Linshang Chemical
PRODUCTS
4-Chloro-Benzeneacetic Acid Hydrazide
Linshang Chemical
|
HS Code |
893210 |
| Name | 4-Chloro-Benzeneacetic Acid Hydrazide |
| Chemical Formula | C8H9ClN2O |
| Molecular Weight | 184.62 g/mol |
| Appearance | White to off - white solid |
| Melting Point | 160 - 164 °C |
| Solubility In Water | Slightly soluble |
| Solubility In Organic Solvents | Soluble in some organic solvents like ethanol |
| Odor | Odorless or very faint odor |
| Purity | Typically high - purity (e.g., 98%+) |
| Stability | Stable under normal conditions |
As an accredited 4-Chloro-Benzeneacetic Acid Hydrazide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - chloro - benzeneacetic Acid Hydrazide packaged in a sealed plastic bag. |
| Storage | 4 - chloro - benzeneacetic Acid Hydrazide should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, ignition sources, and incompatible substances such as strong oxidizing agents. Store it in a tightly closed container to prevent moisture absorption and contamination, ensuring its stability and safety during storage. |
| Shipping | 4 - chloro - benzeneacetic Acid Hydrazide is shipped in well - sealed containers, following strict chemical transport regulations. Packaging ensures protection from external factors, with proper labeling for hazard awareness during transit. |
Competitive 4-Chloro-Benzeneacetic Acid Hydrazide prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 4-Chloro-Benzeneacetic Acid Hydrazide in China?
As a trusted 4-Chloro-Benzeneacetic Acid Hydrazide manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 4-Chloro-Benzeneacetic Acid Hydrazide supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 4-chloro-benzeneacetic Acid Hydrazide?
Hydrazine 4-chlorophenylacetate has a wide range of uses. In the field of medicine, it is an important intermediate in organic synthesis. In the preparation of many drugs, hydrazine 4-chlorophenylacetate is often used as the starting material or key reaction intermediate. Through a series of chemical reactions, its structure is modified and modified, and drug molecules with specific pharmacological activities can be prepared for the treatment of diseases, such as in the development and synthesis of some antibacterial drugs and anti-tumor drugs.
In the chemical industry, hydrazine 4-chlorophenylacetate is often used in the synthesis of fine chemicals. It can participate in the preparation of various organic compounds with special properties, which play an important role in coatings, plastics, rubber and other fields. For example, by reacting with other compounds, polymer material additives with special structures and properties can be synthesized, thereby improving the stability and corrosion resistance of materials.
In terms of scientific research and exploration, hydrazine 4-chlorophenylacetate also provides an important material basis for organic chemistry research. Researchers use it to study various organic reaction mechanisms, explore new synthesis methods and paths, and expand the knowledge boundary of organic chemistry, providing possibilities for the synthesis of more innovative compounds.
In the chemical industry, hydrazine 4-chlorophenylacetate is often used in the synthesis of fine chemicals. It can participate in the preparation of various organic compounds with special properties, which play an important role in coatings, plastics, rubber and other fields. For example, by reacting with other compounds, polymer material additives with special structures and properties can be synthesized, thereby improving the stability and corrosion resistance of materials.
In terms of scientific research and exploration, hydrazine 4-chlorophenylacetate also provides an important material basis for organic chemistry research. Researchers use it to study various organic reaction mechanisms, explore new synthesis methods and paths, and expand the knowledge boundary of organic chemistry, providing possibilities for the synthesis of more innovative compounds.
4-chloro-benzeneacetic the physical properties of Acid Hydrazide
4-Chlorophenylacetate hydrazide is one of the organic compounds. Its physical properties are unique, let me explain in detail.
Looking at its appearance, under room temperature and pressure, it is mostly white to white crystalline powder, with a delicate texture, just like the first snow in winter, pure and simple.
Smell it, this compound has very little smell, almost odorless, no pungent smell to disturb people's sense of smell, quite mild.
Talking about the melting point, 4-chlorophenylacetate hydrazide is about 170-175 ° C. When the temperature rises to this range, it slowly melts from a solid state to a liquid state, just like ice and snow meet warm sun, quietly changing shape.
Its solubility also has characteristics. In common organic solvents, such as ethanol and acetone, it exhibits a certain solubility. In ethanol, it can be partially dissolved, just like fish entering water. Although it cannot be completely fused, it is also somewhat compatible; in acetone, the dissolution is slightly better, and a larger amount can be dissolved in it. However, in water, its solubility is relatively small, and only a small amount is soluble, just like a stone thrown into the sea, and it is difficult to find traces.
In addition, the density of 4-chlorophenylacetate hydrazide is moderate. Although there is no exact density value like a metal, it is in the common range among organic compounds. It is not too light and erratic, nor is it heavy and difficult to move. Under normal storage conditions, in a dry and cool place, it can maintain its own structure and properties, and does not easily decompose and deteriorate. However, in case of extreme conditions such as high temperature, strong acid and alkali, its chemical structure may change, and its physical properties will also change.
Looking at its appearance, under room temperature and pressure, it is mostly white to white crystalline powder, with a delicate texture, just like the first snow in winter, pure and simple.
Smell it, this compound has very little smell, almost odorless, no pungent smell to disturb people's sense of smell, quite mild.
Talking about the melting point, 4-chlorophenylacetate hydrazide is about 170-175 ° C. When the temperature rises to this range, it slowly melts from a solid state to a liquid state, just like ice and snow meet warm sun, quietly changing shape.
Its solubility also has characteristics. In common organic solvents, such as ethanol and acetone, it exhibits a certain solubility. In ethanol, it can be partially dissolved, just like fish entering water. Although it cannot be completely fused, it is also somewhat compatible; in acetone, the dissolution is slightly better, and a larger amount can be dissolved in it. However, in water, its solubility is relatively small, and only a small amount is soluble, just like a stone thrown into the sea, and it is difficult to find traces.
In addition, the density of 4-chlorophenylacetate hydrazide is moderate. Although there is no exact density value like a metal, it is in the common range among organic compounds. It is not too light and erratic, nor is it heavy and difficult to move. Under normal storage conditions, in a dry and cool place, it can maintain its own structure and properties, and does not easily decompose and deteriorate. However, in case of extreme conditions such as high temperature, strong acid and alkali, its chemical structure may change, and its physical properties will also change.
4-chloro-benzeneacetic the chemistry of Acid Hydrazide
Hydrazine 4-chlorophenylacetate has unique chemical properties and is of great research value. Its properties are mostly white crystalline powders, which are relatively stable at room temperature and pressure.
Looking at its solubility, it has a certain solubility in common organic solvents such as ethanol and acetone. This characteristic is just like what the ancients said: "Each thing has its own tolerance, and in different environments, it has different states." In water, its solubility is relatively limited, which is due to its molecular structural properties.
When it comes to chemical activity, hydrazine 4-chlorophenylacetate contains chlorine atoms and hydrazine groups, which give it active reactivity. Chlorine atoms can participate in nucleophilic substitution reactions, just like the ancient art of war "using motion to control stillness". External nucleophilic reagents are easy to attack, substitution occurs, and new compounds are formed. And hydrazine groups, with strong reductivity, are prone to oxidation reactions when encountering suitable oxidants, just like warriors who encounter enemies and fight bravely.
In addition, they can react with a variety of acids to generate corresponding salts. This reaction is like a harmony of yin and yang, each taking what they need to form a new chemical state. In the field of organic synthesis, hydrazine 4-chlorophenylacetate is often used as an important intermediate to participate in the construction of many complex organic compounds, just like the cornerstone of building an exquisite pavilion, adding to the great cause of organic synthesis.
And because its structure contains a benzene ring, it has a certain aroma, which not only affects its physical properties, but also guides the direction and process of the reaction in the chemical reaction, like a guiding needle in the dark, making the reaction follow a specific path.
Looking at its solubility, it has a certain solubility in common organic solvents such as ethanol and acetone. This characteristic is just like what the ancients said: "Each thing has its own tolerance, and in different environments, it has different states." In water, its solubility is relatively limited, which is due to its molecular structural properties.
When it comes to chemical activity, hydrazine 4-chlorophenylacetate contains chlorine atoms and hydrazine groups, which give it active reactivity. Chlorine atoms can participate in nucleophilic substitution reactions, just like the ancient art of war "using motion to control stillness". External nucleophilic reagents are easy to attack, substitution occurs, and new compounds are formed. And hydrazine groups, with strong reductivity, are prone to oxidation reactions when encountering suitable oxidants, just like warriors who encounter enemies and fight bravely.
In addition, they can react with a variety of acids to generate corresponding salts. This reaction is like a harmony of yin and yang, each taking what they need to form a new chemical state. In the field of organic synthesis, hydrazine 4-chlorophenylacetate is often used as an important intermediate to participate in the construction of many complex organic compounds, just like the cornerstone of building an exquisite pavilion, adding to the great cause of organic synthesis.
And because its structure contains a benzene ring, it has a certain aroma, which not only affects its physical properties, but also guides the direction and process of the reaction in the chemical reaction, like a guiding needle in the dark, making the reaction follow a specific path.
What is the production method of 4-chloro-benzeneacetic Acid Hydrazide?
The preparation method of 4-chlorophenylacetic acid hydrazide has been known for a long time, and it has been tempered by practice.
First, 4-chlorophenylacetic acid is used as the starting material. First, 4-chlorophenylacetic acid and an appropriate amount of thionyl chloride are co-placed in a reaction kettle. The two are compatible in an appropriate ratio, and they are reacted at a certain temperature (about 60-80 ° C). The function of thionyl chloride is to convert the carboxyl group of 4-chlorophenylacetic acid into an active acid chloride group. During the reaction process, hydrogen chloride and sulfur dioxide gas escape, which can be discharged by a ventilation device. After the reaction is completed, the unreacted thionyl chloride is removed by reduced pressure distillation to obtain 4-chlorophenylacetyl chloride.
Then, take an appropriate amount of hydrazine hydrate and slowly drop it into a reaction vessel containing 4-chlorophenylacetyl chloride. The ratio of hydrazine hydrate to 4-chlorophenylacetyl chloride needs to be precisely controlled, and the reaction temperature should be maintained at a low temperature (about 0-10 ° C) to prevent side reactions. After adding it dropwise, let it continue the reaction at room temperature for several hours. After the reaction is completed, pour the reaction mixture into an appropriate amount of ice water, and solid precipitates. After suction filtration, washing and drying, the crude product of 4-chlorophenylacetate hydrazide can be obtained. Then recrystallize with a suitable organic solvent (such as ethanol-water mixed solvent) to obtain pure 4-chlorophenylacetate hydrazide.
Second, there are also those who use 4-chlorophenylacetonitrile as the starting material. First, 4-chlorophenylacetonitrile is heated with sodium hydroxide solution, and it undergoes a hydrolytic reaction to generate 4-chlorophenylacetate. After acidification, 4-chlorophenylacetic acid is precipitated. The subsequent steps are similar to those using 4-chlorophenylacetic acid as the starting material. 4-chlorophenylacetyl chloride is first prepared, and then reacted with hydrazine hydrate to obtain 4-chlorophenylacetohydrazide.
These two methods have their own advantages and disadvantages, but they are both effective paths for the preparation of 4-chlorophenylacetohydrazide. In practice, the choice should be made carefully according to various factors such as the availability of raw materials, cost and product quality.
First, 4-chlorophenylacetic acid is used as the starting material. First, 4-chlorophenylacetic acid and an appropriate amount of thionyl chloride are co-placed in a reaction kettle. The two are compatible in an appropriate ratio, and they are reacted at a certain temperature (about 60-80 ° C). The function of thionyl chloride is to convert the carboxyl group of 4-chlorophenylacetic acid into an active acid chloride group. During the reaction process, hydrogen chloride and sulfur dioxide gas escape, which can be discharged by a ventilation device. After the reaction is completed, the unreacted thionyl chloride is removed by reduced pressure distillation to obtain 4-chlorophenylacetyl chloride.
Then, take an appropriate amount of hydrazine hydrate and slowly drop it into a reaction vessel containing 4-chlorophenylacetyl chloride. The ratio of hydrazine hydrate to 4-chlorophenylacetyl chloride needs to be precisely controlled, and the reaction temperature should be maintained at a low temperature (about 0-10 ° C) to prevent side reactions. After adding it dropwise, let it continue the reaction at room temperature for several hours. After the reaction is completed, pour the reaction mixture into an appropriate amount of ice water, and solid precipitates. After suction filtration, washing and drying, the crude product of 4-chlorophenylacetate hydrazide can be obtained. Then recrystallize with a suitable organic solvent (such as ethanol-water mixed solvent) to obtain pure 4-chlorophenylacetate hydrazide.
Second, there are also those who use 4-chlorophenylacetonitrile as the starting material. First, 4-chlorophenylacetonitrile is heated with sodium hydroxide solution, and it undergoes a hydrolytic reaction to generate 4-chlorophenylacetate. After acidification, 4-chlorophenylacetic acid is precipitated. The subsequent steps are similar to those using 4-chlorophenylacetic acid as the starting material. 4-chlorophenylacetyl chloride is first prepared, and then reacted with hydrazine hydrate to obtain 4-chlorophenylacetohydrazide.
These two methods have their own advantages and disadvantages, but they are both effective paths for the preparation of 4-chlorophenylacetohydrazide. In practice, the choice should be made carefully according to various factors such as the availability of raw materials, cost and product quality.
4-chloro-benzeneacetic precautions during use of Acid Hydrazide
4-Hydrazine chlorophenylacetate requires attention to many matters during use. This is a fine chemical material with unique properties, which is related to the safety and effect of operation.
First, safety protection must be comprehensive. Because it has certain chemical activity, or is harmful to the human body. When operating, it is necessary to adapt protective equipment, such as protective clothing, gloves and goggles, to prevent skin contact and eye splashing. In case of accidental contact, rinse with plenty of water immediately and seek medical attention according to the actual situation.
Second, storage conditions should not be ignored. It should be placed in a cool, dry and well-ventilated place, away from fire and heat sources, and avoid direct sunlight. At the same time, it should be stored separately from oxidants, acids, etc., and must not be mixed to prevent dangerous chemical reactions.
Third, it is essential to accurately grasp the dosage. According to the specific reaction or application scenario, the appropriate dosage is determined by rigorous calculation and test. If the dosage is too small or the reaction is incomplete, the desired effect cannot be achieved; if the dosage is too large, it may cause side reactions, increase costs, and even bring safety hazards.
Fourth, the operating environment needs to be kept well ventilated. During use, harmful gases may be volatilized. Good ventilation can discharge exhaust gas in time, reduce the concentration of harmful substances in the air, and protect the health of operators.
Fifth, it is indispensable to be familiar with emergency treatment methods. Prepare a response strategy for unexpected situations such as leaks and fires in advance. In the event of a leak, quickly evacuate unrelated personnel, isolate the leakage area, and select an appropriate way to clean up according to the characteristics of the material. In case of fire, use suitable fire extinguishing equipment to fight it.
First, safety protection must be comprehensive. Because it has certain chemical activity, or is harmful to the human body. When operating, it is necessary to adapt protective equipment, such as protective clothing, gloves and goggles, to prevent skin contact and eye splashing. In case of accidental contact, rinse with plenty of water immediately and seek medical attention according to the actual situation.
Second, storage conditions should not be ignored. It should be placed in a cool, dry and well-ventilated place, away from fire and heat sources, and avoid direct sunlight. At the same time, it should be stored separately from oxidants, acids, etc., and must not be mixed to prevent dangerous chemical reactions.
Third, it is essential to accurately grasp the dosage. According to the specific reaction or application scenario, the appropriate dosage is determined by rigorous calculation and test. If the dosage is too small or the reaction is incomplete, the desired effect cannot be achieved; if the dosage is too large, it may cause side reactions, increase costs, and even bring safety hazards.
Fourth, the operating environment needs to be kept well ventilated. During use, harmful gases may be volatilized. Good ventilation can discharge exhaust gas in time, reduce the concentration of harmful substances in the air, and protect the health of operators.
Fifth, it is indispensable to be familiar with emergency treatment methods. Prepare a response strategy for unexpected situations such as leaks and fires in advance. In the event of a leak, quickly evacuate unrelated personnel, isolate the leakage area, and select an appropriate way to clean up according to the characteristics of the material. In case of fire, use suitable fire extinguishing equipment to fight it.
Scan to WhatsApp
