Linshang Chemical
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4-Chloro-3-Nitrobenzenesulfonanilide
Linshang Chemical
|
HS Code |
399274 |
| Chemical Formula | C12H9ClN2O4S |
| Molecular Weight | 312.73 |
| Appearance | Typically a solid |
| Odor | May have a characteristic chemical odor |
| Melting Point | Data - specific value needed |
| Boiling Point | Data - specific value needed |
| Solubility In Water | Low solubility, likely sparingly soluble |
| Solubility In Organic Solvents | Soluble in some organic solvents like ethanol, acetone |
| Density | Data - specific value needed |
| Flash Point | Data - specific value needed |
| Purity | Can vary based on production quality |
| Stability | Stable under normal conditions, but may react with strong oxidants |
As an accredited 4-Chloro-3-Nitrobenzenesulfonanilide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - chloro - 3 - nitrobenzenesulfonanilide packaged in a sealed plastic bag. |
| Storage | 4 - chloro - 3 - nitrobenzenesulfonanilide should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container to prevent moisture absorption and contamination. Label the storage container clearly for easy identification and to ensure proper handling and safety. |
| Shipping | 4 - chloro - 3 - nitrobenzenesulfonanilide is a chemical. Shipping should be in accordance with regulations for hazardous chemicals. It must be properly packaged to prevent leakage, and transported by carriers approved for such substances. |
Competitive 4-Chloro-3-Nitrobenzenesulfonanilide prices that fit your budget—flexible terms and customized quotes for every order.
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What is the chemical structure of 4-chloro-3-nitrobenzenesulfonanilide?
The chemical structure of 4-chloro-3-nitrobenzenesulfonyl aniline is composed of a benzene ring as a group, which is coated with a specific substituent group. Above the benzene ring, the chlorine atom at position 4 is connected to the nitro group at position 3, and the benzene ring is connected to the sulfonyl group, which is in turn related to the aniline group.
In this case, the benzene ring has a six-membered cyclic carbon frame and is the core of the aromatic compound. The chlorine atom at position 4 is connected to the carbon of the benzene ring by a covalent bond. The electronegativity of chlorine is quite high, which can affect the distribution of electron clouds in the molecule. The nitro group at position 3 is composed of a nitrogen-oxygen double bond and a nitrogen-oxygen single bond, which has strong electron-absorbing properties, causing the electron cloud density of the benzene ring to decrease, which affects its chemical activity.
Sulfonyl group (-SO 2O -), whose sulfur atom is connected to two oxygen atoms by double bonds, is connected to the benzene ring and the aniline group. The aniline group is a structure in which the amino group (-NH2O) is connected to the benzene ring. The amino group has the property of electron supplier. After being connected to the sulfonyl group, the interaction between the two groups makes the electron cloud distribution of the molecule more complicated.
Overall, the chemical structure of 4-chloro-3-nitrobenzenesulfonyl aniline presents unique physical and chemical properties through the interaction of each group. Each group does not exist in isolation, and its electronic effect and space effect interact with each other to determine the performance of the compound in chemical reactions and physical properties. Such a structure makes the compound have specific uses and research value in the fields of organic synthesis, medicinal chemistry, etc.
In this case, the benzene ring has a six-membered cyclic carbon frame and is the core of the aromatic compound. The chlorine atom at position 4 is connected to the carbon of the benzene ring by a covalent bond. The electronegativity of chlorine is quite high, which can affect the distribution of electron clouds in the molecule. The nitro group at position 3 is composed of a nitrogen-oxygen double bond and a nitrogen-oxygen single bond, which has strong electron-absorbing properties, causing the electron cloud density of the benzene ring to decrease, which affects its chemical activity.
Sulfonyl group (-SO 2O -), whose sulfur atom is connected to two oxygen atoms by double bonds, is connected to the benzene ring and the aniline group. The aniline group is a structure in which the amino group (-NH2O) is connected to the benzene ring. The amino group has the property of electron supplier. After being connected to the sulfonyl group, the interaction between the two groups makes the electron cloud distribution of the molecule more complicated.
Overall, the chemical structure of 4-chloro-3-nitrobenzenesulfonyl aniline presents unique physical and chemical properties through the interaction of each group. Each group does not exist in isolation, and its electronic effect and space effect interact with each other to determine the performance of the compound in chemical reactions and physical properties. Such a structure makes the compound have specific uses and research value in the fields of organic synthesis, medicinal chemistry, etc.
What are the physical properties of 4-chloro-3-nitrobenzenesulfonanilide?
4-Chloro-3-nitrobenzenesulfonylaniline, this is an organic compound. Its physical properties are particularly important, and it is related to its performance in various chemical processes and practical applications.
First of all, its appearance, at room temperature and pressure, is mostly in the form of a solid, either powdered or crystalline, depending on the synthesis conditions and purity. This solid appearance is easy to store and transport, and it is easy to control in many chemical reactions.
Second, the melting point value is crucial for the identification and purification of this compound. After experimental determination, its melting point is in a specific temperature range, and it is recorded in different literature or slightly different, but it is all in a similar range. The existence of the melting point allows the purity of the compound to be judged by the melting point determination method. If the purity is high, the melting point range is narrow and close to the theoretical value; if it contains impurities, the melting point decreases and the melting range becomes wider.
Furthermore, the solubility of 4-chloro-3-nitrobenzenesulfonylaniline in organic solvents varies. In halogenated hydrocarbon organic solvents such as dichloromethane and chloroform, it exhibits certain solubility, because its molecular structure is similar to that of halogenated hydrocarbons. In water, its solubility is very small, because the molecular polarity of the compound is quite different from water, and it is difficult for water molecules to form effective interactions with it. This solubility characteristic determines its application in separation, purification and reaction solvent selection.
Also known as density, although density data may be difficult to obtain, it has a significant impact on the distribution and behavior in a specific system. When it comes to liquid-liquid extraction or heterogeneous reaction systems, the density difference determines its position in different phases and the diffusion rate.
In addition, the color of the compound is also one of its physical properties. It is usually colorless to light yellow. This color feature may assist in preliminary identification, and in some reaction processes, color changes may be used as an indication of the reaction process.
In summary, the physical properties of 4-chloro-3-nitrobenzenesulfonylaniline, such as appearance, melting point, solubility, density, and color, each have their own unique characteristics, which are of great significance for chemical research, chemical production, and related fields.
First of all, its appearance, at room temperature and pressure, is mostly in the form of a solid, either powdered or crystalline, depending on the synthesis conditions and purity. This solid appearance is easy to store and transport, and it is easy to control in many chemical reactions.
Second, the melting point value is crucial for the identification and purification of this compound. After experimental determination, its melting point is in a specific temperature range, and it is recorded in different literature or slightly different, but it is all in a similar range. The existence of the melting point allows the purity of the compound to be judged by the melting point determination method. If the purity is high, the melting point range is narrow and close to the theoretical value; if it contains impurities, the melting point decreases and the melting range becomes wider.
Furthermore, the solubility of 4-chloro-3-nitrobenzenesulfonylaniline in organic solvents varies. In halogenated hydrocarbon organic solvents such as dichloromethane and chloroform, it exhibits certain solubility, because its molecular structure is similar to that of halogenated hydrocarbons. In water, its solubility is very small, because the molecular polarity of the compound is quite different from water, and it is difficult for water molecules to form effective interactions with it. This solubility characteristic determines its application in separation, purification and reaction solvent selection.
Also known as density, although density data may be difficult to obtain, it has a significant impact on the distribution and behavior in a specific system. When it comes to liquid-liquid extraction or heterogeneous reaction systems, the density difference determines its position in different phases and the diffusion rate.
In addition, the color of the compound is also one of its physical properties. It is usually colorless to light yellow. This color feature may assist in preliminary identification, and in some reaction processes, color changes may be used as an indication of the reaction process.
In summary, the physical properties of 4-chloro-3-nitrobenzenesulfonylaniline, such as appearance, melting point, solubility, density, and color, each have their own unique characteristics, which are of great significance for chemical research, chemical production, and related fields.
What are the main uses of 4-chloro-3-nitrobenzenesulfonanilide?
4-Chloro-3-nitrobenzenesulfonylaniline, this is an organic compound with a wide range of uses. In the field of medicine, it is often a key intermediate for synthetic drugs. Due to its specific structure, it can interact with many targets in organisms. By modifying and modifying its structure, drugs with different pharmacological activities can be developed, such as antibacterial, anti-inflammatory and other drugs.
In the field of pesticides, it also plays an important role. As a raw material for synthetic pesticides, highly efficient and low-toxic pesticide products can be prepared. Such pesticides have excellent pest control effects, which can effectively protect crops from insect infestation and improve crop yield and quality.
In the field of materials science, 4-chloro-3-nitrobenzenesulfonylaniline is also used. It can participate in the synthesis of polymer materials and endow materials with special properties, such as improving material heat resistance and corrosion resistance, thereby broadening the scope of material applications. It is of great value in aerospace, automobile manufacturing and other fields that require strict material properties.
Furthermore, in the field of organic synthetic chemistry, as an important organic synthesis intermediate, it can build complex organic molecular structures through various chemical reactions, providing a key material foundation for the development of organic synthetic chemistry, promoting organic synthetic chemistry to continuously move to new heights, and developing more novel and unique organic compounds.
In the field of pesticides, it also plays an important role. As a raw material for synthetic pesticides, highly efficient and low-toxic pesticide products can be prepared. Such pesticides have excellent pest control effects, which can effectively protect crops from insect infestation and improve crop yield and quality.
In the field of materials science, 4-chloro-3-nitrobenzenesulfonylaniline is also used. It can participate in the synthesis of polymer materials and endow materials with special properties, such as improving material heat resistance and corrosion resistance, thereby broadening the scope of material applications. It is of great value in aerospace, automobile manufacturing and other fields that require strict material properties.
Furthermore, in the field of organic synthetic chemistry, as an important organic synthesis intermediate, it can build complex organic molecular structures through various chemical reactions, providing a key material foundation for the development of organic synthetic chemistry, promoting organic synthetic chemistry to continuously move to new heights, and developing more novel and unique organic compounds.
What are 4-chloro-3-nitrobenzenesulfonanilide synthesis methods?
The synthesis method of 4-chloro-3-nitrobenzenesulfonylaniline has existed in ancient times, and is described in detail below.
First, benzenesulfonyl chloride is used as the starting material. First, benzenesulfonyl chloride and aniline are mixed in a suitable reaction vessel, with the assistance of acid binding agents such as pyridine to maintain the acid-base environment of the reaction system. After nucleophilic substitution, benzenesulfonylaniline can be formed into benzenesulfonylaniline. Subsequently, benzenesulfonylaniline is nitrified and chlorinated. During nitrification, mixed acid (a mixture of nitric acid and sulfuric acid) is used as the nitrifying agent to precisely control the reaction temperature and time, so that nitro groups Following the chlorination reagent, such as chlorine gas or chlorine-containing compounds, in the presence of catalysts, the substitution of chlorine atoms in the benzene ring is achieved to obtain 4-chloro-3-nitrobenzene sulfonyl aniline. The raw materials for this route are relatively common, but the steps are slightly complicated, and the reaction conditions of each step need to be carefully regulated.
Second, start from nitroaniline. Nitroaniline reacts with chlorosulfonic acid. Chlorosulfonic acid has both the functions of sulfonation and chlorination. Sulfonyl chloride groups and chlorine atoms can be introduced in one step to generate 4-chloro-3-nitrobenzene sulfonyl chloride. Then, 4-chloro-3-nitrobenzenesulfonyl chloride reacts with aniline to form the target product 4-chloro-3-nitrobenzenesulfonyl aniline under mild conditions. This path step is relatively simple, but chlorosulfonic acid is highly corrosive, the operation needs to be cautious, and the requirements for the reaction equipment are also high.
Third, chlorobenzene is used as the starting material. First, chlorobenzene is nitrified to obtain o-nitrochlorobenzene or p-nitrochlorobenzene. After separation and purification, p-nitrochlorobenzene is then sulfonated with fuming sulfuric acid to obtain 4-chloro-3-nitrobenzenesulfonic acid. 4-Chloro-3-nitrobenzenesulfonyl chloride is obtained by reacting with thionyl chloride and other reagents, and finally reacting with aniline to produce 4-chloro-3-nitrobenzenesulfonyl aniline. The raw material cost of this method is low, but the reaction route is long, the separation process is complicated, and the overall yield may be affected.
First, benzenesulfonyl chloride is used as the starting material. First, benzenesulfonyl chloride and aniline are mixed in a suitable reaction vessel, with the assistance of acid binding agents such as pyridine to maintain the acid-base environment of the reaction system. After nucleophilic substitution, benzenesulfonylaniline can be formed into benzenesulfonylaniline. Subsequently, benzenesulfonylaniline is nitrified and chlorinated. During nitrification, mixed acid (a mixture of nitric acid and sulfuric acid) is used as the nitrifying agent to precisely control the reaction temperature and time, so that nitro groups Following the chlorination reagent, such as chlorine gas or chlorine-containing compounds, in the presence of catalysts, the substitution of chlorine atoms in the benzene ring is achieved to obtain 4-chloro-3-nitrobenzene sulfonyl aniline. The raw materials for this route are relatively common, but the steps are slightly complicated, and the reaction conditions of each step need to be carefully regulated.
Second, start from nitroaniline. Nitroaniline reacts with chlorosulfonic acid. Chlorosulfonic acid has both the functions of sulfonation and chlorination. Sulfonyl chloride groups and chlorine atoms can be introduced in one step to generate 4-chloro-3-nitrobenzene sulfonyl chloride. Then, 4-chloro-3-nitrobenzenesulfonyl chloride reacts with aniline to form the target product 4-chloro-3-nitrobenzenesulfonyl aniline under mild conditions. This path step is relatively simple, but chlorosulfonic acid is highly corrosive, the operation needs to be cautious, and the requirements for the reaction equipment are also high.
Third, chlorobenzene is used as the starting material. First, chlorobenzene is nitrified to obtain o-nitrochlorobenzene or p-nitrochlorobenzene. After separation and purification, p-nitrochlorobenzene is then sulfonated with fuming sulfuric acid to obtain 4-chloro-3-nitrobenzenesulfonic acid. 4-Chloro-3-nitrobenzenesulfonyl chloride is obtained by reacting with thionyl chloride and other reagents, and finally reacting with aniline to produce 4-chloro-3-nitrobenzenesulfonyl aniline. The raw material cost of this method is low, but the reaction route is long, the separation process is complicated, and the overall yield may be affected.
4-chloro-3-nitrobenzenesulfonanilide what are the precautions during use
4-Chloro-3-nitrobenzenesulfonylaniline is an organic compound, and many matters need to be paid careful attention during use.
The first thing to pay attention to is its toxicity. This compound may be toxic to some extent and pose a potential threat to human health. When operating, be sure to wear suitable protective equipment, such as gloves, protective glasses and gas masks, to prevent skin contact, inhalation of dust or steam, and thus avoid the risk of poisoning.
For the second time, pay attention to its chemical activity. 4-Chloro-3-nitrobenzenesulfonylaniline contains active groups such as chlorine, nitro and sulfonamide, and is chemically active. In use, it should be avoided from contact with strong oxidizing agents, strong reducing agents and alkali substances to prevent violent chemical reactions, such as explosions, fires and other dangerous situations. When storing, it should also be separated from such substances to ensure safe storage.
Furthermore, pay attention to its impact on the environment. If this compound accidentally enters the environment, or causes pollution to water, soil and air. During use, its discharge should be strictly controlled and waste should be properly disposed of. The waste generated by the experiment cannot be discarded at will. In accordance with relevant regulations, suitable methods should be used for harmless disposal to reduce the harm to the environment.
In addition, the experimental procedures and safe operation guidelines should be strictly followed during operation. Before the experiment, it is necessary to fully familiarize yourself with its physical and chemical properties and possible dangerous situation countermeasures. During the experiment, keep the operating environment well ventilated to discharge harmful vapors in time. At the same time, precisely control the reaction conditions, such as temperature, pressure and reaction time, to ensure that the reaction proceeds as expected and avoid accidents.
In short, when using 4-chloro-3-nitrobenzenesulfonylaniline, it is necessary to attach great importance to safety and environmental protection, and operate with caution to prevent damage to yourself and the environment.
The first thing to pay attention to is its toxicity. This compound may be toxic to some extent and pose a potential threat to human health. When operating, be sure to wear suitable protective equipment, such as gloves, protective glasses and gas masks, to prevent skin contact, inhalation of dust or steam, and thus avoid the risk of poisoning.
For the second time, pay attention to its chemical activity. 4-Chloro-3-nitrobenzenesulfonylaniline contains active groups such as chlorine, nitro and sulfonamide, and is chemically active. In use, it should be avoided from contact with strong oxidizing agents, strong reducing agents and alkali substances to prevent violent chemical reactions, such as explosions, fires and other dangerous situations. When storing, it should also be separated from such substances to ensure safe storage.
Furthermore, pay attention to its impact on the environment. If this compound accidentally enters the environment, or causes pollution to water, soil and air. During use, its discharge should be strictly controlled and waste should be properly disposed of. The waste generated by the experiment cannot be discarded at will. In accordance with relevant regulations, suitable methods should be used for harmless disposal to reduce the harm to the environment.
In addition, the experimental procedures and safe operation guidelines should be strictly followed during operation. Before the experiment, it is necessary to fully familiarize yourself with its physical and chemical properties and possible dangerous situation countermeasures. During the experiment, keep the operating environment well ventilated to discharge harmful vapors in time. At the same time, precisely control the reaction conditions, such as temperature, pressure and reaction time, to ensure that the reaction proceeds as expected and avoid accidents.
In short, when using 4-chloro-3-nitrobenzenesulfonylaniline, it is necessary to attach great importance to safety and environmental protection, and operate with caution to prevent damage to yourself and the environment.
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