition, the compound has hygroscopicity. In a humid environment, it is easy to absorb moisture in the air, causing its physical properties to change and even affecting chemical stability. Therefore, it needs to be stored in a dry environment to prevent deterioration.
The physical properties of 4-chloro-3-nitrobenzene-1-sulfonyl chloride, such as appearance, melting point, solubility, and hygroscopicity, have a key impact on its storage, transportation, and application in organic synthesis. Only by fully understanding and making rational use of these properties can it play a greater role in related fields.
Looking at its properties, it is mostly white to light yellow crystalline powder under normal conditions, which is convenient for preliminary identification. The melting point is also a key physical property, which is about a specific temperature range. This property is of great significance to its state control under different reaction conditions. If the temperature is lower than the melting point, it is in a solid state and has a stable structure; if it is close to or higher than the melting point, it gradually melts into a liquid state, and the active level of molecules increases, which is conducive to participating in various chemical reactions.
Furthermore, 4-chloro-3-nitrobenzene-1-sulfonyl chloride has a certain solubility. In organic solvents, such as common aromatic hydrocarbons and halogenated hydrocarbon solvents, it exhibits good solubility. This solubility facilitates its use as a reactant or intermediate in organic synthesis reactions. In the reaction system, it can be evenly dispersed in solvents and fully contacted with other reactants to accelerate the reaction process and improve the reaction efficiency.
In addition, the compound has hygroscopicity. In a humid environment, it is easy to absorb moisture in the air, causing its physical properties to change and even affecting chemical stability. Therefore, it needs to be stored in a dry environment to prevent deterioration.
The physical properties of 4-chloro-3-nitrobenzene-1-sulfonyl chloride, such as appearance, melting point, solubility, and hygroscopicity, have a key impact on its storage, transportation, and application in organic synthesis. Only by fully understanding and making rational use of these properties can it play a greater role in related fields.
What are the precautions for 4-chloro-3-nitrobenzene-1-sulfonyl Chloride in storage and transportation?
4-Chloro-3-nitrobenzene-1-sulfonyl chloride is a chemical substance, and many matters need to be paid attention to during storage and transportation.
First word storage. This material is very active and easy to react in case of moisture, so it must be stored in a dry place, and the humidity of the warehouse should be controlled within a specific range to prevent it from being deteriorated by moisture. In addition, it is corrosive and toxic. When stored in isolation from other substances, such as flammable, explosive, and oxidizing substances, it should not be coexisted in the same room to avoid accidental changes. At the same time, the warehouse temperature must also be suitable, not too high, to prevent reactions such as decomposition. And it should be clearly marked, indicating its characteristics, danger warnings, etc., for easy access and management.
As for transportation. The transporter must be familiar with the nature and hazards of this object, and have the corresponding protection and emergency response capabilities. The transportation equipment must be kept tight to prevent its leakage. Avoid bumps and vibrations on the way to prevent package damage. If it is a long-distance transportation, it is necessary to regularly check the condition of the package. The transportation environment should also be kept dry, cool, and away from fire and heat sources. In the event of a leak, it must be dealt with immediately according to the established emergency plan to evacuate the crowd and avoid the spread of pollution. The transportation documentation must be detailed, with information such as quantity, start and end point, for traceability.
All of these are for the storage and transportation of 4-chloro-3-nitrobenzene-1-sulfonyl chloride.
First word storage. This material is very active and easy to react in case of moisture, so it must be stored in a dry place, and the humidity of the warehouse should be controlled within a specific range to prevent it from being deteriorated by moisture. In addition, it is corrosive and toxic. When stored in isolation from other substances, such as flammable, explosive, and oxidizing substances, it should not be coexisted in the same room to avoid accidental changes. At the same time, the warehouse temperature must also be suitable, not too high, to prevent reactions such as decomposition. And it should be clearly marked, indicating its characteristics, danger warnings, etc., for easy access and management.
As for transportation. The transporter must be familiar with the nature and hazards of this object, and have the corresponding protection and emergency response capabilities. The transportation equipment must be kept tight to prevent its leakage. Avoid bumps and vibrations on the way to prevent package damage. If it is a long-distance transportation, it is necessary to regularly check the condition of the package. The transportation environment should also be kept dry, cool, and away from fire and heat sources. In the event of a leak, it must be dealt with immediately according to the established emergency plan to evacuate the crowd and avoid the spread of pollution. The transportation documentation must be detailed, with information such as quantity, start and end point, for traceability.
All of these are for the storage and transportation of 4-chloro-3-nitrobenzene-1-sulfonyl chloride.
4-chloro-3-nitrobenzene-1-sulfonyl Chloride Effects on the Environment and Human Body
4-Chloro-3-nitrobenzene-1-sulfonyl chloride, this material is strong and toxic, causing serious harm to the environment and human beings.
In terms of the environment, it enters the natural environment and is difficult to degrade and persists for a long time. If it reaches the soil, it can cause soil quality to deteriorate, hinder the uptake of nutrients and water by plant roots, hinder the growth of vegetation, or cause species diversity to be impaired. It flows into the water body, poisons the water quality, and aquatic organisms such as fish, shrimp, shellfish, etc. After contact or ingestion, physiological functions are disrupted, and even death, disrupting the aquatic ecological balance. And it can be enriched through the food chain, and the low-level organisms are enriched in trace amounts. It is passed through the layers, and the internal accumulation in high-level organisms increases sharply, and the harm is more extensive.
It is also harmful to the human body. It enters the body through the respiratory tract and irritates the mucosa of the respiratory tract, causing cough, asthma, breathing difficulties, and long-term exposure or increasing the risk of respiratory diseases such as asthma and lung cancer. If it is exposed to the skin, it is highly corrosive and can burn the skin, cause redness, swelling, pain, ulceration, improper handling or scarring and cause infection. Accidentally ingested, it can damage the digestive tract, cause nausea, vomiting, abdominal pain, diarrhea, and even life-threatening. In addition, it may be potentially carcinogenic, teratogenic, mutagenic, affect genetic materials, damage the reproductive system, and have serious adverse effects on fetal development. Therefore, such dangerous chemicals should be treated with extreme caution, and strict procedures should be followed from production, transportation to use and disposal to prevent their release from harming the environment and human body.
In terms of the environment, it enters the natural environment and is difficult to degrade and persists for a long time. If it reaches the soil, it can cause soil quality to deteriorate, hinder the uptake of nutrients and water by plant roots, hinder the growth of vegetation, or cause species diversity to be impaired. It flows into the water body, poisons the water quality, and aquatic organisms such as fish, shrimp, shellfish, etc. After contact or ingestion, physiological functions are disrupted, and even death, disrupting the aquatic ecological balance. And it can be enriched through the food chain, and the low-level organisms are enriched in trace amounts. It is passed through the layers, and the internal accumulation in high-level organisms increases sharply, and the harm is more extensive.
It is also harmful to the human body. It enters the body through the respiratory tract and irritates the mucosa of the respiratory tract, causing cough, asthma, breathing difficulties, and long-term exposure or increasing the risk of respiratory diseases such as asthma and lung cancer. If it is exposed to the skin, it is highly corrosive and can burn the skin, cause redness, swelling, pain, ulceration, improper handling or scarring and cause infection. Accidentally ingested, it can damage the digestive tract, cause nausea, vomiting, abdominal pain, diarrhea, and even life-threatening. In addition, it may be potentially carcinogenic, teratogenic, mutagenic, affect genetic materials, damage the reproductive system, and have serious adverse effects on fetal development. Therefore, such dangerous chemicals should be treated with extreme caution, and strict procedures should be followed from production, transportation to use and disposal to prevent their release from harming the environment and human body.
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