4-Chloro-N-(Prop-2-Ynyl)Benzenesulfonamide
Linshang Chemical
HS Code |
158161 |
Chemical Formula | C9H8ClNO2S |
Molecular Weight | 229.68 |
Appearance | Solid (predicted) |
Boiling Point | Estimated around 380 - 400 °C under normal pressure |
Solubility In Water | Low solubility, hydrophobic nature due to non - polar benzene ring and prop - 2 - ynyl group |
Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform, toluene |
Density | Estimated density based on similar compounds around 1.3 - 1.4 g/cm³ |
Flash Point | Estimated to be relatively high, around 180 - 200 °C |
As an accredited 4-Chloro-N-(Prop-2-Ynyl)Benzenesulfonamide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
Packing | 500g of 4 - chloro - N - (prop - 2 - ynyl)benzenesulfonamide packaged in air - tight containers. |
Storage | 4 - chloro - N - (prop - 2 - ynyl)benzenesulfonamide should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly sealed container to prevent moisture absorption and potential reactions. This helps maintain its chemical integrity and reduces the risk of decomposition or dangerous reactions. |
Shipping | 4 - chloro - N - (prop - 2 - ynyl)benzenesulfonamide is shipped in accordance with strict chemical transport regulations. Packed securely in appropriate containers, it's transported with care to ensure safety during transit. |
Competitive 4-Chloro-N-(Prop-2-Ynyl)Benzenesulfonamide prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 4-Chloro-N-(Prop-2-Ynyl)Benzenesulfonamide supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
The first is the benzene ring, which is a common basic structure of organic compounds and has unique stability and electron cloud distribution. In this molecule, the benzene ring is the core structure, providing the basis for the connection of other groups. The six carbon atoms of the benzene ring are connected in the form of conjugated double bonds to form a stable planar structure.
The second is the chlorine atom connected to the benzene ring para-site. The introduction of this chlorine atom greatly affects the physical and chemical properties of the molecule. Chlorine atoms have high electronegativity, which can change the distribution of benzene ring electron clouds, enhance molecular polarity, and affect their solubility, boiling point and other physical properties. At the same time, in chemical reactions, chlorine atoms can participate in many nucleophilic substitution reactions as leaving groups, greatly expanding the reactivity and derivatization possibilities of molecules.
Furthermore, the N - (prop-2-ynyl) group connected to the benzene ring sulfonyl group. The sulfonyl group (-SO 2O -) has strong electron absorption, further changing the density of the benzene ring electron cloud, and it is connected to the nitrogen atom to form a sulfonamide structure. This structure is common in many drugs and bioactive molecules. Because sulfonamide groups can form hydrogen bonds and other intermolecular forces, it is crucial for the interaction between molecules and biological targets. The prop-2-ynyl group attached to the nitrogen atom contains a carbon-carbon triple bond, which gives the molecule unique reactivity. The carbon-carbon triple bond can undergo reactions such as addition and cyclization, enriching the chemical transformation path of the molecule.
Overall, the chemical structure of 4-chloro-N- (prop-2-ynyl) benzenesulfonamide fuses various groups such as benzene ring, chlorine atom, sulfonamide and proparynyl group, and the interaction of each group endows the molecule with unique physical and chemical properties and reactivity, and has potential application value in organic synthesis, pharmaceutical chemistry and other fields.
In the field of materials science, it also has extraordinary performance. It can be introduced into the structure of polymer materials by means of chemical modification to give new properties to the materials. For example, incorporating it into polymers may improve the solubility and stability of polymers, or even endow materials with special optical and electrical properties, expanding the application of materials in optical devices, electronic components and other fields.
In addition, in the field of organic synthesis, as a compound containing special functional groups, 4-chloro-N - (2-proparynyl) benzenesulfonamide can participate in a variety of organic reactions, such as nucleophilic substitution, cyclization reactions, etc., providing an effective way to synthesize organic compounds with complex structures and specific functions, assisting the continuous development of organic synthesis chemistry, and promoting the creation and innovation of new organic materials and drugs.
Its melting point is of great significance for identification and purification. After determination, the melting point is within a specific range, which is like a precise ruler, defining the state transition node of a substance. When heated to a specific temperature, it gradually melts from a solid state to a liquid state. This temperature range is stable, which is its inherent characteristic.
In terms of solubility, it varies in different solvents. In organic solvents, such as common ethanol and acetone, it has a certain solubility, just like fish entering water, it can be better dispersed and dissolved to form a uniform stable solution. However, in water, the solubility is poor, just like oil droplets entering water, it is difficult to melt with water, and only a small amount can be dispersed and suspended.
Its density is also an important physical property. Although it is not intuitive, it has a significant impact in many application scenarios. The density data is specific, and when mixed with other substances or participating in reactions, it affects the distribution and behavior of substances, just like the distribution of different weights in the same container.
In addition, the compound has certain stability and can maintain its own structure and properties under normal conditions. However, under specific conditions, such as high temperature, strong acid and alkali environment, structure or change, chemical reactions are triggered, new substances are formed, and the stability is like a strong fortress.
4-chloro-N- (prop-2-ynyl) benzenesulfonamide has unique physical properties. These properties play a crucial role in the preparation, separation, purification and application of substances in the fields of chemical engineering and pharmaceutical research and development.
The first step is often to use benzenesulfonyl chloride as the starting material. Benzenesulfonyl chloride and propane-2-alkynylamine can undergo nucleophilic substitution under suitable reaction conditions. This reaction requires the selection of appropriate solvents, such as dichloromethane, N, N-dimethylformamide (DMF), etc., to help the reactants fully dissolve and promote the reaction. At the same time, it is necessary to add an appropriate amount of alkali, such as triethylamine, potassium carbonate, etc., whose function is to neutralize the acid generated by the reaction and promote the positive progress of the reaction.
In the second step, the control of temperature is crucial during the reaction process. Generally speaking, the reaction is relatively mild under low temperature conditions, which can reduce the occurrence of side reactions. However, if the temperature is too low, the reaction rate will slow down. Therefore, it is often necessary to maintain the reaction temperature at a certain range between 0 ° C and room temperature according to the specific situation of the experiment.
Furthermore, the reaction time also needs to be precisely controlled. If the time is too short, the reactants cannot be fully converted; if the time is too long, it may cause excessive reactions or product decomposition. The reaction process is monitored by TLC (thin-layer chromatography) or other analytical methods. When the raw material point basically disappears and the product point reaches the expected strength, the reaction can be terminated.
After the reaction is completed, the subsequent separation and purification steps are also indispensable. Column chromatography is often used, using silica gel as the stationary phase, to select a suitable eluent, such as a mixed solvent of petroleum ether and ethyl acetate, and to adjust the ratio of the two to effectively separate the target product from the reaction mixture. Or recrystallization method can be used, selecting a solvent with a large difference in the solubility of the product with temperature, heating and dissolving, cooling crystallization, filtration, etc., to obtain high-purity 4-chloro-N- (propylene-2-alkynyl) benzenesulfonamide.
In this way, through a series of delicate reaction operations and separation and purification steps, the target product 4-chloro-N- (propyl-2-alkynyl) benzenesulfonamide can be obtained.
First, protective measures must be comprehensive. This compound may be harmful to the human body, and it is necessary to wear appropriate protective equipment when operating. For example, protective gloves should be worn to avoid direct contact with the skin to prevent the skin from being irritated or absorbing harmful substances; protective glasses should be worn to prevent it from accidentally splashing into the eyes and causing damage to the eyes; protective clothing should also be worn to comprehensively reduce the risk of exposure.
Second, ventilation conditions should be good. In the place where the compound is used, adequate ventilation facilities must be ensured. Because of its or volatilization of harmful gases, good ventilation can discharge harmful gases in time, reduce the concentration of harmful substances in the air, and reduce the risk of inhalation. If the ventilation is poor, the accumulation of harmful gases can easily cause respiratory discomfort and even more serious health problems.
Third, the operating specifications should be strictly observed. When taking the compound, it should be carried out according to accurate experimental procedures or operating guidelines. Precise weighing to avoid abnormal reactions caused by improper dosage. During operation, caution should be taken to prevent the compound from spilling. If it is accidentally spilled, it should be handled immediately according to the established cleaning procedures to prevent pollution of the environment and harm to personnel.
Fourth, storage management should be proper. 4-Chloro-N- (propylene-2-alkynyl) benzenesulfonamide should be stored in a dry, cool and ventilated place, away from fire and heat sources. Due to its chemical properties or make it flammable and explosive under specific conditions. At the same time, it should be stored separately from other chemicals to avoid mutual reaction and cause danger. It is also necessary to clearly label the compound name, properties and precautions on the storage container for identification and management.
Fifth, emergency treatment should be familiar. Before use, relevant personnel must be familiar with the emergency treatment methods in case of an accident. If you accidentally come into contact with the skin, you should immediately rinse with a large amount of water, and then seek medical attention according to the specific situation. If you splash into the eyes, you need to rinse with a large amount of water quickly and seek professional medical assistance as soon as possible. In the event of an emergency such as a fire, you should clearly know the applicable fire extinguishing equipment and countermeasures to ensure that it can be dealt with in a timely and effective manner to reduce losses and hazards.

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