4-Chloro-5-Fluorobenzene-1,2-Diamine
HS Code |
235237 |
Chemical Formula | C6H6ClFN2 |
Molar Mass | 160.577 g/mol |
Appearance | Solid (likely white or off - white powder) |
Odor | May have a characteristic amine - like odor |
Solubility In Water | Poorly soluble (amine - based aromatic compound, low polarity) |
Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, acetone |
Pka Amine Groups | Amine groups likely have pKa values in the range typical for aromatic amines (around 4 - 5) |
As an accredited 4-Chloro-5-Fluorobenzene-1,2-Diamine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
Packing | 100g of 4 - chloro - 5 - fluorobenzene - 1,2 - diamine packaged in a sealed plastic bag. |
Storage | 4 - chloro - 5 - fluorobenzene - 1,2 - diamine should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly sealed container, preferably made of corrosion - resistant materials. Label the storage container clearly to prevent misuse. This helps maintain its stability and safety during storage. |
Shipping | 4 - chloro - 5 - fluorobenzene - 1,2 - diamine is shipped in sealed, corrosion - resistant containers. It's transported under regulated conditions to prevent exposure, ensuring compliance with safety and environmental regulations for chemical shipments. |
Competitive 4-Chloro-5-Fluorobenzene-1,2-Diamine prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to sales01@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: sales01@alchemist-chem.com


As a leading 4-Chloro-5-Fluorobenzene-1,2-Diamine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
In the chemical industry, it is often a key intermediate in organic synthesis. From the perspective of organic synthesis, due to the unique layout of chlorine, fluorine and amino groups in the molecular structure, it can be combined with other compounds through many chemical reactions, such as nucleophilic substitution, coupling reactions, etc., to build a diverse and complex organic molecular structure. With its active chemical properties, it can effectively introduce specific functional groups, paving the way for the creation of organic materials with unique properties.
In the field of medicine, its importance cannot be underestimated. Numerous studies have shown that compounds containing such structures often exhibit significant biological activities. For example, in the research and development of antibacterial drugs, this compound can be used as a lead compound to develop new antibacterial drugs with high inhibitory activity against specific bacteria by modifying and optimizing its structure. The chlorine and fluorine atoms in its structure can affect the interaction between the drug and the target, change the lipid solubility and stability of the drug, and thereby improve the efficacy and pharmacokinetic properties of the drug. In the field of anti-tumor drug research, it may also be able to combine its unique chemical structure with specific targets in tumor cells to interfere with the growth and proliferation process of tumor cells, providing novel ideas and directions for the creation of anti-tumor drugs.
In summary, although 4-chloro-5-fluorobenzene-1,2-diamine is an organic compound, it has broad application prospects in the chemical and pharmaceutical fields, and has made great contributions to promoting technological progress and innovation in related fields.
Looking at its shape, under room temperature and pressure, it is mostly solid, and its texture is delicate, like powder chips, pure in color, often white or off-white, with a simple but pure appearance, like uncontaminated jade.
When it comes to the melting point, this material has a specific melting point, about a certain temperature range. When the outside temperature rises to this range, it will be like ice and snow meeting warm sun, gradually melting from solid to liquid, just like hard ice turning into soft water, showing the wonderful transformation of material form.
The boiling point is also its important characteristic. Under specific pressure conditions, when the temperature reaches the corresponding boiling point, 4-chloro-5-fluorobenzene-1,2-diamine will quickly transform from liquid to gaseous state, just like the emergence of immortals, curling up, showing another magical change in the state of matter.
In terms of solubility, in common organic solvents, such as ethanol, ether, etc., it shows a certain solubility. In ethanol, like fish entering water, it can be moderately dissolved and blend with the solvent to form a uniform and stable system; in water, its solubility is poor, like oil floating in water, difficult to blend, showing hydrophobic characteristics.
The density cannot be ignored either. Its density has a specific value compared to water. It is placed in water, or sinks or floats, so that the relationship between its density and water can be distinguished, revealing its unique position in the material world.
In addition, the smell of 4-chloro-5-fluorobenzene-1,2-diamine is weak and specific. Only by smelling it closely can you perceive the unique smell. Although it is not strong and pungent, it is unique, which becomes another characteristic to distinguish this substance. These many physical properties together outline the unique appearance of 4-chloro-5-fluorobenzene-1,2-diamine in the material world.
In terms of stability, its structure is relatively stable at room temperature and pressure without special reagents or conditions. However, in the case of strong oxidizing agents, the amine group is easily oxidized, resulting in structural changes. In the case of electrophilic reagents, the density of the electron cloud of the benzene ring is increased due to the amine group supply, which is more prone to electrophilic substitution reaction, which damages its stability.
And because of its halogen atoms, under certain conditions, such as high temperature and strong alkali environment, halogen atoms may undergo substitution or elimination reactions, which may change the structure of the compound. In addition, conditions such as light may also affect its stability, or induce luminescent chemical reactions. Therefore, the stability of 4-chloro-5-fluorobenzene-1,2-diamine is not absolute, but varies according to the specific environment and conditions.
First take appropriate starting materials, such as compounds containing chlorine, fluorine and benzene ring structures, which is the basis for preparation. For example, starting with a specific substituted benzene derivative, the substituent on it can be properly converted to gradually reach the structure of the target product.
One method can also be used for nucleophilic substitution reaction. Using benzene derivatives containing halogen atoms as substrates, an amino group is introduced. Halogen atoms are highly active and can react with ammonia or amine nucleophiles. In this process, it is particularly important to precisely control the reaction conditions. The temperature affects the reaction rate and selectivity. If the temperature is too high, side reactions may occur and unnecessary by-products may be generated; if the temperature is too low, the reaction rate will be slow and take a long time.
Furthermore, the choice of reaction solvent is also key. Suitable solvents can not only dissolve the reactants, but also have a significant impact on the reaction mechanism and rate. Some polar solvents may promote the nucleophilic substitution reaction, because the polar environment can stabilize the reaction intermediates, making the reaction prone to occur.
In addition, the use of catalytic systems can also improve the reaction efficiency. Suitable catalysts can reduce the activation energy of the reaction and accelerate the reaction process. In the step of introducing amino groups, specific metal catalysts or organic catalysts can be selected to optimize the reaction path.
In the synthesis process, it is still necessary to pay attention to the sequence of reaction steps. Reasonable arrangement of reaction steps can avoid unnecessary side reactions and improve the yield of the target product. And after each step of reaction, it must go through fine separation and purification steps to ensure the purity of the product and provide high-quality raw materials for the next reaction. In this way, after multiple steps of carefully designed and operated reactions, 4-chloro-5-fluorobenzene-1,2-diamine can be obtained.
In the past market, the price of such chemical materials fluctuated widely. If the production source is wide and the supply exceeds the demand, the price may be easy; if the raw materials are scarce and the production is difficult, the supply is scarce, and the demand is still high, the price will be high.
If you want to know the price, you can consult the chemical raw material suppliers. They have been involved in this industry for a long time, and they must know the current market. Or you can visit the professional chemical trading platform, whose prices are up-to-date and accurate, which can be your reference. Or you can participate in industry exhibitions, seminars, and discuss with industry leaders, and you can also hear about the price. Although the specific price range has not been stated, following this route, you will be able to get an overview of the intermarket price of 4-chloro-5-fluorobenzene-1,2-diamine.

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