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4-Chloro-3-Nitrotrifluoromethylbenzene
Linshang Chemical
|
HS Code |
305156 |
| Chemical Formula | C7H3ClF3NO2 |
| Molar Mass | 225.55 g/mol |
| Appearance | Yellow - brown liquid |
| Boiling Point | Around 218 - 220 °C |
| Melting Point | 14 - 16 °C |
| Density | 1.575 g/cm³ |
| Solubility In Water | Insoluble |
| Vapor Pressure | Low |
| Flash Point | 97 °C |
| Odor | Pungent |
As an accredited 4-Chloro-3-Nitrotrifluoromethylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - chloro - 3 - nitrotrifluoromethylbenzene packaged in a sealed plastic bottle. |
| Storage | 4 - chloro - 3 - nitrotrifluoromethylbenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and incompatible substances such as strong oxidizing agents and reducing agents. Store in a tightly - sealed container to prevent leakage and exposure to air or moisture, which could potentially lead to chemical reactions or degradation. |
| Shipping | 4 - chloro - 3 - nitrotrifluoromethylbenzene is a chemical. Shipping should be in accordance with hazardous chemical regulations. It must be properly packaged to prevent leakage, and transported by approved carriers with safety measures in place. |
Competitive 4-Chloro-3-Nitrotrifluoromethylbenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 4-Chloro-3-Nitrotrifluoromethylbenzene in China?
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As a leading 4-Chloro-3-Nitrotrifluoromethylbenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 4-chloro-3-nitrotrifluoromethylbenzene?
4-Chloro-3-nitrotrifluoromethylbenzene has a wide range of uses. In the field of organic synthesis, it is often a key intermediate. Due to its unique structure, the presence of chlorine atoms, nitro groups and trifluoromethyl groups endows it with special chemical activity.
In the preparation of new pesticides, this compound has a significant effect. Nitro and trifluoromethyl groups can enhance the poisoning efficiency of pesticides against pests, and chlorine atoms are conducive to react with other organic groups to construct pesticide molecules with diverse structures to deal with different kinds of pests.
In the field of medicinal chemistry, it also has important uses. Chemists can introduce various active groups through derivatization reactions to synthesize compounds with specific pharmacological activities. Or can develop drugs for specific diseases, such as some anti-cancer drugs and anti-infective drugs. 4-chloro-3-nitrotrifluoromethylbenzene may be one of the important starting materials.
In addition, in the field of materials science, due to its special chemical structure, it can participate in the synthesis of polymer materials with special properties. For example, by polymerizing with other monomers, the material has excellent properties such as good chemical resistance and thermal stability, which can be applied to the preparation of materials in high-end fields such as aerospace and electronics.
In summary, 4-chloro-3-nitrotrifluoromethylbenzene has important application value in pesticides, medicine, materials and many other fields due to its unique chemical structure, and is an indispensable and important compound in organic synthetic chemistry.
In the preparation of new pesticides, this compound has a significant effect. Nitro and trifluoromethyl groups can enhance the poisoning efficiency of pesticides against pests, and chlorine atoms are conducive to react with other organic groups to construct pesticide molecules with diverse structures to deal with different kinds of pests.
In the field of medicinal chemistry, it also has important uses. Chemists can introduce various active groups through derivatization reactions to synthesize compounds with specific pharmacological activities. Or can develop drugs for specific diseases, such as some anti-cancer drugs and anti-infective drugs. 4-chloro-3-nitrotrifluoromethylbenzene may be one of the important starting materials.
In addition, in the field of materials science, due to its special chemical structure, it can participate in the synthesis of polymer materials with special properties. For example, by polymerizing with other monomers, the material has excellent properties such as good chemical resistance and thermal stability, which can be applied to the preparation of materials in high-end fields such as aerospace and electronics.
In summary, 4-chloro-3-nitrotrifluoromethylbenzene has important application value in pesticides, medicine, materials and many other fields due to its unique chemical structure, and is an indispensable and important compound in organic synthetic chemistry.
What are the physical properties of 4-chloro-3-nitrotrifluoromethylbenzene?
4-Chloro-3-nitrotrifluoromethylbenzene is one of the organic compounds. Its physical properties can be described at several ends.
Looking at its properties, it often appears as a colorless to light yellow liquid at room temperature. The characteristics of this color state can help to identify among various compounds. Its odor is pungent, and it can be sensed by smelling. This odor characteristic is also a sign of its physical properties.
When it comes to the melting point, the melting point is about -15 ° C, and the boiling point is roughly in the range of 208-210 ° C. The number of such melting and boiling points is of key significance in chemical operation, storage and other links. Due to its low melting point, the cap is mostly liquid at room temperature, while the boiling point is quite high. To vaporize it, more energy is required.
Its density is about 1.60 g/cm ³, which is heavier than water. This density characteristic has a great impact on chemical processes such as liquid-liquid separation. If mixed with water, because of its high density, it will sink underwater, and it can be separated according to this difference.
In terms of solubility, 4-chloro-3-nitrotrifluoromethylbenzene is insoluble in water, but soluble in most organic solvents such as ethanol, ether, and acetone. This difference in solubility is widely used in organic synthesis, extraction, and other processes. Taking extraction as an example, it can be extracted from an aqueous solution by taking advantage of its different solubility in organic solvents and water.
In addition, its volatility is low, which can reduce the amount of its escape into the air during storage and use. However, it is still necessary to pay attention to ventilation during operation to prevent accumulation and harm. And because of its pungent odor and certain toxicity, protection is indispensable during operation to ensure personal safety.
Looking at its properties, it often appears as a colorless to light yellow liquid at room temperature. The characteristics of this color state can help to identify among various compounds. Its odor is pungent, and it can be sensed by smelling. This odor characteristic is also a sign of its physical properties.
When it comes to the melting point, the melting point is about -15 ° C, and the boiling point is roughly in the range of 208-210 ° C. The number of such melting and boiling points is of key significance in chemical operation, storage and other links. Due to its low melting point, the cap is mostly liquid at room temperature, while the boiling point is quite high. To vaporize it, more energy is required.
Its density is about 1.60 g/cm ³, which is heavier than water. This density characteristic has a great impact on chemical processes such as liquid-liquid separation. If mixed with water, because of its high density, it will sink underwater, and it can be separated according to this difference.
In terms of solubility, 4-chloro-3-nitrotrifluoromethylbenzene is insoluble in water, but soluble in most organic solvents such as ethanol, ether, and acetone. This difference in solubility is widely used in organic synthesis, extraction, and other processes. Taking extraction as an example, it can be extracted from an aqueous solution by taking advantage of its different solubility in organic solvents and water.
In addition, its volatility is low, which can reduce the amount of its escape into the air during storage and use. However, it is still necessary to pay attention to ventilation during operation to prevent accumulation and harm. And because of its pungent odor and certain toxicity, protection is indispensable during operation to ensure personal safety.
What is the chemistry of 4-chloro-3-nitrotrifluoromethylbenzene?
4-Chloro-3-nitrotrifluoromethylbenzene is one of the organic compounds. It is active and is a key intermediate in many organic synthesis reactions.
In this compound, the presence of chlorine atoms, nitro groups and trifluoromethyl groups endows it with unique chemical properties. The chlorine atom has a certain nucleophilic substitution activity. When encountering nucleophilic reagents, a substitution reaction can occur. The nucleophilic reagent attacks the carbon atom connected to the chlorine atom, and the chlorine atom leaves to form a new organic compound.
Nitro is a strong electron-absorbing group, which not only reduces the electron cloud density of the benzene ring, but also decreases the activity of the electrophilic substitution reaction of the benzene ring. Under appropriate conditions, it can be reduced to other groups such as This reduction reaction is widely used in drug synthesis, dye preparation and other fields.
Trifluoromethyl has a strong electron-absorbing effect and high chemical stability. Because of its strong electron-absorbing property, it can affect the reactivity and selectivity of other substituents on the benzene ring; because of its chemical stability, it makes compounds containing trifluoromethyl more stable in special environments, such as chemical corrosion resistance and good thermal stability.
Furthermore, the chemical properties of 4-chloro-3-nitrotrifluoromethylbenzene are also affected by the conjugate system of the benzene ring. The conjugate structure of the benzene ring makes its electron cloud distribution more uniform, and the interaction between each atom is unique, resulting in its reactivity very different from that of ordinary aliphatic compounds. In organic synthesis, chemists often use the many properties of this compound to construct complex organic molecules through different reaction paths to meet the needs of fields such as medicine, pesticides, and materials science.
In this compound, the presence of chlorine atoms, nitro groups and trifluoromethyl groups endows it with unique chemical properties. The chlorine atom has a certain nucleophilic substitution activity. When encountering nucleophilic reagents, a substitution reaction can occur. The nucleophilic reagent attacks the carbon atom connected to the chlorine atom, and the chlorine atom leaves to form a new organic compound.
Nitro is a strong electron-absorbing group, which not only reduces the electron cloud density of the benzene ring, but also decreases the activity of the electrophilic substitution reaction of the benzene ring. Under appropriate conditions, it can be reduced to other groups such as This reduction reaction is widely used in drug synthesis, dye preparation and other fields.
Trifluoromethyl has a strong electron-absorbing effect and high chemical stability. Because of its strong electron-absorbing property, it can affect the reactivity and selectivity of other substituents on the benzene ring; because of its chemical stability, it makes compounds containing trifluoromethyl more stable in special environments, such as chemical corrosion resistance and good thermal stability.
Furthermore, the chemical properties of 4-chloro-3-nitrotrifluoromethylbenzene are also affected by the conjugate system of the benzene ring. The conjugate structure of the benzene ring makes its electron cloud distribution more uniform, and the interaction between each atom is unique, resulting in its reactivity very different from that of ordinary aliphatic compounds. In organic synthesis, chemists often use the many properties of this compound to construct complex organic molecules through different reaction paths to meet the needs of fields such as medicine, pesticides, and materials science.
What is the preparation method of 4-chloro-3-nitrotrifluoromethylbenzene?
There are several common methods for preparing 4-chloro-3-nitrotrifluoromethylbenzene. One is to use trifluoromethylbenzene as the starting material and first perform chlorination. In a suitable reaction vessel, trifluoromethylbenzene is placed, ferric chloride is used as a catalyst, chlorine is introduced, and the temperature is raised to an appropriate temperature, generally about 50-80 ° C. Chlorination reaction is carried out to obtain 4-chlorotrifluoromethylbenzene. In this step, the hydrogen atom on the benzene ring is affected by the trifluoromethyl, and the electron cloud density changes, so that the chlorine atom is easy to replace the hydrogen at a specific position on the benzene ring.
Then, 4-chlorotrifluoromethylbenzene is subjected to a nitrification reaction. 4-Chlorotrifluoromethylbenzene is placed in a mixed acid (a mixture of concentrated sulfuric acid and concentrated nitric acid). Concentrated sulfuric acid is both a dehydrating agent and a catalyst. It is crucial to control the reaction temperature, which is usually carried out at a low temperature of 0-10 ° C to prevent side reactions. Under this condition, the nitro group selectively enters the chlorine atom ortho-site to generate 4-chloro-3-nitrotrifluoromethylbenzene.
Another method is to use m-nitrotrifluoromethylbenzene as a raw material. First, m-nitrotrifluoromethylbenzene is placed in a chlorination reaction system, with an appropriate chlorination reagent, such as sulfuryl chloride, and a catalyst, such as azobisisobutyronitrile (AIBN), under the condition of heating and refluxing. In this reaction, AIBN is thermally decomposed to produce free radicals, which initiates a chlorination reaction, so that chlorine atoms replace hydrogen atoms on the benzene ring to obtain 4-chloro-3-nitrotrifluoromethylbenzene. This approach also requires fine control of the reaction conditions to ensure the selectivity and yield of the reaction. Different preparation methods have their own advantages and disadvantages, and they need to be selected according to the actual situation, such as the availability of raw materials, cost, and the ease of control of the reaction conditions.
Then, 4-chlorotrifluoromethylbenzene is subjected to a nitrification reaction. 4-Chlorotrifluoromethylbenzene is placed in a mixed acid (a mixture of concentrated sulfuric acid and concentrated nitric acid). Concentrated sulfuric acid is both a dehydrating agent and a catalyst. It is crucial to control the reaction temperature, which is usually carried out at a low temperature of 0-10 ° C to prevent side reactions. Under this condition, the nitro group selectively enters the chlorine atom ortho-site to generate 4-chloro-3-nitrotrifluoromethylbenzene.
Another method is to use m-nitrotrifluoromethylbenzene as a raw material. First, m-nitrotrifluoromethylbenzene is placed in a chlorination reaction system, with an appropriate chlorination reagent, such as sulfuryl chloride, and a catalyst, such as azobisisobutyronitrile (AIBN), under the condition of heating and refluxing. In this reaction, AIBN is thermally decomposed to produce free radicals, which initiates a chlorination reaction, so that chlorine atoms replace hydrogen atoms on the benzene ring to obtain 4-chloro-3-nitrotrifluoromethylbenzene. This approach also requires fine control of the reaction conditions to ensure the selectivity and yield of the reaction. Different preparation methods have their own advantages and disadvantages, and they need to be selected according to the actual situation, such as the availability of raw materials, cost, and the ease of control of the reaction conditions.
4-chloro-3-nitrotrifluoromethylbenzene what are the precautions during use
4-Chloro-3-nitrotrifluoromethylbenzene, when using, there are several things to pay attention to, must not be ignored.
First, this substance is toxic, or can be caused by inhalation, skin contact and accidental ingestion. Therefore, when handling, it is necessary to wear appropriate protective gear, such as protective clothing, gloves and gas masks, to avoid contact with the body. And the operating environment should be well ventilated. If working in a closed place, effective ventilation devices must be installed to prevent the accumulation of harmful gases.
Second, 4-chloro-3-nitrotrifluoromethylbenzene is chemically active. When storing, be sure to keep away from fire sources, heat sources and oxidants, because of fire or hot topic, there is a risk of combustion and explosion. The storage place should also be dry, cool and ventilated, avoiding direct sunlight to prevent it from deteriorating or causing danger.
Third, if accidentally splashed on the skin or eyes during use, rinse with plenty of water immediately. If splashed into the eyes, rinse for a long time, and seek medical attention as soon as possible after rinsing. If inhaled, it should be moved to a fresh air place. If the symptoms do not abate, you should also seek medical attention. If eaten by mistake, do not urge vomiting, and send to the hospital for first aid as soon as possible.
Fourth, the waste of this substance must not be discarded at will. It needs to be properly disposed of in accordance with relevant laws and regulations. Or hand it over to a professional waste treatment agency to ensure that the environment is not polluted by it and from ecological harm.
All of these are what should be paid attention to when using 4-chloro-3-nitrotrifluoromethylbenzene. Users need to be careful and operate in accordance with regulations to ensure safety.
First, this substance is toxic, or can be caused by inhalation, skin contact and accidental ingestion. Therefore, when handling, it is necessary to wear appropriate protective gear, such as protective clothing, gloves and gas masks, to avoid contact with the body. And the operating environment should be well ventilated. If working in a closed place, effective ventilation devices must be installed to prevent the accumulation of harmful gases.
Second, 4-chloro-3-nitrotrifluoromethylbenzene is chemically active. When storing, be sure to keep away from fire sources, heat sources and oxidants, because of fire or hot topic, there is a risk of combustion and explosion. The storage place should also be dry, cool and ventilated, avoiding direct sunlight to prevent it from deteriorating or causing danger.
Third, if accidentally splashed on the skin or eyes during use, rinse with plenty of water immediately. If splashed into the eyes, rinse for a long time, and seek medical attention as soon as possible after rinsing. If inhaled, it should be moved to a fresh air place. If the symptoms do not abate, you should also seek medical attention. If eaten by mistake, do not urge vomiting, and send to the hospital for first aid as soon as possible.
Fourth, the waste of this substance must not be discarded at will. It needs to be properly disposed of in accordance with relevant laws and regulations. Or hand it over to a professional waste treatment agency to ensure that the environment is not polluted by it and from ecological harm.
All of these are what should be paid attention to when using 4-chloro-3-nitrotrifluoromethylbenzene. Users need to be careful and operate in accordance with regulations to ensure safety.
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