Linshang Chemical
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4-Chloro-Benzenecarboximidamidmonohydrochloride
Linshang Chemical
|
HS Code |
611765 |
| Chemical Formula | C7H8Cl2N2 |
| Molar Mass | 191.06 g/mol |
| Appearance | Solid (usually white or off - white powder) |
| Physical State At Room Temperature | Solid |
| Solubility In Water | Moderately soluble |
| Solubility In Organic Solvents | Soluble in some polar organic solvents like ethanol |
| Melting Point | Typically in the range of 200 - 220°C (approximate, may vary based on purity) |
| Ph In Aqueous Solution | Acidic due to the presence of hydrochloride salt |
As an accredited 4-Chloro-Benzenecarboximidamidmonohydrochloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - chloro - benzenecarboximidamidmonohydrochloride packaged in a sealed plastic bag. |
| Storage | 4 - chloro - benzenecarboximidamidmonohydrochloride should be stored in a cool, dry, well - ventilated area. Keep it away from sources of heat, ignition, and incompatible substances. Store in a tightly closed container to prevent moisture absorption and degradation. Avoid storing near strong oxidizers or bases to maintain its chemical integrity. |
| Shipping | 4 - chloro - benzenecarboximidamidmonohydrochloride is shipped in sealed, corrosion - resistant containers. They are carefully packed to prevent breakage. Shipments follow strict chemical transport regulations to ensure safety during transit. |
Competitive 4-Chloro-Benzenecarboximidamidmonohydrochloride prices that fit your budget—flexible terms and customized quotes for every order.
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Tel: +8615365006308
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As a leading 4-Chloro-Benzenecarboximidamidmonohydrochloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemical structure of 4-chloro-benzenecarboximidamidmonohydrochloride?
4-chloro-benzenecarboximidamidmonohydrochloride, that is, 4-chlorobenzamidine hydrochloride. The chemical structure of this substance can be described as follows.
The benzene ring is its core structure, which is a typical structure of aromatic hydrocarbons. It consists of six carbon atoms connected by conjugated double bonds to form a hexagon. At position 4 of the benzene ring, there is a chlorine atom connected, and the chlorine atom is covalently bound to the carbon atom of the benzene ring. At position 1 of the benzene ring, there is a formamidine group connected, the structure of the formamidine group is\ (C (= NH) NH_2\), and the carbon atom of the formamidine group is connected to the carbon atom of the benzene ring at position 1 by a carbon-carbon And because of the name hydrochloride, it can be seen that the solitary pair electrons of the nitrogen atom in formamidine group combine with the hydrogen ion in hydrochloric acid to form a coordination bond, which has a positive charge and forms an ionic bond with chloride ions to maintain electrical neutrality.
In this structure, the benzene ring gives it a certain stability and aromaticity. The introduction of chlorine atoms can change its electron cloud distribution and chemical activity. The presence of formamidine groups makes it have a certain alkalinity and an activity check point for reacting with other substances. The form of hydrochloride affects its solubility and other physical properties.
The benzene ring is its core structure, which is a typical structure of aromatic hydrocarbons. It consists of six carbon atoms connected by conjugated double bonds to form a hexagon. At position 4 of the benzene ring, there is a chlorine atom connected, and the chlorine atom is covalently bound to the carbon atom of the benzene ring. At position 1 of the benzene ring, there is a formamidine group connected, the structure of the formamidine group is\ (C (= NH) NH_2\), and the carbon atom of the formamidine group is connected to the carbon atom of the benzene ring at position 1 by a carbon-carbon And because of the name hydrochloride, it can be seen that the solitary pair electrons of the nitrogen atom in formamidine group combine with the hydrogen ion in hydrochloric acid to form a coordination bond, which has a positive charge and forms an ionic bond with chloride ions to maintain electrical neutrality.
In this structure, the benzene ring gives it a certain stability and aromaticity. The introduction of chlorine atoms can change its electron cloud distribution and chemical activity. The presence of formamidine groups makes it have a certain alkalinity and an activity check point for reacting with other substances. The form of hydrochloride affects its solubility and other physical properties.
What are the main uses of 4-chloro-benzenecarboximidamidmonohydrochloride?
4-Chloro-benzamidine hydrochloride has a wide range of uses. In the field of medicinal chemistry, it is often a key raw material for the creation of antibacterial and anti-inflammatory drugs. Due to the special structure of chlorine atoms, benzene rings and amidine groups, it is endowed with the ability to interact with specific biological targets. After modification, new drugs with good efficacy and small side effects can be prepared.
In the field of organic synthesis, it is also an important intermediate. It can borrow many organic reactions and combine with various reagents to build complex organic molecular structures. If reacted with compounds containing active groups, new carbon-nitrogen or carbon-carbon bonds can be formed, expanding the complexity and diversity of molecules, and assisting in the synthesis of organic materials or fine chemicals with specific functions.
In addition, in the field of agricultural chemistry, it may be able to participate in the creation of new pesticides. With its specific effect on the physiological mechanism of harmful organisms, it can achieve the effect of controlling pests and diseases, and is more selective and environmentally friendly than traditional pesticides, contributing to the green development of modern agriculture. This is a common and important use of 4-chloro-benzamidine hydrochloride.
In the field of organic synthesis, it is also an important intermediate. It can borrow many organic reactions and combine with various reagents to build complex organic molecular structures. If reacted with compounds containing active groups, new carbon-nitrogen or carbon-carbon bonds can be formed, expanding the complexity and diversity of molecules, and assisting in the synthesis of organic materials or fine chemicals with specific functions.
In addition, in the field of agricultural chemistry, it may be able to participate in the creation of new pesticides. With its specific effect on the physiological mechanism of harmful organisms, it can achieve the effect of controlling pests and diseases, and is more selective and environmentally friendly than traditional pesticides, contributing to the green development of modern agriculture. This is a common and important use of 4-chloro-benzamidine hydrochloride.
What are the physical properties of 4-chloro-benzenecarboximidamidmonohydrochloride?
4-Chlorobenzamidine hydrochloride, this is an organic compound. Its physical properties are particularly important and relevant to its application in many fields.
Looking at its properties, it is normally a white to light yellow crystalline powder, which is easy to store and use. It has a certain solubility and is soluble in water, but the solubility varies with temperature. Usually, when the temperature increases, the solubility also increases. Due to the increase in temperature, the thermal movement of molecules is intensified, and the interaction between solvent and solute molecules is enhanced. In organic solvents, such as ethanol, acetone, etc., it also has a certain solubility, but the degree of solubility varies depending on the type of solvent.
Melting point is also a key physical property. 4-Chlorobenzamidine hydrochloride has a specific melting point, at which the substance changes from solid to liquid. The determination of the melting point can help to distinguish its purity. If the sample purity is high, the melting point range is narrow and close to the theoretical value; if it contains impurities, the melting point decreases and the melting range becomes wider.
In addition, its density also has a fixed number. Density reflects the mass of a unit volume of a substance and is important for considering its distribution and behavior in solutions or mixtures.
The physical properties of 4-chlorobenzamidine hydrochloride, such as properties, solubility, melting point and density, are of great significance in the fields of chemical industry and medicine, providing a key basis for its preparation, purification and application.
Looking at its properties, it is normally a white to light yellow crystalline powder, which is easy to store and use. It has a certain solubility and is soluble in water, but the solubility varies with temperature. Usually, when the temperature increases, the solubility also increases. Due to the increase in temperature, the thermal movement of molecules is intensified, and the interaction between solvent and solute molecules is enhanced. In organic solvents, such as ethanol, acetone, etc., it also has a certain solubility, but the degree of solubility varies depending on the type of solvent.
Melting point is also a key physical property. 4-Chlorobenzamidine hydrochloride has a specific melting point, at which the substance changes from solid to liquid. The determination of the melting point can help to distinguish its purity. If the sample purity is high, the melting point range is narrow and close to the theoretical value; if it contains impurities, the melting point decreases and the melting range becomes wider.
In addition, its density also has a fixed number. Density reflects the mass of a unit volume of a substance and is important for considering its distribution and behavior in solutions or mixtures.
The physical properties of 4-chlorobenzamidine hydrochloride, such as properties, solubility, melting point and density, are of great significance in the fields of chemical industry and medicine, providing a key basis for its preparation, purification and application.
What is 4-chloro-benzenecarboximidamidmonohydrochloride synthesis method?
The synthesis of 4-chlorobenzamidine hydrochloride is a key issue in the field of organic synthesis. To synthesize this substance, several paths are often followed.
One of them can be started from 4-chlorobenzonitrile. First, 4-chlorobenzonitrile reacts with excess ammonia under high temperature and pressure and with appropriate catalysts. Ammonia molecules attack cyanyl groups and undergo nucleophilic addition reactions to form 4-chlorobenzamidine intermediates. This intermediate then interacts with hydrogen chloride gas or hydrochloric acid solution to form a salt to obtain 4-chlorobenzamidine hydrochloride. During the reaction process, precise temperature and pressure control are required to ensure the smooth progress of the reaction and the purity of the product.
Second, 4-chlorobenzoic acid is used as the starting material. The 4-chlorobenzoic acid is first converted into its acyl chloride form, which is often achieved by reagents such as sulfoxide chloride. The generated 4-chlorobenzoyl chloride reacts with ammonia to form 4-chlorobenzamide. Subsequently, 4-chlorobenzamide can dehydrate under specific conditions, such as co-heating with phosphorus pentachloride, phosphorus oxychloride and other reagents, to form 4-chlorobenzonitrile. The subsequent steps are the same as the above method of using 4-chlorobenzonitrile as the raw material, that is, interacting with ammonia and hydrogen chloride to obtain the target product.
In addition, there are also methods for synthesizing 4-chlorobenzamidine hydrochloride through multi-step reaction with other related compounds as starting materials. However, regardless of the route, attention should be paid to the control of reaction conditions, the separation and purification of intermediate products, in order to improve the yield and purity of the final product. Each method has its own advantages and disadvantages, and the appropriate synthesis method should be weighed according to the actual situation, such as the availability of raw materials, cost, equipment conditions, etc.
One of them can be started from 4-chlorobenzonitrile. First, 4-chlorobenzonitrile reacts with excess ammonia under high temperature and pressure and with appropriate catalysts. Ammonia molecules attack cyanyl groups and undergo nucleophilic addition reactions to form 4-chlorobenzamidine intermediates. This intermediate then interacts with hydrogen chloride gas or hydrochloric acid solution to form a salt to obtain 4-chlorobenzamidine hydrochloride. During the reaction process, precise temperature and pressure control are required to ensure the smooth progress of the reaction and the purity of the product.
Second, 4-chlorobenzoic acid is used as the starting material. The 4-chlorobenzoic acid is first converted into its acyl chloride form, which is often achieved by reagents such as sulfoxide chloride. The generated 4-chlorobenzoyl chloride reacts with ammonia to form 4-chlorobenzamide. Subsequently, 4-chlorobenzamide can dehydrate under specific conditions, such as co-heating with phosphorus pentachloride, phosphorus oxychloride and other reagents, to form 4-chlorobenzonitrile. The subsequent steps are the same as the above method of using 4-chlorobenzonitrile as the raw material, that is, interacting with ammonia and hydrogen chloride to obtain the target product.
In addition, there are also methods for synthesizing 4-chlorobenzamidine hydrochloride through multi-step reaction with other related compounds as starting materials. However, regardless of the route, attention should be paid to the control of reaction conditions, the separation and purification of intermediate products, in order to improve the yield and purity of the final product. Each method has its own advantages and disadvantages, and the appropriate synthesis method should be weighed according to the actual situation, such as the availability of raw materials, cost, equipment conditions, etc.
What are the precautions in storage and transportation of 4-chloro-benzenecarboximidamidmonohydrochloride?
4-Chloro-benzamidine hydrochloride is a chemical substance. When storing and transporting, pay attention to many things to ensure safety and quality.
First, when storing, place it in a cool, dry and well-ventilated place. This substance is susceptible to moisture. If the ambient humidity is high, it may cause deliquescence, which in turn affects the purity and performance. Therefore, the humidity of the warehouse should be maintained at a low level and should be equipped with a humidity adjustment device for timely control.
Second, temperature is also crucial. Excessive temperature may cause chemical reactions and cause it to deteriorate. Generally speaking, the storage temperature should be controlled within a specific range, and it must not be exposed to high temperature environments. Temperature monitoring equipment should be installed in the warehouse to monitor temperature changes in real time. Once any abnormalities are detected, corresponding measures should be taken immediately.
Third, this substance must be stored separately from oxidants, acids, alkalis, etc. Because of its active chemical properties, it comes into contact with the above substances, or causes violent reactions, or even causes serious accidents such as fires and explosions. Therefore, the storage area should be clearly divided, and different categories of chemical substances should be stored separately, and obvious labels should be set.
Fourth, during transportation, the packaging must be tight. Ensure that the packaging is not damaged or leaked, so as not to cause harm to transportation personnel and the environment. Choosing the right means of transportation is also indispensable. Transportation vehicles should have good protective measures to deal with emergencies.
Fifth, transportation and storage personnel should be professionally trained to be familiar with the characteristics of the substance and emergency treatment methods. In the event of an accident such as leakage, countermeasures can be taken quickly and effectively to minimize losses.
In short, all aspects of the storage and transportation of 4-chloro-benzamidine hydrochloride need to be treated with caution, and relevant norms and requirements should be strictly followed to ensure the safety and stability of the whole process.
First, when storing, place it in a cool, dry and well-ventilated place. This substance is susceptible to moisture. If the ambient humidity is high, it may cause deliquescence, which in turn affects the purity and performance. Therefore, the humidity of the warehouse should be maintained at a low level and should be equipped with a humidity adjustment device for timely control.
Second, temperature is also crucial. Excessive temperature may cause chemical reactions and cause it to deteriorate. Generally speaking, the storage temperature should be controlled within a specific range, and it must not be exposed to high temperature environments. Temperature monitoring equipment should be installed in the warehouse to monitor temperature changes in real time. Once any abnormalities are detected, corresponding measures should be taken immediately.
Third, this substance must be stored separately from oxidants, acids, alkalis, etc. Because of its active chemical properties, it comes into contact with the above substances, or causes violent reactions, or even causes serious accidents such as fires and explosions. Therefore, the storage area should be clearly divided, and different categories of chemical substances should be stored separately, and obvious labels should be set.
Fourth, during transportation, the packaging must be tight. Ensure that the packaging is not damaged or leaked, so as not to cause harm to transportation personnel and the environment. Choosing the right means of transportation is also indispensable. Transportation vehicles should have good protective measures to deal with emergencies.
Fifth, transportation and storage personnel should be professionally trained to be familiar with the characteristics of the substance and emergency treatment methods. In the event of an accident such as leakage, countermeasures can be taken quickly and effectively to minimize losses.
In short, all aspects of the storage and transportation of 4-chloro-benzamidine hydrochloride need to be treated with caution, and relevant norms and requirements should be strictly followed to ensure the safety and stability of the whole process.
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