Linshang Chemical
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4-Chloro-Alpha-Hydroxy-Benzeneaceticacid
Linshang Chemical
|
HS Code |
874519 |
| Name | 4-Chloro-α-Hydroxy-Benzeneacetic acid |
| Molecular Formula | C8H7ClO3 |
| Molecular Weight | 186.592 g/mol |
| Appearance | White to off - white solid |
| Boiling Point | Approx. 370.9°C at 760 mmHg |
| Melting Point | 125 - 129°C |
| Solubility In Water | Slightly soluble |
| Solubility In Organic Solvents | Soluble in ethanol, methanol, etc. |
| Pka | Approx. 3.12 |
| Density | 1.463 g/cm³ |
As an accredited 4-Chloro-Alpha-Hydroxy-Benzeneaceticacid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - chloro - α - hydroxy - benzeneacetic acid packaged in air - tight plastic bags. |
| Storage | 4 - chloro - α - hydroxy - benzeneacetic acid should be stored in a cool, dry place. Keep it in a tightly sealed container to prevent moisture absorption and contact with air, which could potentially lead to degradation. Store away from heat sources, ignition sources, and incompatible substances like strong oxidizing agents to ensure safety and maintain its chemical integrity. |
| Shipping | 4 - chloro - α - hydroxy - benzeneacetic acid is shipped in well - sealed, corrosion - resistant containers. Shipment follows strict chemical transport regulations, ensuring safe handling and minimizing environmental risk during transit. |
Competitive 4-Chloro-Alpha-Hydroxy-Benzeneaceticacid prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 4-Chloro-Alpha-Hydroxy-Benzeneaceticacid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemistry of 4-chloro-alpha-hydroxy-benzeneacetic acid?
4-Chloro - α - hydroxyphenylacetic acid is an organic compound with unique chemical properties.
This compound contains chlorine atoms, hydroxyl groups, benzene rings and carboxyl structures. The introduction of chlorine atoms changes the polarity of the molecule, affecting its physical and chemical properties. Chlorine atoms have electron-absorbing effects, which can enhance the electrophilicity of molecules. In chemical reactions, or make the adjacent and para-sites of the benzene ring more prone to electrophilic substitution.
The presence of α-hydroxy groups can participate in many reactions due to the active hydrogen atoms of hydroxyl groups. Hydroxyl groups can undergo esterification reactions, and under the action of catalysts with acids, ester compounds are formed. They can also be oxidized and can be converted into carbonyl groups under the action of appropriate oxidizing agents. The
benzene ring imparts a certain stability to the molecular conjugate system. The benzene ring can undergo typical electrophilic substitution reactions such as halogenation, nitrification, and sulfonation. The carboxyl group is acidic and can neutralize with the base to form the corresponding carboxylate. The carboxyl group can also participate in the esterification reaction and react with alcohol to form an ester, which is a common reaction in organic synthesis.
4-chloro - α - hydroxyphenylacetic acid presents various chemical properties due to the interaction of its functional groups. It may have important applications in organic synthesis, medicinal chemistry, and other fields. It can be used as an intermediate to participate in the preparation of complex compounds.
This compound contains chlorine atoms, hydroxyl groups, benzene rings and carboxyl structures. The introduction of chlorine atoms changes the polarity of the molecule, affecting its physical and chemical properties. Chlorine atoms have electron-absorbing effects, which can enhance the electrophilicity of molecules. In chemical reactions, or make the adjacent and para-sites of the benzene ring more prone to electrophilic substitution.
The presence of α-hydroxy groups can participate in many reactions due to the active hydrogen atoms of hydroxyl groups. Hydroxyl groups can undergo esterification reactions, and under the action of catalysts with acids, ester compounds are formed. They can also be oxidized and can be converted into carbonyl groups under the action of appropriate oxidizing agents. The
benzene ring imparts a certain stability to the molecular conjugate system. The benzene ring can undergo typical electrophilic substitution reactions such as halogenation, nitrification, and sulfonation. The carboxyl group is acidic and can neutralize with the base to form the corresponding carboxylate. The carboxyl group can also participate in the esterification reaction and react with alcohol to form an ester, which is a common reaction in organic synthesis.
4-chloro - α - hydroxyphenylacetic acid presents various chemical properties due to the interaction of its functional groups. It may have important applications in organic synthesis, medicinal chemistry, and other fields. It can be used as an intermediate to participate in the preparation of complex compounds.
Where is 4-chloro-alpha-hydroxy-benzeneacetic acid used?
4-Chloro - α - hydroxyphenylacetic acid, which is useful in many fields.
In the field of medicine, its position is particularly important. It can be used as a key intermediate for the preparation of a variety of drugs. For example, when developing some anti-inflammatory drugs, 4-chloro - α - hydroxyphenylacetic acid can be converted into an active ingredient with excellent anti-inflammatory effect through a series of delicate chemical reactions. This ingredient can precisely act on the target of inflammation in the human body, effectively reduce the inflammatory response and relieve the pain of patients. It has also made a name for itself in the development of anti-tumor drugs. By ingenious chemical modification and combination, new anti-tumor compounds can be synthesized, which may interfere with the growth and proliferation of tumor cells, providing a new opportunity to conquer tumor diseases.
In the chemical field, its use is also quite extensive. In the preparation of fine chemical products, it is an indispensable raw material. Taking fragrance synthesis as an example, with its unique chemical structure, compounds with special aromas can be derived, which can be used to prepare high-end perfumes, cosmetic fragrances, etc., giving the product a unique and charming flavor. In dye synthesis, 4-chloro - α - hydroxyphenylacetic acid participates in the reaction, which can prepare bright-colored and stable dyes, which are widely used in the textile printing and dyeing industry to make fabrics show colorful colors.
Furthermore, in the field of organic synthesis research, it is like a key to open the door to the synthesis of many novel organic compounds. Researchers use it as a starting material to explore the structure and properties of new organic molecules by designing exquisite synthesis routes, which promotes the continuous development of organic chemistry and lays the foundation for innovation in related fields such as materials science.
In the field of medicine, its position is particularly important. It can be used as a key intermediate for the preparation of a variety of drugs. For example, when developing some anti-inflammatory drugs, 4-chloro - α - hydroxyphenylacetic acid can be converted into an active ingredient with excellent anti-inflammatory effect through a series of delicate chemical reactions. This ingredient can precisely act on the target of inflammation in the human body, effectively reduce the inflammatory response and relieve the pain of patients. It has also made a name for itself in the development of anti-tumor drugs. By ingenious chemical modification and combination, new anti-tumor compounds can be synthesized, which may interfere with the growth and proliferation of tumor cells, providing a new opportunity to conquer tumor diseases.
In the chemical field, its use is also quite extensive. In the preparation of fine chemical products, it is an indispensable raw material. Taking fragrance synthesis as an example, with its unique chemical structure, compounds with special aromas can be derived, which can be used to prepare high-end perfumes, cosmetic fragrances, etc., giving the product a unique and charming flavor. In dye synthesis, 4-chloro - α - hydroxyphenylacetic acid participates in the reaction, which can prepare bright-colored and stable dyes, which are widely used in the textile printing and dyeing industry to make fabrics show colorful colors.
Furthermore, in the field of organic synthesis research, it is like a key to open the door to the synthesis of many novel organic compounds. Researchers use it as a starting material to explore the structure and properties of new organic molecules by designing exquisite synthesis routes, which promotes the continuous development of organic chemistry and lays the foundation for innovation in related fields such as materials science.
What are the preparation methods of 4-chloro-alpha-hydroxy-benzeneacetic acid?
4-Chloro- - α - hydroxyphenylacetic acid can be prepared by various methods. First, 4-chloroacetophenone can be started. Place 4-chloroacetophenone in an appropriate reaction vessel, add an appropriate amount of strong base, such as sodium hydroxide solution, so that it occurs at a specific temperature and reaction time. In this reaction, the methyl group in 4-chloroacetophenone is gradually converted under the action of alkali and halogen elements, and finally generates 4-chloro- - α - sodium salt of hydroxyphenylacetic acid. After acidification, 4-chloro - α - hydroxyphenylacetic acid can be obtained.
Furthermore, 4-chlorobenzaldehyde can also be used as a raw material. Shilling 4-chlorobenzaldehyde and hydrocyanic acid undergo an addition reaction to generate the corresponding cyanoalcohol. This process requires attention to the control of reaction conditions, such as temperature, catalyst addition, etc., to promote the smooth progress of the reaction. Then the cyanoalcohol is hydrolyzed, and under the catalysis of acid or base, the cyanyl group is converted into a carboxyl group to obtain 4-chloro - α - hydroxyphenylacetic acid.
There is also a method of using 4-chlorobenzoic acid as a starting material. First, 4-chlorobenzoic acid is reduced to 4-chlorobenzanol, and a suitable reducing agent, such as lithium aluminum hydride, can be selected. 4-Chlorobenzyl alcohol is then halogenated to introduce halogen atoms, and then through a series of reactions, including oxidation steps, the final product 4-chloro - α - hydroxyphenylacetic acid is obtained. Each method has advantages and disadvantages, and the choice needs to be weighed according to actual needs, such as the availability of raw materials, cost, product purity requirements, etc.
Furthermore, 4-chlorobenzaldehyde can also be used as a raw material. Shilling 4-chlorobenzaldehyde and hydrocyanic acid undergo an addition reaction to generate the corresponding cyanoalcohol. This process requires attention to the control of reaction conditions, such as temperature, catalyst addition, etc., to promote the smooth progress of the reaction. Then the cyanoalcohol is hydrolyzed, and under the catalysis of acid or base, the cyanyl group is converted into a carboxyl group to obtain 4-chloro - α - hydroxyphenylacetic acid.
There is also a method of using 4-chlorobenzoic acid as a starting material. First, 4-chlorobenzoic acid is reduced to 4-chlorobenzanol, and a suitable reducing agent, such as lithium aluminum hydride, can be selected. 4-Chlorobenzyl alcohol is then halogenated to introduce halogen atoms, and then through a series of reactions, including oxidation steps, the final product 4-chloro - α - hydroxyphenylacetic acid is obtained. Each method has advantages and disadvantages, and the choice needs to be weighed according to actual needs, such as the availability of raw materials, cost, product purity requirements, etc.
What is the market price of 4-chloro-alpha-hydroxy-benzeneacetic acid?
4-Chloro - α - hydroxyphenylacetic acid, the price of this product in the market is difficult to determine. The change in its price depends on many reasons.
First, it is related to the amount of output. If the production area is fertile, the output is abundant, and the supply in the city is abundant, the price may stabilize; on the contrary, if it encounters natural disasters and insect pests that are unfavorable, resulting in a sharp decrease in output and a lack of supply, the price will rise.
Second, it depends on the demand situation. In the pharmaceutical, chemical and other industries, if the demand for this product is strong, it is widely used and urgent, the price will easily rise; if the industry development is slow and the demand is few, the price will also drop.
Third, the price of raw materials is also the main factor. If the price of all raw materials required for the synthesis of this substance rises, the cost of production will increase, and the price of 4-chloro - α - hydroxyphenylacetic acid will also rise; if the price of raw materials falls, the cost will drop, and the price may also be lowered.
Fourth, the difficulty and refinement of the process also affect the price. If the preparation method is complicated, exquisite techniques and expensive tools are required, the cost will be high and the price will be high; if the process is innovative, the efficiency will be improved, and the cost may be reduced, the price will also be more affordable.
Fifth, the city's regulations and decrees also have an impact. The increase or decrease of tariffs and the strictness of environmental protection regulations can cause the price to change. Tariffs increase and environmental protection regulations are strict, and the cost increases and the price rises; otherwise, the price may decrease.
In summary, the price of 4-chloro - α - hydroxyphenylacetic acid in the market varies from time to time and situation to situation, high or low, and it is difficult to have a constant number. It is necessary to look at all factors and study the school in detail to get the general idea.
First, it is related to the amount of output. If the production area is fertile, the output is abundant, and the supply in the city is abundant, the price may stabilize; on the contrary, if it encounters natural disasters and insect pests that are unfavorable, resulting in a sharp decrease in output and a lack of supply, the price will rise.
Second, it depends on the demand situation. In the pharmaceutical, chemical and other industries, if the demand for this product is strong, it is widely used and urgent, the price will easily rise; if the industry development is slow and the demand is few, the price will also drop.
Third, the price of raw materials is also the main factor. If the price of all raw materials required for the synthesis of this substance rises, the cost of production will increase, and the price of 4-chloro - α - hydroxyphenylacetic acid will also rise; if the price of raw materials falls, the cost will drop, and the price may also be lowered.
Fourth, the difficulty and refinement of the process also affect the price. If the preparation method is complicated, exquisite techniques and expensive tools are required, the cost will be high and the price will be high; if the process is innovative, the efficiency will be improved, and the cost may be reduced, the price will also be more affordable.
Fifth, the city's regulations and decrees also have an impact. The increase or decrease of tariffs and the strictness of environmental protection regulations can cause the price to change. Tariffs increase and environmental protection regulations are strict, and the cost increases and the price rises; otherwise, the price may decrease.
In summary, the price of 4-chloro - α - hydroxyphenylacetic acid in the market varies from time to time and situation to situation, high or low, and it is difficult to have a constant number. It is necessary to look at all factors and study the school in detail to get the general idea.
What is the effect of 4-chloro-alpha-hydroxy-benzeneacetic acid on the environment?
4-Chloro - α - hydroxy-phenylacetic acid, the impact of this substance on the environment is quite complex and cannot be ignored.
Its chemical properties are active. If it flows into the water body, it can react with various substances in the water. In the aquatic ecosystem, it may cause some aquatic organisms to suffer from it. It may interfere with the physiological and metabolic processes of aquatic organisms, such as affecting the photosynthesis of algae, inhibiting the growth of algae, and then affecting the balance of the entire aquatic food chain.
If it escapes in the soil, or is acted upon by soil microorganisms, it changes the chemical composition and microbial community structure of the soil. And it may migrate with the initialization of rainwater, polluting the surrounding water bodies.
In the atmosphere, although it is volatile or not high, if it exists on the surface of aerosols and other particulate matter, or diffuses through atmospheric circulation, the impact range is wider. Its degradation products may also have different environmental activities and toxicity, or further affect the stability of the ecological environment.
And because of its certain acidity, if it exists in large quantities in the environment, or affects the acid-base balance of the environment, it will affect the pH of soil and water, and then affect the survival and reproduction of organisms in it.
All these, 4-chloro - α - hydroxy-phenylacetic acid has a lot of impact on the environment, and needs to be studied in detail to ensure the safety of the ecological environment.
Its chemical properties are active. If it flows into the water body, it can react with various substances in the water. In the aquatic ecosystem, it may cause some aquatic organisms to suffer from it. It may interfere with the physiological and metabolic processes of aquatic organisms, such as affecting the photosynthesis of algae, inhibiting the growth of algae, and then affecting the balance of the entire aquatic food chain.
If it escapes in the soil, or is acted upon by soil microorganisms, it changes the chemical composition and microbial community structure of the soil. And it may migrate with the initialization of rainwater, polluting the surrounding water bodies.
In the atmosphere, although it is volatile or not high, if it exists on the surface of aerosols and other particulate matter, or diffuses through atmospheric circulation, the impact range is wider. Its degradation products may also have different environmental activities and toxicity, or further affect the stability of the ecological environment.
And because of its certain acidity, if it exists in large quantities in the environment, or affects the acid-base balance of the environment, it will affect the pH of soil and water, and then affect the survival and reproduction of organisms in it.
All these, 4-chloro - α - hydroxy-phenylacetic acid has a lot of impact on the environment, and needs to be studied in detail to ensure the safety of the ecological environment.
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