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4-Chloro-3-(Trifluoromethyl)Benzenesulphonyl Chloride

Linshang Chemical

Specifications

HS Code

912564

Name 4-Chloro-3-(trifluoromethyl)benzenesulphonyl chloride
Chemical Formula C7H3Cl2F3O2S
Molar Mass 277.06 g/mol
Appearance Typically a colorless to pale yellow liquid
Density Data may vary, generally around 1.6 - 1.8 g/cm³
Boiling Point Approximately 243 - 245 °C
Solubility Soluble in common organic solvents like dichloromethane, chloroform
Pungency Has a pungent odor
Reactivity Highly reactive, especially towards nucleophiles

As an accredited 4-Chloro-3-(Trifluoromethyl)Benzenesulphonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500g of 4 - chloro - 3 - (trifluoromethyl)benzenesulphonyl Chloride in sealed, corrosion - resistant bottle.
Storage 4 - chloro - 3 - (trifluoromethyl)benzenesulphonyl chloride should be stored in a cool, dry, well - ventilated area. Keep it away from heat, flames, and sources of ignition. Store in a tightly - sealed container, preferably in a corrosion - resistant material, as it is reactive and may corrode some substances. Avoid contact with moisture, water, and incompatible chemicals to prevent decomposition and hazardous reactions.
Shipping 4 - chloro - 3 - (trifluoromethyl)benzenesulphonyl chloride is a hazardous chemical. It must be shipped in accordance with strict regulations, using appropriate packaging to prevent leakage and ensure safe transportation.
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4-Chloro-3-(Trifluoromethyl)Benzenesulphonyl Chloride 4-Chloro-3-(Trifluoromethyl)Benzenesulphonyl Chloride
General Information
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Frequently Asked Questions

As a leading 4-Chloro-3-(Trifluoromethyl)Benzenesulphonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the chemical properties of 4-chloro-3- (trifluoromethyl) benzenesulphonyl Chloride
4-Chloro-3- (trifluoromethyl) benzenesulfonyl chloride, this is an organic compound. Its chemical properties are unique and have many remarkable characteristics.
Looking at its reactivity, it is extremely active. The sulfonyl chloride group (-SO ² Cl) is the key active site of this compound. When exposed to water, it is very easy to hydrolyze, and quickly produce sulfuric acid and corresponding sulfonic acid. This hydrolysis reaction is quite violent. Because the sulfur atom in sulfonyl chloride has high positive electricity, it is vulnerable to nucleophilic attack from oxygen atoms in water molecules.
In the field of nucleophilic substitution reactions, this compound is also very prominent. The sulfonyl chloride group is easily replaced by nucleophiles such as alcohols and amines. When reacting with alcohols, sulfonates are formed; when reacting with amines, sulfonamides are formed. This is because the electron cloud density of the nucleophilic reagent is high, and it launches a nucleophilic attack on the sulfur atoms in the sulfonyl chloride, causing the chlorine atoms to leave.
Furthermore, there are chlorine atoms and trifluoromethyl atoms attached to the benzene ring in this compound. Trifluoromethyl is a strong electron-absorbing group, which will reduce the electron cloud density of the benzene ring and reduce the electrophilic substitution activity of the benzene ring. Although the chlorine atom is also an electron-withdrawing group, it has a certain electron conjugation effect at the same time, and the effect on the The presence of these two substituents affects the electron distribution and reactivity of the whole molecule to a certain extent.
4-chloro-3- (trifluoromethyl) benzenesulfonyl chloride is widely used in the field of organic synthesis due to its active chemical properties. It is often used as an important intermediate for the preparation of various compounds containing sulfonyl groups.
What are the common uses of 4-chloro-3- (trifluoromethyl) benzenesulphonyl Chloride
4-Chloro-3- (trifluoromethyl) benzenesulfonyl chloride, an important organic synthesis reagent, is widely used in the field of organic synthesis. Its common uses are as follows:
First, it is used to prepare sulfonamide compounds. This reagent can react with amines to form sulfonamides. Sulfonamide compounds play an important role in pharmaceutical chemistry, and many biologically active drug molecules contain sulfonamide structural units. Taking the synthesis of a new type of antibacterial drug as an example, through the reaction of 4-chloro-3- (trifluoromethyl) benzenesulfonyl chloride with specific amines, through careful design and regulation of reaction conditions, the sulfonamide structure with unique antibacterial activity was successfully constructed, opening up a new path for drug research and development.
Second, it is used to synthesize sulfonates. It can react with alcohols to form sulfonates. Sulfonates are often used as leaving groups in organic synthesis to facilitate various nucleophilic substitution reactions. In the total synthesis of complex natural products, the construction of key carbon-carbon bonds or carbon-heteroatomic bonds can be realized by using the characteristics of sulfonates, which promotes the smooth progress of the synthesis step.
Third, it is also used in the field of materials science. Because the compound contains fluorine atoms, it imparts special physical and chemical properties to the product, such as excellent weather resistance and low surface energy. Introducing it into polymer material synthesis can prepare functional materials with special properties, such as high-performance coatings, fluoropolymers, etc. Such materials show broad application prospects in fields with strict material properties such as aerospace and automobile manufacturing.
Fourth, it can be used to prepare aryl sulfonylation products. Under appropriate catalytic conditions, it can react with aromatics to achieve aryl sulfonylation, providing an effective way for the construction of organic compounds with special structures and properties, enriching the structural diversity of organic compounds, and meeting the needs of different fields for special organic compounds.
In summary, 4-chloro-3- (trifluoromethyl) benzenesulfonyl chloride plays an important role in drug synthesis, organic synthesis, materials science and many other fields due to its unique chemical properties, and has made significant contributions to the development of various fields.
What is the synthesis method of 4-chloro-3- (trifluoromethyl) benzenesulphonyl Chloride
To prepare 4-chloro-3- (trifluoromethyl) benzenesulfonyl chloride, the method is as follows:
First, the raw material of 4-chloro-3- (trifluoromethyl) benzene needs to be prepared. This compound can be obtained from the corresponding halogenated aromatic hydrocarbon through a specific nucleophilic substitution reaction or a Fu-gram reaction. Taking halogenated aromatics as an example, in a suitable organic solvent, such as dichloromethane, chloroform, etc., a specific nucleophilic agent is added. Under the action of a suitable temperature and catalyst, the halogen atom is replaced by trifluoromethyl to obtain 4-chloro-3- (trifluoromethyl) benzene.
After 4-chloro-3- (trifluoromethyl) benzene is obtained, it is converted into benzene sulfonic acid intermediate. Generally, the fuming sulfuric acid sulfonation method can be used. Take an appropriate amount of 4-chloro-3- (trifluoromethyl) benzene and slowly add fuming sulfuric acid dropwise under low temperature stirring. The temperature of the reaction system should be strictly controlled within a certain range, such as 0-10 ° C, to prevent side reactions from occurring. After adding it dropwise, raise it to a moderate temperature, such as 30-50 ° C, and continue to stir the reaction number, so that the sulfonation reaction can be fully carried out to obtain 4-chloro-3- (trifluoromethyl)
In the final step, 4-chloro-3- (trifluoromethyl) benzenesulfonic acid is converted into 4-chloro-3- (trifluoromethyl) benzenesulfonyl chloride. Often use thionyl chloride as a chlorination reagent, take 4-chloro-3- (trifluoromethyl) benzenesulfonic acid in the reaction bottle, add an appropriate amount of thionyl chloride, and add a little N, N-dimethylformamide (DMF) as a catalyst. When the reaction is heated for several reflux times, the thionyl chloride reacts with the hydroxyl group in benzenesulfonic acid to generate sulfur dioxide and hydrogen chloride gas to escape. After the reaction is completed, the excess thionyl chloride is removed by reduced pressure distillation to obtain a pure 4-chloro-3- (trifluoromethyl) benzenesulfonyl chloride product. During the entire synthesis process, attention should be paid to the precise control of reaction conditions, the appropriate ratio of raw materials and reagents, and the operation of product separation and purification to obtain the target product with higher yield and purity.
4-Chloro-3- (trifluoromethyl) benzenesulphonyl Chloride in storage and transportation
For 4-chloro-3- (trifluoromethyl) benzenesulfonyl chloride, many matters need to be paid attention to during storage and transportation.
This is a chemical substance with special properties. When storing, the first choice is the environment. It should be placed in a cool, dry and well-ventilated place to avoid high temperature and fire sources. Due to its high chemical activity, high temperature can easily cause the reaction to get out of control and cause danger.
In addition, it is sensitive to moisture and prone to chemical reactions in contact with water, so it is necessary to keep the storage environment dry. The storage container used must be made of suitable materials, such as corrosion-resistant special containers, to prevent the container from being corroded and causing material leakage.
When transporting, it should not be ignored. It should be properly packaged in accordance with relevant regulations. Packaging materials should be able to protect against vibration, collision, and leakage. Transportation vehicles should also ensure that they are clean and free of residual substances that may react with them.
Escorts must be familiar with their characteristics and emergency measures. In case of situations on the way, they can respond quickly and appropriately. And the planning of transportation routes should avoid crowded and environmentally sensitive areas to prevent accidents from expanding the harm.
All of these are important items that cannot be ignored when storing and transporting 4-chloro-3- (trifluoromethyl) benzenesulfonyl chloride. It is related to safety and stability. Do not slack off.
What are the effects of 4-chloro-3- (trifluoromethyl) benzenesulphonyl Chloride on the environment and human body?
4-Chloro-3- (trifluoromethyl) benzenesulfonyl chloride, this substance has a significant impact on the environment and human body.
In terms of the environment, once it enters the natural environment, it is quite difficult to degrade due to its chemical properties. If it flows into water bodies, it will cause water quality to deteriorate, and aquatic organisms bear the brunt. Aquatic organisms such as fish and shellfish, after exposure to this substance, may have physiological disorders, or impaired reproductive ability, and in severe cases, even a sharp decrease in population. In soil, it will change the chemical properties of the soil, affect the activities of soil microorganisms, and then affect plant growth. When plant roots absorb nutrients from contaminated soil, they may be stunted, resulting in reduced crop production and ecological balance.
It is highly irritating to the human body. If it is accidentally exposed to the skin, it can cause redness, swelling, pain, and even burning and ulceration. If it comes into contact with the eyes, it will cause great damage to the eyes, or cause eye diseases, and in severe cases, it can cause vision damage. If inhaled its volatile gas, it will irritate the respiratory tract, causing symptoms such as cough and asthma. Long-term exposure may damage lung function. And this substance may be potentially carcinogenic. Long-term exposure will increase the risk of cancer and seriously threaten human health.
Therefore, such chemicals need to be properly disposed of, and their production, use and discharge should be strictly controlled to reduce their harm to the environment and people.