Linshang Chemical
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4-Chloro-N,N-Dimethyl-3-Nitrobenzenesulphonamide
Linshang Chemical
|
HS Code |
767984 |
| Chemical Formula | C8H9ClN2O4S |
| Molar Mass | 266.69 g/mol |
| Appearance | Solid (usually a powder) |
| Physical State At Room Temp | Solid |
| Color | Typically pale yellow to off - white |
| Solubility In Water | Low solubility |
| Solubility In Organic Solvents | Soluble in some organic solvents like dichloromethane, chloroform |
| Melting Point | N/A (actual value needs experimental determination) |
| Boiling Point | N/A (actual value needs experimental determination) |
| Density | N/A (actual value needs experimental determination) |
| Odor | May have a faint, characteristic odor |
| Stability | Stable under normal conditions, but may react with strong oxidizing or reducing agents |
As an accredited 4-Chloro-N,N-Dimethyl-3-Nitrobenzenesulphonamide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram bottles containing 4 - chloro - N,N - dimethyl - 3 - nitrobenzenesulphonamide. |
| Storage | 4-chloro-N,N -dimethyl-3-nitrobenzenesulphonamide should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition points. Keep it in a tightly sealed container to prevent moisture and air exposure, which could potentially lead to chemical degradation. Store it separately from incompatible substances like strong oxidizing agents and bases to avoid reactions. |
| Shipping | 4 - chloro - N,N - dimethyl - 3 - nitrobenzenesulphonamide is shipped in well - sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations to ensure safety during transit. |
Competitive 4-Chloro-N,N-Dimethyl-3-Nitrobenzenesulphonamide prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 4-chloro-N, N-dimethyl-3-nitrobenzenesulphonamide
4-Chloro-N, N-dimethyl-3-nitrobenzene sulfonamide, this is an organic compound. It is active and has unique chemical properties.
Its sulfonamide group is weakly acidic. In an alkaline environment, it is easy to interact with bases to form corresponding salts. This reaction is like a combination of two substances, each has its own place, and salts are born from it.
The chlorine atom is above the benzene ring, which is abnormally active. In many nucleophilic substitution reactions, it is easy to be replaced by nucleophilic reagents. Just like the competition between the strong, the chlorine atom is squeezed away by the stronger nucleophilic reagent, and its own position is occupied.
Nitro is a strong electron-absorbing group, which has a great influence on the electron cloud density of the benzene ring. The electron cloud density on the benzene ring decreases, making it more difficult to electrophilic substitution reaction of the benzene ring. It is like setting up obstacles to make it more difficult for electrophilic reagents to enter the benzene ring.
Because there are various active groups in the molecule, this compound can participate in many organic synthesis reactions. It can be used to prepare complex organic compounds, and it is a key key in the field of organic synthesis, opening the door to new substances.
In addition, under certain conditions, it may exhibit redox properties, because groups such as nitro and sulfonamide can undergo oxidation or reduction changes in specific reactions, adding various possibilities for the reaction, just like on the stage, each role changes its attitude according to different instructions. In conclusion, 4-chloro-N, N-dimethyl-3-nitrobenzenesulfonamide is rich in chemical properties and plays an important role in organic chemistry research and synthesis practice.
Its sulfonamide group is weakly acidic. In an alkaline environment, it is easy to interact with bases to form corresponding salts. This reaction is like a combination of two substances, each has its own place, and salts are born from it.
The chlorine atom is above the benzene ring, which is abnormally active. In many nucleophilic substitution reactions, it is easy to be replaced by nucleophilic reagents. Just like the competition between the strong, the chlorine atom is squeezed away by the stronger nucleophilic reagent, and its own position is occupied.
Nitro is a strong electron-absorbing group, which has a great influence on the electron cloud density of the benzene ring. The electron cloud density on the benzene ring decreases, making it more difficult to electrophilic substitution reaction of the benzene ring. It is like setting up obstacles to make it more difficult for electrophilic reagents to enter the benzene ring.
Because there are various active groups in the molecule, this compound can participate in many organic synthesis reactions. It can be used to prepare complex organic compounds, and it is a key key in the field of organic synthesis, opening the door to new substances.
In addition, under certain conditions, it may exhibit redox properties, because groups such as nitro and sulfonamide can undergo oxidation or reduction changes in specific reactions, adding various possibilities for the reaction, just like on the stage, each role changes its attitude according to different instructions. In conclusion, 4-chloro-N, N-dimethyl-3-nitrobenzenesulfonamide is rich in chemical properties and plays an important role in organic chemistry research and synthesis practice.
What are the physical properties of 4-chloro-N, N-dimethyl-3-nitrobenzenesulphonamide
4-Chloro-N, N-dimethyl-3-nitrobenzenesulfonamide is one of the organic compounds. Its physical properties are quite important, and it is related to the characteristics of many uses and reactions of this compound.
Looking at its properties, it usually shows a solid state under normal conditions, either in powder form or in crystalline form, which varies depending on the preparation method and purity. Its color is usually white to light yellow, but if it contains impurities, the color may be deviated.
Melting point is one of the key indicators for the identification of this compound. Generally speaking, its melting point is within a specific range, but the exact value varies slightly according to different literature and test conditions. The determination of the melting point is of great significance in identifying the purity of the compound and determining whether it meets the standard. If the melting point deviates too much from the standard value, there may be impurities incorporated, or there are problems in the preparation process.
Solubility is also an important physical property. This compound has different solubility in organic solvents. In polar organic solvents, such as ethanol and acetone, it may have a certain solubility, because some groups in the molecular structure can interact with polar solvents. However, in non-polar solvents, such as n-hexane, the solubility is low. Its solubility in water is very small, and the polarity of its molecular structure is not enough to form an effective interaction with water molecules.
In addition, its density is also one of its characteristics. The density is considered in the industrial operation and experimental design of this compound. The density value has reference value for calculating the dosage and determining the ratio of the reaction system.
The physical properties of 4-chloro-N, N-dimethyl-3-nitrobenzenesulfonamide, such as properties, melting point, solubility and density, are of critical significance in organic synthesis, analytical chemistry and related industrial application fields, and can provide an important basis for its research, production and application.
Looking at its properties, it usually shows a solid state under normal conditions, either in powder form or in crystalline form, which varies depending on the preparation method and purity. Its color is usually white to light yellow, but if it contains impurities, the color may be deviated.
Melting point is one of the key indicators for the identification of this compound. Generally speaking, its melting point is within a specific range, but the exact value varies slightly according to different literature and test conditions. The determination of the melting point is of great significance in identifying the purity of the compound and determining whether it meets the standard. If the melting point deviates too much from the standard value, there may be impurities incorporated, or there are problems in the preparation process.
Solubility is also an important physical property. This compound has different solubility in organic solvents. In polar organic solvents, such as ethanol and acetone, it may have a certain solubility, because some groups in the molecular structure can interact with polar solvents. However, in non-polar solvents, such as n-hexane, the solubility is low. Its solubility in water is very small, and the polarity of its molecular structure is not enough to form an effective interaction with water molecules.
In addition, its density is also one of its characteristics. The density is considered in the industrial operation and experimental design of this compound. The density value has reference value for calculating the dosage and determining the ratio of the reaction system.
The physical properties of 4-chloro-N, N-dimethyl-3-nitrobenzenesulfonamide, such as properties, melting point, solubility and density, are of critical significance in organic synthesis, analytical chemistry and related industrial application fields, and can provide an important basis for its research, production and application.
What are the main uses of 4-chloro-N, N-dimethyl-3-nitrobenzenesulphonamide
4-Chloro-N, N-dimethyl-3-nitrobenzenesulfonamide, this is an organic compound. It has a wide range of uses and is often used as an intermediate in drug synthesis. Due to its special chemical structure, it can participate in a variety of reactions, help to construct complex drug molecular structures, and lay the foundation for the creation of drugs with specific curative effects.
In the field of pesticides, it also plays a key role. It can be converted into pesticide active ingredients through a series of reactions, showing toxic effects on pests or inhibiting plant pathogens, thereby ensuring the healthy growth of crops and improving the yield and quality of agricultural products.
In the field of materials science, this compound can be used to prepare special functional materials. By reacting with other compounds, materials are endowed with unique properties, such as improving material stability, oxidation resistance, etc., which have potential application value in electronic materials, polymer materials, etc.
At the level of chemical research, as an important intermediate in organic synthesis, chemists use it to explore new reaction paths and reaction mechanisms, expand the boundaries of organic synthesis chemistry knowledge, and provide assistance for the development of more efficient and green synthesis methods. In short, 4-chloro-N, N-dimethyl-3-nitrobenzenesulfonamide has important uses in many fields, and is of great significance to promote the development of related industries and scientific research.
In the field of pesticides, it also plays a key role. It can be converted into pesticide active ingredients through a series of reactions, showing toxic effects on pests or inhibiting plant pathogens, thereby ensuring the healthy growth of crops and improving the yield and quality of agricultural products.
In the field of materials science, this compound can be used to prepare special functional materials. By reacting with other compounds, materials are endowed with unique properties, such as improving material stability, oxidation resistance, etc., which have potential application value in electronic materials, polymer materials, etc.
At the level of chemical research, as an important intermediate in organic synthesis, chemists use it to explore new reaction paths and reaction mechanisms, expand the boundaries of organic synthesis chemistry knowledge, and provide assistance for the development of more efficient and green synthesis methods. In short, 4-chloro-N, N-dimethyl-3-nitrobenzenesulfonamide has important uses in many fields, and is of great significance to promote the development of related industries and scientific research.
What is the synthesis method of 4-chloro-N, N-dimethyl-3-nitrobenzenesulphonamide
The synthesis method of 4-chloro-N, N-dimethyl-3-nitrobenzenesulfonamide is as follows.
First take an appropriate amount of 3-nitro-4-chlorobenzenesulfonyl chloride and place it in the reactor. This is the key raw material for the initiation of the reaction, and it can be prepared or reacted in multiple steps to obtain a pure product. An appropriate amount of organic solvent, such as dichloromethane, is injected into the kettle. This solvent can well disperse the raw materials and facilitate the reaction. Stir well to reduce the temperature of the system to a specific low temperature, about 0 ° C to 5 ° C, to ensure a smooth and controllable reaction.
Then, slowly add the solution of N, N-dimethylamine dropwise The dropwise addition process requires caution to maintain the mildness of the reaction system. N, N-dimethylamine slowly integrates into the system and undergoes a nucleophilic substitution reaction with 3-nitro-4-chlorobenzenesulfonyl chloride. The lone pair electron of the nitrogen atom in the amine group attacks the sulfur atom of the sulfonyl chloride, and the chlorine atom leaves, gradually forming the target product 4-chloro-N, N-dimethyl-3-nitrobenzenesulfonamide.
After the dropwise addition is completed, maintain low temperature stirring for a period of time to make the reaction fully proceed. After that, slowly heat up to room temperature and continue stirring for a few times to make the reaction complete. After the reaction is completed, the reaction solution is poured into an appropriate amount Take the organic phase and wash it with an appropriate amount of sodium bicarbonate solution to remove unreacted acids and impurities. Then dry it with anhydrous sodium sulfate, filter out the desiccant, and remove the organic solvent by reduced pressure distillation to obtain the crude product.
The crude product is refined by column chromatography or recrystallization. If column chromatography is used, select a suitable silica gel column, and use a specific proportion of petroleum ether and ethyl acetate mixture as eluent to separate pure 4-chloro-N, N-dimethyl-3-nitrobenzenesulfonamide. If it is recrystallized, choose a suitable solvent, such as ethanol-water mixed solvent, heat to dissolve the crude product, cool the crystallization, suction filtration, and drying to obtain a pure target product, whose purity can meet various needs.
First take an appropriate amount of 3-nitro-4-chlorobenzenesulfonyl chloride and place it in the reactor. This is the key raw material for the initiation of the reaction, and it can be prepared or reacted in multiple steps to obtain a pure product. An appropriate amount of organic solvent, such as dichloromethane, is injected into the kettle. This solvent can well disperse the raw materials and facilitate the reaction. Stir well to reduce the temperature of the system to a specific low temperature, about 0 ° C to 5 ° C, to ensure a smooth and controllable reaction.
Then, slowly add the solution of N, N-dimethylamine dropwise The dropwise addition process requires caution to maintain the mildness of the reaction system. N, N-dimethylamine slowly integrates into the system and undergoes a nucleophilic substitution reaction with 3-nitro-4-chlorobenzenesulfonyl chloride. The lone pair electron of the nitrogen atom in the amine group attacks the sulfur atom of the sulfonyl chloride, and the chlorine atom leaves, gradually forming the target product 4-chloro-N, N-dimethyl-3-nitrobenzenesulfonamide.
After the dropwise addition is completed, maintain low temperature stirring for a period of time to make the reaction fully proceed. After that, slowly heat up to room temperature and continue stirring for a few times to make the reaction complete. After the reaction is completed, the reaction solution is poured into an appropriate amount Take the organic phase and wash it with an appropriate amount of sodium bicarbonate solution to remove unreacted acids and impurities. Then dry it with anhydrous sodium sulfate, filter out the desiccant, and remove the organic solvent by reduced pressure distillation to obtain the crude product.
The crude product is refined by column chromatography or recrystallization. If column chromatography is used, select a suitable silica gel column, and use a specific proportion of petroleum ether and ethyl acetate mixture as eluent to separate pure 4-chloro-N, N-dimethyl-3-nitrobenzenesulfonamide. If it is recrystallized, choose a suitable solvent, such as ethanol-water mixed solvent, heat to dissolve the crude product, cool the crystallization, suction filtration, and drying to obtain a pure target product, whose purity can meet various needs.
4-Chloro-N, N-dimethyl-3-nitrobenzenesulphonamide What are the precautions during use?
4-Chloro-N, N-dimethyl-3-nitrobenzenesulfonamide is a special chemical substance, and many matters need to be paid special attention during use.
Bear the brunt, and safety protection should not be underestimated. Because it has certain chemical activity, or poses a hazard to the human body. When operating, you must wear appropriate protective equipment, such as protective clothing, protective gloves and protective glasses, to prevent the substance from coming into direct contact with the skin and eyes. And you need to wear a gas mask to avoid inhaling its dust or volatile gases, otherwise it may cause respiratory discomfort or even more serious health problems.
Furthermore, the storage link cannot be ignored. It should be stored in a cool, dry and well-ventilated place, away from fire and heat sources. Due to its chemical properties, it may be dangerous to heat or open flames. At the same time, it should be stored separately from oxidants, acids, alkalis, etc., and must not be mixed to avoid chemical reactions and safety accidents.
During use, precise operation steps and dosage control are extremely critical. It must be operated in strict accordance with experimental procedures or production requirements, and cannot be changed without authorization. Take an appropriate amount of the substance to avoid waste and prevent adverse consequences due to excessive use. In the reaction system, the amount of its dosage may have a great impact on the reaction process and product purity.
In addition, after use, it is essential to properly dispose of the remaining substances and waste. Do not discard it at will, and dispose of it in accordance with relevant environmental protection regulations. For the unused substance, it should be sealed and stored for subsequent use. The waste generated by the experiment needs to be collected by classification and handed over to professional treatment institutions to prevent pollution to the environment.
In short, when using 4-chloro-N, N-dimethyl-3-nitrobenzenesulfonamide, many aspects such as safety protection, correct storage, standardized operation and proper disposal of waste need to be treated strictly, and a little carelessness may lead to serious consequences.
Bear the brunt, and safety protection should not be underestimated. Because it has certain chemical activity, or poses a hazard to the human body. When operating, you must wear appropriate protective equipment, such as protective clothing, protective gloves and protective glasses, to prevent the substance from coming into direct contact with the skin and eyes. And you need to wear a gas mask to avoid inhaling its dust or volatile gases, otherwise it may cause respiratory discomfort or even more serious health problems.
Furthermore, the storage link cannot be ignored. It should be stored in a cool, dry and well-ventilated place, away from fire and heat sources. Due to its chemical properties, it may be dangerous to heat or open flames. At the same time, it should be stored separately from oxidants, acids, alkalis, etc., and must not be mixed to avoid chemical reactions and safety accidents.
During use, precise operation steps and dosage control are extremely critical. It must be operated in strict accordance with experimental procedures or production requirements, and cannot be changed without authorization. Take an appropriate amount of the substance to avoid waste and prevent adverse consequences due to excessive use. In the reaction system, the amount of its dosage may have a great impact on the reaction process and product purity.
In addition, after use, it is essential to properly dispose of the remaining substances and waste. Do not discard it at will, and dispose of it in accordance with relevant environmental protection regulations. For the unused substance, it should be sealed and stored for subsequent use. The waste generated by the experiment needs to be collected by classification and handed over to professional treatment institutions to prevent pollution to the environment.
In short, when using 4-chloro-N, N-dimethyl-3-nitrobenzenesulfonamide, many aspects such as safety protection, correct storage, standardized operation and proper disposal of waste need to be treated strictly, and a little carelessness may lead to serious consequences.
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