Linshang Chemical
PRODUCTS
4-Chloro-3-Nitrobenzenesulphonamide
Linshang Chemical
|
HS Code |
635752 |
| Chemical Formula | C6H5ClN2O5S |
| Molecular Weight | 254.63 |
| Appearance | Solid |
| Melting Point | 197 - 200 °C |
| Solubility In Water | Low |
| Solubility In Organic Solvents | Soluble in some organic solvents like DMSO |
| Hazard Class | Irritant (can cause eye, skin and respiratory irritation) |
As an accredited 4-Chloro-3-Nitrobenzenesulphonamide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - chloro - 3 - nitrobenzenesulphonamide in a sealed, labeled chemical - grade container. |
| Storage | 4 - chloro - 3 - nitrobenzenesulphonamide should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly sealed container to prevent moisture absorption and contamination. Separate from incompatible substances. This storage method helps maintain its chemical stability and reduces the risk of dangerous reactions. |
| Shipping | 4 - chloro - 3 - nitrobenzenesulphonamide should be shipped in tightly sealed, corrosion - resistant containers. It must be labeled as a chemical with proper handling instructions. Ship via methods compliant with hazardous chemical transport regulations. |
Competitive 4-Chloro-3-Nitrobenzenesulphonamide prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 4-Chloro-3-Nitrobenzenesulphonamide in China?
As a trusted 4-Chloro-3-Nitrobenzenesulphonamide manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 4-Chloro-3-Nitrobenzenesulphonamide supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemistry of 4-chloro-3-nitrobenzenesulphonamide?
4-Chloro-3-nitrobenzenesulfonamide is also an organic compound. It is active and mostly contains chlorine, nitro and sulfonamide groups in its structure.
Chlorine atoms have nucleophilic substitution activity, and can be replaced and changed in structure when encountering nucleophilic reagents. In alkaline media, nucleophilic reagents are easy to attack chlorine-linked carbon, causing chlorine to dissociate and form new bonds.
Nitro groups have strong electron-absorbing properties, which reduce the electron cloud density of the benzene ring and make it difficult to electrophilic substitution of the benzene ring, but increase the activity of ortho groups. If encountered with nucleophilic reagents, ortho reactions are prone to occur.
Sulfonamide groups are weakly acidic and And it has the ability of hydrogen bond donor and receptor, and can interact with other molecules by hydrogen bond, affecting the solubility, melting point, boiling point, etc.
4-chloro-3-nitrobenzenesulfonamide is widely used in organic synthesis. It can be used as an intermediate to prepare compounds containing special structures through a series of reactions. It is also used in pharmaceutical research and development. Because of its active structure or pharmacological activity, it can provide a basis for the creation of new drugs. In short, because of its unique chemical properties, it has an important position in organic chemistry and related fields.
Chlorine atoms have nucleophilic substitution activity, and can be replaced and changed in structure when encountering nucleophilic reagents. In alkaline media, nucleophilic reagents are easy to attack chlorine-linked carbon, causing chlorine to dissociate and form new bonds.
Nitro groups have strong electron-absorbing properties, which reduce the electron cloud density of the benzene ring and make it difficult to electrophilic substitution of the benzene ring, but increase the activity of ortho groups. If encountered with nucleophilic reagents, ortho reactions are prone to occur.
Sulfonamide groups are weakly acidic and And it has the ability of hydrogen bond donor and receptor, and can interact with other molecules by hydrogen bond, affecting the solubility, melting point, boiling point, etc.
4-chloro-3-nitrobenzenesulfonamide is widely used in organic synthesis. It can be used as an intermediate to prepare compounds containing special structures through a series of reactions. It is also used in pharmaceutical research and development. Because of its active structure or pharmacological activity, it can provide a basis for the creation of new drugs. In short, because of its unique chemical properties, it has an important position in organic chemistry and related fields.
What are the physical properties of 4-chloro-3-nitrobenzenesulphonamide?
4-Chloro-3-nitrobenzenesulfonamide is a kind of organic compound. Its physical properties can be well observed.
When it comes to appearance, this compound is often in the form of a white to light yellow crystalline powder. Viewed, the powder is delicate, with positive color and pure quality, like a thin frost, and its fine crystalline glow can be seen under light.
As for the melting point, it is about 170-174 ° C. When heat is applied and the temperature is gradually approaching this range, it slowly melts from the solid state to the liquid state. The characteristics of this melting point are like a checkpoint, which is one of the key marks for the identification of this compound, and it is also related to the transformation and application of its state in many industrial processes and experimental operations involving this substance.
In terms of solubility, 4-chloro-3-nitrobenzenesulfonamide is slightly soluble in water. Water is the source of all things, but this compound can only be slightly soluble in it, as if it is separated from water. However, in organic solvents such as ethanol and acetone, its solubility is better. Ethanol and acetone, the commonly used organic solvents, meet 4-chloro-3-nitrobenzenesulfonamide, just like old friends, can make this compound better disperse and dissolve. This property is of great significance in many links such as organic synthesis, separation and purification, and provides many conveniences and possibilities for related operations.
Although there is no exact value of its density detailed in exact books, according to its molecular structure and the commonality of similar compounds, it can be known that its density should be slightly larger than that of water. When placed in water, it can be seen that it sinks slowly, which is also one of its physical properties.
In addition, its smell is weak, it smells fine, only has a faint special smell, and it is not pungent and unpleasant. However, it is also one of its unique physical characteristics. It is also observable when identifying and manipulating this compound.
Such various physical properties are indispensable reference elements in many fields such as industrial production, scientific research experiments, quality inspection, etc., to help people clarify the characteristics of 4-chloro-3-nitrobenzenesulfonamide and make good use of it.
When it comes to appearance, this compound is often in the form of a white to light yellow crystalline powder. Viewed, the powder is delicate, with positive color and pure quality, like a thin frost, and its fine crystalline glow can be seen under light.
As for the melting point, it is about 170-174 ° C. When heat is applied and the temperature is gradually approaching this range, it slowly melts from the solid state to the liquid state. The characteristics of this melting point are like a checkpoint, which is one of the key marks for the identification of this compound, and it is also related to the transformation and application of its state in many industrial processes and experimental operations involving this substance.
In terms of solubility, 4-chloro-3-nitrobenzenesulfonamide is slightly soluble in water. Water is the source of all things, but this compound can only be slightly soluble in it, as if it is separated from water. However, in organic solvents such as ethanol and acetone, its solubility is better. Ethanol and acetone, the commonly used organic solvents, meet 4-chloro-3-nitrobenzenesulfonamide, just like old friends, can make this compound better disperse and dissolve. This property is of great significance in many links such as organic synthesis, separation and purification, and provides many conveniences and possibilities for related operations.
Although there is no exact value of its density detailed in exact books, according to its molecular structure and the commonality of similar compounds, it can be known that its density should be slightly larger than that of water. When placed in water, it can be seen that it sinks slowly, which is also one of its physical properties.
In addition, its smell is weak, it smells fine, only has a faint special smell, and it is not pungent and unpleasant. However, it is also one of its unique physical characteristics. It is also observable when identifying and manipulating this compound.
Such various physical properties are indispensable reference elements in many fields such as industrial production, scientific research experiments, quality inspection, etc., to help people clarify the characteristics of 4-chloro-3-nitrobenzenesulfonamide and make good use of it.
What are the main uses of 4-chloro-3-nitrobenzenesulphonamide?
4-Chloro-3-nitrobenzenesulfonamide is one of the organic compounds. Its main uses are quite extensive. In the field of medicine, it is often used as a key intermediate for antibacterial drugs. The genine structure contains specific groups, which can be chemically modified to prepare drugs with antibacterial activity. By interfering with bacterial physiological processes, such as inhibiting cell wall synthesis and hindering protein production, the antibacterial effect can be achieved.
In pesticides, it also has important uses. It can be used as a starting material for the creation of new pesticides. Through a series of chemical reactions, compounds with insecticidal, bactericidal or herbicidal activities can be synthesized. Such compounds use their unique mechanism of action to control crop diseases, pests or weeds, ensure crop growth and increase yield.
Furthermore, in the field of materials science, 4-chloro-3-nitrobenzenesulfonamide can be used to prepare special polymer materials. The active groups it contains can participate in the polymerization reaction and endow the material with unique properties, such as improving the heat resistance and chemical corrosion resistance of the material, so that the material can be applied in specific industrial environments or high-end technical fields.
In addition, in chemical research, this compound is an important reagent. Chemists use it to conduct research on various organic synthesis reactions, explore new reaction paths, and expand chemical synthesis methods to enrich the knowledge system of organic chemistry and lay the foundation for the creation of more new compounds. In conclusion, 4-chloro-3-nitrobenzenesulfonamide plays an indispensable role in many fields such as medicine, pesticides, materials and chemical research.
In pesticides, it also has important uses. It can be used as a starting material for the creation of new pesticides. Through a series of chemical reactions, compounds with insecticidal, bactericidal or herbicidal activities can be synthesized. Such compounds use their unique mechanism of action to control crop diseases, pests or weeds, ensure crop growth and increase yield.
Furthermore, in the field of materials science, 4-chloro-3-nitrobenzenesulfonamide can be used to prepare special polymer materials. The active groups it contains can participate in the polymerization reaction and endow the material with unique properties, such as improving the heat resistance and chemical corrosion resistance of the material, so that the material can be applied in specific industrial environments or high-end technical fields.
In addition, in chemical research, this compound is an important reagent. Chemists use it to conduct research on various organic synthesis reactions, explore new reaction paths, and expand chemical synthesis methods to enrich the knowledge system of organic chemistry and lay the foundation for the creation of more new compounds. In conclusion, 4-chloro-3-nitrobenzenesulfonamide plays an indispensable role in many fields such as medicine, pesticides, materials and chemical research.
What are 4-chloro-3-nitrobenzenesulphonamide synthesis methods?
To prepare 4-chloro-3-nitrobenzenesulfonamide, there are many methods, which can be obtained from benzene and obtained by multi-step reaction.
First, benzene is used as a group, and the method of chlorination is used to make benzene and chlorine under the catalysis of ferric chloride to produce chlorobenzene. This is a typical reaction of electrophilic substitution of aromatic hydrocarbons. The chlorine atom enters the benzene ring to form chlorobenzene.
times, the chlorobenzene is nitrified. The mixed acid of concentrated nitric acid and concentrated sulfuric acid is used as the nitrifying agent, chlorobenzene responds with it, and the nitro group enters the benzene ring to obtain 4-chloronitrobenzene. This step needs to control the reaction temperature
Furthermore, 4-chloronitrobenzene is sulfonated. The 4-chloronitrobenzene is co-heated with fuming sulfuric acid, and the sulfonic acid group enters the benzene ring to obtain 4-chloro-3-nitrobenzene sulfonic acid. This reaction is also electrophilic substitution, and the sulfonic acid group selection is affected by the existing groups in the benzene ring.
Finally, 4-chloro-3-nitrobenzene sulfonic acid reacts with ammonia. The nitrogen in the ammonia molecule has a lone pair electron, which can attack the sulfur atom of the sulfonic acid group. Through a series of proton transfer processes, the sulfonic acid group is converted into a sulfonamide group, and then 4-chloro-3-nitrobenzene sulfonamide is
There are other methods, such as using other compounds containing benzene ring as the starting material, or changing the reaction sequence, all of which need to be precisely controlled according to the reaction conditions of each step, so as to achieve the purpose of high yield and high purity product. During the reaction process, factors such as temperature, catalyst, and reactant ratio need to be carefully handled before the reaction can proceed smoothly to obtain the required 4-chloro-3-nitrobenzenesulfonamide.
First, benzene is used as a group, and the method of chlorination is used to make benzene and chlorine under the catalysis of ferric chloride to produce chlorobenzene. This is a typical reaction of electrophilic substitution of aromatic hydrocarbons. The chlorine atom enters the benzene ring to form chlorobenzene.
times, the chlorobenzene is nitrified. The mixed acid of concentrated nitric acid and concentrated sulfuric acid is used as the nitrifying agent, chlorobenzene responds with it, and the nitro group enters the benzene ring to obtain 4-chloronitrobenzene. This step needs to control the reaction temperature
Furthermore, 4-chloronitrobenzene is sulfonated. The 4-chloronitrobenzene is co-heated with fuming sulfuric acid, and the sulfonic acid group enters the benzene ring to obtain 4-chloro-3-nitrobenzene sulfonic acid. This reaction is also electrophilic substitution, and the sulfonic acid group selection is affected by the existing groups in the benzene ring.
Finally, 4-chloro-3-nitrobenzene sulfonic acid reacts with ammonia. The nitrogen in the ammonia molecule has a lone pair electron, which can attack the sulfur atom of the sulfonic acid group. Through a series of proton transfer processes, the sulfonic acid group is converted into a sulfonamide group, and then 4-chloro-3-nitrobenzene sulfonamide is
There are other methods, such as using other compounds containing benzene ring as the starting material, or changing the reaction sequence, all of which need to be precisely controlled according to the reaction conditions of each step, so as to achieve the purpose of high yield and high purity product. During the reaction process, factors such as temperature, catalyst, and reactant ratio need to be carefully handled before the reaction can proceed smoothly to obtain the required 4-chloro-3-nitrobenzenesulfonamide.
4-chloro-3-nitrobenzenesulphonamide what are the precautions during use
4-Chloro-3-nitrobenzenesulfonamide is an important chemical substance. During use, many precautions must be taken.
First priority safety protection. This substance is dangerous and may cause skin, eyes and respiratory tract irritation. Therefore, when using it, be sure to wear appropriate protective equipment, such as gloves, goggles and gas masks, to prevent direct contact with the body and avoid injury. The place of operation also needs to be well ventilated to allow volatile gases to quickly dissipate, keep the air fresh and protect the health of the operator.
Furthermore, proper storage is also key. It should be placed in a cool, dry and ventilated place, away from fire and heat sources, to prevent temperature and humidity discomfort, causing changes in their properties and causing danger. And it needs to be stored separately from oxidizing agents, acids, alkalis and other substances. Due to contact with them or chemical reactions, unpredictable disasters will occur.
During use, precise control of dosage is extremely necessary. According to specific experimental or production needs, accurate instrument measurement is used to avoid waste and prevent improper dosage from affecting the reaction process or product quality. At the same time, strictly follow the established operating procedures, and each step is carried out according to the standard. Do not make changes to ensure the smooth and safe reaction.
Also, the treatment after use should not be underestimated. The remaining 4-chloro-3-nitrobenzenesulfonamide and related waste must not be discarded at will. It needs to be properly disposed of in accordance with relevant regulations, or recycled for reuse, or handled by professional methods to minimize the impact on the environment and maintain ecological balance.
In short, the use of 4-chloro-3-nitrobenzenesulfonamide, safety protection, proper storage, accurate dosage and reasonable handling, all matters need to be treated with caution, and no slack can be achieved in order to achieve the intended purpose and ensure the safety of people and the environment.
First priority safety protection. This substance is dangerous and may cause skin, eyes and respiratory tract irritation. Therefore, when using it, be sure to wear appropriate protective equipment, such as gloves, goggles and gas masks, to prevent direct contact with the body and avoid injury. The place of operation also needs to be well ventilated to allow volatile gases to quickly dissipate, keep the air fresh and protect the health of the operator.
Furthermore, proper storage is also key. It should be placed in a cool, dry and ventilated place, away from fire and heat sources, to prevent temperature and humidity discomfort, causing changes in their properties and causing danger. And it needs to be stored separately from oxidizing agents, acids, alkalis and other substances. Due to contact with them or chemical reactions, unpredictable disasters will occur.
During use, precise control of dosage is extremely necessary. According to specific experimental or production needs, accurate instrument measurement is used to avoid waste and prevent improper dosage from affecting the reaction process or product quality. At the same time, strictly follow the established operating procedures, and each step is carried out according to the standard. Do not make changes to ensure the smooth and safe reaction.
Also, the treatment after use should not be underestimated. The remaining 4-chloro-3-nitrobenzenesulfonamide and related waste must not be discarded at will. It needs to be properly disposed of in accordance with relevant regulations, or recycled for reuse, or handled by professional methods to minimize the impact on the environment and maintain ecological balance.
In short, the use of 4-chloro-3-nitrobenzenesulfonamide, safety protection, proper storage, accurate dosage and reasonable handling, all matters need to be treated with caution, and no slack can be achieved in order to achieve the intended purpose and ensure the safety of people and the environment.
Scan to WhatsApp
