Linshang Chemical
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4-Chloro-7-(4-Methylbenzenesulfonyl)-7H-Pyrrolo[2,3-D]Pyrimidine
Linshang Chemical
|
HS Code |
688329 |
| Chemical Formula | C15H12ClN3O2S |
| Molar Mass | 333.79 g/mol |
| Appearance | Typically a solid (color may vary depending on purity) |
| Melting Point | Data may vary, requires specific experimental determination |
| Solubility In Water | Low solubility in water due to its non - polar nature |
| Solubility In Organic Solvents | Soluble in some organic solvents like dichloromethane, chloroform |
| Density | Data may vary, requires experimental measurement |
| Pka | Relevant acid - base dissociation constants need experimental determination |
| Stability | Stable under normal conditions, but may react with strong oxidizing or reducing agents |
As an accredited 4-Chloro-7-(4-Methylbenzenesulfonyl)-7H-Pyrrolo[2,3-D]Pyrimidine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - chloro - 7 - (4 - methylbenzenesulfonyl)-7H - pyrrolo[2,3 - d]pyrimidine in sealed chemical - grade containers. |
| Storage | 4 - chloro - 7 - (4 - methylbenzenesulfonyl)-7H - pyrrolo[2,3 - d]pyrimidine should be stored in a cool, dry place, away from direct sunlight. Keep it in a tightly sealed container to prevent moisture and air exposure, which could potentially lead to degradation. Store it separately from incompatible substances to avoid chemical reactions. Ensure the storage area is well - ventilated. |
| Shipping | 4-chloro-7-(4 - methylbenzenesulfonyl)-7H - pyrrolo[2,3 - d]pyrimidine is shipped in sealed, corrosion - resistant containers. Strict adherence to chemical shipping regulations ensures safe transport, avoiding exposure and potential hazards. |
Competitive 4-Chloro-7-(4-Methylbenzenesulfonyl)-7H-Pyrrolo[2,3-D]Pyrimidine prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
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What is the main use of 4-chloro-7- (4-methylbenzenesulfonyl) -7h-pyrrolo [2,3-d] pyrimidine
4-Chloro-7- (4-methylbenzenesulfonyl) -7H-pyrrolido [2,3-d] pyrimidine is an organic compound. It has a wide range of uses and is often a key intermediate for the creation of new drugs in the field of medicinal chemistry.
During the development of caffeine drugs, a specific chemical structure needs to be constructed to interact with targets in organisms to achieve the purpose of treating diseases. The unique chemical structure of this compound can be modified by various chemical reactions, and then a series of biologically active substances can be derived.
For example, in the exploration of anti-cancer drugs, scientists hope to find molecules that can precisely act on specific targets of cancer cells by modifying their structures, inhibit cancer cell proliferation, induce apoptosis, and cause little damage to normal cells.
In the field of materials science, it may also have potential uses. Or it can participate in the preparation of organic materials with special properties, such as photoelectric materials. Its molecular structure can affect the electronic transport and optical properties of materials, etc., or it is expected to be used to manufacture high-efficiency Light Emitting Diodes, solar cells and other photoelectric devices.
Furthermore, in the field of organic synthetic chemistry, it is an important synthetic building block. Chemists can use it to react with other organic reagents to build more complex molecular structures, expand the variety and function of organic compounds, and promote the development of organic synthetic chemistry.
During the development of caffeine drugs, a specific chemical structure needs to be constructed to interact with targets in organisms to achieve the purpose of treating diseases. The unique chemical structure of this compound can be modified by various chemical reactions, and then a series of biologically active substances can be derived.
For example, in the exploration of anti-cancer drugs, scientists hope to find molecules that can precisely act on specific targets of cancer cells by modifying their structures, inhibit cancer cell proliferation, induce apoptosis, and cause little damage to normal cells.
In the field of materials science, it may also have potential uses. Or it can participate in the preparation of organic materials with special properties, such as photoelectric materials. Its molecular structure can affect the electronic transport and optical properties of materials, etc., or it is expected to be used to manufacture high-efficiency Light Emitting Diodes, solar cells and other photoelectric devices.
Furthermore, in the field of organic synthetic chemistry, it is an important synthetic building block. Chemists can use it to react with other organic reagents to build more complex molecular structures, expand the variety and function of organic compounds, and promote the development of organic synthetic chemistry.
What are the synthesis methods of 4-chloro-7- (4-methylbenzenesulfonyl) -7h-pyrrolo [2,3-d] pyrimidine
The synthesis method of 4-chloro-7- (4-methylbenzenesulfonyl) -7H-pyrrolido [2,3-d] pyrimidine is now the first step. This synthesis method follows the usual path of organic synthesis, and uses common reagents and ingenious steps to achieve the construction of the target molecule.
First, it is often started with suitable precursors containing pyrrole and pyrimidine structures. There are pyrrole derivatives with active reaction check points and pyrimidine derivatives as starting materials. By taking advantage of the wonderful organic reaction, the two are cleverly connected. In the choice of reaction conditions, the consideration of temperature and solvent is very critical. For example, a polar aprotic solvent is used to catalyze the condensation of the two in a moderately heated state to form the basic skeleton of pyrrolidine.
Furthermore, chlorine atoms are introduced at specific positions. By means of halogenation reaction, suitable halogenating reagents, such as chlorine-containing halogenating agents, can be used to precisely replace chlorine atoms at the target check point in a controlled reaction environment. This step requires detailed control of the reactivity and selectivity, or the help of catalysts, or the adjustment of the reaction temperature and time, so that the chlorine atoms can be connected at the desired position.
As for the introduction of 4-methylbenzenesulfonyl group, 4-methylbenzenesulfonyl chloride is often used as a reagent to react with the constructed pyrrolopyrimidine skeleton in an alkaline environment. The basic conditions can assist the activation of the substrate, so that the sulfonyl group can be successfully connected to the target nitrogen atom, and the final result is 4-chloro-7- (4-methylbenzenesulfonyl) -7H-pyrrolido [2,3-d] pyrimidine.
On the road to synthesis, all the details need to be considered, from the purity of the raw materials to the monitoring of the reaction process, all of which are related to the yield and purity of the product. The beauty of synthesis requires scientific methods and rigorous state to construct this organic molecule.
First, it is often started with suitable precursors containing pyrrole and pyrimidine structures. There are pyrrole derivatives with active reaction check points and pyrimidine derivatives as starting materials. By taking advantage of the wonderful organic reaction, the two are cleverly connected. In the choice of reaction conditions, the consideration of temperature and solvent is very critical. For example, a polar aprotic solvent is used to catalyze the condensation of the two in a moderately heated state to form the basic skeleton of pyrrolidine.
Furthermore, chlorine atoms are introduced at specific positions. By means of halogenation reaction, suitable halogenating reagents, such as chlorine-containing halogenating agents, can be used to precisely replace chlorine atoms at the target check point in a controlled reaction environment. This step requires detailed control of the reactivity and selectivity, or the help of catalysts, or the adjustment of the reaction temperature and time, so that the chlorine atoms can be connected at the desired position.
As for the introduction of 4-methylbenzenesulfonyl group, 4-methylbenzenesulfonyl chloride is often used as a reagent to react with the constructed pyrrolopyrimidine skeleton in an alkaline environment. The basic conditions can assist the activation of the substrate, so that the sulfonyl group can be successfully connected to the target nitrogen atom, and the final result is 4-chloro-7- (4-methylbenzenesulfonyl) -7H-pyrrolido [2,3-d] pyrimidine.
On the road to synthesis, all the details need to be considered, from the purity of the raw materials to the monitoring of the reaction process, all of which are related to the yield and purity of the product. The beauty of synthesis requires scientific methods and rigorous state to construct this organic molecule.
What are the physicochemical properties of 4-chloro-7- (4-methylbenzenesulfonyl) -7h-pyrrolo [2,3-d] pyrimidine
4-Chloro-7- (4-methylbenzenesulfonyl) -7H-pyrrolido [2,3-d] pyrimidine has many physical and chemical properties. Under normal temperature, it is mostly in the form of a solid state, and its shape or crystalline state is relatively stable, and it is not easy to change significantly on its own.
When it comes to solubility, this substance exhibits different behaviors in organic solvents. In common organic solvents such as dichloromethane, N, N-dimethylformamide, it has a certain solubility and can form a uniform solution. However, in water, its solubility is very small, because its molecular structure contains hydrophobic groups such as benzene ring and sulfonyl group, which makes it difficult to dissolve in water.
Then again, its melting point has been experimentally determined to be within a certain range. This melting point characteristic can be used as an important basis for identifying this substance. The specific value of the melting point is also related to the purity of the substance. If the purity is high, the melting point range is relatively narrow and stable.
In terms of chemical properties, the chlorine atom in the molecule has a certain reactivity. Under suitable reaction conditions, a nucleophilic substitution reaction can occur, which is replaced by other nucleophilic reagents, thereby constructing a new chemical structure. Benzenesulfonyl groups have a significant impact on the electron cloud distribution of the whole molecule, and can participate in many chemical reactions involving electron transfer. In addition, the pyrrolidine ring system, as the core structure of this compound, also endows it with unique chemical activity. Under specific reagents and reaction conditions, substitution, addition and other reactions on the ring can occur, showing rich chemical changes.
When it comes to solubility, this substance exhibits different behaviors in organic solvents. In common organic solvents such as dichloromethane, N, N-dimethylformamide, it has a certain solubility and can form a uniform solution. However, in water, its solubility is very small, because its molecular structure contains hydrophobic groups such as benzene ring and sulfonyl group, which makes it difficult to dissolve in water.
Then again, its melting point has been experimentally determined to be within a certain range. This melting point characteristic can be used as an important basis for identifying this substance. The specific value of the melting point is also related to the purity of the substance. If the purity is high, the melting point range is relatively narrow and stable.
In terms of chemical properties, the chlorine atom in the molecule has a certain reactivity. Under suitable reaction conditions, a nucleophilic substitution reaction can occur, which is replaced by other nucleophilic reagents, thereby constructing a new chemical structure. Benzenesulfonyl groups have a significant impact on the electron cloud distribution of the whole molecule, and can participate in many chemical reactions involving electron transfer. In addition, the pyrrolidine ring system, as the core structure of this compound, also endows it with unique chemical activity. Under specific reagents and reaction conditions, substitution, addition and other reactions on the ring can occur, showing rich chemical changes.
What is the price range of 4-chloro-7- (4-methylbenzenesulfonyl) -7h-pyrrolo [2,3-d] pyrimidine in the market?
4-Chloro-7- (4-methylbenzenesulfonyl) -7H-pyrrolido [2,3-d] pyrimidine, the price of this substance in the market is difficult to determine. Its price often varies due to various factors, and it is difficult to fix the value.
First, the difficulty of preparation is the key. If the synthesis method is complicated, the raw materials required are rare and expensive, or the reaction conditions are harsh, resulting in a large increase in the cost of preparation, and its price in the market will be high. On the contrary, if the preparation method is simple, the raw materials are easy to obtain and cheap, the price may be slightly lower.
Second, the supply and demand of the market also affect its price. If there are many applicants, but there are few producers, the supply is in short supply, and the price will rise; if there are many producers, but there are few applicants, and the supply exceeds the demand, the price may drop.
Third, the quality is also related to the price. Those with high quality, the price may be high; those with inferior quality, the price may be inferior.
Fourth, the difference in region can also cause the price to change. In different places, the price may vary due to the difference in transportation fees and taxes.
Because there is no conclusive market market market market, it is difficult to determine its exact price. However, if you want to know the price, you can consult the supplier of chemical raw materials, the platform of chemical trading, or relevant industry personnel to obtain a more accurate price.
First, the difficulty of preparation is the key. If the synthesis method is complicated, the raw materials required are rare and expensive, or the reaction conditions are harsh, resulting in a large increase in the cost of preparation, and its price in the market will be high. On the contrary, if the preparation method is simple, the raw materials are easy to obtain and cheap, the price may be slightly lower.
Second, the supply and demand of the market also affect its price. If there are many applicants, but there are few producers, the supply is in short supply, and the price will rise; if there are many producers, but there are few applicants, and the supply exceeds the demand, the price may drop.
Third, the quality is also related to the price. Those with high quality, the price may be high; those with inferior quality, the price may be inferior.
Fourth, the difference in region can also cause the price to change. In different places, the price may vary due to the difference in transportation fees and taxes.
Because there is no conclusive market market market market, it is difficult to determine its exact price. However, if you want to know the price, you can consult the supplier of chemical raw materials, the platform of chemical trading, or relevant industry personnel to obtain a more accurate price.
What are the safety and toxicity of 4-chloro-7- (4-methylbenzenesulfonyl) -7h-pyrrolo [2,3-d] pyrimidine
4-Chloro-7- (4-methylbenzenesulfonyl) -7H-pyrrolido [2,3-d] pyrimidine, this substance is related to the safety of life and people, and its safety and toxicity cannot be ignored.
Observe this substance, as described in various books, and have not been described in detail. If you want to investigate its nature, you must follow the scientific method and observe its appearance in experiments. Take animals as an experiment to observe changes in body shape, behavior, and organs after ingestion, inhalation, or skin contact. If the dose is small and no abnormality is seen, the harm can be temporarily cut off; if the dose is slightly increased, and there are discomforts, such as burnout, food loss, body loss, or even organ damage, it can be known that its toxicity is not shallow.
It is also tested in the environment, and the decomposition path and products are important. If it is easy to decompose into harmless things, it is not harmful to water, soil and air; if it is difficult to decompose, it will accumulate in the environment, which is a superficial calamity. Or enter the food chain, accumulate layer by layer, and endanger all living beings.
Furthermore, in the application of humans, preventive measures must be set up. Those who handle this thing should use protective equipment, such as clothes, covers, and gloves, to avoid their close proximity. The place where you are located should be well ventilated to avoid the gathering of gas. Although the details are not confirmed today, you should treat it with caution and prevent problems before they occur, which is the way to protect the people and their lives.
Observe this substance, as described in various books, and have not been described in detail. If you want to investigate its nature, you must follow the scientific method and observe its appearance in experiments. Take animals as an experiment to observe changes in body shape, behavior, and organs after ingestion, inhalation, or skin contact. If the dose is small and no abnormality is seen, the harm can be temporarily cut off; if the dose is slightly increased, and there are discomforts, such as burnout, food loss, body loss, or even organ damage, it can be known that its toxicity is not shallow.
It is also tested in the environment, and the decomposition path and products are important. If it is easy to decompose into harmless things, it is not harmful to water, soil and air; if it is difficult to decompose, it will accumulate in the environment, which is a superficial calamity. Or enter the food chain, accumulate layer by layer, and endanger all living beings.
Furthermore, in the application of humans, preventive measures must be set up. Those who handle this thing should use protective equipment, such as clothes, covers, and gloves, to avoid their close proximity. The place where you are located should be well ventilated to avoid the gathering of gas. Although the details are not confirmed today, you should treat it with caution and prevent problems before they occur, which is the way to protect the people and their lives.
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