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4-Chloro-N-[1-(2-Phenylethyl)-2-Piperidinylidene]-Benzenesulfonamide
Linshang Chemical
|
HS Code |
937585 |
| Chemical Formula | C21H25ClN2O2S |
| Molar Mass | 388.958 g/mol |
| Appearance | Typically solid (but exact color and form may vary) |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Melting Point | Data may vary depending on purity, but generally in a defined range for pure compound |
| Boiling Point | Relevant data exists based on its molecular structure and intermolecular forces |
| Density | Characteristic value related to its mass - volume ratio |
| Pka | Indicates its acidic or basic nature in solution |
| Logp | Measure of its lipophilicity, relevant for drug - like properties |
As an accredited 4-Chloro-N-[1-(2-Phenylethyl)-2-Piperidinylidene]-Benzenesulfonamide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 4 - chloro - N - [1 - (2 - phenylethyl)-2 - piperidinylidene] - benzenesulfonamide in sealed container. |
| Storage | Store 4 - chloro - N - [1 - (2 - phenylethyl)-2 - piperidinylidene] - benzenesulfonamide in a cool, dry place away from direct sunlight. Keep it in a tightly sealed container to prevent moisture and air exposure. Avoid storing near sources of heat or ignition. Store separately from incompatible substances to prevent chemical reactions. |
| Shipping | 4 - chloro - n - [1 - (2 - phenylethyl)-2 - piperidinylidene] - benzenesulfonamide is shipped in sealed, corrosion - resistant containers. It follows strict chemical shipping regulations to ensure safety during transit, with proper labeling and handling precautions. |
Competitive 4-Chloro-N-[1-(2-Phenylethyl)-2-Piperidinylidene]-Benzenesulfonamide prices that fit your budget—flexible terms and customized quotes for every order.
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What is the chemical structure of 4-chloro-n- [1- (2-phenylethyl) -2-piperidinylidene] -benzenesulfonamide?
This is the chemical structure analysis of 4-chloro-N- [1- (2-phenylethyl) -2 -piperidinyl] -benzenesulfonamide. Looking at its name, it can be disassembled gradually to explain its structure.
"4-chloro" indicates that there is a chlorine atom attached to the fourth position of the benzene ring. This chlorine atom is a key substituent derived from the benzene ring, which affects the electron cloud distribution and reactivity of the compound.
"Benzenesulfonamide", indicating that the core structure contains a benzene ring and a sulfonamide group. The benzene ring has a conjugated system and is stable; the sulfonamide group - SO 2O NH -, in which the sulfur atom is double-bonded with two oxygen atoms, and is connected to the amino group. This structure endows the compound with specific chemical and physical properties.
"N - [1- (2-phenylethyl) -2 -piperidine subunit]", revealing the group to which the nitrogen atom of the sulfonamide group is attached. The piperidine ring is a hexadic nitrogen-containing heterocycle, and the 2-piperidine subunit refers to the 2-position carbon of 1 - (2 -phenylethyl), that is, the piperidine ring is connected to 2-phenylethyl at the first position. One end of this ethyl is connected to the piperidine ring, and the other end is connected to the benzene ring, which further enriches the molecular structure and affects the steric resistance and electronic effects.
In summary, this compound is based on benzene sulfonamide as the core, and the 4-position of the benzene ring has chlorine substitution. The nitrogen atom of the sulfonamide is connected with complex groups containing piperidine ring and phenethyl group. The interaction of each part determines the unique chemical behavior and biological activity of the
"4-chloro" indicates that there is a chlorine atom attached to the fourth position of the benzene ring. This chlorine atom is a key substituent derived from the benzene ring, which affects the electron cloud distribution and reactivity of the compound.
"Benzenesulfonamide", indicating that the core structure contains a benzene ring and a sulfonamide group. The benzene ring has a conjugated system and is stable; the sulfonamide group - SO 2O NH -, in which the sulfur atom is double-bonded with two oxygen atoms, and is connected to the amino group. This structure endows the compound with specific chemical and physical properties.
"N - [1- (2-phenylethyl) -2 -piperidine subunit]", revealing the group to which the nitrogen atom of the sulfonamide group is attached. The piperidine ring is a hexadic nitrogen-containing heterocycle, and the 2-piperidine subunit refers to the 2-position carbon of 1 - (2 -phenylethyl), that is, the piperidine ring is connected to 2-phenylethyl at the first position. One end of this ethyl is connected to the piperidine ring, and the other end is connected to the benzene ring, which further enriches the molecular structure and affects the steric resistance and electronic effects.
In summary, this compound is based on benzene sulfonamide as the core, and the 4-position of the benzene ring has chlorine substitution. The nitrogen atom of the sulfonamide is connected with complex groups containing piperidine ring and phenethyl group. The interaction of each part determines the unique chemical behavior and biological activity of the
What are the main uses of 4-chloro-n- [1- (2-phenylethyl) -2-piperidinylidene] -benzenesulfonamide?
4-Chloro-n- [1- (2-phenylethyl) -2-piperidinylidene] -benzenesulfonamide, an organic compound. Its main uses are quite extensive, and it is often used as a key intermediate in the research and development of active pharmaceutical ingredients in the field of medicine. The special structure of this compound may endow it with specific biological activities, can interact with specific targets in the body, or can regulate physiological processes, and then be used for disease treatment.
In the process of medicinal chemistry research, chemists use it as a basis, modify and optimize the structure, and hope to obtain new drugs with better efficacy and less side effects. For example, by adjusting the substituents of benzene rings, piperidine rings, etc., to explore their effects on biological activities, and to find compounds with optimal pharmacological properties.
In addition, in the field of materials science, this compound may also have potential applications. Because its structure contains groups such as benzene ring and sulfonamide group, it may endow the material with specific physical and chemical properties. For example, in the synthesis of polymer materials, the introduction of this compound structural unit may improve the mechanical properties, thermal stability or optical properties of the material.
Furthermore, in the field of organic synthesis chemistry, it can be used as an important synthetic building block. With its unique chemical structure, chemists can use various organic reactions to connect it with other compounds to construct more complex organic molecular structures, providing an effective way for the total synthesis of new functional materials or natural products. Overall, 4-chloro-n- [1- (2-phenylethyl) -2-piperidinylidene] -benzenesulfonamide has important uses and research value in many fields such as medicine, materials and organic synthesis.
In the process of medicinal chemistry research, chemists use it as a basis, modify and optimize the structure, and hope to obtain new drugs with better efficacy and less side effects. For example, by adjusting the substituents of benzene rings, piperidine rings, etc., to explore their effects on biological activities, and to find compounds with optimal pharmacological properties.
In addition, in the field of materials science, this compound may also have potential applications. Because its structure contains groups such as benzene ring and sulfonamide group, it may endow the material with specific physical and chemical properties. For example, in the synthesis of polymer materials, the introduction of this compound structural unit may improve the mechanical properties, thermal stability or optical properties of the material.
Furthermore, in the field of organic synthesis chemistry, it can be used as an important synthetic building block. With its unique chemical structure, chemists can use various organic reactions to connect it with other compounds to construct more complex organic molecular structures, providing an effective way for the total synthesis of new functional materials or natural products. Overall, 4-chloro-n- [1- (2-phenylethyl) -2-piperidinylidene] -benzenesulfonamide has important uses and research value in many fields such as medicine, materials and organic synthesis.
What is the synthesis of 4-chloro-n- [1- (2-phenylethyl) -2-piperidinylidene] -benzenesulfonamide?
To prepare 4 - chloro - n - [1 - (2 - phenylethyl) -2 - piperidinylidene] - benzenesulfonamide, the method is as follows:
First take phenethylamine, dissolve it in a suitable solvent, add a catalyst, and control the temperature to react with a specific halogenate. This halogenate needs to contain structural fragments related to the construction of piperidine rings. During the reaction, careful attention should be paid to the control of temperature and duration, so that the amino group of phenethylamine and the halogenate undergo nucleophilic substitution, and the initial intermediate with phenethyl groups is formed.
Then this intermediate is used as a base to introduce the piperidine ring structure. A compound containing a similar structure of piperidone is taken, and the carbonyl group of piperidone is activated by a specific reagent, and then reacted with the above intermediate. This process requires an inert gas-protected environment, and a specific base is used as a catalyst to promote the condensation of the two, resulting in a product with a structure of 1 - (2 - phenylethyl) -2 - piperidinylidene.
Subsequently, benzenesulfonyl chloride derivatives are prepared, using chlorobenzene as the starting material, through a sulfonation reaction, a sulfonyl group is introduced, and then treated with a chlorination reagent to obtain 4-chlorobenzenesulfonyl chloride.
Finally, the product containing 1- (2 -phenylethyl) -2 -piperidinylidene is reacted with 4-chlorobenzenesulfonyl chloride in an alkaline environment. Organic bases such as pyridine or triethylamine are used as acid binding agents to amide the two to generate 4-chloro-n- [1- (2 -phenylethyl) -2 -piperidinylidene] -benzenesulfonamide. After the reaction is completed, the target product can be purified by extraction, column chromatography, etc. Throughout the synthesis process, the conditions of each step of the reaction need to be precisely controlled to improve the yield and product purity.
First take phenethylamine, dissolve it in a suitable solvent, add a catalyst, and control the temperature to react with a specific halogenate. This halogenate needs to contain structural fragments related to the construction of piperidine rings. During the reaction, careful attention should be paid to the control of temperature and duration, so that the amino group of phenethylamine and the halogenate undergo nucleophilic substitution, and the initial intermediate with phenethyl groups is formed.
Then this intermediate is used as a base to introduce the piperidine ring structure. A compound containing a similar structure of piperidone is taken, and the carbonyl group of piperidone is activated by a specific reagent, and then reacted with the above intermediate. This process requires an inert gas-protected environment, and a specific base is used as a catalyst to promote the condensation of the two, resulting in a product with a structure of 1 - (2 - phenylethyl) -2 - piperidinylidene.
Subsequently, benzenesulfonyl chloride derivatives are prepared, using chlorobenzene as the starting material, through a sulfonation reaction, a sulfonyl group is introduced, and then treated with a chlorination reagent to obtain 4-chlorobenzenesulfonyl chloride.
Finally, the product containing 1- (2 -phenylethyl) -2 -piperidinylidene is reacted with 4-chlorobenzenesulfonyl chloride in an alkaline environment. Organic bases such as pyridine or triethylamine are used as acid binding agents to amide the two to generate 4-chloro-n- [1- (2 -phenylethyl) -2 -piperidinylidene] -benzenesulfonamide. After the reaction is completed, the target product can be purified by extraction, column chromatography, etc. Throughout the synthesis process, the conditions of each step of the reaction need to be precisely controlled to improve the yield and product purity.
What are the physicochemical properties of 4-chloro-n- [1- (2-phenylethyl) -2-piperidinylidene] -benzenesulfonamide?
4 - chloro - n - [1 - (2 - phenylethyl) - 2 - piperidinylidene] - benzenesulfonamide is an organic compound with unique physical and chemical properties, which is of great significance in chemical research and related fields.
Looking at its physical properties, under normal circumstances, this compound is mostly solid, and it has a certain crystallinity due to intermolecular forces. However, its specific appearance may be white to light yellow powder or crystal. The formation of this color is related to the conjugate system and electron transition in the molecular structure. In terms of melting point, after careful determination, it is about a specific temperature range. This temperature reflects the stability of the molecular lattice and the strength of intermolecular forces. Near the melting point, the thermal motion of the molecules intensifies, which is enough to break the lattice binding and cause the substance to change from solid to liquid.
Solubility is another key physical property. In organic solvents, such as ethanol and acetone, the compound exhibits a certain solubility due to the principle of similar miscibility. The polarity of ethanol interacts with the partial structure of the compound, which is conducive to its dispersion and dissolution; in water, the solubility is relatively low due to the poor adaptability of the polarity of water molecules to the overall structure of the compound.
Talking about the chemical properties, the chlorine atoms in the compound are active and can participate in nucleophilic substitution reactions. Due to their electronegativity differences, chlorine atoms are vulnerable to attack by nucleophiles, and new compounds are formed when they leave. The benzenesulfonamide group is also active and can react with a variety of reagents, such as neutralization with bases, because the lone pair electrons on the nitrogen atom can bind protons. In addition, the double bonds of the 1- (2-phenethyl) -2-piperidine subunit moiety can undergo addition reactions, and add electrophilic reagents or free radicals to expand the molecular structure and generate a variety of derivatives, providing a rich path for organic synthesis. Under redox conditions, functional groups within the molecule may undergo corresponding oxidation or reduction reactions, further enriching its chemical behavior.
Looking at its physical properties, under normal circumstances, this compound is mostly solid, and it has a certain crystallinity due to intermolecular forces. However, its specific appearance may be white to light yellow powder or crystal. The formation of this color is related to the conjugate system and electron transition in the molecular structure. In terms of melting point, after careful determination, it is about a specific temperature range. This temperature reflects the stability of the molecular lattice and the strength of intermolecular forces. Near the melting point, the thermal motion of the molecules intensifies, which is enough to break the lattice binding and cause the substance to change from solid to liquid.
Solubility is another key physical property. In organic solvents, such as ethanol and acetone, the compound exhibits a certain solubility due to the principle of similar miscibility. The polarity of ethanol interacts with the partial structure of the compound, which is conducive to its dispersion and dissolution; in water, the solubility is relatively low due to the poor adaptability of the polarity of water molecules to the overall structure of the compound.
Talking about the chemical properties, the chlorine atoms in the compound are active and can participate in nucleophilic substitution reactions. Due to their electronegativity differences, chlorine atoms are vulnerable to attack by nucleophiles, and new compounds are formed when they leave. The benzenesulfonamide group is also active and can react with a variety of reagents, such as neutralization with bases, because the lone pair electrons on the nitrogen atom can bind protons. In addition, the double bonds of the 1- (2-phenethyl) -2-piperidine subunit moiety can undergo addition reactions, and add electrophilic reagents or free radicals to expand the molecular structure and generate a variety of derivatives, providing a rich path for organic synthesis. Under redox conditions, functional groups within the molecule may undergo corresponding oxidation or reduction reactions, further enriching its chemical behavior.
What is the market outlook for 4-chloro-n- [1- (2-phenylethyl) -2-piperidinylidene] -benzenesulfonamide?
4-Chloro-n- [1- (2-phenylethyl) -2-piperidinylidene] -benzenesulfonamide, which is a specific organic compound. Looking at its market prospects, it is like a cloud in the sky, unpredictable, but contains many opportunities.
In the field of scientific research, it is like a shining star and exudes unique charm. Many scientific researchers have devoted themselves to exploring, hoping to use its structural properties to unearth unknown mysteries. For example, in the field of medicinal chemistry, researchers hope to use it as a cornerstone to build a new molecular framework for drugs and find a cure for difficult diseases. Because of its exquisite structure, it may have the potential to fit with specific biological targets, just like a key and a keyhole, precisely docked, and exert unique pharmacological effects. This also prompts the relevant research to continue to heat up, and the market demand is gradually accumulating at the scientific research level, such as a trickle, gradually becoming a river.
In terms of industrial applications, it is like fertile soil to be cultivated. With the improvement of chemical technology, the demand for special structural compounds is increasing day by day. 4-chloro-n- [1- (2-phenylethyl) -2-piperidinylidene] -benzenesulfonamide may emerge in the field of material modification, injecting vitality into the research and development of new materials. Its special chemical properties may endow materials with excellent properties such as enhanced stability and improved flexibility, thus opening up a wide range of industrial applications. Although it has not yet been widely used in industrial production, its potential value has attracted the attention of many chemical companies, like a dark tide, accumulating strength for future market outbreaks.
However, its market prospects are not smooth. The complexity of the synthesis process is like a roadblock, hindering its large-scale production and promotion. High production costs keep product prices high, restricting market expansion. And safety assessments and other links also need to be cautious, like walking on thin ice in the abyss. Only by properly solving such problems can we be like a butterfly breaking the cocoon, soaring freely in the market sky, releasing unlimited potential, and making its market prospect from a hazy dawn to a bright sun, illuminating the way forward in fields such as chemicals and medicine.
In the field of scientific research, it is like a shining star and exudes unique charm. Many scientific researchers have devoted themselves to exploring, hoping to use its structural properties to unearth unknown mysteries. For example, in the field of medicinal chemistry, researchers hope to use it as a cornerstone to build a new molecular framework for drugs and find a cure for difficult diseases. Because of its exquisite structure, it may have the potential to fit with specific biological targets, just like a key and a keyhole, precisely docked, and exert unique pharmacological effects. This also prompts the relevant research to continue to heat up, and the market demand is gradually accumulating at the scientific research level, such as a trickle, gradually becoming a river.
In terms of industrial applications, it is like fertile soil to be cultivated. With the improvement of chemical technology, the demand for special structural compounds is increasing day by day. 4-chloro-n- [1- (2-phenylethyl) -2-piperidinylidene] -benzenesulfonamide may emerge in the field of material modification, injecting vitality into the research and development of new materials. Its special chemical properties may endow materials with excellent properties such as enhanced stability and improved flexibility, thus opening up a wide range of industrial applications. Although it has not yet been widely used in industrial production, its potential value has attracted the attention of many chemical companies, like a dark tide, accumulating strength for future market outbreaks.
However, its market prospects are not smooth. The complexity of the synthesis process is like a roadblock, hindering its large-scale production and promotion. High production costs keep product prices high, restricting market expansion. And safety assessments and other links also need to be cautious, like walking on thin ice in the abyss. Only by properly solving such problems can we be like a butterfly breaking the cocoon, soaring freely in the market sky, releasing unlimited potential, and making its market prospect from a hazy dawn to a bright sun, illuminating the way forward in fields such as chemicals and medicine.
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