Linshang Chemical
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4-Chloro-N-(2-Chloro-4-Nitrophenyl)-3-(Trifluoromethyl)Benzenesulfonamide
Linshang Chemical
|
HS Code |
420914 |
| Chemical Formula | C13H6Cl2F3N2O4S |
| Molecular Weight | 417.16 |
| Appearance | Typically a solid (appearance may vary depending on purity and preparation) |
| Physical State At Room Temperature | Solid |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform, etc. |
| Melting Point | Data would depend on purity, but generally has a defined melting range |
| Boiling Point | Elevated boiling point due to its molecular structure and intermolecular forces |
| Vapor Pressure | Low vapor pressure due to its solid state and relatively high molecular weight |
| Stability | Stable under normal conditions, but may react with strong oxidizing or reducing agents |
As an accredited 4-Chloro-N-(2-Chloro-4-Nitrophenyl)-3-(Trifluoromethyl)Benzenesulfonamide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram vial of 4 - chloro - N - (2 - chloro - 4 - nitrophenyl)-3-(trifluoromethyl)benzenesulfonamide. |
| Storage | Store 4 - chloro - N - (2 - chloro - 4 - nitrophenyl)-3 - (trifluoromethyl)benzenesulfonamide in a cool, dry place away from heat sources and direct sunlight. Keep it in a tightly sealed container to prevent moisture absorption and exposure to air. Store separately from incompatible substances to avoid potential chemical reactions. Ensure proper ventilation in the storage area. |
| Shipping | The chemical 4 - chloro - N - (2 - chloro - 4 - nitrophenyl)-3 - (trifluoromethyl)benzenesulfonamide is shipped in accordance with strict hazardous chemical regulations. It's carefully packaged to prevent leakage, transported by approved carriers, ensuring safety during transit. |
Competitive 4-Chloro-N-(2-Chloro-4-Nitrophenyl)-3-(Trifluoromethyl)Benzenesulfonamide prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 4-Chloro-N-(2-Chloro-4-Nitrophenyl)-3-(Trifluoromethyl)Benzenesulfonamide supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 4-chloro-n- (2-chloro-4-nitrophenyl) -3- (trifluoromethyl) benzenesulfonamide
4-Chloro-N- (2-chloro-4-nitrophenyl) -3 - (trifluoromethyl) benzenesulfonamide is an organic compound. Its chemical properties are quite complex and unique.
From the structural point of view, the compound contains many functional groups such as chlorine atoms, nitro groups, trifluoromethyl groups and benzenesulfonamide groups. The presence of chlorine atoms and nitro groups has a significant impact on the electron cloud distribution of the compound, reducing the electron cloud density of the benzene ring, resulting in different chemical activities. Nitro has strong electron absorption, which can greatly reduce the electron cloud density of the benzene ring o and para-position, making the electrophilic substitution reaction more difficult, but the nucleophilic substitution reaction activity may be improved.
Trifluoromethyl, as a strong electron-withdrawing group, has high electronegativity. It not only affects the molecular polarity, but also has a great impact on the physical and chemical properties of the entire compound. It can enhance the lipid solubility of molecules and affect the solubility of compounds in different solvents. In chemical reactions, the presence of trifluoromethyl may change the reaction check point and reactivity. For example, due to its strong electron-withdrawing effect, the chemical bond electron cloud at the adjacent position may be biased towards trifluoromethyl, making the bond more prone to certain reactions.
Benzenesulfonamide group contains heteroatoms such as sulfur and nitrogen, and has certain alkalinity and coordination ability. This group may participate in the formation of hydrogen bonds, which affects the crystal structure of the compound and the interaction between molecules. In chemical reactions, benzenesulfonamide groups can undergo hydrolysis, substitution and other reactions. The hydrogen atom on the nitrogen atom may have a certain acidity and can be substituted under specific conditions.
The solubility of this compound may be affected by its many functional groups. In general, due to the inclusion of multiple polar and non-polar groups, it may have a certain solubility in both polar and non-polar solvents, but the specific solubility still depends on the type of solvent and temperature.
In terms of stability, in view of the relatively active groups such as nitro, under high temperature, light or specific chemical environments, decomposition and rearrangement may occur. However, in normal temperature and general chemical environments, if there are no specific conditions to initiate the reaction, it may remain relatively stable.
From the structural point of view, the compound contains many functional groups such as chlorine atoms, nitro groups, trifluoromethyl groups and benzenesulfonamide groups. The presence of chlorine atoms and nitro groups has a significant impact on the electron cloud distribution of the compound, reducing the electron cloud density of the benzene ring, resulting in different chemical activities. Nitro has strong electron absorption, which can greatly reduce the electron cloud density of the benzene ring o and para-position, making the electrophilic substitution reaction more difficult, but the nucleophilic substitution reaction activity may be improved.
Trifluoromethyl, as a strong electron-withdrawing group, has high electronegativity. It not only affects the molecular polarity, but also has a great impact on the physical and chemical properties of the entire compound. It can enhance the lipid solubility of molecules and affect the solubility of compounds in different solvents. In chemical reactions, the presence of trifluoromethyl may change the reaction check point and reactivity. For example, due to its strong electron-withdrawing effect, the chemical bond electron cloud at the adjacent position may be biased towards trifluoromethyl, making the bond more prone to certain reactions.
Benzenesulfonamide group contains heteroatoms such as sulfur and nitrogen, and has certain alkalinity and coordination ability. This group may participate in the formation of hydrogen bonds, which affects the crystal structure of the compound and the interaction between molecules. In chemical reactions, benzenesulfonamide groups can undergo hydrolysis, substitution and other reactions. The hydrogen atom on the nitrogen atom may have a certain acidity and can be substituted under specific conditions.
The solubility of this compound may be affected by its many functional groups. In general, due to the inclusion of multiple polar and non-polar groups, it may have a certain solubility in both polar and non-polar solvents, but the specific solubility still depends on the type of solvent and temperature.
In terms of stability, in view of the relatively active groups such as nitro, under high temperature, light or specific chemical environments, decomposition and rearrangement may occur. However, in normal temperature and general chemical environments, if there are no specific conditions to initiate the reaction, it may remain relatively stable.
What are the physical properties of 4-chloro-n- (2-chloro-4-nitrophenyl) -3- (trifluoromethyl) benzenesulfonamide
4 - chloro - N - (2 - chloro - 4 - nitrophenyl) - 3 - (trifluoromethyl) benzenesulfonamide, this is an organic compound. Its physical properties are crucial and affect many chemical application fields.
Looking at its appearance, it is often in a solid state, mostly white or almost white powder, with fine texture. This appearance characteristic can be used for reference in the preliminary identification and quality judgment of related products.
When it comes to melting point, the melting point of this compound is within a specific range. Determination of melting point is an important means to identify its purity and distinguish compounds. Accurate melting point data can help chemists determine whether the substance is pure or mixed with impurities. The presence of impurities often causes the melting point to decrease or the melting range to widen.
In terms of solubility, it has a certain solubility in organic solvents, such as common acetone and dichloromethane. This property is crucial in organic synthesis and separation and purification. Chemists can use this to select suitable solvents to realize the dissolution, reaction, separation and other operations of the compound. However, in water, its solubility is poor. This difference makes it necessary to take special consideration of its dispersion and reaction conditions when it comes to chemical reactions or applications in the aqueous phase.
In addition, its density is also an important physical property. Although the exact density value needs to be determined by precise experiments, the density data are of guiding significance for the conversion of mass and volume, storage and transportation conditions of substances.
The physical properties of 4 - chloro - N - (2 - chloro - 4 - nitrophenyl) - 3 - (trifluoromethyl) benzenesulfonamide play an indispensable role in chemical research, production practice and other aspects, providing a key basis for the operation and application of related fields.
Looking at its appearance, it is often in a solid state, mostly white or almost white powder, with fine texture. This appearance characteristic can be used for reference in the preliminary identification and quality judgment of related products.
When it comes to melting point, the melting point of this compound is within a specific range. Determination of melting point is an important means to identify its purity and distinguish compounds. Accurate melting point data can help chemists determine whether the substance is pure or mixed with impurities. The presence of impurities often causes the melting point to decrease or the melting range to widen.
In terms of solubility, it has a certain solubility in organic solvents, such as common acetone and dichloromethane. This property is crucial in organic synthesis and separation and purification. Chemists can use this to select suitable solvents to realize the dissolution, reaction, separation and other operations of the compound. However, in water, its solubility is poor. This difference makes it necessary to take special consideration of its dispersion and reaction conditions when it comes to chemical reactions or applications in the aqueous phase.
In addition, its density is also an important physical property. Although the exact density value needs to be determined by precise experiments, the density data are of guiding significance for the conversion of mass and volume, storage and transportation conditions of substances.
The physical properties of 4 - chloro - N - (2 - chloro - 4 - nitrophenyl) - 3 - (trifluoromethyl) benzenesulfonamide play an indispensable role in chemical research, production practice and other aspects, providing a key basis for the operation and application of related fields.
What are the application fields of 4-chloro-n- (2-chloro-4-nitrophenyl) -3- (trifluoromethyl) benzenesulfonamide
4-Chloro-N- (2-chloro-4-nitrophenyl) -3- (trifluoromethyl) benzenesulfonamide is an organic compound. Looking at its structure and characteristics, its application field is quite extensive.
In the field of pharmaceutical chemistry, it may become a key intermediate for drug development. Because the molecule contains chlorine, nitro, trifluoromethyl and other groups, it can endow compounds with specific biological activities. Chlorine atoms can enhance the lipid solubility of molecules, facilitate the passage through biological membranes, or have affinity and inhibition to certain disease targets. The presence of nitro groups may affect the distribution of electron clouds of compounds and change the way they interact with biological macromolecules. For example, it can form hydrogen bonds or electrostatic interactions with specific amino acid residues of proteins, which may have potential applications in anti-cancer, antibacterial and other drug research.
In the field of pesticide chemistry, it also has potential value. The introduction of trifluoromethyl can often improve the biological activity and stability of compounds. This compound may have excellent control effects on specific pests and pathogens. With its unique structure interfering with the physiological metabolism of pests or the cell wall and cell membrane synthesis of pathogens, it provides the possibility for the development of new high-efficiency and low-toxicity pesticides.
In the field of materials science, due to its unique structure, it may be used to prepare functional materials. For example, in organic photoelectric materials, its special electronic structure may affect the photoelectric properties of materials. Through rational design and modification, it may improve the properties of material charge transport and luminous efficiency. It is used in organic Light Emitting Diode (OLED), solar cells and other fields. In addition, in the field of chemical synthesis, as an important intermediate, it can participate in many organic synthesis reactions, and through the transformation and modification of its functional groups, more complex and diverse organic compounds can be constructed, providing the basis and possibility for the development of organic synthesis chemistry.
In the field of pharmaceutical chemistry, it may become a key intermediate for drug development. Because the molecule contains chlorine, nitro, trifluoromethyl and other groups, it can endow compounds with specific biological activities. Chlorine atoms can enhance the lipid solubility of molecules, facilitate the passage through biological membranes, or have affinity and inhibition to certain disease targets. The presence of nitro groups may affect the distribution of electron clouds of compounds and change the way they interact with biological macromolecules. For example, it can form hydrogen bonds or electrostatic interactions with specific amino acid residues of proteins, which may have potential applications in anti-cancer, antibacterial and other drug research.
In the field of pesticide chemistry, it also has potential value. The introduction of trifluoromethyl can often improve the biological activity and stability of compounds. This compound may have excellent control effects on specific pests and pathogens. With its unique structure interfering with the physiological metabolism of pests or the cell wall and cell membrane synthesis of pathogens, it provides the possibility for the development of new high-efficiency and low-toxicity pesticides.
In the field of materials science, due to its unique structure, it may be used to prepare functional materials. For example, in organic photoelectric materials, its special electronic structure may affect the photoelectric properties of materials. Through rational design and modification, it may improve the properties of material charge transport and luminous efficiency. It is used in organic Light Emitting Diode (OLED), solar cells and other fields. In addition, in the field of chemical synthesis, as an important intermediate, it can participate in many organic synthesis reactions, and through the transformation and modification of its functional groups, more complex and diverse organic compounds can be constructed, providing the basis and possibility for the development of organic synthesis chemistry.
What is the synthesis method of 4-chloro-n- (2-chloro-4-nitrophenyl) -3- (trifluoromethyl) benzenesulfonamide
To prepare 4-chloro-N- (2-chloro-4-nitrophenyl) -3 - (trifluoromethyl) benzenesulfonamide, the following ancient method can be used.
First, the corresponding starting materials need to be prepared, that is, benzene derivatives containing specific substituents. One is benzenesulfonyl chloride with 4-chloro-3 - (trifluoromethyl) structure, and the other is 2-chloro-4-nitroaniline. These two are the key substrates for synthesis.
Dissolve 2-chloro-4-nitroaniline in a clean reaction vessel with an appropriate amount of organic solvent. Common organic solvents such as dichloromethane, N, N-dimethylformamide are acceptable, depending on the reaction conditions and subsequent treatment. When it is fully dissolved, the solution is homogeneous, and the reaction system is cooled to a moderate low temperature, about 0 ° C to 5 ° C. This is to control the reaction rate and prevent side reactions.
Then, under stirring, slowly add 4-chloro-3- (trifluoromethyl) benzenesulfonyl chloride dropwise. The rate of dropwise addition should be slow, so that the two are in full contact and the reaction is smooth. After the dropwise addition, gradually heat up to room temperature, and continue to stir, so that the reaction can be fully carried out. During this period, the reaction process can be monitored by thin-layer chromatography (TLC), and the change of the raw material point can be observed to judge the degree of reaction.
When the reaction is nearly complete, that is, the raw material point is almost gone, carry out post-treatment. First pour the reaction solution into an appropriate amount of water, neutralize it with a dilute alkali solution such as sodium carbonate, and adjust the pH to a weakly alkaline one. At this time, the product is transferred to the aqueous phase due to salt formation. Separate the liquid, take the aqueous phase containing the product, and then acidify it with a dilute acid such as hydrochloric acid solution, adjust the pH to an acidic one, and the product is precipitated.
The precipitated product is collected by suction filtration and obtained as a crude product. In order to obtain high-purity product, Ethanol, ethyl acetate and other solvents can be selected. After recrystallization, impurities are removed, and the product is obtained.
The whole synthesis process needs to abide by the operating specifications, control the reaction conditions, and ensure the accurate ratio of raw materials. Only in this way can the target product 4-chloro-N- (2-chloro-4-nitrophenyl) -3 - (trifluoromethyl) benzenesulfonamide be obtained.
First, the corresponding starting materials need to be prepared, that is, benzene derivatives containing specific substituents. One is benzenesulfonyl chloride with 4-chloro-3 - (trifluoromethyl) structure, and the other is 2-chloro-4-nitroaniline. These two are the key substrates for synthesis.
Dissolve 2-chloro-4-nitroaniline in a clean reaction vessel with an appropriate amount of organic solvent. Common organic solvents such as dichloromethane, N, N-dimethylformamide are acceptable, depending on the reaction conditions and subsequent treatment. When it is fully dissolved, the solution is homogeneous, and the reaction system is cooled to a moderate low temperature, about 0 ° C to 5 ° C. This is to control the reaction rate and prevent side reactions.
Then, under stirring, slowly add 4-chloro-3- (trifluoromethyl) benzenesulfonyl chloride dropwise. The rate of dropwise addition should be slow, so that the two are in full contact and the reaction is smooth. After the dropwise addition, gradually heat up to room temperature, and continue to stir, so that the reaction can be fully carried out. During this period, the reaction process can be monitored by thin-layer chromatography (TLC), and the change of the raw material point can be observed to judge the degree of reaction.
When the reaction is nearly complete, that is, the raw material point is almost gone, carry out post-treatment. First pour the reaction solution into an appropriate amount of water, neutralize it with a dilute alkali solution such as sodium carbonate, and adjust the pH to a weakly alkaline one. At this time, the product is transferred to the aqueous phase due to salt formation. Separate the liquid, take the aqueous phase containing the product, and then acidify it with a dilute acid such as hydrochloric acid solution, adjust the pH to an acidic one, and the product is precipitated.
The precipitated product is collected by suction filtration and obtained as a crude product. In order to obtain high-purity product, Ethanol, ethyl acetate and other solvents can be selected. After recrystallization, impurities are removed, and the product is obtained.
The whole synthesis process needs to abide by the operating specifications, control the reaction conditions, and ensure the accurate ratio of raw materials. Only in this way can the target product 4-chloro-N- (2-chloro-4-nitrophenyl) -3 - (trifluoromethyl) benzenesulfonamide be obtained.
What is the market outlook for 4-chloro-n- (2-chloro-4-nitrophenyl) -3- (trifluoromethyl) benzenesulfonamide?
Today, there are 4-chloro-n- (2-chloro-4-nitrophenyl) -3- (trifluoromethyl) benzenesulfonamide, which is an organic compound. In terms of market prospects, it is necessary to look at multiple aspects.
Looking at the field of medicine, because of its unique structure, or potential biological activity. Or it can be used as a lead compound, which can be finely modified and deeply studied to create new drugs. Nowadays, there is a strong demand for specific and highly effective compounds in pharmaceutical research and development. If it can show excellent pharmacological properties, such as high affinity and selectivity for specific disease targets, it will definitely attract the attention of pharmaceutical companies, and the market potential is vast.
There are also opportunities in the field of pesticides. Such fluorine-containing chlorine compounds may have excellent insecticidal, bactericidal or herbicidal properties. In the current pursuit of green and efficient pesticides, if they can meet environmentally friendly standards, such as low toxicity and easy degradation, they may emerge in the pesticide market and be favored by farmers and agricultural enterprises.
However, there are also challenges. Synthetic processes may be complex and expensive, and if they are difficult to optimize to be economically feasible, they may limit their large-scale production and marketing activities. Furthermore, regulations and supervision are becoming increasingly strict. In pharmaceutical and pesticide applications, it is necessary to pass a lot of safety and effectiveness tests, which is time-consuming and laborious. If they fail to meet the standards, the road to the market will be full of thorns.
Overall, the 4-chloro-n- (2-chloro-4-nitrophenyl) -3- (trifluoromethyl) benzenesulfonamide market has both opportunities and challenges. If we can overcome the synthesis problem, pass the test of regulations, and fully tap its biological activity advantages, we will be able to open up a world in the fields of medicine and pesticides, and the prospects are promising; otherwise, we may be trapped in many obstacles and difficult to develop our ambitions.
Looking at the field of medicine, because of its unique structure, or potential biological activity. Or it can be used as a lead compound, which can be finely modified and deeply studied to create new drugs. Nowadays, there is a strong demand for specific and highly effective compounds in pharmaceutical research and development. If it can show excellent pharmacological properties, such as high affinity and selectivity for specific disease targets, it will definitely attract the attention of pharmaceutical companies, and the market potential is vast.
There are also opportunities in the field of pesticides. Such fluorine-containing chlorine compounds may have excellent insecticidal, bactericidal or herbicidal properties. In the current pursuit of green and efficient pesticides, if they can meet environmentally friendly standards, such as low toxicity and easy degradation, they may emerge in the pesticide market and be favored by farmers and agricultural enterprises.
However, there are also challenges. Synthetic processes may be complex and expensive, and if they are difficult to optimize to be economically feasible, they may limit their large-scale production and marketing activities. Furthermore, regulations and supervision are becoming increasingly strict. In pharmaceutical and pesticide applications, it is necessary to pass a lot of safety and effectiveness tests, which is time-consuming and laborious. If they fail to meet the standards, the road to the market will be full of thorns.
Overall, the 4-chloro-n- (2-chloro-4-nitrophenyl) -3- (trifluoromethyl) benzenesulfonamide market has both opportunities and challenges. If we can overcome the synthesis problem, pass the test of regulations, and fully tap its biological activity advantages, we will be able to open up a world in the fields of medicine and pesticides, and the prospects are promising; otherwise, we may be trapped in many obstacles and difficult to develop our ambitions.
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