Linshang Chemical
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4-Chloro-N-(4-Phenyl-1,3-Thiazol-2-Yl)Benzenesulfonamide
Linshang Chemical
|
HS Code |
222735 |
| Chemical Formula | C15H11ClN2O2S2 |
| Molar Mass | 350.84 g/mol |
| Appearance | Solid (usually white to off - white powder) |
| Solubility In Water | Low solubility in water |
| Solubility In Organic Solvents | Soluble in some organic solvents like DMSO, DMF |
| Melting Point | Typically in a specific temperature range (data needed from literature) |
| Density | Value to be determined from experimental data |
| Pka | Relevant acidic or basic groups' pKa values to be found in literature |
| Logp | Partition coefficient value indicating lipophilicity (literature - based) |
As an accredited 4-Chloro-N-(4-Phenyl-1,3-Thiazol-2-Yl)Benzenesulfonamide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - chloro - N - (4 - phenyl - 1,3 - thiazol - 2 - yl)benzenesulfonamide in sealed plastic bags. |
| Storage | 4 - chloro - N - (4 - phenyl - 1,3 - thiazol - 2 - yl)benzenesulfonamide should be stored in a cool, dry place away from direct sunlight. Keep it in a well - sealed container to prevent moisture absorption and exposure to air, which could potentially lead to degradation. Store it separately from incompatible substances to avoid chemical reactions. Ensure proper ventilation in the storage area. |
| Shipping | 4 - chloro - N - (4 - phenyl - 1,3 - thiazol - 2 - yl)benzenesulfonamide is shipped in accordance with strict chemical transport regulations. Packed securely in suitable containers, ensuring proper handling to prevent spills and maintain product integrity during transit. |
Competitive 4-Chloro-N-(4-Phenyl-1,3-Thiazol-2-Yl)Benzenesulfonamide prices that fit your budget—flexible terms and customized quotes for every order.
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What is the chemical structure of 4-chloro-n- (4-phenyl-1,3-thiazol-2-yl) benzenesulfonamide
This is the chemical structure analysis of 4-chloro-N- (4-phenyl-1,3-thiazole-2-yl) benzenesulfonamide.
According to its name, it can be disassembled step by step. For "4-chloro", there is a chlorine atom attached to the benzene ring at position 4. The group of benzenesulfonamide is formed by connecting the benzene ring with the sulfonyl group (-SO _ 2 -) and the amino group (-NH _ 2). And "N- (4-phenyl-1,3-thiazole-2-yl) " indicates that the nitrogen atom of the amino group is related to the 4-phenyl-1,3-thiazole-2-base. The 4-phenyl-1,3-thiazole-2-yl group is based on the 1,3-thiazole ring and is connected with a phenyl group at the 4th position, and the 2 position of the thiazole ring is connected to the nitrogen atom of the benzenesulfonamide.
Its chemical structure, with the benzene ring as a main frame, has a chlorine atom at the 4th position; the other side of the benzene ring is connected with a sulfonyl group, a sulfonyl group and then an amino group; the nitrogen atom of the amino group is connected with 4-phenyl-1,3-thiazole-2-yl. In this way, the parts are connected in an orderly manner according to the name, forming the chemical structure of 4-chloro-N- (4-phenyl-1,3-thiazole-2-yl) benzenesulfonamide.
According to its name, it can be disassembled step by step. For "4-chloro", there is a chlorine atom attached to the benzene ring at position 4. The group of benzenesulfonamide is formed by connecting the benzene ring with the sulfonyl group (-SO _ 2 -) and the amino group (-NH _ 2). And "N- (4-phenyl-1,3-thiazole-2-yl) " indicates that the nitrogen atom of the amino group is related to the 4-phenyl-1,3-thiazole-2-base. The 4-phenyl-1,3-thiazole-2-yl group is based on the 1,3-thiazole ring and is connected with a phenyl group at the 4th position, and the 2 position of the thiazole ring is connected to the nitrogen atom of the benzenesulfonamide.
Its chemical structure, with the benzene ring as a main frame, has a chlorine atom at the 4th position; the other side of the benzene ring is connected with a sulfonyl group, a sulfonyl group and then an amino group; the nitrogen atom of the amino group is connected with 4-phenyl-1,3-thiazole-2-yl. In this way, the parts are connected in an orderly manner according to the name, forming the chemical structure of 4-chloro-N- (4-phenyl-1,3-thiazole-2-yl) benzenesulfonamide.
What are the physical properties of 4-chloro-n- (4-phenyl-1,3-thiazol-2-yl) benzenesulfonamide
4 - chloro - N - (4 - phenyl - 1,3 - thiazol - 2 - yl) benzenesulfonamide is an organic compound. Its physical properties are very important, and it is related to the performance of this compound in various environments and reactions.
The properties of this compound are mostly solid at room temperature, usually white or off-white crystalline powder. This form is conducive to storage and transportation because of its relatively high stability. Looking at its color, white or off-white indicates that its purity is usually high. If it contains impurities, the color may change.
Melting point is also one of the key physical properties. After many experiments, its melting point is in a specific temperature range, which is of great significance for the identification and purification of the compound. Knowing the melting point, the purity of the compound can be determined by the melting point measurement experiment. If the measured melting point is similar to the literature, the purity may be higher; if the deviation is large, it may contain impurities.
In terms of solubility, the compound exhibits different solubility characteristics in organic solvents. In some common organic solvents, such as ethanol and acetone, it has a certain solubility. This property makes it widely used in organic synthesis and drug development. Researchers can use these solvents to dissolve it, participate in various chemical reactions, or prepare solutions for subsequent research. In water, its solubility is relatively poor, which is related to the role of hydrophobic groups in the molecular structure of the compound.
In addition, the density of this compound is also a specific value. Although the degree of attention in practical applications may not be as good as the melting point and solubility, in specific chemical production and theoretical research, density data can help to accurately calculate the amount of reaction materials, determine the volume of the reaction system, etc., which is essential to ensure the smooth progress of the reaction and the stability of product quality.
In summary, the physical properties of 4-chloro-N- (4-phenyl-1,3-thiazol-2-yl) benzenesulfonamide, from the properties, melting point, solubility to density, have a profound impact on its application in scientific research, production and other fields. Scientific research and production personnel need to fully grasp these properties in order to make better use of this compound.
The properties of this compound are mostly solid at room temperature, usually white or off-white crystalline powder. This form is conducive to storage and transportation because of its relatively high stability. Looking at its color, white or off-white indicates that its purity is usually high. If it contains impurities, the color may change.
Melting point is also one of the key physical properties. After many experiments, its melting point is in a specific temperature range, which is of great significance for the identification and purification of the compound. Knowing the melting point, the purity of the compound can be determined by the melting point measurement experiment. If the measured melting point is similar to the literature, the purity may be higher; if the deviation is large, it may contain impurities.
In terms of solubility, the compound exhibits different solubility characteristics in organic solvents. In some common organic solvents, such as ethanol and acetone, it has a certain solubility. This property makes it widely used in organic synthesis and drug development. Researchers can use these solvents to dissolve it, participate in various chemical reactions, or prepare solutions for subsequent research. In water, its solubility is relatively poor, which is related to the role of hydrophobic groups in the molecular structure of the compound.
In addition, the density of this compound is also a specific value. Although the degree of attention in practical applications may not be as good as the melting point and solubility, in specific chemical production and theoretical research, density data can help to accurately calculate the amount of reaction materials, determine the volume of the reaction system, etc., which is essential to ensure the smooth progress of the reaction and the stability of product quality.
In summary, the physical properties of 4-chloro-N- (4-phenyl-1,3-thiazol-2-yl) benzenesulfonamide, from the properties, melting point, solubility to density, have a profound impact on its application in scientific research, production and other fields. Scientific research and production personnel need to fully grasp these properties in order to make better use of this compound.
What are the main uses of 4-chloro-n- (4-phenyl-1,3-thiazol-2-yl) benzenesulfonamide?
4 - chloro - N - (4 - phenyl - 1,3 - thiazol - 2 - yl) benzenesulfonamide, Chinese name or 4 - chloro - N - (4 - phenyl - 1,3 - thiazol - 2 - yl) benzenesulfonamide, this is an organic compound, its main use is involved in the field of medicine and chemical industry.
In the process of pharmaceutical research and development, or with antibacterial and anti-inflammatory properties. Gainthiazole and benzenesulfonamide structural units often endow compounds with specific biological activities. Thiazole compounds are widely found in many biologically active natural products and synthetic drugs. They can interact with targets in organisms, such as specific enzymes or receptors, to intervene in physiological and pathological processes. Benzenesulfonamide groups are also commonly used in antibacterial, diuretic and other drugs, and can inhibit key enzyme activities to achieve therapeutic purposes. This compound may bind to key targets in bacteria by virtue of its structural characteristics, interfering with the normal physiological metabolism of bacteria, thereby exerting antibacterial effect and providing potential directions for the development of new antibacterial drugs.
In the chemical industry, or as an intermediate in organic synthesis. With its structure of chlorine atoms, benzene rings, thiazole rings and sulfonamide groups, compounds with more complex structures and different functions can be derived through various chemical reactions. For example, chlorine atoms can participate in nucleophilic substitution reactions, introduce other functional groups, expand the structural diversity of compounds, and assist in the synthesis of materials or fine chemicals with special properties, thus contributing to chemical synthesis and enriching the variety of chemical products to meet different industrial needs.
In the process of pharmaceutical research and development, or with antibacterial and anti-inflammatory properties. Gainthiazole and benzenesulfonamide structural units often endow compounds with specific biological activities. Thiazole compounds are widely found in many biologically active natural products and synthetic drugs. They can interact with targets in organisms, such as specific enzymes or receptors, to intervene in physiological and pathological processes. Benzenesulfonamide groups are also commonly used in antibacterial, diuretic and other drugs, and can inhibit key enzyme activities to achieve therapeutic purposes. This compound may bind to key targets in bacteria by virtue of its structural characteristics, interfering with the normal physiological metabolism of bacteria, thereby exerting antibacterial effect and providing potential directions for the development of new antibacterial drugs.
In the chemical industry, or as an intermediate in organic synthesis. With its structure of chlorine atoms, benzene rings, thiazole rings and sulfonamide groups, compounds with more complex structures and different functions can be derived through various chemical reactions. For example, chlorine atoms can participate in nucleophilic substitution reactions, introduce other functional groups, expand the structural diversity of compounds, and assist in the synthesis of materials or fine chemicals with special properties, thus contributing to chemical synthesis and enriching the variety of chemical products to meet different industrial needs.
What are the synthesis methods of 4-chloro-n- (4-phenyl-1,3-thiazol-2-yl) benzenesulfonamide
To prepare 4-chloro-n- (4-phenyl-1,3-thiazol-2-yl) benzenesulfonamide, the following methods can be followed.
First, 4-chlorobenzenesulfonamide chloride and 2-amino-4-phenylthiazole are used as starting materials. In a suitable reaction medium, such as dichloromethane or toluene, adding acid binding agents, such as triethylamine or pyridine, can promote the smooth progress of the acylation reaction. In this process, the sulfonyl group of 4-chlorobenzenesulfonamide chloride reacts with the amino group of 2-amino-4-phenylthiazole to form the target product 4-chloro-n- (4-phenyl-1,3-thiazol-2-yl) benzenesulfonamide. During the reaction, attention should be paid to the control of the reaction temperature and time. Generally, the reaction can be reacted between room temperature and 50 ° C for several hours, and then the product can be purified by column chromatography or recrystallization to obtain a pure product.
Second, 4-chlorobenzenesulfonamide can be prepared first, and 4-chlorobenzenesulfonyl chloride can be obtained by reacting with excess concentrated ammonia water. Next, 4-chlorobenzenesulfonamide is reacted with 4-phenyl-1,3-thiazole-2-formaldehyde in a suitable base catalyzed by potassium carbonate or sodium carbonate in a suitable solvent such as N, N-dimethylformamide. The reaction process goes through nucleophilic addition and dehydration to obtain 4-chloro-n- (4-phenyl-1,3-thiazol-2-yl) benzenesulfonamide. After the reaction, it also needs to go through separation and purification steps such as filtration, extraction, distillation and recrystallization to improve the purity of the product.
These two types of methods are both feasible paths for the preparation of 4-chloro-n- (4-phenyl-1,3-thiazol-2-yl) benzenesulfonamide. In practice, according to the availability of raw materials, the difficulty of reaction conditions and the purity requirements of the product, choose the appropriate one and use it.
First, 4-chlorobenzenesulfonamide chloride and 2-amino-4-phenylthiazole are used as starting materials. In a suitable reaction medium, such as dichloromethane or toluene, adding acid binding agents, such as triethylamine or pyridine, can promote the smooth progress of the acylation reaction. In this process, the sulfonyl group of 4-chlorobenzenesulfonamide chloride reacts with the amino group of 2-amino-4-phenylthiazole to form the target product 4-chloro-n- (4-phenyl-1,3-thiazol-2-yl) benzenesulfonamide. During the reaction, attention should be paid to the control of the reaction temperature and time. Generally, the reaction can be reacted between room temperature and 50 ° C for several hours, and then the product can be purified by column chromatography or recrystallization to obtain a pure product.
Second, 4-chlorobenzenesulfonamide can be prepared first, and 4-chlorobenzenesulfonyl chloride can be obtained by reacting with excess concentrated ammonia water. Next, 4-chlorobenzenesulfonamide is reacted with 4-phenyl-1,3-thiazole-2-formaldehyde in a suitable base catalyzed by potassium carbonate or sodium carbonate in a suitable solvent such as N, N-dimethylformamide. The reaction process goes through nucleophilic addition and dehydration to obtain 4-chloro-n- (4-phenyl-1,3-thiazol-2-yl) benzenesulfonamide. After the reaction, it also needs to go through separation and purification steps such as filtration, extraction, distillation and recrystallization to improve the purity of the product.
These two types of methods are both feasible paths for the preparation of 4-chloro-n- (4-phenyl-1,3-thiazol-2-yl) benzenesulfonamide. In practice, according to the availability of raw materials, the difficulty of reaction conditions and the purity requirements of the product, choose the appropriate one and use it.
What are the potential side effects of 4-chloro-n- (4-phenyl-1,3-thiazol-2-yl) benzenesulfonamide
4 - chloro - n - (4 - phenyl - 1,3 - thiazol - 2 - yl) benzenesulfonamide, this is an organic compound, which is often referred to by its abbreviation or vulgar name. It may have several potential side effects, which are detailed below.
Bearing the brunt first, it concerns the digestive system. Taking this compound may cause gastrointestinal discomfort, such as nausea and vomiting. It is like walking on a boat on a wave, and the stability of the stomach is disturbed by it. There seems to be something surging in the abdomen, which makes people nauseous, and the desire to eat is greatly reduced. What's more, it may cause diarrhea, the normal transportation and transformation of the intestines are disordered, the water and grain essence cannot be transported normally, and the body is also becoming haggard.
Furthermore, it also affects the blood system. It may reduce the number of platelets and damage the coagulation function. Just like the number of soldiers in the army is insufficient, when encountering foreign enemies (bleeding), it is difficult to quickly gather to resist. If you stumble slightly, you are prone to petechiae and petechiae, and the surface of the body is like a mottled picture, showing the strangeness of the body.
In the nervous system, it may cause headaches and dizziness. The head seems to be bound by a tight spell, pain strikes, and when standing and walking, it seems to be in the middle of clouds, the world is spinning, the sense of balance is lost, and daily movements are hindered.
In addition, long-term or heavy use may also cause damage to liver and kidney function. Liver and kidney are like the filter of the body, responsible for metabolism and excretion of waste. However, this compound may cause the function of the filter to decline, and the toxins in the body cannot be excreted in time, which in turn affects the flow of qi and blood in the whole body and the function of the organs, causing a series of complex diseases.
Therefore, when using this compound, be cautious and pay close attention to the body's reaction. If you feel unwell, seek medical attention immediately. Don't take it lightly.
Bearing the brunt first, it concerns the digestive system. Taking this compound may cause gastrointestinal discomfort, such as nausea and vomiting. It is like walking on a boat on a wave, and the stability of the stomach is disturbed by it. There seems to be something surging in the abdomen, which makes people nauseous, and the desire to eat is greatly reduced. What's more, it may cause diarrhea, the normal transportation and transformation of the intestines are disordered, the water and grain essence cannot be transported normally, and the body is also becoming haggard.
Furthermore, it also affects the blood system. It may reduce the number of platelets and damage the coagulation function. Just like the number of soldiers in the army is insufficient, when encountering foreign enemies (bleeding), it is difficult to quickly gather to resist. If you stumble slightly, you are prone to petechiae and petechiae, and the surface of the body is like a mottled picture, showing the strangeness of the body.
In the nervous system, it may cause headaches and dizziness. The head seems to be bound by a tight spell, pain strikes, and when standing and walking, it seems to be in the middle of clouds, the world is spinning, the sense of balance is lost, and daily movements are hindered.
In addition, long-term or heavy use may also cause damage to liver and kidney function. Liver and kidney are like the filter of the body, responsible for metabolism and excretion of waste. However, this compound may cause the function of the filter to decline, and the toxins in the body cannot be excreted in time, which in turn affects the flow of qi and blood in the whole body and the function of the organs, causing a series of complex diseases.
Therefore, when using this compound, be cautious and pay close attention to the body's reaction. If you feel unwell, seek medical attention immediately. Don't take it lightly.
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