Linshang Chemical
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4-Chloro-3-Nitrobenzeneboronic Acid
Linshang Chemical
|
HS Code |
930370 |
| Chemical Formula | C6H5BClNO4 |
| Molecular Weight | 201.37 |
| Appearance | Off - white to yellow solid |
| Melting Point | 142 - 147 °C |
| Solubility In Water | Slightly soluble |
| Solubility In Organic Solvents | Soluble in some organic solvents like dichloromethane, ethanol |
| Pka Value | Around 8 - 9 (approximate for boronic acid group) |
| Stability | Stable under normal conditions, but moisture - sensitive |
| Boiling Point | Decomposes before boiling |
As an accredited 4-Chloro-3-Nitrobenzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 4 - chloro - 3 - nitrobenzeneboronic acid packaged in a sealed plastic bag. |
| Storage | 4 - Chloro - 3 - nitrobenzeneboronic acid should be stored in a cool, dry place away from heat sources and ignition points. Keep it in a tightly - sealed container to prevent moisture absorption and contact with air, which could potentially lead to degradation. Store separately from incompatible substances, like strong oxidizing agents and bases, to avoid chemical reactions. |
| Shipping | 4 - chloro - 3 - nitrobenzeneboronic acid is shipped in sealed, corrosion - resistant containers. It's handled with care, following strict regulations due to its chemical nature, ensuring safe transport to prevent spills and environmental hazards. |
Competitive 4-Chloro-3-Nitrobenzeneboronic Acid prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 4-Chloro-3-Nitrobenzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 4-chloro-3-nitrobenzeneboronic Acid?
4-Chloro-3-nitrophenylboronic acid, a crucial reagent in organic synthesis, is widely used in many fields.
First, it plays a key role in the field of drug synthesis. Because the design and construction of drug molecules often require precise chemical reactions, 4-chloro-3-nitrophenylboronic acid can be used as a key intermediate. Through coupling reactions with other organic compounds, such as the Suzuki reaction, carbon-carbon bonds can be effectively formed, thus laying the foundation for the synthesis of drug molecules with specific structures and activities. It can be seen in the synthesis of many anticancer and antimicrobial drugs. By introducing specific functional groups, drug molecules are endowed with unique pharmacological activities, which helps to develop more efficient and safe drugs.
Second, it is also indispensable in the field of materials science. With the increase in demand for advanced materials, the synthesis of functional organic materials has attracted much attention. 4-chloro-3-nitrophenylboronic acid can participate in the preparation of photoelectric materials, such as organic Light Emitting Diode (OLED) materials. Due to its unique electronic structure and chemical properties, through rational design and reaction, the material can have excellent photoelectric properties, such as high luminous efficiency, good color purity, etc., to promote the progress of display technology.
Third, in the study of organic synthesis methodology, 4-chloro-3-nitrophenylboronic acid provides chemists with rich research materials. The existence of its different substituents makes it exhibit diverse reactivity and selectivity in chemical reactions. Chemists can use this to explore novel reaction pathways and mechanisms, expand the boundaries of organic synthesis, and inject new vitality into the development of organic chemistry.
In conclusion, 4-chloro-3-nitrophenylboronic acid, with its unique chemical structure and properties, plays an irreplaceable role in the fields of drug synthesis, materials science, and organic synthesis methodology, and is of great significance for promoting the progress of related fields.
First, it plays a key role in the field of drug synthesis. Because the design and construction of drug molecules often require precise chemical reactions, 4-chloro-3-nitrophenylboronic acid can be used as a key intermediate. Through coupling reactions with other organic compounds, such as the Suzuki reaction, carbon-carbon bonds can be effectively formed, thus laying the foundation for the synthesis of drug molecules with specific structures and activities. It can be seen in the synthesis of many anticancer and antimicrobial drugs. By introducing specific functional groups, drug molecules are endowed with unique pharmacological activities, which helps to develop more efficient and safe drugs.
Second, it is also indispensable in the field of materials science. With the increase in demand for advanced materials, the synthesis of functional organic materials has attracted much attention. 4-chloro-3-nitrophenylboronic acid can participate in the preparation of photoelectric materials, such as organic Light Emitting Diode (OLED) materials. Due to its unique electronic structure and chemical properties, through rational design and reaction, the material can have excellent photoelectric properties, such as high luminous efficiency, good color purity, etc., to promote the progress of display technology.
Third, in the study of organic synthesis methodology, 4-chloro-3-nitrophenylboronic acid provides chemists with rich research materials. The existence of its different substituents makes it exhibit diverse reactivity and selectivity in chemical reactions. Chemists can use this to explore novel reaction pathways and mechanisms, expand the boundaries of organic synthesis, and inject new vitality into the development of organic chemistry.
In conclusion, 4-chloro-3-nitrophenylboronic acid, with its unique chemical structure and properties, plays an irreplaceable role in the fields of drug synthesis, materials science, and organic synthesis methodology, and is of great significance for promoting the progress of related fields.
What are the physical properties of 4-chloro-3-nitrobenzeneboronic Acid?
4-Chloro-3-nitrophenylboronic acid, which is white to light yellow solid. Its melting point is quite high, usually between 240-245 ° C. This property makes it quite stable at room temperature and pressure, and it is not easy to melt or change state due to slight changes in external temperature.
When it comes to solubility, it is slightly soluble in water. Although the boric acid group in the molecule can form hydrogen bonds with water, the presence of chlorine atoms and nitro groups reduces its hydrophilicity. However, it has good solubility in some organic solvents, such as dichloromethane, N, N-dimethylformamide, etc. In dichloromethane, due to the non-polarity of dichloromethane and the non-polarity of the molecular structure of 4-chloro-3-nitrophenylboronic acid, it can dissolve well.
4-chloro-3-nitrophenylboronic acid has a certain acidity, which originates from the boric acid group to give protons. At the same time, the chlorine atom and nitro group in the molecule are electron-withdrawing groups, which will enhance the acidity of the boric acid group. Its acidity makes it a weakly acidic catalyst in organic synthesis and participates in specific reaction processes.
From the perspective of chemical stability, it can remain relatively stable under normal environmental conditions. However, when exposed to strong oxidizing agents or reducing agents, chemical reactions will occur. Nitro groups are easily reduced, and chlorine atoms can also undergo substitution reactions under appropriate conditions. In addition, high temperature environments may also promote their decomposition, releasing toxic nitrogen oxides and chloride gases.
When it comes to solubility, it is slightly soluble in water. Although the boric acid group in the molecule can form hydrogen bonds with water, the presence of chlorine atoms and nitro groups reduces its hydrophilicity. However, it has good solubility in some organic solvents, such as dichloromethane, N, N-dimethylformamide, etc. In dichloromethane, due to the non-polarity of dichloromethane and the non-polarity of the molecular structure of 4-chloro-3-nitrophenylboronic acid, it can dissolve well.
4-chloro-3-nitrophenylboronic acid has a certain acidity, which originates from the boric acid group to give protons. At the same time, the chlorine atom and nitro group in the molecule are electron-withdrawing groups, which will enhance the acidity of the boric acid group. Its acidity makes it a weakly acidic catalyst in organic synthesis and participates in specific reaction processes.
From the perspective of chemical stability, it can remain relatively stable under normal environmental conditions. However, when exposed to strong oxidizing agents or reducing agents, chemical reactions will occur. Nitro groups are easily reduced, and chlorine atoms can also undergo substitution reactions under appropriate conditions. In addition, high temperature environments may also promote their decomposition, releasing toxic nitrogen oxides and chloride gases.
What are the chemical properties of 4-chloro-3-nitrobenzeneboronic Acid?
4-Chloro-3-nitrophenylboronic acid is an important reagent in the field of organic synthesis. Its chemical properties are unique and have typical characteristics of boric acid.
The boric acid group in this compound can participate in many key chemical reactions. When exposed to bases, the boric acid group easily reacts with the base to form the corresponding borate. This property is often used in organic synthesis to adjust the pH of the reaction system, which in turn affects the process and direction of the reaction.
4-chloro-3-nitrophenylboronic acid can also participate in the Suzuki coupling reaction. In this reaction, the boric acid group can be coupled with the organic halide under the action of palladium catalyst to form a carbon-carbon bond. This reaction is widely used in the construction of the structure of complex organic molecules, and can effectively realize the connection of different organic fragments. It is of great value in many fields such as drug synthesis and materials science.
Furthermore, the chlorine atom and nitro group in the molecule also endow the compound with unique reactivity. The chlorine atom can undergo nucleophilic substitution reaction, which can be replaced by other nucleophilic reagents, and then different functional groups are introduced to enrich the structural diversity of the molecule. Nitro is a strong electron-absorbing group, which not only affects the electron cloud distribution of the molecule, decreases the electron cloud density of the benzene ring, but also affects the reactivity of other groups connected to it. In some reduction reactions, nitro can be reduced to other functional groups such as amino groups, which further expands the application path of this compound in organic synthesis and provides possibilities for the synthesis of various nitrogen-containing organic compounds.
The boric acid group in this compound can participate in many key chemical reactions. When exposed to bases, the boric acid group easily reacts with the base to form the corresponding borate. This property is often used in organic synthesis to adjust the pH of the reaction system, which in turn affects the process and direction of the reaction.
4-chloro-3-nitrophenylboronic acid can also participate in the Suzuki coupling reaction. In this reaction, the boric acid group can be coupled with the organic halide under the action of palladium catalyst to form a carbon-carbon bond. This reaction is widely used in the construction of the structure of complex organic molecules, and can effectively realize the connection of different organic fragments. It is of great value in many fields such as drug synthesis and materials science.
Furthermore, the chlorine atom and nitro group in the molecule also endow the compound with unique reactivity. The chlorine atom can undergo nucleophilic substitution reaction, which can be replaced by other nucleophilic reagents, and then different functional groups are introduced to enrich the structural diversity of the molecule. Nitro is a strong electron-absorbing group, which not only affects the electron cloud distribution of the molecule, decreases the electron cloud density of the benzene ring, but also affects the reactivity of other groups connected to it. In some reduction reactions, nitro can be reduced to other functional groups such as amino groups, which further expands the application path of this compound in organic synthesis and provides possibilities for the synthesis of various nitrogen-containing organic compounds.
What is the synthesis method of 4-chloro-3-nitrobenzeneboronic Acid?
The synthesis of 4-chloro-3-nitrophenylboronic acid is an important topic in the field of organic synthesis. Its synthesis is often done through multiple methods.
First, halogenated aromatics are used as starting materials. Take 4-chloro-3-nitrochlorobenzene and react it with metal reagents such as magnesium to make Grignard's reagent. This process is carried out in a harsh environment without water and oxygen to ensure a smooth reaction. Grignard's reagent is very active. After it is prepared, it quickly reacts with borate esters such as trimethyl borate. After the reaction is completed, 4-chloro-3-nitrophenylboronic acid can be obtained through a hydrolysis step. During hydrolysis, it is recommended to precisely control the temperature and pH to avoid side reactions.
Second, the cross-coupling reaction catalyzed by palladium is used as the diameter. 4-Chloro-3-nitrochlorobenzene reacts with pinacol borate in the presence of palladium catalysts, such as tetra (triphenylphosphine) palladium, in suitable solvents. In this reaction, the choice of base is crucial, and weak bases such as potassium carbonate and sodium carbonate are often used to assist the reaction. Solvents also need to be carefully selected, such as toluene, dioxane and other organic solvents, which can create an environment conducive to the reaction. In the reaction, the palladium catalyst promotes the bonding between halogenated aromatics and borate esters, and efficiently generates the target product.
In addition, the diazonium salt conversion method is also used. First, 4-chloro-3-nitroaniline is reacted through diazotization to form a diazonium salt. This reaction is operated at low temperature and in an acidic environment to maintain the stability of the diazonium salt. Subsequently, the diazonium salt reacts with boric acid or its derivatives and undergoes a series of transformations to obtain 4-chloro-3-nitrophenylboronic acid. Although this path step is complicated, the conditions are mild and it has many advantages for specific needs.
Each synthesis method has its own advantages and disadvantages. In practical application, the choice needs to be weighed according to factors such as raw material availability, cost, and product purity to achieve the best synthesis effect.
First, halogenated aromatics are used as starting materials. Take 4-chloro-3-nitrochlorobenzene and react it with metal reagents such as magnesium to make Grignard's reagent. This process is carried out in a harsh environment without water and oxygen to ensure a smooth reaction. Grignard's reagent is very active. After it is prepared, it quickly reacts with borate esters such as trimethyl borate. After the reaction is completed, 4-chloro-3-nitrophenylboronic acid can be obtained through a hydrolysis step. During hydrolysis, it is recommended to precisely control the temperature and pH to avoid side reactions.
Second, the cross-coupling reaction catalyzed by palladium is used as the diameter. 4-Chloro-3-nitrochlorobenzene reacts with pinacol borate in the presence of palladium catalysts, such as tetra (triphenylphosphine) palladium, in suitable solvents. In this reaction, the choice of base is crucial, and weak bases such as potassium carbonate and sodium carbonate are often used to assist the reaction. Solvents also need to be carefully selected, such as toluene, dioxane and other organic solvents, which can create an environment conducive to the reaction. In the reaction, the palladium catalyst promotes the bonding between halogenated aromatics and borate esters, and efficiently generates the target product.
In addition, the diazonium salt conversion method is also used. First, 4-chloro-3-nitroaniline is reacted through diazotization to form a diazonium salt. This reaction is operated at low temperature and in an acidic environment to maintain the stability of the diazonium salt. Subsequently, the diazonium salt reacts with boric acid or its derivatives and undergoes a series of transformations to obtain 4-chloro-3-nitrophenylboronic acid. Although this path step is complicated, the conditions are mild and it has many advantages for specific needs.
Each synthesis method has its own advantages and disadvantages. In practical application, the choice needs to be weighed according to factors such as raw material availability, cost, and product purity to achieve the best synthesis effect.
4-chloro-3-nitrobenzeneboronic Acid in storage and transportation
4-Chloro-3-nitrophenylboronic acid, when storing and transporting, need to pay attention to many matters. This is a chemical substance with unique properties. If it is not handled properly, it may be dangerous.
First words storage. First, choose a dry, cool and well-ventilated place. Cover because it is afraid of moisture, if it is in a humid place, or reacts with water vapor, causing quality deterioration. And if the temperature is too high, it is easy to cause its chemical changes and damage its characteristics. Second, it must be stored in isolation from oxidizing agents, reducing agents and alkalis. 4-Chloro-3-nitrophenylboronic acid has specific chemical activities. In case of these kinds of substances, it may react violently, and even cause heat, fire and even explosion. Third, the place of storage should be clearly marked, indicating the name, characteristics and emergency treatment methods of the object, so that the relevant personnel can see at a glance, and can respond quickly if something happens.
Times and transportation. When transporting, the packaging must be tight. Wrap it with special packaging materials to prevent it from leaking. During loading and unloading, the operator should handle it with care, and do not subject it to severe vibration or impact. Due to impact or excessive vibration, or breaking its packaging, material leakage is caused, and chemical reactions may be caused. In addition, the transportation vehicle should also be selected, and the vehicle should be clean, dry, and free of other chemical residues to prevent cross-contamination. At the same time, during transportation, the packaging should be regularly checked whether it is in good condition. If there is any abnormality, it should be dealt with immediately. In this way, 4-chloro-3-nitrophenylboronic acid can be safely stored and transported.
First words storage. First, choose a dry, cool and well-ventilated place. Cover because it is afraid of moisture, if it is in a humid place, or reacts with water vapor, causing quality deterioration. And if the temperature is too high, it is easy to cause its chemical changes and damage its characteristics. Second, it must be stored in isolation from oxidizing agents, reducing agents and alkalis. 4-Chloro-3-nitrophenylboronic acid has specific chemical activities. In case of these kinds of substances, it may react violently, and even cause heat, fire and even explosion. Third, the place of storage should be clearly marked, indicating the name, characteristics and emergency treatment methods of the object, so that the relevant personnel can see at a glance, and can respond quickly if something happens.
Times and transportation. When transporting, the packaging must be tight. Wrap it with special packaging materials to prevent it from leaking. During loading and unloading, the operator should handle it with care, and do not subject it to severe vibration or impact. Due to impact or excessive vibration, or breaking its packaging, material leakage is caused, and chemical reactions may be caused. In addition, the transportation vehicle should also be selected, and the vehicle should be clean, dry, and free of other chemical residues to prevent cross-contamination. At the same time, during transportation, the packaging should be regularly checked whether it is in good condition. If there is any abnormality, it should be dealt with immediately. In this way, 4-chloro-3-nitrophenylboronic acid can be safely stored and transported.
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