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4-Chloro-3-(Trifluoromethyl)Benzenesulfonyl Chloride
Linshang Chemical
|
HS Code |
475891 |
| Name | 4-Chloro-3-(Trifluoromethyl)Benzenesulfonyl Chloride |
| Molecular Formula | C7H3Cl2F3O2S |
| Molecular Weight | 277.06 |
| Appearance | Colorless to light yellow liquid |
| Cas Number | 13284-96-5 |
| Boiling Point | 240 - 242 °C |
| Density | 1.65 g/cm³ |
| Flash Point | 120 °C |
| Solubility | Reacts with water, soluble in organic solvents |
| Purity | Typically high purity in commercial products, e.g., 97%+ |
As an accredited 4-Chloro-3-(Trifluoromethyl)Benzenesulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 4 - chloro - 3 - (trifluoromethyl)benzenesulfonyl chloride in a sealed chemical - grade bottle. |
| Storage | 4 - chloro - 3 - (trifluoromethyl)benzenesulfonyl chloride should be stored in a cool, dry, well - ventilated area. Keep it away from heat, ignition sources, and moisture. Store it in a tightly sealed container, preferably made of corrosion - resistant materials. Avoid contact with incompatible substances like bases, reducing agents, and water to prevent decomposition and potential hazardous reactions. |
| Shipping | 4 - chloro - 3 - (trifluoromethyl)benzenesulfonyl chloride is a hazardous chemical. It must be shipped in accordance with strict regulations, using appropriate containers to prevent leakage, and labeled clearly for safe transportation. |
Competitive 4-Chloro-3-(Trifluoromethyl)Benzenesulfonyl Chloride prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 4-chloro-3- (trifluoromethyl) benzenesulfonyl Chloride
4-Chloro-3- (trifluoromethyl) benzenesulfonyl chloride, this material is strong and active. It is highly corrosive and can be damaged by contact. It will explode in contact with water, generate acid mist and put hot topic.
Looking at its structure, the chlorine atom and trifluoromethyl are combined in the benzene ring, which greatly increases its reactivity. Benzenesulfonyl chloride group is the key to introducing sulfonyl groups in organic synthesis. It can react quickly with alcohols and amines to form esters and amides.
In the field of chemical preparation, it is often used as a raw material for the preparation of fine chemicals such as medicine, pesticides, and dyes. Due to its high activity, the controllability of the reaction needs to be carefully checked to prevent accidents. In the process of organic synthesis, it is often the cornerstone of building complex molecular structures. However, due to its corrosiveness and reactivity, it must follow strict procedures and be fully protected to ensure safety and smooth reaction.
Looking at its structure, the chlorine atom and trifluoromethyl are combined in the benzene ring, which greatly increases its reactivity. Benzenesulfonyl chloride group is the key to introducing sulfonyl groups in organic synthesis. It can react quickly with alcohols and amines to form esters and amides.
In the field of chemical preparation, it is often used as a raw material for the preparation of fine chemicals such as medicine, pesticides, and dyes. Due to its high activity, the controllability of the reaction needs to be carefully checked to prevent accidents. In the process of organic synthesis, it is often the cornerstone of building complex molecular structures. However, due to its corrosiveness and reactivity, it must follow strict procedures and be fully protected to ensure safety and smooth reaction.
What are the common uses of 4-chloro-3- (trifluoromethyl) benzenesulfonyl Chloride
4-Chloro-3- (trifluoromethyl) benzenesulfonyl chloride, which is a crucial reagent in organic synthesis, has a wide range of common uses.
First, in the field of drug synthesis, it can be used as a key intermediate. The structure of benzenesulfonyl chloride can react with many nucleophiles containing nitrogen and oxygen, thereby constructing molecular structures with specific biological activities. For example, when reacted with amine compounds, sulfonamide derivatives can be formed. Many sulfonamide drugs have antibacterial and diuretic effects, and this reaction may be used to create new types of such drugs.
Second, in the field of materials science, it can be used to modify the surface of materials. Due to the presence of benzene ring and trifluoromethyl, the product is endowed with special physical and chemical properties, such as hydrophobicity and chemical stability. Reacting it with polymer materials may improve the surface properties of materials, such as improving fouling resistance and wear resistance, etc., which is very useful in the improvement of coatings, fibers and other materials.
Third, in organic synthesis chemistry experiments, it is often used as a sulfonylation reagent. It can react with alcohols, phenols, etc., introduce sulfonyl groups, and then achieve precise regulation of the structure and properties of organic compounds. It helps chemists synthesize various complex and functional organic molecules, expanding a broad approach for the study of organic synthesis chemistry.
Fourth, it also plays an important role in the field of pesticide synthesis. Through rational design of the reaction, it can be converted into bioactive compounds such as insecticides and weeds, providing new and efficient pesticide products for agricultural production to ensure the yield and quality of crops.
First, in the field of drug synthesis, it can be used as a key intermediate. The structure of benzenesulfonyl chloride can react with many nucleophiles containing nitrogen and oxygen, thereby constructing molecular structures with specific biological activities. For example, when reacted with amine compounds, sulfonamide derivatives can be formed. Many sulfonamide drugs have antibacterial and diuretic effects, and this reaction may be used to create new types of such drugs.
Second, in the field of materials science, it can be used to modify the surface of materials. Due to the presence of benzene ring and trifluoromethyl, the product is endowed with special physical and chemical properties, such as hydrophobicity and chemical stability. Reacting it with polymer materials may improve the surface properties of materials, such as improving fouling resistance and wear resistance, etc., which is very useful in the improvement of coatings, fibers and other materials.
Third, in organic synthesis chemistry experiments, it is often used as a sulfonylation reagent. It can react with alcohols, phenols, etc., introduce sulfonyl groups, and then achieve precise regulation of the structure and properties of organic compounds. It helps chemists synthesize various complex and functional organic molecules, expanding a broad approach for the study of organic synthesis chemistry.
Fourth, it also plays an important role in the field of pesticide synthesis. Through rational design of the reaction, it can be converted into bioactive compounds such as insecticides and weeds, providing new and efficient pesticide products for agricultural production to ensure the yield and quality of crops.
What is the synthesis method of 4-chloro-3- (trifluoromethyl) benzenesulfonyl Chloride
The synthesis of 4-chloro-3- (trifluoromethyl) benzenesulfonyl chloride is a key issue in the field of organic synthesis. This compound has important uses in many fields such as medicine, pesticides and material science, so it is extremely important to explore its effective synthesis path.
The synthesis of this compound in the past is by a routine method. First, 4-chloro-3- (trifluoromethyl) benzene is used as the starting material, and the sulfonate group is introduced through a sulfonation reaction, and then treated with a chlorination agent to convert it into sulfonyl chloride. Specifically, 4-chloro-3- (trifluoromethyl) benzene is first heated with sulfonating reagents such as concentrated sulfuric acid and fuming sulfuric acid, and a sulfonic acid group is introduced at a specific position in the benzene ring to generate 4-chloro-3- (trifluoromethyl) benzenesulfonic acid. This step should pay attention to the control of reaction temperature and time to prevent excessive sulfonation or other side reactions. After obtaining 4-chloro-3- (trifluoromethyl) benzenesulfonic acid, it is then treated with chlorinated agents such as phosphorus pentachloride and dichlorosulfoxide. Taking dichlorosulfoxide as an example, the two react in suitable solvents (such as toluene, dichloromethane, etc.), and the chlorine atom of dichlorosulfoxide replaces the hydroxyl group of the sulfonic acid group to form the target product 4-chloro-3- (trifluoromethyl) benzenesulfonyl chloride. In this process, factors such as the choice of solvent, the ratio of reactants, and reaction conditions (such as temperature and reaction time) have a great influence on the reaction yield and product purity.
Second, or from other benzene derivatives containing specific substituents, the target molecular structure can be gradually constructed through multi-step reactions. However, this path often involves complex reaction steps and the separation and purification of intermediates, and the operation is relatively cumbersome.
When synthesizing 4-chloro-3- (trifluoromethyl) benzenesulfonyl chloride, it is necessary to fine-tune the reaction conditions, strictly control the purity and ratio of the reactants, and select appropriate reaction solvents and catalysts, so as to improve the reaction efficiency, obtain high-purity target products, and achieve the purpose of synthesis.
The synthesis of this compound in the past is by a routine method. First, 4-chloro-3- (trifluoromethyl) benzene is used as the starting material, and the sulfonate group is introduced through a sulfonation reaction, and then treated with a chlorination agent to convert it into sulfonyl chloride. Specifically, 4-chloro-3- (trifluoromethyl) benzene is first heated with sulfonating reagents such as concentrated sulfuric acid and fuming sulfuric acid, and a sulfonic acid group is introduced at a specific position in the benzene ring to generate 4-chloro-3- (trifluoromethyl) benzenesulfonic acid. This step should pay attention to the control of reaction temperature and time to prevent excessive sulfonation or other side reactions. After obtaining 4-chloro-3- (trifluoromethyl) benzenesulfonic acid, it is then treated with chlorinated agents such as phosphorus pentachloride and dichlorosulfoxide. Taking dichlorosulfoxide as an example, the two react in suitable solvents (such as toluene, dichloromethane, etc.), and the chlorine atom of dichlorosulfoxide replaces the hydroxyl group of the sulfonic acid group to form the target product 4-chloro-3- (trifluoromethyl) benzenesulfonyl chloride. In this process, factors such as the choice of solvent, the ratio of reactants, and reaction conditions (such as temperature and reaction time) have a great influence on the reaction yield and product purity.
Second, or from other benzene derivatives containing specific substituents, the target molecular structure can be gradually constructed through multi-step reactions. However, this path often involves complex reaction steps and the separation and purification of intermediates, and the operation is relatively cumbersome.
When synthesizing 4-chloro-3- (trifluoromethyl) benzenesulfonyl chloride, it is necessary to fine-tune the reaction conditions, strictly control the purity and ratio of the reactants, and select appropriate reaction solvents and catalysts, so as to improve the reaction efficiency, obtain high-purity target products, and achieve the purpose of synthesis.
What to pay attention to when storing 4-chloro-3- (trifluoromethyl) benzenesulfonyl Chloride
4-Chloro-3- (trifluoromethyl) benzenesulfonyl chloride is an important chemical agent. When storing, be sure to pay attention to many matters.
First, its nature is lively, and it is easy to react with water. Therefore, it must be placed in a dry place to avoid it from contact with water vapor. If stored in a humid place, water vapor will cause severe changes, causing the agent to deteriorate and lose its effectiveness.
Second, this substance is highly corrosive and harmful to the skin, eyes and respiratory tract. When storing, it must be stored in a corrosion-resistant device, and the seal must be tight. If there is a leak in the container and the medicine leaks out, it will not only pollute the surroundings, but also easily hurt people.
Furthermore, 4-chloro-3- (trifluoromethyl) benzenesulfonyl chloride is easily decomposed by heat, or it may cause a dangerous state. Therefore, when stored in a cool place, avoid heat and light. Do not approach fire or heat sources to prevent accidents.
Also, the storage place should be well ventilated. If the ventilation is poor, the volatile gas of the medicine will gather in one place. Once it reaches a certain concentration, it will be exposed to open fire or static electricity, and there will be a risk of explosion.
And when storing, it must also be separated from other chemicals, especially reducing substances, alkaline substances, etc. Because of its chemical properties, it is easy to mix with it, and it is easy to cause chemical reactions, resulting in danger.
In short, the storage of 4-chloro-3- (trifluoromethyl) benzenesulfonyl chloride must be based on its properties, beware of water, rot, heat, mixing, etc., to protect its quality and avoid health hazards.
First, its nature is lively, and it is easy to react with water. Therefore, it must be placed in a dry place to avoid it from contact with water vapor. If stored in a humid place, water vapor will cause severe changes, causing the agent to deteriorate and lose its effectiveness.
Second, this substance is highly corrosive and harmful to the skin, eyes and respiratory tract. When storing, it must be stored in a corrosion-resistant device, and the seal must be tight. If there is a leak in the container and the medicine leaks out, it will not only pollute the surroundings, but also easily hurt people.
Furthermore, 4-chloro-3- (trifluoromethyl) benzenesulfonyl chloride is easily decomposed by heat, or it may cause a dangerous state. Therefore, when stored in a cool place, avoid heat and light. Do not approach fire or heat sources to prevent accidents.
Also, the storage place should be well ventilated. If the ventilation is poor, the volatile gas of the medicine will gather in one place. Once it reaches a certain concentration, it will be exposed to open fire or static electricity, and there will be a risk of explosion.
And when storing, it must also be separated from other chemicals, especially reducing substances, alkaline substances, etc. Because of its chemical properties, it is easy to mix with it, and it is easy to cause chemical reactions, resulting in danger.
In short, the storage of 4-chloro-3- (trifluoromethyl) benzenesulfonyl chloride must be based on its properties, beware of water, rot, heat, mixing, etc., to protect its quality and avoid health hazards.
4-Chloro-3- (trifluoromethyl) benzenesulfonyl Chloride safety precautions during use
4-Chloro-3- (trifluoromethyl) benzenesulfonyl chloride is an active chemical reagent, which is widely used in chemical, pharmaceutical and other fields. However, during its use, safety should not be underestimated.
The first to bear the brunt is the comprehensive protective equipment. Users must wear protective clothing, which must have excellent corrosion resistance and can effectively block the contact of the reagent with the skin to avoid skin erosion. At the same time, protective gloves are also indispensable, and material adaptations must be selected to ensure hand safety. Facial protection is also essential. Protective masks or goggles should be worn properly to prevent the reagent from splashing into the eye and causing serious injury to the eye.
Furthermore, the operating environment must also be treated with caution. The operation of this reagent should be carried out in a well-ventilated place, the best place is in the fume hood. The fume hood can quickly discharge the volatile reagent gas and reduce the concentration of harmful gases in the air, thereby effectively reducing the harm to the operator's respiratory system. At the same time, fireworks should be strictly prohibited in the operating place. Because the reagent may have flammable and explosive properties, it may cause serious safety accidents in case of open flames or hot topics.
In addition, the storage of reagents is also exquisite. Store in a cool, dry and ventilated place, away from fire and heat sources. The storage container must be well sealed to prevent leakage of reagents. And, it should be stored separately from oxidants, alkalis and other substances, and must not be mixed, otherwise it is easy to cause chemical reactions and cause danger.
During operation, the action should be gentle and cautious. When using reagents, special tools should be used and strictly follow the operating procedures. If a leak occurs accidentally, do not panic, and emergency measures should be taken immediately. In the event of a small leak, sprinkle soda ash and other alkaline substances on the ground for neutralization, and then rinse with plenty of water. In the event of a large leak, quickly evacuate the contaminated area to a safe area and isolate it, strictly restricting personnel access. At the same time, emergency responders must wear protective equipment to avoid exposing themselves to danger, and then use appropriate materials for containment and handling.
The first to bear the brunt is the comprehensive protective equipment. Users must wear protective clothing, which must have excellent corrosion resistance and can effectively block the contact of the reagent with the skin to avoid skin erosion. At the same time, protective gloves are also indispensable, and material adaptations must be selected to ensure hand safety. Facial protection is also essential. Protective masks or goggles should be worn properly to prevent the reagent from splashing into the eye and causing serious injury to the eye.
Furthermore, the operating environment must also be treated with caution. The operation of this reagent should be carried out in a well-ventilated place, the best place is in the fume hood. The fume hood can quickly discharge the volatile reagent gas and reduce the concentration of harmful gases in the air, thereby effectively reducing the harm to the operator's respiratory system. At the same time, fireworks should be strictly prohibited in the operating place. Because the reagent may have flammable and explosive properties, it may cause serious safety accidents in case of open flames or hot topics.
In addition, the storage of reagents is also exquisite. Store in a cool, dry and ventilated place, away from fire and heat sources. The storage container must be well sealed to prevent leakage of reagents. And, it should be stored separately from oxidants, alkalis and other substances, and must not be mixed, otherwise it is easy to cause chemical reactions and cause danger.
During operation, the action should be gentle and cautious. When using reagents, special tools should be used and strictly follow the operating procedures. If a leak occurs accidentally, do not panic, and emergency measures should be taken immediately. In the event of a small leak, sprinkle soda ash and other alkaline substances on the ground for neutralization, and then rinse with plenty of water. In the event of a large leak, quickly evacuate the contaminated area to a safe area and isolate it, strictly restricting personnel access. At the same time, emergency responders must wear protective equipment to avoid exposing themselves to danger, and then use appropriate materials for containment and handling.
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