Linshang Chemical
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4-Chloro-Benzeneethanamine
Linshang Chemical
|
HS Code |
819843 |
| Chemical Formula | C8H10ClN |
| Molecular Weight | 155.624 g/mol |
| Appearance | Typically a solid or liquid |
| Boiling Point | Approximately 253 - 255 °C |
| Melting Point | Around 37 - 39 °C |
| Solubility In Water | Poorly soluble in water |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, diethyl ether |
| Odor | May have a characteristic amine - like odor |
As an accredited 4-Chloro-Benzeneethanamine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - chloro - benzeneethanamine packaged in a sealed, chemical - resistant bottle. |
| Storage | 4 - chloro - benzeneethanamine should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly - sealed container to prevent exposure to air and moisture. Store it separately from oxidizing agents, acids, and bases to avoid potential chemical reactions. Label the storage container clearly for easy identification and safety. |
| Shipping | 4 - chloro - benzeneethanamine is shipped in accordance with strict chemical regulations. It's carefully packaged in suitable containers to prevent leakage, and transported by carriers experienced in handling hazardous chemicals, ensuring safety during transit. |
Competitive 4-Chloro-Benzeneethanamine prices that fit your budget—flexible terms and customized quotes for every order.
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What is the chemical structure of 4-chloro-benzeneethanamine?
4-Chloro-benzeneethanamine is 4-chlorophenethylamine, and its chemical structure is as follows. This substance is an organic compound containing benzene ring and ethylamine group, and the chlorine atom is at the position 4 of the benzene ring.
From the structural analysis, it is based on the benzene ring, which is a six-membered carbon ring with a conjugated large π bond, resulting in its special stability and chemical activity. Ethylamine ($- CH_2CH_2NH_2 $) is connected to the benzene ring. In the ethylamine group, the nitrogen atom has lone pairs of electrons, which makes the substance alkaline and can react with acids to form salts. The chlorine atom ($Cl $) is located at the 4th position of the benzene ring. The chlorine atom is electronegative. The electron-withdrawing induction effect can affect the electron cloud density distribution of the benzene ring, and change the electrophilic substitution reaction activity and positional selectivity on the benzene ring.
Using benzene as the starting material, through the acylation reaction of Fu-g, benzene and chloroacetyl chloride under the catalysis of anhydrous aluminum trichloride, 4-chloroacetophenone is formed. Because the carbonyl group is the meta-locator, the main product is obtained in this step. Then 4-chloroacetophenone is reduced by the reduction reaction. If sodium borohydride or lithium aluminum hydride are used as the reducing agent, the carbonyl group can Then 4-chlorophenethylamine was substituted with ammonia under the action of catalyst, and the hydroxyl group was replaced by amino group, and finally 4-chlorophenethylamine was obtained.
4-chlorophenethylamine has a unique chemical structure. The interaction between phenyl ring, ethylamine group and chlorine atom endows it with various chemical properties and is widely used in the fields of organic synthesis and medicinal chemistry.
From the structural analysis, it is based on the benzene ring, which is a six-membered carbon ring with a conjugated large π bond, resulting in its special stability and chemical activity. Ethylamine ($- CH_2CH_2NH_2 $) is connected to the benzene ring. In the ethylamine group, the nitrogen atom has lone pairs of electrons, which makes the substance alkaline and can react with acids to form salts. The chlorine atom ($Cl $) is located at the 4th position of the benzene ring. The chlorine atom is electronegative. The electron-withdrawing induction effect can affect the electron cloud density distribution of the benzene ring, and change the electrophilic substitution reaction activity and positional selectivity on the benzene ring.
Using benzene as the starting material, through the acylation reaction of Fu-g, benzene and chloroacetyl chloride under the catalysis of anhydrous aluminum trichloride, 4-chloroacetophenone is formed. Because the carbonyl group is the meta-locator, the main product is obtained in this step. Then 4-chloroacetophenone is reduced by the reduction reaction. If sodium borohydride or lithium aluminum hydride are used as the reducing agent, the carbonyl group can Then 4-chlorophenethylamine was substituted with ammonia under the action of catalyst, and the hydroxyl group was replaced by amino group, and finally 4-chlorophenethylamine was obtained.
4-chlorophenethylamine has a unique chemical structure. The interaction between phenyl ring, ethylamine group and chlorine atom endows it with various chemical properties and is widely used in the fields of organic synthesis and medicinal chemistry.
What are the physical properties of 4-chloro-benzeneethanamine?
4-Chloro-phenethylamine, this is an organic compound. Looking at its physical properties, it is mostly a colorless to light yellow liquid under normal conditions, with a special smell and a pungent smell. Its boiling point is related to many factors. Under normal pressure, it is about a certain temperature range, but the exact value varies slightly due to measurement conditions. The melting point of this substance is also a specific value. At a specific temperature, it gradually changes from a solid state to a liquid state.
In terms of solubility, 4-chloro-phenethylamine is slightly soluble in water, because its molecular structure contains hydrophobic groups such as benzene ring, making it difficult to dissolve in water with strong polarity. However, it is easily soluble in a variety of organic solvents, such as ethanol, ether, chloroform, etc. In ethanol, it can be rapidly dissolved to form a uniform solution. Due to the fact that ethanol and 4-chloro-phenethylamine molecules can form certain interactions, such as van der Waals force, to promote the dissolution process.
The density of 4-chloro-phenethylamine is also a specific physical parameter. Compared with water, its density may be different. This property is quite important in some operations involving liquid-liquid separation. Its volatility exists to a certain extent. In an open environment, it will slowly evaporate into the air, and because it has a certain pungent odor, it can be perceived when it evaporates.
In summary, the physical properties of 4-chloro-phenethylamine, such as state, odor, melting point, solubility, density, and volatility, are of great significance in chemical research, industrial production, and related application fields.
In terms of solubility, 4-chloro-phenethylamine is slightly soluble in water, because its molecular structure contains hydrophobic groups such as benzene ring, making it difficult to dissolve in water with strong polarity. However, it is easily soluble in a variety of organic solvents, such as ethanol, ether, chloroform, etc. In ethanol, it can be rapidly dissolved to form a uniform solution. Due to the fact that ethanol and 4-chloro-phenethylamine molecules can form certain interactions, such as van der Waals force, to promote the dissolution process.
The density of 4-chloro-phenethylamine is also a specific physical parameter. Compared with water, its density may be different. This property is quite important in some operations involving liquid-liquid separation. Its volatility exists to a certain extent. In an open environment, it will slowly evaporate into the air, and because it has a certain pungent odor, it can be perceived when it evaporates.
In summary, the physical properties of 4-chloro-phenethylamine, such as state, odor, melting point, solubility, density, and volatility, are of great significance in chemical research, industrial production, and related application fields.
What are the main uses of 4-chloro-benzeneethanamine?
4-Chloro-benzeneethanamine, Chinese name 4-chlorophenethylamine, is an organic compound with a wide range of uses and plays a key role in many fields.
In the field of medicinal chemistry, this compound is an important synthesis intermediate. Through a series of chemical reactions, it can be converted into drug molecules with specific pharmacological activities. Taking the synthesis of some antidepressant drugs as an example, 4-chlorophenethylamine can be used as a starting material. Through the functional transformation and modification of its amino group and chlorine atom, it can construct a structure that is in line with the target of human neurotransmitters, and then achieve the purpose of regulating the level of neurotransmitters and relieving depression symptoms.
In the field of materials science, 4-chlorophenethylamine also has applications. Because the amino group in its molecular structure is reactive, it can react with other compounds containing specific functional groups to form polymeric materials with unique properties. These polymers may have excellent electrical conductivity, optical properties or mechanical properties, and are very useful in electronic devices, optical materials, etc. For example, the preparation of polymer films with special electrical conductivity can be used to make flexible display screens or new sensors.
Furthermore, in the field of organic synthesis chemistry, it is an important building block for the construction of complex organic molecules. Due to the unique reactivity of chlorine atoms and amino groups, many reactions such as nucleophilic substitution and electrophilic addition can be carried out, resulting in the synthesis of organic compounds with diverse structures, providing an important material basis for organic synthesis chemists to explore new molecular structures and reaction pathways.
In the field of medicinal chemistry, this compound is an important synthesis intermediate. Through a series of chemical reactions, it can be converted into drug molecules with specific pharmacological activities. Taking the synthesis of some antidepressant drugs as an example, 4-chlorophenethylamine can be used as a starting material. Through the functional transformation and modification of its amino group and chlorine atom, it can construct a structure that is in line with the target of human neurotransmitters, and then achieve the purpose of regulating the level of neurotransmitters and relieving depression symptoms.
In the field of materials science, 4-chlorophenethylamine also has applications. Because the amino group in its molecular structure is reactive, it can react with other compounds containing specific functional groups to form polymeric materials with unique properties. These polymers may have excellent electrical conductivity, optical properties or mechanical properties, and are very useful in electronic devices, optical materials, etc. For example, the preparation of polymer films with special electrical conductivity can be used to make flexible display screens or new sensors.
Furthermore, in the field of organic synthesis chemistry, it is an important building block for the construction of complex organic molecules. Due to the unique reactivity of chlorine atoms and amino groups, many reactions such as nucleophilic substitution and electrophilic addition can be carried out, resulting in the synthesis of organic compounds with diverse structures, providing an important material basis for organic synthesis chemists to explore new molecular structures and reaction pathways.
What are the preparation methods of 4-chloro-benzeneethanamine?
The preparation method of 4-chloro-phenethylamine, through the ages, many parties have their own methods.
First, 4-chlorophenylacetic acid can be started. First, 4-chlorophenylacetic acid is co-heated with thionyl chloride, and the two interact. The hydroxyl group of the carboxyl group in 4-chlorophenylacetic acid is replaced by the chlorine atom, so 4-chlorophenylacetyl chloride is obtained. Then, it is combined with excess ammonia gas in a suitable organic solvent. The nitrogen atom of ammonia attacks the carbonyl carbon of the acid chloride, and the chlorine atom leaves to form 4-chlorophenylacetamide first. Then treated with a strong reducing agent such as lithium aluminum hydride, the carbonyl group of the amide is reduced to methylene, and the final product is 4-chloro-phenethylamine.
Second, 4-chlorophenylacetonitrile is used as the starting material. In an alcohol solvent, Raney nickel is used as the catalyst to introduce hydrogen, and the cyanyl group is gradually hydrogenated and reduced. First, the imine intermediate is obtained, and the imine is further hydrogenated, and finally converted to 4-chloro-phenethylamine. During this process, the activity of Raney nickel catalyst, the pressure of hydrogen and the reaction temperature all have a great influence on the reaction process and product yield.
Third, using 4-chlorobrombenzene and vinyl magnesium bromide as raw materials, in ether solvents such as anhydrous ether, the bromine atom of 4-chlorobrombenzene is replaced by vinyl group by Grignard reaction to obtain 4-chlorobrombenzene. Subsequently, the double bond is borohydrized and oxidized by sodium borohydride-nickel chloride system, so that the double bond is converted into alcohol hydroxyl group, and then the hydroxyl group is replaced with halogen atom, and then the nucleophilic substitution reaction occurs with ammonia. After multiple steps of conversion, 4-chloro-phenethylamine can also be obtained. Although this path step is complicated, the reaction conditions of each step are relatively mild, and the product selectivity can be controlled.
First, 4-chlorophenylacetic acid can be started. First, 4-chlorophenylacetic acid is co-heated with thionyl chloride, and the two interact. The hydroxyl group of the carboxyl group in 4-chlorophenylacetic acid is replaced by the chlorine atom, so 4-chlorophenylacetyl chloride is obtained. Then, it is combined with excess ammonia gas in a suitable organic solvent. The nitrogen atom of ammonia attacks the carbonyl carbon of the acid chloride, and the chlorine atom leaves to form 4-chlorophenylacetamide first. Then treated with a strong reducing agent such as lithium aluminum hydride, the carbonyl group of the amide is reduced to methylene, and the final product is 4-chloro-phenethylamine.
Second, 4-chlorophenylacetonitrile is used as the starting material. In an alcohol solvent, Raney nickel is used as the catalyst to introduce hydrogen, and the cyanyl group is gradually hydrogenated and reduced. First, the imine intermediate is obtained, and the imine is further hydrogenated, and finally converted to 4-chloro-phenethylamine. During this process, the activity of Raney nickel catalyst, the pressure of hydrogen and the reaction temperature all have a great influence on the reaction process and product yield.
Third, using 4-chlorobrombenzene and vinyl magnesium bromide as raw materials, in ether solvents such as anhydrous ether, the bromine atom of 4-chlorobrombenzene is replaced by vinyl group by Grignard reaction to obtain 4-chlorobrombenzene. Subsequently, the double bond is borohydrized and oxidized by sodium borohydride-nickel chloride system, so that the double bond is converted into alcohol hydroxyl group, and then the hydroxyl group is replaced with halogen atom, and then the nucleophilic substitution reaction occurs with ammonia. After multiple steps of conversion, 4-chloro-phenethylamine can also be obtained. Although this path step is complicated, the reaction conditions of each step are relatively mild, and the product selectivity can be controlled.
4-chloro-benzeneethanamine what are the precautions during use
4-Chloro-phenethylamine is also an organic compound. When using it, many matters must not be ignored.
First safety protection. This compound is toxic and irritating. When exposed, be sure to wear complete protective equipment. Protective gloves are selected to be chemically resistant to protect your hands; protective glasses can prevent it from splashing into your eyes and avoid eye injuries; masks are also indispensable to prevent inhalation of its volatile aerosols and protect the respiratory system.
Furthermore, proper storage is required. It should be placed in a cool, dry and well-ventilated place, away from fire and heat sources. Because of its flammability, it can cause the risk of combustion and explosion in case of open flame and hot topic, so the storage environment must not be careless. And it needs to be stored separately from oxidants, acids, etc., to avoid dangerous reactions caused by mixed storage.
During use, the operation specification is the key. Operating in the fume hood can effectively discharge volatile gas, reduce the concentration in the air, and reduce the harm to the invisible. Take accurate measurement, take it according to the amount required for experiment or production, do not waste, and prevent excessive accidents. At the same time, the operation should be stable and fine to avoid spillage. If it is accidentally spilled, take emergency measures immediately, such as absorbing it with inert materials such as sand and vermiculite, and then properly dispose of it.
After the experiment or production is completed, the disposal of the residue should not be underestimated. It should not be dumped at will, and it needs to be handled in a professional manner in accordance with relevant environmental regulations. Or hand it over to a qualified treatment agency, or chemically treat it according to a specific process to ensure that the environment is not polluted.
All of these are important things that should be paid attention to when using 4-chloro-phenethylamine, and it should be treated with caution.
First safety protection. This compound is toxic and irritating. When exposed, be sure to wear complete protective equipment. Protective gloves are selected to be chemically resistant to protect your hands; protective glasses can prevent it from splashing into your eyes and avoid eye injuries; masks are also indispensable to prevent inhalation of its volatile aerosols and protect the respiratory system.
Furthermore, proper storage is required. It should be placed in a cool, dry and well-ventilated place, away from fire and heat sources. Because of its flammability, it can cause the risk of combustion and explosion in case of open flame and hot topic, so the storage environment must not be careless. And it needs to be stored separately from oxidants, acids, etc., to avoid dangerous reactions caused by mixed storage.
During use, the operation specification is the key. Operating in the fume hood can effectively discharge volatile gas, reduce the concentration in the air, and reduce the harm to the invisible. Take accurate measurement, take it according to the amount required for experiment or production, do not waste, and prevent excessive accidents. At the same time, the operation should be stable and fine to avoid spillage. If it is accidentally spilled, take emergency measures immediately, such as absorbing it with inert materials such as sand and vermiculite, and then properly dispose of it.
After the experiment or production is completed, the disposal of the residue should not be underestimated. It should not be dumped at will, and it needs to be handled in a professional manner in accordance with relevant environmental regulations. Or hand it over to a qualified treatment agency, or chemically treat it according to a specific process to ensure that the environment is not polluted.
All of these are important things that should be paid attention to when using 4-chloro-phenethylamine, and it should be treated with caution.
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