Linshang Chemical
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4-Chloro-3-(Trifluoromethyl)Benzeneboronic Acid
Linshang Chemical
|
HS Code |
340237 |
| Chemical Formula | C7H5BClF3O2 |
| Molecular Weight | 226.37 |
| Appearance | White to off - white solid |
| Purity | Typically high - purity (e.g., 97%+) |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene |
| Solubility In Water | Poorly soluble in water |
| Melting Point | 126 - 130 °C |
| Stability | Stable under normal conditions, but moisture - sensitive |
| Cas Number | 175205 - 46 - 4 |
As an accredited 4-Chloro-3-(Trifluoromethyl)Benzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 4 - chloro - 3 - (trifluoromethyl)benzeneboronic acid in a sealed chemical - grade vial. |
| Storage | 4 - chloro - 3 - (trifluoromethyl)benzeneboronic acid should be stored in a cool, dry place away from heat and ignition sources. Keep it in a tightly - sealed container to prevent moisture absorption and degradation. Store separately from incompatible substances, such as strong oxidizing agents and bases, to avoid potential chemical reactions. |
| Shipping | 4 - chloro - 3 - (trifluoromethyl)benzeneboronic acid is shipped in well - sealed, corrosion - resistant containers. Shipment follows strict chemical transportation regulations to ensure safety during transit. |
Competitive 4-Chloro-3-(Trifluoromethyl)Benzeneboronic Acid prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 4-chloro-3- (trifluoromethyl) benzeneboronic Acid
4-Chloro-3- (trifluoromethyl) phenylboronic acid is a crucial reagent in organic synthesis. It is active and often plays a key role in the formation of carbon-carbon bonds, especially in the Suzuki coupling reaction.
This compound has many remarkable chemical properties. Looking at its structure, the electron cloud density around the boron atom is affected by the presence of electron-absorbing groups such as fluorine atoms, resulting in its unique chemical activity. The presence of chlorine atoms and trifluoromethyl groups on the benzene ring also profoundly affects the electron distribution and steric hindrance of the molecule.
In the Suzuki coupling reaction, 4-chloro-3- (trifluoromethyl) phenylboronic acid can react with halogenated aromatics or olefins under the action of palladium catalysts and bases to efficiently generate biaryl or alkenylated products. This reaction is of great significance for the construction of complex organic molecular structures and has wide applications in drug synthesis, materials science and many other fields.
Because of the electron-deficient nature of boron atoms, 4-chloro-3- (trifluoromethyl) phenylboronic acid can interact with electron-rich molecules as Lewis acids, resulting in novel reaction pathways and products. At the same time, the strong electron-absorbing effect of trifluoromethyl can enhance the stability and fat solubility of the molecule, which is also crucial for its application in bioactive molecules and materials.
Its physical properties are also worthy of attention. Under normal conditions, it may be white to light yellow solids, and it has a certain solubility in common organic solvents such as dichloromethane and toluene. This property provides convenient conditions for its participation in various organic reactions. When storing and using, pay attention to moisture protection, because phenylboronic acid compounds may undergo reactions such as hydrolysis in contact with water or in humid environments, which affects their chemical properties and reactivity.
This compound has many remarkable chemical properties. Looking at its structure, the electron cloud density around the boron atom is affected by the presence of electron-absorbing groups such as fluorine atoms, resulting in its unique chemical activity. The presence of chlorine atoms and trifluoromethyl groups on the benzene ring also profoundly affects the electron distribution and steric hindrance of the molecule.
In the Suzuki coupling reaction, 4-chloro-3- (trifluoromethyl) phenylboronic acid can react with halogenated aromatics or olefins under the action of palladium catalysts and bases to efficiently generate biaryl or alkenylated products. This reaction is of great significance for the construction of complex organic molecular structures and has wide applications in drug synthesis, materials science and many other fields.
Because of the electron-deficient nature of boron atoms, 4-chloro-3- (trifluoromethyl) phenylboronic acid can interact with electron-rich molecules as Lewis acids, resulting in novel reaction pathways and products. At the same time, the strong electron-absorbing effect of trifluoromethyl can enhance the stability and fat solubility of the molecule, which is also crucial for its application in bioactive molecules and materials.
Its physical properties are also worthy of attention. Under normal conditions, it may be white to light yellow solids, and it has a certain solubility in common organic solvents such as dichloromethane and toluene. This property provides convenient conditions for its participation in various organic reactions. When storing and using, pay attention to moisture protection, because phenylboronic acid compounds may undergo reactions such as hydrolysis in contact with water or in humid environments, which affects their chemical properties and reactivity.
What are the main uses of 4-chloro-3- (trifluoromethyl) benzeneboronic Acid
4-Chloro-3- (trifluoromethyl) phenylboronic acid has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. First, it can be used to form carbon-carbon bonds. Through the coupling reaction of Suzuki, it is combined with halogenated aromatics or halogenated olefins. With the help of palladium catalysts and bases, biphenyl or alkenylated products can be efficiently generated. Such products are of great significance in pharmaceutical chemistry, and the backbone of many drug molecules often depends on them.
Furthermore, in the field of materials science, it also has important functions. It can participate in the preparation of materials with special photoelectric properties, such as organic Light Emitting Diode (OLED) materials. Through rational molecular design and reaction, it is introduced into the material structure, which can regulate the electron cloud distribution and energy level structure of the material, and then optimize the properties of the material such as luminous efficiency and color purity.
In addition, in the field of agricultural chemistry, it may help to synthesize new pesticides. Its unique structure may endow pesticide molecules with novel biological activities, which is beneficial to pest control and crop protection. It can achieve high-efficiency and low-toxicity pesticide efficacy by interacting with specific biological targets, which meets the needs of current green agriculture development.
In summary, 4-chloro-3- (trifluoromethyl) phenylboronic acid plays an important role in many fields such as organic synthesis, materials science, agricultural chemistry, etc., providing a key material basis for technological innovation and Product Research & Development in various fields.
Furthermore, in the field of materials science, it also has important functions. It can participate in the preparation of materials with special photoelectric properties, such as organic Light Emitting Diode (OLED) materials. Through rational molecular design and reaction, it is introduced into the material structure, which can regulate the electron cloud distribution and energy level structure of the material, and then optimize the properties of the material such as luminous efficiency and color purity.
In addition, in the field of agricultural chemistry, it may help to synthesize new pesticides. Its unique structure may endow pesticide molecules with novel biological activities, which is beneficial to pest control and crop protection. It can achieve high-efficiency and low-toxicity pesticide efficacy by interacting with specific biological targets, which meets the needs of current green agriculture development.
In summary, 4-chloro-3- (trifluoromethyl) phenylboronic acid plays an important role in many fields such as organic synthesis, materials science, agricultural chemistry, etc., providing a key material basis for technological innovation and Product Research & Development in various fields.
What is the synthesis method of 4-chloro-3- (trifluoromethyl) benzeneboronic Acid
The synthesis method of 4-chloro-3- (trifluoromethyl) phenylboronic acid is as follows:
First take the appropriate starting material, often starting with halogenated aromatics. For example, choose 4-chloro-3- (trifluoromethyl) bromobenzene, which is commonly used in organic synthesis. React it with a metal reagent, usually magnesium metal, to make Grignard reagent. Under the protection of an inert gas environment, such as nitrogen or argon, 4-chloro-3- (trifluoromethyl) bromobenzene and magnesium chips are placed in an anhydrous ether or tetrahydrofuran solvent, stirred moderately and heated to make the two fully react, and the corresponding Grignard reagent can be obtained.
Then, the Grignard reagent is reacted with borate esters. Trimethyl borate or triethyl borate are commonly used, and the borate ester is slowly added dropwise to the reaction system containing Grignard reagent in a low temperature environment. After adding it dropwise, it is gradually warmed to room temperature, so that the reaction can be fully carried out. After this reaction, boron groups can be introduced on the benzene ring.
The reaction is over, and the product needs to be treated. First, a dilute acid solution, such as dilute hydrochloric acid, quenches the reaction and decomposes the unreacted reagents and intermediates. Subsequently, the product is extracted with an organic solvent, such as multiple extractions with dichloromethane. The organic phases are combined and dried with anhydrous sodium sulfate to remove the moisture. After that, the organic solvent is removed by reduced pressure distillation to obtain a crude product.
Finally, the crude product is purified. Column chromatography can be used to select a suitable silica gel column, and n-hexane and ethyl acetate are mixed in a certain proportion as the eluent. After this operation, pure 4-chloro-3- (trifluoromethyl) phenylboronic acid can be obtained. This is a common method for synthesizing the compound, and the target product can be obtained through careful operation in each step.
First take the appropriate starting material, often starting with halogenated aromatics. For example, choose 4-chloro-3- (trifluoromethyl) bromobenzene, which is commonly used in organic synthesis. React it with a metal reagent, usually magnesium metal, to make Grignard reagent. Under the protection of an inert gas environment, such as nitrogen or argon, 4-chloro-3- (trifluoromethyl) bromobenzene and magnesium chips are placed in an anhydrous ether or tetrahydrofuran solvent, stirred moderately and heated to make the two fully react, and the corresponding Grignard reagent can be obtained.
Then, the Grignard reagent is reacted with borate esters. Trimethyl borate or triethyl borate are commonly used, and the borate ester is slowly added dropwise to the reaction system containing Grignard reagent in a low temperature environment. After adding it dropwise, it is gradually warmed to room temperature, so that the reaction can be fully carried out. After this reaction, boron groups can be introduced on the benzene ring.
The reaction is over, and the product needs to be treated. First, a dilute acid solution, such as dilute hydrochloric acid, quenches the reaction and decomposes the unreacted reagents and intermediates. Subsequently, the product is extracted with an organic solvent, such as multiple extractions with dichloromethane. The organic phases are combined and dried with anhydrous sodium sulfate to remove the moisture. After that, the organic solvent is removed by reduced pressure distillation to obtain a crude product.
Finally, the crude product is purified. Column chromatography can be used to select a suitable silica gel column, and n-hexane and ethyl acetate are mixed in a certain proportion as the eluent. After this operation, pure 4-chloro-3- (trifluoromethyl) phenylboronic acid can be obtained. This is a common method for synthesizing the compound, and the target product can be obtained through careful operation in each step.
Precautions for 4-chloro-3- (trifluoromethyl) benzeneboronic Acid during Storage and Transportation
4-Chloro-3- (trifluoromethyl) phenylboronic acid, which is a commonly used reagent in organic synthesis. During storage and transportation, there are many key points to be paid attention to.
Let's talk about storage first. Because of its active nature, it is easy to react with water, oxygen, etc., so it needs to be strictly sealed and stored. It should be placed in a dry, cool and well-ventilated place, and must not be exposed to humid or high temperature environments. Because in a humid environment, water molecules are prone to interact with the boron atoms of phenylboronic acid, causing it to hydrolyze, thereby destroying its structure and activity; high temperature will also accelerate its chemical reaction process, reducing its purity and stability. And it should be kept away from fire sources and oxidants. Although this reagent is not flammable and explosive, it may also cause violent reactions and endanger safety when it encounters strong oxidants.
As for transportation, it should not be taken lightly. It needs to be properly packaged to ensure that it will not be damaged and leaked due to collision and vibration during transportation. Choose suitable packaging materials, such as glass bottle jackets for cushioning materials, or use special plastic containers. At the same time, it is also necessary to maintain suitable temperature and humidity conditions during transportation to avoid excessive temperature fluctuations or excessive humidity. Transport personnel should also be aware of its nature and precautions, so that they can take prompt and correct measures in case of emergencies.
Only by paying careful attention to the above points during storage and transportation can the quality and safety of 4-chloro-3- (trifluoromethyl) phenylboronic acid be ensured, so that it can be fully utilized in the field of organic synthesis.
Let's talk about storage first. Because of its active nature, it is easy to react with water, oxygen, etc., so it needs to be strictly sealed and stored. It should be placed in a dry, cool and well-ventilated place, and must not be exposed to humid or high temperature environments. Because in a humid environment, water molecules are prone to interact with the boron atoms of phenylboronic acid, causing it to hydrolyze, thereby destroying its structure and activity; high temperature will also accelerate its chemical reaction process, reducing its purity and stability. And it should be kept away from fire sources and oxidants. Although this reagent is not flammable and explosive, it may also cause violent reactions and endanger safety when it encounters strong oxidants.
As for transportation, it should not be taken lightly. It needs to be properly packaged to ensure that it will not be damaged and leaked due to collision and vibration during transportation. Choose suitable packaging materials, such as glass bottle jackets for cushioning materials, or use special plastic containers. At the same time, it is also necessary to maintain suitable temperature and humidity conditions during transportation to avoid excessive temperature fluctuations or excessive humidity. Transport personnel should also be aware of its nature and precautions, so that they can take prompt and correct measures in case of emergencies.
Only by paying careful attention to the above points during storage and transportation can the quality and safety of 4-chloro-3- (trifluoromethyl) phenylboronic acid be ensured, so that it can be fully utilized in the field of organic synthesis.
4-Chloro-3- (trifluoromethyl) benzeneboronic Acid
4-Chloro-3- (trifluoromethyl) phenylboronic acid is widely used in the chemical industry. It is often used as a key intermediate in the field of pharmaceutical synthesis. Due to the unique reactivity of boron-containing groups, it can react with many compounds according to specific mechanisms to help build complex drug molecular structures. For example, when developing new antimalarial drugs, this compound can participate in specific carbon-boron bond formation reactions, shape the core skeleton of the drug, and pave the way for the creation of high-efficiency and low-toxicity antimalarial new drugs.
In the field of materials science, it has also emerged. When preparing optoelectronic functional materials, its structural properties can adjust the distribution of the material's electron cloud and improve the material's optoelectronic properties. For example, when preparing organic Light Emitting Diode (OLED) materials, the introduction of this compound structural unit can optimize the material's luminous efficiency and stability, and improve the OLED display performance.
Looking at the market, demand is on the rise. With the continuous advancement of pharmaceutical research and development, the demand for new drug creation is increasing. Many pharmaceutical companies and scientific research institutions frequently purchase to explore the synthesis path of new drugs. The expansion of the field of materials science has also prompted related companies to increase their demand for it. However, its preparation process is challenging, and the production scale is limited, making it difficult for the market supply to fully match the growth rate of demand.
Its price is affected by supply and demand and preparation costs. Because the preparation requires specific reaction conditions and raw materials, the cost is not low, so the price is relatively high. However, with technological innovation, if the preparation process is optimized, the cost may decrease and the price may fluctuate. Some suppliers with advanced synthesis technology stand out in the market competition due to cost advantages, while those with lagging technology may have limited market share due to cost disadvantages. Overall, the market prospect of this compound is broad, and it is necessary to overcome the preparation problems in order to promote the stable development of the market.
In the field of materials science, it has also emerged. When preparing optoelectronic functional materials, its structural properties can adjust the distribution of the material's electron cloud and improve the material's optoelectronic properties. For example, when preparing organic Light Emitting Diode (OLED) materials, the introduction of this compound structural unit can optimize the material's luminous efficiency and stability, and improve the OLED display performance.
Looking at the market, demand is on the rise. With the continuous advancement of pharmaceutical research and development, the demand for new drug creation is increasing. Many pharmaceutical companies and scientific research institutions frequently purchase to explore the synthesis path of new drugs. The expansion of the field of materials science has also prompted related companies to increase their demand for it. However, its preparation process is challenging, and the production scale is limited, making it difficult for the market supply to fully match the growth rate of demand.
Its price is affected by supply and demand and preparation costs. Because the preparation requires specific reaction conditions and raw materials, the cost is not low, so the price is relatively high. However, with technological innovation, if the preparation process is optimized, the cost may decrease and the price may fluctuate. Some suppliers with advanced synthesis technology stand out in the market competition due to cost advantages, while those with lagging technology may have limited market share due to cost disadvantages. Overall, the market prospect of this compound is broad, and it is necessary to overcome the preparation problems in order to promote the stable development of the market.
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