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4-Chloro-N-(2-Chloro-4-Nitrophenyl)-3-(Trifluoromethyl)-Benzenesulfonamid
Linshang Chemical
|
HS Code |
694586 |
| Chemical Formula | C13H6Cl2F3NO4S |
| Molecular Weight | 398.157 g/mol |
| Appearance | Solid (predicted) |
| Physical State | Solid |
| Melting Point | N/A |
| Boiling Point | N/A |
| Solubility | Poorly soluble in water (predicted) |
| Density | N/A |
| Vapor Pressure | Low (predicted) |
| Stability | Stable under normal conditions |
As an accredited 4-Chloro-N-(2-Chloro-4-Nitrophenyl)-3-(Trifluoromethyl)-Benzenesulfonamid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 kg of 4 - chloro - N - (2 - chloro - 4 - nitrophenyl)-3-(trifluoromethyl)benzenesulfonamid in sealed chemical - grade packaging. |
| Storage | Store 4 - chloro - N - (2 - chloro - 4 - nitrophenyl)-3 - (trifluoromethyl) - benzenesulfonamide in a cool, dry, well - ventilated area. Keep it away from heat sources, ignition sources, and incompatible substances. Store in a tightly sealed container to prevent exposure to moisture and air, which could potentially degrade the chemical. Label the storage container clearly. |
| Shipping | 4 - chloro - N - (2 - chloro - 4 - nitrophenyl)-3 - (trifluoromethyl) - benzenesulfonamid is shipped in accordance with strict chemical transport regulations. It's packaged securely to prevent leakage during transit, ensuring safety. |
Competitive 4-Chloro-N-(2-Chloro-4-Nitrophenyl)-3-(Trifluoromethyl)-Benzenesulfonamid prices that fit your budget—flexible terms and customized quotes for every order.
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What is the chemical structure of 4-chloro-n- (2-chloro-4-nitrophenyl) -3- (trifluoromethyl) -benzenesulfonamid?
This compound is 4-chloro-N- (2-chloro-4-nitrophenyl) -3- (trifluoromethyl) benzenesulfonamide. The chemical structure of this compound is as follows:
The main structure of this compound is benzenesulfonamide. Benzenesulfonamide is formed by connecting a benzene ring to a sulfonamide group (-SO 2O NH-). On this basic structure, the 4th position of the benzene ring is replaced by a chlorine atom (Cl).
Furthermore, the nitrogen atom (N) of the sulfonamide group is connected to another benzene ring. This benzene ring also has a chlorine atom (Cl) at position 2, and a nitro group (-NO 2O) at position 4.
In addition, at position 3 of the main benzene ring, trifluoromethyl (-CF) is attached. In this way, the chemical structure of 4-chloro-N- (2-chloro-4-nitrophenyl) -3- (trifluoromethyl) benzenesulfonamide is formed. Its structure contains multiple functional groups, which interact to give the compound specific chemical and physical properties.
The main structure of this compound is benzenesulfonamide. Benzenesulfonamide is formed by connecting a benzene ring to a sulfonamide group (-SO 2O NH-). On this basic structure, the 4th position of the benzene ring is replaced by a chlorine atom (Cl).
Furthermore, the nitrogen atom (N) of the sulfonamide group is connected to another benzene ring. This benzene ring also has a chlorine atom (Cl) at position 2, and a nitro group (-NO 2O) at position 4.
In addition, at position 3 of the main benzene ring, trifluoromethyl (-CF) is attached. In this way, the chemical structure of 4-chloro-N- (2-chloro-4-nitrophenyl) -3- (trifluoromethyl) benzenesulfonamide is formed. Its structure contains multiple functional groups, which interact to give the compound specific chemical and physical properties.
What are the main uses of 4-chloro-n- (2-chloro-4-nitrophenyl) -3- (trifluoromethyl) -benzenesulfonamid?
4-Chloro-N- (2-chloro-4-nitrophenyl) -3 - (trifluoromethyl) benzenesulfonamide is widely used. In the field of medicine, it is often used as a key intermediate to help the research and development of new drugs. Due to its unique chemical structure and activity, it can interact with specific biological targets, so it plays an important role in the creation of antibacterial, anti-inflammatory and anti-tumor drugs, or can improve the efficacy of drugs and reduce adverse reactions.
In the field of pesticides, it also plays an important role. With its unique ability to inhibit or kill certain pests and pathogens, high-efficiency pesticides can be prepared to ensure the healthy growth of crops and improve yield and quality. Its structural stability and regulation of biological activity allow pesticides to be more targeted and durable, reducing their negative impact on the environment.
Furthermore, in the field of materials science, 4-chloro-N- (2-chloro-4-nitrophenyl) -3- (trifluoromethyl) benzenesulfonamide may be used to improve material properties. By combining with materials such as polymers, materials are endowed with properties such as UV resistance, oxidation resistance and enhanced mechanical properties, and are widely used in the production of plastics, fibers and other materials to expand the scope of material applications.
In summary, 4-chloro-N- (2-chloro-4-nitrophenyl) -3- (trifluoromethyl) benzenesulfonamide has shown important value and application potential in many fields such as medicine, pesticides and materials science, promoting technological development and innovation in various fields.
In the field of pesticides, it also plays an important role. With its unique ability to inhibit or kill certain pests and pathogens, high-efficiency pesticides can be prepared to ensure the healthy growth of crops and improve yield and quality. Its structural stability and regulation of biological activity allow pesticides to be more targeted and durable, reducing their negative impact on the environment.
Furthermore, in the field of materials science, 4-chloro-N- (2-chloro-4-nitrophenyl) -3- (trifluoromethyl) benzenesulfonamide may be used to improve material properties. By combining with materials such as polymers, materials are endowed with properties such as UV resistance, oxidation resistance and enhanced mechanical properties, and are widely used in the production of plastics, fibers and other materials to expand the scope of material applications.
In summary, 4-chloro-N- (2-chloro-4-nitrophenyl) -3- (trifluoromethyl) benzenesulfonamide has shown important value and application potential in many fields such as medicine, pesticides and materials science, promoting technological development and innovation in various fields.
What is the synthesis method of 4-chloro-n- (2-chloro-4-nitrophenyl) -3- (trifluoromethyl) -benzenesulfonamid?
To prepare 4-chloro-N- (2-chloro-4-nitrophenyl) -3- (trifluoromethyl) benzenesulfonamide, the method is as follows:
First take an appropriate amount of 3- (trifluoromethyl) benzenesulfonyl chloride and place it in a clean reactor. In a low-temperature bath, slowly drop into an alkaline solution containing 2-chloro-4-nitroaniline, such as an alcohol solution of potassium carbonate. When adding dropwise, keep stirring to make the two fully contact the reaction. In this step, the active chlorine atom of benzenesulfonyl chloride is easily nucleophilic substituted with the amino group of aniline to form the corresponding sulfonamide intermediate.
After the dropwise addition is completed, maintain the reaction temperature, and continue to stir for a few times to ensure the complete reaction. After the reaction is completed, the reaction liquid is poured into a large amount of ice water, and solids are precipitated. Suction filtration to obtain the crude product.
The crude product is recrystallized with an appropriate organic solvent, such as ethanol-water mixed solvent, heated and dissolved, filtered hot, cooled and crystallized, and then filtered to obtain pure 4-chloro-N- (2-chloro-4-nitrophenyl) -3 - (trifluoromethyl) benzenesulfonamide crystals. During operation, it is necessary to pay attention to the precise control of temperature and reagent dosage at each step, and ensure that the reaction environment is clean to prevent impurities from mixing in and affecting the purity and yield of the product.
First take an appropriate amount of 3- (trifluoromethyl) benzenesulfonyl chloride and place it in a clean reactor. In a low-temperature bath, slowly drop into an alkaline solution containing 2-chloro-4-nitroaniline, such as an alcohol solution of potassium carbonate. When adding dropwise, keep stirring to make the two fully contact the reaction. In this step, the active chlorine atom of benzenesulfonyl chloride is easily nucleophilic substituted with the amino group of aniline to form the corresponding sulfonamide intermediate.
After the dropwise addition is completed, maintain the reaction temperature, and continue to stir for a few times to ensure the complete reaction. After the reaction is completed, the reaction liquid is poured into a large amount of ice water, and solids are precipitated. Suction filtration to obtain the crude product.
The crude product is recrystallized with an appropriate organic solvent, such as ethanol-water mixed solvent, heated and dissolved, filtered hot, cooled and crystallized, and then filtered to obtain pure 4-chloro-N- (2-chloro-4-nitrophenyl) -3 - (trifluoromethyl) benzenesulfonamide crystals. During operation, it is necessary to pay attention to the precise control of temperature and reagent dosage at each step, and ensure that the reaction environment is clean to prevent impurities from mixing in and affecting the purity and yield of the product.
What are the physicochemical properties of 4-chloro-n- (2-chloro-4-nitrophenyl) -3- (trifluoromethyl) -benzenesulfonamid?
4-Chloro-N- (2-chloro-4-nitrophenyl) -3 - (trifluoromethyl) benzenesulfonamide, this is an organic compound. Looking at its physical and chemical properties, it should be as follows:
First, physical properties. Under normal conditions, it is often in a solid state, due to the presence of various forces between molecules, resulting in a certain melting point. However, the exact melting point value needs to be accurately determined by experiments. Due to different purity and experimental conditions, the melting point may vary. Its appearance may be white to light yellow powder, and this color is related to molecular structure and impurities. If it contains a conjugated system, it may deepen the color. As for the solubility, because there are both polar groups in the molecule, such as sulfonamide group, nitro group, and non-polar groups, such as benzene ring and trifluoromethyl group, the solubility varies in different solvents. In polar organic solvents, such as dimethyl sulfoxide (DMSO), N, N-dimethylformamide (DMF), there may be a certain solubility, because polar groups can form hydrogen bonds with solvents or other intermolecular forces. In water, the solubility may be limited, and non-polar groups hinder its full interaction with water molecules.
Re-state the chemical properties. The chlorine atom in the molecule is quite active. Because the chlorine atom on the benzene ring is affected by the ortho-nitro group and the para-sulfonamide group, the electron cloud density changes, and nucleophilic substitution reactions are prone to occur. The aryl ring can initiate an electrophilic substitution reaction when it encounters an electrophilic reagent. Although there are multiple substituents on the benzene ring, the steric hindrance and electronic effects will affect the reactivity and check point. Trifluoromethyl is a strong electron-absorbing group, which reduces the electron cloud density of the benzene ring, making the electrophilic substitution reaction more difficult than benzene, and the reaction check point may be relatively high in the electron cloud density. The nitrogen atom in the sulfonamide group has lone pairs of electrons, which can be used as a nucleophilic reagent to participate in the reaction. At the same time, the sulfonamide bond can be hydrolyzed under specific conditions. 2-Chloro-4-nitrophenyl part, the nitro group is a strong electron-absorbing group
First, physical properties. Under normal conditions, it is often in a solid state, due to the presence of various forces between molecules, resulting in a certain melting point. However, the exact melting point value needs to be accurately determined by experiments. Due to different purity and experimental conditions, the melting point may vary. Its appearance may be white to light yellow powder, and this color is related to molecular structure and impurities. If it contains a conjugated system, it may deepen the color. As for the solubility, because there are both polar groups in the molecule, such as sulfonamide group, nitro group, and non-polar groups, such as benzene ring and trifluoromethyl group, the solubility varies in different solvents. In polar organic solvents, such as dimethyl sulfoxide (DMSO), N, N-dimethylformamide (DMF), there may be a certain solubility, because polar groups can form hydrogen bonds with solvents or other intermolecular forces. In water, the solubility may be limited, and non-polar groups hinder its full interaction with water molecules.
Re-state the chemical properties. The chlorine atom in the molecule is quite active. Because the chlorine atom on the benzene ring is affected by the ortho-nitro group and the para-sulfonamide group, the electron cloud density changes, and nucleophilic substitution reactions are prone to occur. The aryl ring can initiate an electrophilic substitution reaction when it encounters an electrophilic reagent. Although there are multiple substituents on the benzene ring, the steric hindrance and electronic effects will affect the reactivity and check point. Trifluoromethyl is a strong electron-absorbing group, which reduces the electron cloud density of the benzene ring, making the electrophilic substitution reaction more difficult than benzene, and the reaction check point may be relatively high in the electron cloud density. The nitrogen atom in the sulfonamide group has lone pairs of electrons, which can be used as a nucleophilic reagent to participate in the reaction. At the same time, the sulfonamide bond can be hydrolyzed under specific conditions. 2-Chloro-4-nitrophenyl part, the nitro group is a strong electron-absorbing group
What are the precautions for using 4-chloro-n- (2-chloro-4-nitrophenyl) -3- (trifluoromethyl) -benzenesulfonamid?
4-Chloro-N- (2-chloro-4-nitrophenyl) -3- (trifluoromethyl) benzenesulfonamide is a rather complex chemical. During use, many precautions must be kept in mind.
Bear the brunt, and safety protection must be comprehensive. This chemical may be toxic and irritating, and appropriate protective equipment must be worn when contacting, such as laboratory clothes, gloves and goggles. The operation should be carried out in a well-ventilated environment, preferably in a fume hood, to prevent the accumulation of harmful gases and endanger personal safety.
Furthermore, accurate weighing and operation should not be compromised. Due to its special chemical properties, a slight deviation in the dosage may have a significant impact on the experimental results or the reaction process. Use a precise weighing instrument, measure accurately according to the experimental requirements, and be careful when operating to avoid spills and other conditions.
Storage conditions are also crucial. It should be stored in a dry, cool and ventilated place, away from fire and heat sources. Because of its instability, improper storage conditions may cause it to deteriorate or cause dangerous reactions. At the same time, it should be properly isolated from other chemical substances to prevent interaction.
When conducting related reactions, the reaction conditions must be strictly controlled. Factors such as temperature, reaction time, and the proportion of reactants all have a profound impact on the reaction results. It is necessary to precisely adjust the parameters according to the principle of chemical reaction and past experience to ensure that the reaction proceeds in the expected direction.
After use, the disposal of remaining substances and waste should not be ignored. To follow relevant environmental protection regulations and laboratory requirements, proper disposal must not be discarded at will to avoid pollution to the environment.
In short, when using 4-chloro-N- (2-chloro-4-nitrophenyl) -3 - (trifluoromethyl) benzenesulfonamide, many links from protection, operation, storage to waste disposal must be strictly treated to ensure the safety of personnel, the smooth operation of the experiment and the environment is not endangered.
Bear the brunt, and safety protection must be comprehensive. This chemical may be toxic and irritating, and appropriate protective equipment must be worn when contacting, such as laboratory clothes, gloves and goggles. The operation should be carried out in a well-ventilated environment, preferably in a fume hood, to prevent the accumulation of harmful gases and endanger personal safety.
Furthermore, accurate weighing and operation should not be compromised. Due to its special chemical properties, a slight deviation in the dosage may have a significant impact on the experimental results or the reaction process. Use a precise weighing instrument, measure accurately according to the experimental requirements, and be careful when operating to avoid spills and other conditions.
Storage conditions are also crucial. It should be stored in a dry, cool and ventilated place, away from fire and heat sources. Because of its instability, improper storage conditions may cause it to deteriorate or cause dangerous reactions. At the same time, it should be properly isolated from other chemical substances to prevent interaction.
When conducting related reactions, the reaction conditions must be strictly controlled. Factors such as temperature, reaction time, and the proportion of reactants all have a profound impact on the reaction results. It is necessary to precisely adjust the parameters according to the principle of chemical reaction and past experience to ensure that the reaction proceeds in the expected direction.
After use, the disposal of remaining substances and waste should not be ignored. To follow relevant environmental protection regulations and laboratory requirements, proper disposal must not be discarded at will to avoid pollution to the environment.
In short, when using 4-chloro-N- (2-chloro-4-nitrophenyl) -3 - (trifluoromethyl) benzenesulfonamide, many links from protection, operation, storage to waste disposal must be strictly treated to ensure the safety of personnel, the smooth operation of the experiment and the environment is not endangered.
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