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4-Chloro-N-[(2Z)-1-(2-Phenylethyl)-2-Piperidinylidene]Benzenesulfonamide
Linshang Chemical
|
HS Code |
441211 |
| Chemical Formula | C21H25ClN2O2S |
| Molecular Weight | 388.95 |
As an accredited 4-Chloro-N-[(2Z)-1-(2-Phenylethyl)-2-Piperidinylidene]Benzenesulfonamide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 4 - chloro - N - [(2z)-1-(2 - phenylethyl)-2 - piperidinylidene]benzenesulfonamide in sealed container. |
| Storage | Store 4 - chloro - N - [(2Z)-1-(2 - phenylethyl)-2 - piperidinylidene]benzenesulfonamide in a cool, dry place away from direct sunlight. Keep it in a tightly sealed container to prevent moisture absorption and contact with reactive substances. Avoid storage near heat sources or in areas with high humidity to maintain its chemical integrity. |
| Shipping | 4 - chloro - n - [(2z)-1-(2 - phenylethyl)-2 - piperidinylidene]benzenesulfonamide is shipped in well - sealed, specialized containers. These are designed to prevent any leakage, following strict chemical shipping regulations to ensure safety during transit. |
Competitive 4-Chloro-N-[(2Z)-1-(2-Phenylethyl)-2-Piperidinylidene]Benzenesulfonamide prices that fit your budget—flexible terms and customized quotes for every order.
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What is the chemical structure of 4-chloro-n- [ (2z) -1- (2-phenylethyl) -2-piperidinylidene] benzenesulfonamide?
4 - chloro - N - [ (2Z) - 1 - (2 - phenylethyl) - 2 - piperidinylidene] benzenesulfonamide is an organic compound, and its naming follows the naming rules of organic chemistry. It is composed of multiple parts, and each part corresponds to a specific structural fragment. Its chemical structure can be inferred from this.
In this compound name, "benzenesulfonamide" indicates that the core structure is benzenesulfonamide, that is, the benzene ring is connected to the sulfonamide group. "4-chloro" indicates that there is a chlorine atom substituted at the 4th position of the benzene ring. " N - [ (2Z) - 1 - (2 - phenylethyl) - 2 - piperidinylidene] "indicates that the nitrogen atom is connected to a specific structure. Among them," (2Z) "represents the configuration of the double bond as Z type;" 1 - (2 - phenylethyl) "refers to the connection of a 2-phenethyl group at position 1, that is, the phenyl ring is connected to an ethyl group;" 2 - piperidinylidene "represents a 2-piperidinyl subgroup, and the 2-piperidinylidene ring is connected to other parts by double bonds.
Based on the above information, the chemical structure of this compound is: with benzene sulfonamide as the core, the benzene ring has a chlorine atom at position 4; the nitrogen atom of the sulfonamide is connected to a Z-type 1- (2-phenethyl) -2 -piperidine subunit. That is, the benzene ring is connected to the sulfonamide group, the nitrogen atom of the sulfonamide is connected to the piperidine ring with a Z-configuration double bond, the piperidine ring at position 1 is connected to the 2-phenethyl group, and the benzene ring at position 4 is a chlorine atom.
In this compound name, "benzenesulfonamide" indicates that the core structure is benzenesulfonamide, that is, the benzene ring is connected to the sulfonamide group. "4-chloro" indicates that there is a chlorine atom substituted at the 4th position of the benzene ring. " N - [ (2Z) - 1 - (2 - phenylethyl) - 2 - piperidinylidene] "indicates that the nitrogen atom is connected to a specific structure. Among them," (2Z) "represents the configuration of the double bond as Z type;" 1 - (2 - phenylethyl) "refers to the connection of a 2-phenethyl group at position 1, that is, the phenyl ring is connected to an ethyl group;" 2 - piperidinylidene "represents a 2-piperidinyl subgroup, and the 2-piperidinylidene ring is connected to other parts by double bonds.
Based on the above information, the chemical structure of this compound is: with benzene sulfonamide as the core, the benzene ring has a chlorine atom at position 4; the nitrogen atom of the sulfonamide is connected to a Z-type 1- (2-phenethyl) -2 -piperidine subunit. That is, the benzene ring is connected to the sulfonamide group, the nitrogen atom of the sulfonamide is connected to the piperidine ring with a Z-configuration double bond, the piperidine ring at position 1 is connected to the 2-phenethyl group, and the benzene ring at position 4 is a chlorine atom.
What are the main physical properties of 4-chloro-n- [ (2z) -1- (2-phenylethyl) -2-piperidinylidene] benzenesulfonamide?
4-Chloro-n- [ (2z) -1- (2-phenylethyl) -2-piperidinylidene] benzenesulfonamide is an organic compound. This material has the following main physical properties:
Looking at its appearance, under normal temperature and pressure, it often takes the shape of a white to light yellow crystalline powder. The powder is delicate and dry to the touch. This morphology is conducive to its dispersion and participation in many chemical reactions and preparations.
When it comes to the melting point, it is about 150-155 ° C. When the temperature gradually rises near the melting point, the thermal motion of the molecules intensifies, the lattice structure begins to disintegrate, and the substance transitions from a solid state to a liquid state. This melting point characteristic has a great impact on its purification, identification, and processing applications under different temperature conditions.
In terms of solubility, it is slightly soluble in common organic solvents such as dichloromethane and chloroform. In these solvents, molecules and solvent molecules interact through van der Waals forces, hydrogen bonds, etc., to disperse uniformly. In water, its solubility is very small, because the molecular structure of hydrophobic groups accounts for a large proportion, and it is difficult to form effective interactions with water molecules. This difference in solubility can be used as an important basis for selecting suitable solvents in the process of separation, purification and preparation of preparations.
Its density is about 1.3-1.4 g/cm ³, which means that the mass of the substance per unit volume is in this range. This density value is of great significance in the storage, transportation, and proportional allocation of substances when mixed with other substances.
In addition, the compound is relatively stable under normal conditions, but when exposed to strong oxidizing agents, strong acids, and strong bases, chemical reactions may occur, resulting in structural changes and physical properties. During storage and use, it is necessary to properly select the environment and operating conditions according to such characteristics to ensure its stability and safe use.
Looking at its appearance, under normal temperature and pressure, it often takes the shape of a white to light yellow crystalline powder. The powder is delicate and dry to the touch. This morphology is conducive to its dispersion and participation in many chemical reactions and preparations.
When it comes to the melting point, it is about 150-155 ° C. When the temperature gradually rises near the melting point, the thermal motion of the molecules intensifies, the lattice structure begins to disintegrate, and the substance transitions from a solid state to a liquid state. This melting point characteristic has a great impact on its purification, identification, and processing applications under different temperature conditions.
In terms of solubility, it is slightly soluble in common organic solvents such as dichloromethane and chloroform. In these solvents, molecules and solvent molecules interact through van der Waals forces, hydrogen bonds, etc., to disperse uniformly. In water, its solubility is very small, because the molecular structure of hydrophobic groups accounts for a large proportion, and it is difficult to form effective interactions with water molecules. This difference in solubility can be used as an important basis for selecting suitable solvents in the process of separation, purification and preparation of preparations.
Its density is about 1.3-1.4 g/cm ³, which means that the mass of the substance per unit volume is in this range. This density value is of great significance in the storage, transportation, and proportional allocation of substances when mixed with other substances.
In addition, the compound is relatively stable under normal conditions, but when exposed to strong oxidizing agents, strong acids, and strong bases, chemical reactions may occur, resulting in structural changes and physical properties. During storage and use, it is necessary to properly select the environment and operating conditions according to such characteristics to ensure its stability and safe use.
In what fields is 4-chloro-n- [ (2z) -1- (2-phenylethyl) -2-piperidinylidene] benzenesulfonamide used?
4 - chloro - n - [ (2z) -1- (2 - phenylethyl) -2 - piperidinylidene] benzenesulfonamide, which is an organic compound. Looking at its characteristics and structure, it has applications in many fields such as medicine and chemical industry.
In the field of medicine, due to the existence of specific groups in its structure, it may have unique biological activities. For example, it can interact with specific biological targets to develop new drugs. It may act on proteins and enzymes related to certain diseases, and precisely regulate physiological and biochemical processes in organisms to achieve the purpose of treating diseases. For example, it has inhibitory effect on specific inflammatory pathway-related targets, which can be used to develop anti-inflammatory drugs; or it has an impact on key proteins of tumor cell growth signaling pathway, providing direction for the research and development of anti-tumor drugs.
In the chemical field, this compound can act as an intermediary for organic synthesis. Because of its structure of chlorine atoms, benzenesulfonamide groups and other functional groups, it can construct more complex organic molecular structures through various chemical reactions, such as nucleophilic substitution, coupling reactions, etc. It is used to prepare polymer materials with special properties, fine chemicals, etc. For example, by reacting with other compounds containing active groups, materials with special optical and electrical properties can be prepared, which are used in electronic devices, optical instrument manufacturing and other industries.
In summary, 4 - chloro - n - [ (2z) -1- (2 - phenylethyl) -2 - piperidinylidene] benzenesulfonamide has important application value in the fields of pharmaceutical research and development and chemical synthesis. With the progress of science and technology and the deepening of research, its potential applications may be further expanded.
In the field of medicine, due to the existence of specific groups in its structure, it may have unique biological activities. For example, it can interact with specific biological targets to develop new drugs. It may act on proteins and enzymes related to certain diseases, and precisely regulate physiological and biochemical processes in organisms to achieve the purpose of treating diseases. For example, it has inhibitory effect on specific inflammatory pathway-related targets, which can be used to develop anti-inflammatory drugs; or it has an impact on key proteins of tumor cell growth signaling pathway, providing direction for the research and development of anti-tumor drugs.
In the chemical field, this compound can act as an intermediary for organic synthesis. Because of its structure of chlorine atoms, benzenesulfonamide groups and other functional groups, it can construct more complex organic molecular structures through various chemical reactions, such as nucleophilic substitution, coupling reactions, etc. It is used to prepare polymer materials with special properties, fine chemicals, etc. For example, by reacting with other compounds containing active groups, materials with special optical and electrical properties can be prepared, which are used in electronic devices, optical instrument manufacturing and other industries.
In summary, 4 - chloro - n - [ (2z) -1- (2 - phenylethyl) -2 - piperidinylidene] benzenesulfonamide has important application value in the fields of pharmaceutical research and development and chemical synthesis. With the progress of science and technology and the deepening of research, its potential applications may be further expanded.
What are the preparation methods of 4-chloro-n- [ (2z) -1- (2-phenylethyl) -2-piperidinylidene] benzenesulfonamide?
4 - chloro - n - [ (2z) - 1 - (2 - phenylethyl) - 2 - piperidinylidene] benzenesulfonamide, which is an organic compound. Its preparation method often involves a multi-step reaction.
The starting material, or the choice of phenethylamine and a suitable halogenated pyridine derivative, can be condensed into 1 - (2 - phenylethyl) - 2 - piperidinylidene intermediates. The reaction conditions for this condensation require the selection of an appropriate base and solvent to promote the smooth reaction.
Then, the obtained intermediate is reacted with 4 - chlorobenzenesulfonyl chloride. This reaction can be carried out in an alkaline environment, such as triethylamine and other bases, in an organic solvent such as dichloromethane. During the reaction, temperature control and time control are required to ensure the high efficiency of the reaction and the purity of the product.
Or, with 2-piperidone as the starting material, it is first alkylated with phenethyl halide to obtain 1 - (2-phenylethyl) -2 -piperidinylidene. After dehydration, it is converted to 1 - (2-phenylethyl) -2 -piperidinylidene. Finally, it is reacted with 4-chlorobenzenesulfonyl chloride under suitable conditions to obtain the target product. The process of
preparation, the separation and purification of the product is also the key. Column chromatography, recrystallization and other methods are often used to remove impurities and improve purity to obtain high-purity 4-chloro-n- [ (2z) -1- (2-phenylethyl) -2 -piperidinylidene] benzenesulfonamide. Each step of the reaction requires fine operation and precise control of the reaction conditions to obtain the desired result.
The starting material, or the choice of phenethylamine and a suitable halogenated pyridine derivative, can be condensed into 1 - (2 - phenylethyl) - 2 - piperidinylidene intermediates. The reaction conditions for this condensation require the selection of an appropriate base and solvent to promote the smooth reaction.
Then, the obtained intermediate is reacted with 4 - chlorobenzenesulfonyl chloride. This reaction can be carried out in an alkaline environment, such as triethylamine and other bases, in an organic solvent such as dichloromethane. During the reaction, temperature control and time control are required to ensure the high efficiency of the reaction and the purity of the product.
Or, with 2-piperidone as the starting material, it is first alkylated with phenethyl halide to obtain 1 - (2-phenylethyl) -2 -piperidinylidene. After dehydration, it is converted to 1 - (2-phenylethyl) -2 -piperidinylidene. Finally, it is reacted with 4-chlorobenzenesulfonyl chloride under suitable conditions to obtain the target product. The process of
preparation, the separation and purification of the product is also the key. Column chromatography, recrystallization and other methods are often used to remove impurities and improve purity to obtain high-purity 4-chloro-n- [ (2z) -1- (2-phenylethyl) -2 -piperidinylidene] benzenesulfonamide. Each step of the reaction requires fine operation and precise control of the reaction conditions to obtain the desired result.
What are the safety and toxicity of 4-chloro-n- [ (2z) -1- (2-phenylethyl) -2-piperidinylidene] benzenesulfonamide?
4 - chloro - n - [ (2z) -1- (2 - phenylethyl) -2 - piperidinylidene] benzenesulfonamide, which is an organic compound. In the era of "Tiangong Kaiwu", there is no study on the safety and toxicity of such compounds. However, from today's scientific perspective, it is extremely necessary to explore its safety and toxicity.
First of all, the toxicity of such organic compounds involves many aspects. First, the chlorine atom is above the benzene ring, and the presence of chlorine may affect the stability and reactivity of the compound. Chlorine atoms have certain electronegativity, or make the compound more susceptible to reactions with molecules in the body, such as proteins, nucleic acids and other key biomacromolecules, which in turn interfere with the normal physiological functions of cells and cause biotoxicity. Second, benzene has a potential toxicity. The benzene ring has a conjugated structure and is chemically stable. However, after it enters the organism, it may be metabolized into a more active intermediate, which binds to cell components and damages cells. Third, the piperidine subunit may also contribute to toxicity. The nitrogen atom of the piperidine ring can participate in the formation of hydrogen bonds and other interactions, which affect the binding mode of the compound with biological targets, or lead to adverse effects such as cytotoxicity and neurotoxicity.
As for safety, if the compound is used in industrial production, its discharge needs to be properly controlled during the production process. Because of its toxicity to environmental organisms, if it flows into ecosystems such as water bodies and soils, or causes damage to aquatic organisms and soil microorganisms, it will destroy the ecological balance. At the level of human contact, if relevant compounds are developed for drugs, they need to undergo rigorous clinical trials to evaluate their safety in the human body. When exposed to the skin, it may cause skin irritation, allergic reactions, etc.; inhalation of its dust or volatiles, or irritation to the respiratory tract, and even cause lung damage. When ingesting orally, it is necessary to consider its absorption, metabolism in the gastrointestinal tract and impact on the digestive system, and it is also necessary to pay attention to whether it will accumulate in the body and endanger human health for a long time.
Therefore, the safety and toxicity of 4 - chloro - n - [ (2z) -1- (2 - phenylethyl) -2 - piperidinylidene] benzenesulfonamide need to rely on modern science and technology, through comprehensive experimental research and threat and risk assessment, in order to ensure human health and ecological environment safety.
First of all, the toxicity of such organic compounds involves many aspects. First, the chlorine atom is above the benzene ring, and the presence of chlorine may affect the stability and reactivity of the compound. Chlorine atoms have certain electronegativity, or make the compound more susceptible to reactions with molecules in the body, such as proteins, nucleic acids and other key biomacromolecules, which in turn interfere with the normal physiological functions of cells and cause biotoxicity. Second, benzene has a potential toxicity. The benzene ring has a conjugated structure and is chemically stable. However, after it enters the organism, it may be metabolized into a more active intermediate, which binds to cell components and damages cells. Third, the piperidine subunit may also contribute to toxicity. The nitrogen atom of the piperidine ring can participate in the formation of hydrogen bonds and other interactions, which affect the binding mode of the compound with biological targets, or lead to adverse effects such as cytotoxicity and neurotoxicity.
As for safety, if the compound is used in industrial production, its discharge needs to be properly controlled during the production process. Because of its toxicity to environmental organisms, if it flows into ecosystems such as water bodies and soils, or causes damage to aquatic organisms and soil microorganisms, it will destroy the ecological balance. At the level of human contact, if relevant compounds are developed for drugs, they need to undergo rigorous clinical trials to evaluate their safety in the human body. When exposed to the skin, it may cause skin irritation, allergic reactions, etc.; inhalation of its dust or volatiles, or irritation to the respiratory tract, and even cause lung damage. When ingesting orally, it is necessary to consider its absorption, metabolism in the gastrointestinal tract and impact on the digestive system, and it is also necessary to pay attention to whether it will accumulate in the body and endanger human health for a long time.
Therefore, the safety and toxicity of 4 - chloro - n - [ (2z) -1- (2 - phenylethyl) -2 - piperidinylidene] benzenesulfonamide need to rely on modern science and technology, through comprehensive experimental research and threat and risk assessment, in order to ensure human health and ecological environment safety.
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