Linshang Chemical
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4-Chloro-3-Trifluoromethyl-Benzenesulfonyl Chloride
Linshang Chemical
|
HS Code |
887378 |
| Chemical Formula | C7H3Cl2F3O2S |
| Molar Mass | 279.06 g/mol |
| Appearance | Typically a colorless to pale yellow liquid |
| Boiling Point | Around 265 - 270 °C |
| Solubility | Soluble in organic solvents like dichloromethane, insoluble in water |
| Vapor Pressure | Low vapor pressure at room temperature |
| Flash Point | Relatively high, indicating low flammability risk |
| Reactivity | Highly reactive towards nucleophiles due to sulfonyl chloride group |
As an accredited 4-Chloro-3-Trifluoromethyl-Benzenesulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 4 - chloro - 3 - trifluoromethyl - benzenesulfonyl chloride in a sealed glass bottle. |
| Storage | 4 - chloro - 3 - trifluoromethyl - benzenesulfonyl chloride should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and incompatible substances like bases, strong oxidizing agents, and water. Store in a tightly - sealed container to prevent exposure to moisture, which can cause hydrolysis. Use appropriate safety cabinets for hazardous chemicals. |
| Shipping | 4 - chloro - 3 - trifluoromethyl - benzenesulfonyl chloride is a chemical. Shipping should be in accordance with hazardous material regulations, using appropriate packaging to prevent leakage, and ensuring proper labeling for safe transportation. |
Competitive 4-Chloro-3-Trifluoromethyl-Benzenesulfonyl Chloride prices that fit your budget—flexible terms and customized quotes for every order.
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What are the main uses of 4-chloro-3-trifluoromethyl-benzenesulfonyl Chloride?
4-Chloro-3-trifluoromethylbenzenesulfonyl chloride has a wide range of uses. In the field of organic synthesis, it is often a key reagent.
First, it can be used to prepare sulfonamide compounds. In many pharmaceutical chemistry research and production, sulfonamide structures often exist in drug molecules, giving drugs specific biological activities. By reacting 4-chloro-3-trifluoromethylbenzenesulfonyl chloride with amino-containing compounds, through appropriate reaction conditions, corresponding sulfonamide derivatives can be successfully prepared. Such derivatives may have antibacterial, anti-inflammatory, anti-tumor and other pharmacological activities, which are of great significance in the development of new drugs.
Second, in the field of materials science, it also has applications. It can participate in the preparation of polymer materials with special properties. For example, by reacting with polymer monomers containing hydroxyl groups or other active groups, the benzenesulfonyl chloride structure is introduced into the main chain or side chain of the polymer, thereby changing the solubility, thermal stability, and surface properties of the polymer material. The modified polymer materials may exhibit unique advantages in the fields of coatings, plastics, and fibers, such as improving the weather resistance and wear resistance of coatings, and enhancing the chemical corrosion resistance of plastics.
Furthermore, in the field of pesticides, 4-chloro-3-trifluoromethylbenzenesulfonyl chloride also plays an important role. It can be used as an intermediate for the synthesis of new pesticides to derive compounds with high insecticidal, bactericidal or herbicidal activities. Because its molecular structure contains chlorine atoms and trifluoromethyl, it endows the synthesized pesticides with unique biological activity and environmental adaptability, or has higher biological activity, lower toxicity and better environmental compatibility, which is conducive to the development of green and efficient pesticide products.
First, it can be used to prepare sulfonamide compounds. In many pharmaceutical chemistry research and production, sulfonamide structures often exist in drug molecules, giving drugs specific biological activities. By reacting 4-chloro-3-trifluoromethylbenzenesulfonyl chloride with amino-containing compounds, through appropriate reaction conditions, corresponding sulfonamide derivatives can be successfully prepared. Such derivatives may have antibacterial, anti-inflammatory, anti-tumor and other pharmacological activities, which are of great significance in the development of new drugs.
Second, in the field of materials science, it also has applications. It can participate in the preparation of polymer materials with special properties. For example, by reacting with polymer monomers containing hydroxyl groups or other active groups, the benzenesulfonyl chloride structure is introduced into the main chain or side chain of the polymer, thereby changing the solubility, thermal stability, and surface properties of the polymer material. The modified polymer materials may exhibit unique advantages in the fields of coatings, plastics, and fibers, such as improving the weather resistance and wear resistance of coatings, and enhancing the chemical corrosion resistance of plastics.
Furthermore, in the field of pesticides, 4-chloro-3-trifluoromethylbenzenesulfonyl chloride also plays an important role. It can be used as an intermediate for the synthesis of new pesticides to derive compounds with high insecticidal, bactericidal or herbicidal activities. Because its molecular structure contains chlorine atoms and trifluoromethyl, it endows the synthesized pesticides with unique biological activity and environmental adaptability, or has higher biological activity, lower toxicity and better environmental compatibility, which is conducive to the development of green and efficient pesticide products.
What are the physical properties of 4-chloro-3-trifluoromethyl-benzenesulfonyl Chloride?
4-Chloro-3-trifluoromethylbenzenesulfonyl chloride, this is an important compound in organic chemistry. Its physical properties are unique and are described below.
Looking at its morphology, under room temperature and pressure, it is mostly colorless to slightly yellow liquid, with a clear texture, such as the purity of a clear spring, or the faint yellow glow, like the first light of dawn. It has a special smell, although it is difficult to describe it accurately in words, in the experimental environment of organic chemistry, this smell is unique and impressive, like the unique "business card" of the chemical world.
When talking about the boiling point, it is about a specific temperature range. This boiling point is the critical temperature at which a substance converts from a liquid state to a gas state. At this temperature point, the molecule obtains enough energy to break free from the liquid phase and rise into a gaseous state. The value of its boiling point is affected by multiple factors such as intermolecular forces. The interaction of chlorine atoms, trifluoromethyl and benzenesulfonyl chloride groups in the molecular structure of this compound jointly determines its boiling point characteristics, just like the cooperative operation of various components in precision machinery.
Melting point is also an important physical property. In a specific low temperature environment, the compound will condense from liquid to solid state, and this temperature is the melting point. Its melting point value reflects the degree of ordering of molecules and the size of lattice energy. In the solid state, the molecules are closely arranged according to specific laws, such as a strict square matrix, and the melting point temperature is like the "key" to open the active state of molecules.
In terms of density, it has a specific value at room temperature, and the mass per unit volume reflects the density of the substance. This density is unique compared with common organic solvents or water. Compared with water, its molecular structure is rich in heavy atoms such as halogen atoms, resulting in a higher density. If it is placed in the same container as water, it can be seen that it is like a pearl sinking to the bottom.
Solubility is also key. In the field of organic solvents, such as common aromatic hydrocarbon solvents such as toluene, xylene, halogenated hydrocarbons such as dichloromethane, chloroform, etc., its solubility is quite good. This is due to the principle of "similarity and miscibility". The molecular structure of the compound is compatible with the molecular structure of the above organic solvent in terms of polarity and intermolecular forces. It is like tenon and mortise interlocking, so it can be mutually soluble. However, in water, due to the difference between molecular polarity and water, coupled with the existence of hydrophobic groups, the solubility is extremely poor, just like the incompatibility of oil and water. The two are distinct.
The physical properties of 4-chloro-3-trifluoromethylbenzenesulfonyl chloride are of great significance in many fields such as organic synthesis. Chemists can use this to control their reaction conditions, separation and purification operations, such as craftsmen using their skills according to material characteristics, and performing wonderful chapters on the stage of chemistry.
Looking at its morphology, under room temperature and pressure, it is mostly colorless to slightly yellow liquid, with a clear texture, such as the purity of a clear spring, or the faint yellow glow, like the first light of dawn. It has a special smell, although it is difficult to describe it accurately in words, in the experimental environment of organic chemistry, this smell is unique and impressive, like the unique "business card" of the chemical world.
When talking about the boiling point, it is about a specific temperature range. This boiling point is the critical temperature at which a substance converts from a liquid state to a gas state. At this temperature point, the molecule obtains enough energy to break free from the liquid phase and rise into a gaseous state. The value of its boiling point is affected by multiple factors such as intermolecular forces. The interaction of chlorine atoms, trifluoromethyl and benzenesulfonyl chloride groups in the molecular structure of this compound jointly determines its boiling point characteristics, just like the cooperative operation of various components in precision machinery.
Melting point is also an important physical property. In a specific low temperature environment, the compound will condense from liquid to solid state, and this temperature is the melting point. Its melting point value reflects the degree of ordering of molecules and the size of lattice energy. In the solid state, the molecules are closely arranged according to specific laws, such as a strict square matrix, and the melting point temperature is like the "key" to open the active state of molecules.
In terms of density, it has a specific value at room temperature, and the mass per unit volume reflects the density of the substance. This density is unique compared with common organic solvents or water. Compared with water, its molecular structure is rich in heavy atoms such as halogen atoms, resulting in a higher density. If it is placed in the same container as water, it can be seen that it is like a pearl sinking to the bottom.
Solubility is also key. In the field of organic solvents, such as common aromatic hydrocarbon solvents such as toluene, xylene, halogenated hydrocarbons such as dichloromethane, chloroform, etc., its solubility is quite good. This is due to the principle of "similarity and miscibility". The molecular structure of the compound is compatible with the molecular structure of the above organic solvent in terms of polarity and intermolecular forces. It is like tenon and mortise interlocking, so it can be mutually soluble. However, in water, due to the difference between molecular polarity and water, coupled with the existence of hydrophobic groups, the solubility is extremely poor, just like the incompatibility of oil and water. The two are distinct.
The physical properties of 4-chloro-3-trifluoromethylbenzenesulfonyl chloride are of great significance in many fields such as organic synthesis. Chemists can use this to control their reaction conditions, separation and purification operations, such as craftsmen using their skills according to material characteristics, and performing wonderful chapters on the stage of chemistry.
What are the chemical properties of 4-chloro-3-trifluoromethyl-benzenesulfonyl Chloride?
4-Chloro-3-trifluoromethylbenzenesulfonyl chloride, this material is strong and has unique chemical properties. Its appearance is often colorless to slightly yellow liquid, and it smells pungent and peculiar, as if it comes from the depths of the underworld, which is intimidating.
In terms of its chemical activity, it is extremely active, as if it has endless restlessness. Among them, the sulfonyl chloride group (-SO 2O Cl) is particularly active, and it is easy to react violently with many nucleophilic reagents, just like dry wood and fire, which will burn at one point. Common nucleophilic reagents, such as alcohols and amines, will quickly combine when they meet, forming a series of new compounds. When reacting with alcohol, it is like a fierce confrontation. The chlorine atom in the sulfonyl chloride group will be replaced by the alkoxy group of the alcohol, resulting in the formation of sulfonic acid esters. This process is like a sword handover between warriors, which is rapid and decisive.
The halogen atoms in its molecule, chlorine and trifluoromethyl, also have a profound impact on its chemical properties. Trifluoromethyl has extremely strong electron absorption, like a greedy predator, attracting the electron cloud strongly, which significantly reduces the electron cloud density of the benzene ring. As a result, the reactivity of the benzene ring has undergone tremendous changes compared with that of the ordinary benzene ring. This not only affects the check point and rate of the electrophilic substitution reaction, but also makes the stability and reaction selectivity of the whole molecule show a unique state. In many chemical reactions, it is like a maverick dancer, following a unique rhythm.
In addition, 4-chloro-3-trifluoromethylbenzenesulfonyl chloride is extremely sensitive to water, like a delicate flower that cannot meet wind and rain. Once it encounters water, it will quickly hydrolyze like an enemy, and the sulfonyl chloride group will be gradually replaced by the hydroxyl group to produce hydrogen chloride gas. This process is accompanied by the release of a pungent smell, like a demon's breath, warning people of its danger. Due to its many unique and lively chemical properties, in the field of organic synthesis, although it is like a double-edged sword, it can be used properly to open up the road to novel compounds, but if it is not careful, it can also cause unpredictable dangers. Therefore, when operating, it is necessary to be extremely cautious, like walking on thin ice.
In terms of its chemical activity, it is extremely active, as if it has endless restlessness. Among them, the sulfonyl chloride group (-SO 2O Cl) is particularly active, and it is easy to react violently with many nucleophilic reagents, just like dry wood and fire, which will burn at one point. Common nucleophilic reagents, such as alcohols and amines, will quickly combine when they meet, forming a series of new compounds. When reacting with alcohol, it is like a fierce confrontation. The chlorine atom in the sulfonyl chloride group will be replaced by the alkoxy group of the alcohol, resulting in the formation of sulfonic acid esters. This process is like a sword handover between warriors, which is rapid and decisive.
The halogen atoms in its molecule, chlorine and trifluoromethyl, also have a profound impact on its chemical properties. Trifluoromethyl has extremely strong electron absorption, like a greedy predator, attracting the electron cloud strongly, which significantly reduces the electron cloud density of the benzene ring. As a result, the reactivity of the benzene ring has undergone tremendous changes compared with that of the ordinary benzene ring. This not only affects the check point and rate of the electrophilic substitution reaction, but also makes the stability and reaction selectivity of the whole molecule show a unique state. In many chemical reactions, it is like a maverick dancer, following a unique rhythm.
In addition, 4-chloro-3-trifluoromethylbenzenesulfonyl chloride is extremely sensitive to water, like a delicate flower that cannot meet wind and rain. Once it encounters water, it will quickly hydrolyze like an enemy, and the sulfonyl chloride group will be gradually replaced by the hydroxyl group to produce hydrogen chloride gas. This process is accompanied by the release of a pungent smell, like a demon's breath, warning people of its danger. Due to its many unique and lively chemical properties, in the field of organic synthesis, although it is like a double-edged sword, it can be used properly to open up the road to novel compounds, but if it is not careful, it can also cause unpredictable dangers. Therefore, when operating, it is necessary to be extremely cautious, like walking on thin ice.
What is the preparation method of 4-chloro-3-trifluoromethyl-benzenesulfonyl Chloride?
The preparation method of 4-chloro-3-trifluoromethylbenzene sulfonyl chloride is an important topic in the field of chemical synthesis. To prepare this substance, the following steps are often followed.
First, use 4-chloro-3-trifluoromethylbenzene as the starting material. In a suitable reaction vessel, mix this raw material with an appropriate amount of fuming sulfuric acid. This mixing process requires careful operation, because fuming sulfuric acid is highly corrosive and oxidizing. When mixing, ensure that the temperature of the reaction system is moderate, and it can generally be controlled in the low temperature range, such as between 0 ° C and 10 ° C, to prevent side reactions from occurring.
After the raw material is fully mixed with fuming sulfuric acid, slowly heat up to a specific temperature, about 50 ° C to 80 ° C, and continue to stir the reaction in this temperature range for several hours. The purpose of this step is to replace the hydrogen atom on the benzene ring with a sulfonic acid group, thereby generating 4-chloro-3-trifluoromethylbenzene sulfonic acid.
After generating 4-chloro-3-trifluoromethylbenzene sulfonic acid, it needs to be further converted into the corresponding sulfonyl chloride. This process allows the reaction product to be cooled, followed by dropwise addition of sulfoxide chloride. The reaction of sulfoxide chloride with sulfonic acid converts the sulfonic acid group into a sulfonyl When adding thionyl chloride dropwise, also pay attention to temperature control, which can be kept at room temperature to about 40 ° C. After the dropwise addition is completed, continue to stir the reaction for a period of time to make the reaction complete.
The reaction is over, and the product needs to be separated and purified. The excess thionyl chloride and other low boiling point impurities can be removed by reduced pressure distillation. Subsequently, the product is further purified by means of recrystallization or column chromatography to obtain high purity 4-chloro-3-trifluoromethylbenzenesulfonyl chloride. The whole preparation process requires strict control of the reaction conditions, including temperature, proportion of reactants, reaction time, etc., to ensure the yield and purity of the product.
First, use 4-chloro-3-trifluoromethylbenzene as the starting material. In a suitable reaction vessel, mix this raw material with an appropriate amount of fuming sulfuric acid. This mixing process requires careful operation, because fuming sulfuric acid is highly corrosive and oxidizing. When mixing, ensure that the temperature of the reaction system is moderate, and it can generally be controlled in the low temperature range, such as between 0 ° C and 10 ° C, to prevent side reactions from occurring.
After the raw material is fully mixed with fuming sulfuric acid, slowly heat up to a specific temperature, about 50 ° C to 80 ° C, and continue to stir the reaction in this temperature range for several hours. The purpose of this step is to replace the hydrogen atom on the benzene ring with a sulfonic acid group, thereby generating 4-chloro-3-trifluoromethylbenzene sulfonic acid.
After generating 4-chloro-3-trifluoromethylbenzene sulfonic acid, it needs to be further converted into the corresponding sulfonyl chloride. This process allows the reaction product to be cooled, followed by dropwise addition of sulfoxide chloride. The reaction of sulfoxide chloride with sulfonic acid converts the sulfonic acid group into a sulfonyl When adding thionyl chloride dropwise, also pay attention to temperature control, which can be kept at room temperature to about 40 ° C. After the dropwise addition is completed, continue to stir the reaction for a period of time to make the reaction complete.
The reaction is over, and the product needs to be separated and purified. The excess thionyl chloride and other low boiling point impurities can be removed by reduced pressure distillation. Subsequently, the product is further purified by means of recrystallization or column chromatography to obtain high purity 4-chloro-3-trifluoromethylbenzenesulfonyl chloride. The whole preparation process requires strict control of the reaction conditions, including temperature, proportion of reactants, reaction time, etc., to ensure the yield and purity of the product.
What are the precautions for 4-chloro-3-trifluoromethyl-benzenesulfonyl Chloride in storage and transportation?
4-Chloro-3-trifluoromethylbenzenesulfonyl chloride, this is a rather special chemical substance. When storing and transporting, many things need to be paid attention to.
First of all, storage, because of its active nature, it is easy to react with many substances, so it must be stored in a dry and cool place. Do not put it in a humid place to prevent moisture dissolution and deterioration. And it must be kept away from fire and heat sources, because heat is very likely to cause violent reactions, or even dangerous. The storage place should also be separated from oxidants, alkalis and other substances to avoid accidents caused by mutual contact.
In addition to transportation, the packaging must be sturdy and reliable to ensure that there will be no leakage during transportation. The transportation vehicle should also be kept clean and no other substances that may react with it should be left. Transportation personnel need to have a detailed understanding of its nature and know the emergency response methods. During transportation, always pay attention to changes in temperature and humidity. In case of high temperature weather, necessary cooling measures should be taken.
In conclusion, the storage and transportation of 4-chloro-3-trifluoromethylbenzenesulfonyl chloride should be treated with caution and strictly follow relevant norms and requirements, so as to ensure safety and avoid accidents.
First of all, storage, because of its active nature, it is easy to react with many substances, so it must be stored in a dry and cool place. Do not put it in a humid place to prevent moisture dissolution and deterioration. And it must be kept away from fire and heat sources, because heat is very likely to cause violent reactions, or even dangerous. The storage place should also be separated from oxidants, alkalis and other substances to avoid accidents caused by mutual contact.
In addition to transportation, the packaging must be sturdy and reliable to ensure that there will be no leakage during transportation. The transportation vehicle should also be kept clean and no other substances that may react with it should be left. Transportation personnel need to have a detailed understanding of its nature and know the emergency response methods. During transportation, always pay attention to changes in temperature and humidity. In case of high temperature weather, necessary cooling measures should be taken.
In conclusion, the storage and transportation of 4-chloro-3-trifluoromethylbenzenesulfonyl chloride should be treated with caution and strictly follow relevant norms and requirements, so as to ensure safety and avoid accidents.
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