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4-Chloro-3-(Trifluoromethyl)Nitrobenzene
Linshang Chemical
|
HS Code |
208014 |
| Chemical Formula | C7H3ClF3NO2 |
| Molecular Weight | 225.55 |
| Appearance | Yellow to brown solid |
| Boiling Point | 229 - 231 °C |
| Melting Point | 45 - 49 °C |
| Density | 1.547 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in many organic solvents |
| Flash Point | 104 °C |
| Vapor Pressure | Low vapor pressure |
| Stability | Stable under normal conditions |
| Hazard Class | Irritant |
As an accredited 4-Chloro-3-(Trifluoromethyl)Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - chloro - 3 - (trifluoromethyl)nitrobenzene in sealed, corrosion - resistant container. |
| Storage | 4 - chloro - 3 - (trifluoromethyl)nitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition points. Keep it in a tightly sealed container to prevent leakage. Store it separately from oxidizing agents, reducing agents, and other reactive chemicals to avoid potential reactions. Ensure proper labeling for easy identification and safety. |
| Shipping | 4 - chloro - 3 - (trifluoromethyl)nitrobenzene is shipped in sealed, corrosion - resistant containers. Shipment follows strict chemical transportation regulations, ensuring proper handling to prevent spills and maintain safety during transit. |
Competitive 4-Chloro-3-(Trifluoromethyl)Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 4-chloro-3- (trifluoromethyl) nitrobenzene
4-Chloro-3- (trifluoromethyl) nitrobenzene is one of the organic compounds. It is active and has a wide range of uses in the field of organic synthesis.
In this compound, the chlorine atom, trifluoromethyl group and nitro group are all key functional groups. Nitro has strong electron absorption, which can greatly reduce the electron cloud density of the benzene ring, making the benzene ring more susceptible to attack by nucleophiles. At the same time, the presence of nitro groups also decreases the chemical stability of the compound. Under certain conditions, it is prone to reduction and other reactions. For example, under suitable reducing agents and reaction conditions, nitro groups can be reduced to amino groups, which is an important path for the preparation of amino-containing compounds in organic synthesis.
Although the chlorine atom is an ortho-para-localized group, its reactivity also changes due to the influence of nitro and trifluoromethyl groups. In nucleophilic substitution reactions, chlorine atoms can be replaced by other nucleophilic reagents, such as hydroxyl groups, alkoxy groups, etc., to form various derivatives.
Trifluoromethyl also has a strong electron-absorbing effect, which can not only affect the electron cloud distribution of the benzene ring, but also significantly change the physical and chemical properties of compounds. Because of its fluorine atom, it can enhance the lipid solubility of compounds and affect the biological activity of compounds, which is of great significance in the fields of medicinal chemistry and materials science. The functional groups contained in 4-chloro-3- (trifluoromethyl) nitrophenyl exhibit active chemical properties and play an important role in many fields such as organic synthesis, drug development, and material preparation. They are key intermediates for the preparation of a variety of organic compounds.
In this compound, the chlorine atom, trifluoromethyl group and nitro group are all key functional groups. Nitro has strong electron absorption, which can greatly reduce the electron cloud density of the benzene ring, making the benzene ring more susceptible to attack by nucleophiles. At the same time, the presence of nitro groups also decreases the chemical stability of the compound. Under certain conditions, it is prone to reduction and other reactions. For example, under suitable reducing agents and reaction conditions, nitro groups can be reduced to amino groups, which is an important path for the preparation of amino-containing compounds in organic synthesis.
Although the chlorine atom is an ortho-para-localized group, its reactivity also changes due to the influence of nitro and trifluoromethyl groups. In nucleophilic substitution reactions, chlorine atoms can be replaced by other nucleophilic reagents, such as hydroxyl groups, alkoxy groups, etc., to form various derivatives.
Trifluoromethyl also has a strong electron-absorbing effect, which can not only affect the electron cloud distribution of the benzene ring, but also significantly change the physical and chemical properties of compounds. Because of its fluorine atom, it can enhance the lipid solubility of compounds and affect the biological activity of compounds, which is of great significance in the fields of medicinal chemistry and materials science. The functional groups contained in 4-chloro-3- (trifluoromethyl) nitrophenyl exhibit active chemical properties and play an important role in many fields such as organic synthesis, drug development, and material preparation. They are key intermediates for the preparation of a variety of organic compounds.
What are the main uses of 4-chloro-3- (trifluoromethyl) nitrobenzene?
4-Chloro-3- (trifluoromethyl) nitrobenzene is an important intermediate in organic synthesis and has key uses in many fields.
First, in the field of pesticides, it is often the key raw material for the creation of new pesticides. Due to the introduction of trifluoromethyl and nitro groups, the compound is endowed with unique biological activity. It can be constructed into a novel pesticide molecule through a series of reactions, which exhibits high-efficiency inhibition or killing performance against pests and pathogens, and makes outstanding contributions to agricultural pest control.
Second, in the field of medicinal chemistry, its importance cannot be underestimated. It can be used as a starting material for the synthesis of specific drugs. Through delicate chemical transformation, using its structural properties to build a molecular framework with pharmacological activity, and then develop therapeutic drugs for specific diseases, which can help human health.
Furthermore, in the field of materials science, it has also emerged. Because of its special substituents, it can participate in the synthesis of functional materials with special properties. Such as the preparation of materials with specific photoelectric properties, which may have unique applications in electronic devices, optical devices, etc., contribute to the development of materials science.
With its unique structure, this compound has become an indispensable and important substance in the fields of pesticides, medicine, materials, etc., and plays a pivotal role in promoting technological innovation and development in various fields.
First, in the field of pesticides, it is often the key raw material for the creation of new pesticides. Due to the introduction of trifluoromethyl and nitro groups, the compound is endowed with unique biological activity. It can be constructed into a novel pesticide molecule through a series of reactions, which exhibits high-efficiency inhibition or killing performance against pests and pathogens, and makes outstanding contributions to agricultural pest control.
Second, in the field of medicinal chemistry, its importance cannot be underestimated. It can be used as a starting material for the synthesis of specific drugs. Through delicate chemical transformation, using its structural properties to build a molecular framework with pharmacological activity, and then develop therapeutic drugs for specific diseases, which can help human health.
Furthermore, in the field of materials science, it has also emerged. Because of its special substituents, it can participate in the synthesis of functional materials with special properties. Such as the preparation of materials with specific photoelectric properties, which may have unique applications in electronic devices, optical devices, etc., contribute to the development of materials science.
With its unique structure, this compound has become an indispensable and important substance in the fields of pesticides, medicine, materials, etc., and plays a pivotal role in promoting technological innovation and development in various fields.
What are the synthesis methods of 4-chloro-3- (trifluoromethyl) nitrobenzene
The synthesis method of 4-chloro-3 - (trifluoromethyl) nitrobenzene has always been the most important in the field of organic synthesis. To obtain this compound, there are several common methods as follows.
First, 4-chloro-3-trifluoromethylaniline is used as the starting material and can be obtained by diazotization and nitrification. First, 4-chloro-3-trifluoromethylaniline interacts with sodium nitrite and inorganic acid at low temperature to undergo diazotization reaction to obtain diazosalt. Then, the diazosalt reacts with nitrifying agents such as sodium nitrite to introduce nitro groups, and then generates 4-chloro-3 - (trifluoromethyl) nitrobenzene. However, this process requires precise control of the reaction temperature and reagent dosage to prevent side reactions from breeding.
Second, 3-trifluoromethyl-4-chlorobenzoic acid is used as the raw material. First, it is converted into an acid chloride, which can be achieved by interacting with reagents such as thionyl chloride. The obtained acid chloride is then ammonolyzed to obtain the corresponding amide. Under specific conditions, the amide reacts with reagents such as sodium hypochlorite and occurs Hoffman rearrangement, and 4-chloro-3- (trifluoromethyl) aniline can be prepared. Subsequent steps of diazotization and nitrification can also obtain the target product. Although this path is slightly complicated, the reaction conditions of each step are relatively mild and easy to control.
Third, the halogenated aromatics are used as raw materials and the cross-coupling reaction is catalyzed by palladium. For example, 4-chloro-3-halogenated benzene (halogen atoms can be bromine, iodine, etc.) and trifluoromethylation reagents are cross-coupled in the presence of palladium catalysts and ligands, and trifluoromethyl is introduced. Subsequently, the resulting product is nitrified to obtain 4-chloro-3- (trifluoromethyl) nitrobenzene. This method relies on high-efficiency palladium catalysts, and the cost of catalysts is high. However, its atomic economy is good, it is environmentally friendly, and has great application potential.
The above synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to carefully choose the appropriate method according to factors such as the availability of raw materials, cost considerations, reaction conditions and the purity requirements of the target product.
First, 4-chloro-3-trifluoromethylaniline is used as the starting material and can be obtained by diazotization and nitrification. First, 4-chloro-3-trifluoromethylaniline interacts with sodium nitrite and inorganic acid at low temperature to undergo diazotization reaction to obtain diazosalt. Then, the diazosalt reacts with nitrifying agents such as sodium nitrite to introduce nitro groups, and then generates 4-chloro-3 - (trifluoromethyl) nitrobenzene. However, this process requires precise control of the reaction temperature and reagent dosage to prevent side reactions from breeding.
Second, 3-trifluoromethyl-4-chlorobenzoic acid is used as the raw material. First, it is converted into an acid chloride, which can be achieved by interacting with reagents such as thionyl chloride. The obtained acid chloride is then ammonolyzed to obtain the corresponding amide. Under specific conditions, the amide reacts with reagents such as sodium hypochlorite and occurs Hoffman rearrangement, and 4-chloro-3- (trifluoromethyl) aniline can be prepared. Subsequent steps of diazotization and nitrification can also obtain the target product. Although this path is slightly complicated, the reaction conditions of each step are relatively mild and easy to control.
Third, the halogenated aromatics are used as raw materials and the cross-coupling reaction is catalyzed by palladium. For example, 4-chloro-3-halogenated benzene (halogen atoms can be bromine, iodine, etc.) and trifluoromethylation reagents are cross-coupled in the presence of palladium catalysts and ligands, and trifluoromethyl is introduced. Subsequently, the resulting product is nitrified to obtain 4-chloro-3- (trifluoromethyl) nitrobenzene. This method relies on high-efficiency palladium catalysts, and the cost of catalysts is high. However, its atomic economy is good, it is environmentally friendly, and has great application potential.
The above synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to carefully choose the appropriate method according to factors such as the availability of raw materials, cost considerations, reaction conditions and the purity requirements of the target product.
What are the precautions for 4-chloro-3- (trifluoromethyl) nitrobenzene during storage and transportation?
4-Chloro-3- (trifluoromethyl) nitrobenzene is a commonly used raw material in organic synthesis. During storage and transportation, all precautions should not be ignored.
When storing, the first environment. It should be placed in a cool, dry and well-ventilated place, away from fire and heat sources. This is because of its flammability, it can cause the risk of combustion and explosion in case of open flames and hot topics. The temperature of the warehouse should be controlled within an appropriate range to prevent its chemical properties from being unstable due to excessive temperature.
Furthermore, it should be stored separately from oxidants, reducing agents, alkalis, etc., and must not be mixed. The cover can react violently with various substances, causing danger. The storage place should be equipped with suitable materials to contain the leakage, just in case.
During transportation, the packaging must be tight and stable. According to its dangerous characteristics, choose the appropriate means of transportation. During transportation, the driving should be stable, avoid sudden brakes and sharp turns, and avoid material leakage caused by damage to the packaging. Transportation personnel should be familiar with the characteristics of this object and emergency disposal methods.
In addition, the transportation vehicle must be equipped with fire protection equipment and leakage emergency treatment equipment. In case of high temperature weather on the way, it is advisable to choose to travel in the morning and evening to avoid the extreme heat during the day. If passing through densely populated areas, special caution is required to prevent accidental leakage from endangering the safety of the public.
In conclusion, the storage and transportation of 4-chloro-3- (trifluoromethyl) nitrobenzene is related to safety and must be carried out in accordance with regulations.
When storing, the first environment. It should be placed in a cool, dry and well-ventilated place, away from fire and heat sources. This is because of its flammability, it can cause the risk of combustion and explosion in case of open flames and hot topics. The temperature of the warehouse should be controlled within an appropriate range to prevent its chemical properties from being unstable due to excessive temperature.
Furthermore, it should be stored separately from oxidants, reducing agents, alkalis, etc., and must not be mixed. The cover can react violently with various substances, causing danger. The storage place should be equipped with suitable materials to contain the leakage, just in case.
During transportation, the packaging must be tight and stable. According to its dangerous characteristics, choose the appropriate means of transportation. During transportation, the driving should be stable, avoid sudden brakes and sharp turns, and avoid material leakage caused by damage to the packaging. Transportation personnel should be familiar with the characteristics of this object and emergency disposal methods.
In addition, the transportation vehicle must be equipped with fire protection equipment and leakage emergency treatment equipment. In case of high temperature weather on the way, it is advisable to choose to travel in the morning and evening to avoid the extreme heat during the day. If passing through densely populated areas, special caution is required to prevent accidental leakage from endangering the safety of the public.
In conclusion, the storage and transportation of 4-chloro-3- (trifluoromethyl) nitrobenzene is related to safety and must be carried out in accordance with regulations.
What are the effects of 4-chloro-3- (trifluoromethyl) nitrobenzene on the environment and human health?
4-Chloro-3- (trifluoromethyl) nitrobenzene is one of the organic compounds. It has an impact on the environment and human health, which cannot be ignored.
At the environmental end, if this compound enters nature, it is quite difficult to degrade. Given its stable structure, it is difficult to make it rapidly decay due to ordinary environmental effects. If it is scattered in the soil or causes soil pollution, it will affect the soil quality, reduce the soil fertility, and then harm the growth of plants. For plants, it may cause their development to be hindered, the germination rate of seeds will decrease, the plants will be short, and even wither and die. If it enters the water body, it will cause the water quality to deteriorate, and aquatic organisms will also suffer from it. Aquatic animals such as fish may be disrupted by physiological functions, their growth and reproduction will be hindered, and the population number may decrease. And because it is difficult to degrade, or accumulated in the food chain, from low-level organisms to high-level organisms, the concentration gradually increases, and the harm is greater.
As for human health, this compound is also a great threat. If people ingest it through breathing, diet or skin contact, it can cause many health problems. It may irritate the respiratory tract, causing coughing, asthma, and even breathing difficulties. In people with sensitive respiratory tract, it is even more harmful. Enter the digestive system, or damage the gastrointestinal mucosa, causing nausea, vomiting, abdominal pain, etc. Long-term exposure, or potentially carcinogenic. Because it contains chlorine, fluorine and nitro groups, it may interfere with the normal metabolism of human cells, causing cell mutation and causing cancer. And it may also affect the nervous system, causing headaches, dizziness, fatigue, difficulty concentrating, and affecting daily work and life.
Therefore, the use and disposal of 4-chloro-3- (trifluoromethyl) nitrobenzene should be handled with caution. Strict regulations must be followed to prevent it from escaping into the environment and endangering the ecology and human well-being.
At the environmental end, if this compound enters nature, it is quite difficult to degrade. Given its stable structure, it is difficult to make it rapidly decay due to ordinary environmental effects. If it is scattered in the soil or causes soil pollution, it will affect the soil quality, reduce the soil fertility, and then harm the growth of plants. For plants, it may cause their development to be hindered, the germination rate of seeds will decrease, the plants will be short, and even wither and die. If it enters the water body, it will cause the water quality to deteriorate, and aquatic organisms will also suffer from it. Aquatic animals such as fish may be disrupted by physiological functions, their growth and reproduction will be hindered, and the population number may decrease. And because it is difficult to degrade, or accumulated in the food chain, from low-level organisms to high-level organisms, the concentration gradually increases, and the harm is greater.
As for human health, this compound is also a great threat. If people ingest it through breathing, diet or skin contact, it can cause many health problems. It may irritate the respiratory tract, causing coughing, asthma, and even breathing difficulties. In people with sensitive respiratory tract, it is even more harmful. Enter the digestive system, or damage the gastrointestinal mucosa, causing nausea, vomiting, abdominal pain, etc. Long-term exposure, or potentially carcinogenic. Because it contains chlorine, fluorine and nitro groups, it may interfere with the normal metabolism of human cells, causing cell mutation and causing cancer. And it may also affect the nervous system, causing headaches, dizziness, fatigue, difficulty concentrating, and affecting daily work and life.
Therefore, the use and disposal of 4-chloro-3- (trifluoromethyl) nitrobenzene should be handled with caution. Strict regulations must be followed to prevent it from escaping into the environment and endangering the ecology and human well-being.
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