Linshang Chemical
PRODUCTS
4-Chloro(Trifluoromethoxy)Benzene
Linshang Chemical
|
HS Code |
542925 |
| Chemical Formula | C7H4ClF3O |
| Molar Mass | 196.553 g/mol |
| Appearance | Colorless liquid |
| Boiling Point | 143 - 145 °C |
| Density | 1.369 g/cm³ |
| Solubility In Water | Insoluble |
| Flash Point | 43 °C |
| Refractive Index | 1.444 |
As an accredited 4-Chloro(Trifluoromethoxy)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - chloro(trifluoromethoxy)benzene packaged in a sealed, chemical - resistant bottle. |
| Storage | 4 - chloro(trifluoromethoxy)benzene should be stored in a cool, well - ventilated area, away from heat sources and ignition points. It should be kept in a tightly sealed container to prevent leakage. Due to its potential hazards, store it separately from oxidizing agents, reducing agents, and incompatible substances. Ensure proper labeling for easy identification and safety. |
| Shipping | 4 - chloro(trifluoromethoxy)benzene is shipped in sealed, corrosion - resistant containers. Special handling is required due to its chemical nature. Shipments follow strict regulations for hazardous chemicals to ensure safety during transit. |
Competitive 4-Chloro(Trifluoromethoxy)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 4-Chloro(Trifluoromethoxy)Benzene in China?
As a trusted 4-Chloro(Trifluoromethoxy)Benzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 4-Chloro(Trifluoromethoxy)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 4-chloro (trifluoromethoxy) benzene?
4-Chloro (trifluoromethoxy) benzene is also an organic compound. It has a wide range of uses and has important applications in chemical, pharmaceutical and other fields.
In the chemical industry, it is often a key intermediate in organic synthesis. It can react with various reagents through many chemical reactions to build organic molecules with more complex structures. For example, in nucleophilic substitution reactions, its chlorine atoms are quite active and can be replaced by other nucleophilic groups, thereby introducing different functional groups, laying the foundation for the synthesis of various organic compounds, such as the synthesis of aromatic compounds with special structures, providing raw materials for the development of new materials.
In the field of medicine, this compound also plays an important role. Its unique chemical structure endows some special properties, and it can be used as a lead compound. After structural modification and optimization, it can develop drugs with specific pharmacological activities. Or it can participate in the construction of the core skeleton of drug molecules. With its fluorine-containing structure, such as lipophilicity, it affects the absorption, distribution, metabolism and excretion process of drugs, thereby improving the efficacy and bioavailability of drugs.
In addition, in the field of materials science, 4-chloro (trifluoromethoxy) benzene can be used to prepare functional polymer materials. By polymerizing with other monomers, its structure is introduced into the main chain or side chain of the polymer, giving the material special properties such as chemical resistance and thermal stability, and meeting the needs of high-performance materials in different fields.
In the chemical industry, it is often a key intermediate in organic synthesis. It can react with various reagents through many chemical reactions to build organic molecules with more complex structures. For example, in nucleophilic substitution reactions, its chlorine atoms are quite active and can be replaced by other nucleophilic groups, thereby introducing different functional groups, laying the foundation for the synthesis of various organic compounds, such as the synthesis of aromatic compounds with special structures, providing raw materials for the development of new materials.
In the field of medicine, this compound also plays an important role. Its unique chemical structure endows some special properties, and it can be used as a lead compound. After structural modification and optimization, it can develop drugs with specific pharmacological activities. Or it can participate in the construction of the core skeleton of drug molecules. With its fluorine-containing structure, such as lipophilicity, it affects the absorption, distribution, metabolism and excretion process of drugs, thereby improving the efficacy and bioavailability of drugs.
In addition, in the field of materials science, 4-chloro (trifluoromethoxy) benzene can be used to prepare functional polymer materials. By polymerizing with other monomers, its structure is introduced into the main chain or side chain of the polymer, giving the material special properties such as chemical resistance and thermal stability, and meeting the needs of high-performance materials in different fields.
What are the physical properties of 4-chloro (trifluoromethoxy) benzene
4-Chloro (trifluoromethoxy) benzene is also an organic compound. Its physical properties are worth studying.
Under normal temperature and pressure, it is mostly a colorless to light yellow transparent liquid. Those with pure quality have a special smell. However, in industrial products, or a slightly irritating smell, although not very strong, it should not be ignored.
When it comes to boiling point, it is about 140-145 ° C. This value is determined under a specific pressure environment. If the pressure changes, the boiling point will also migrate. The boiling point is the critical temperature at which a substance changes from liquid to gas. Above this temperature, molecules can escape from the liquid phase and gradually become gaseous.
Its melting point is about -20 ° C. The melting point is a specific temperature at which a substance changes from a solid state to a liquid state. At this temperature, the lattice structure is destroyed and the molecular activity intensifies, so the orderly arrangement of the solid state changes to the relatively disordered state of the liquid state.
The density of 4-chloro (trifluoromethoxy) benzene is about 1.45-1.50 g/cm ³, which is heavier than water, so if mixed with water, it will sink underwater. This density characteristic is of great significance in separation, storage and related process operations.
As for solubility, the substance is insoluble in water, because water is a highly polar solvent, while 4-chlorine (trifluoromethoxy) benzene molecule has a weak polarity. According to the principle of "similar miscibility", the degree of mutual solubility between the two is limited. However, it is soluble in many organic solvents, such as ethanol, ether, acetone, etc. In the process of organic synthesis reaction system construction, product separation and purification, the solubility of organic solvents is often used to control the reaction process.
In addition, 4-chloro (trifluoromethoxy) benzene has moderate volatility. Although it is not very volatile, some molecules will escape into the air when exposed to the environment or when the temperature rises slightly. This volatility needs to be properly considered during storage, and it should be sealed in a cool and ventilated place to avoid excessive volatilization and loss, and to prevent it from accumulating in the air, causing safety or environmental risks.
Under normal temperature and pressure, it is mostly a colorless to light yellow transparent liquid. Those with pure quality have a special smell. However, in industrial products, or a slightly irritating smell, although not very strong, it should not be ignored.
When it comes to boiling point, it is about 140-145 ° C. This value is determined under a specific pressure environment. If the pressure changes, the boiling point will also migrate. The boiling point is the critical temperature at which a substance changes from liquid to gas. Above this temperature, molecules can escape from the liquid phase and gradually become gaseous.
Its melting point is about -20 ° C. The melting point is a specific temperature at which a substance changes from a solid state to a liquid state. At this temperature, the lattice structure is destroyed and the molecular activity intensifies, so the orderly arrangement of the solid state changes to the relatively disordered state of the liquid state.
The density of 4-chloro (trifluoromethoxy) benzene is about 1.45-1.50 g/cm ³, which is heavier than water, so if mixed with water, it will sink underwater. This density characteristic is of great significance in separation, storage and related process operations.
As for solubility, the substance is insoluble in water, because water is a highly polar solvent, while 4-chlorine (trifluoromethoxy) benzene molecule has a weak polarity. According to the principle of "similar miscibility", the degree of mutual solubility between the two is limited. However, it is soluble in many organic solvents, such as ethanol, ether, acetone, etc. In the process of organic synthesis reaction system construction, product separation and purification, the solubility of organic solvents is often used to control the reaction process.
In addition, 4-chloro (trifluoromethoxy) benzene has moderate volatility. Although it is not very volatile, some molecules will escape into the air when exposed to the environment or when the temperature rises slightly. This volatility needs to be properly considered during storage, and it should be sealed in a cool and ventilated place to avoid excessive volatilization and loss, and to prevent it from accumulating in the air, causing safety or environmental risks.
What are the synthesis methods of 4-chloro (trifluoromethoxy) benzene
4-Chloro (trifluoromethoxy) benzene can be synthesized in several ways.
First, 4-chlorophenol is used as the starting material. First, 4-chlorophenol is mixed with alkaline substances such as sodium hydroxide to form a phenate. This phenate can react with trifluoromethylating reagents such as trifluoromethylsulfonic anhydride or sodium trifluoromethylsulfonate. Under suitable reaction conditions, such as in an organic solvent, at a specific temperature range, after a nucleophilic substitution reaction, the oxygen atom of the phenate attacks the trifluoromethylating reagent, forming a carbon-oxygen bond, thereby generating 4-chloro (trifluoromethoxy) benzene.
Second, it can start from halogenated aromatic hydrocarbons. Take 4-chlorobromobenzene as an example, in the presence of a catalyst, such as a palladium catalyst, with a trifluoromethoxy source, such as sodium trifluoromethoxide or potassium trifluoromethoxy, in a suitable solvent, through metal-catalyzed coupling reaction. The palladium catalyst activates the carbon-halogen bond of halogenated aromatics, and the oxygen-negative ion of the trifluoromethoxy source attacks nucleophilic attack, realizes the construction of carbon-oxygen bonds, and achieves the synthesis of 4-chloro (trifluoromethoxy) benzene.
Third, uses trifluoromethoxy benzene as a raw material. It is first halogenated, and chlorine atoms are introduced at specific positions in the benzene ring under the action of suitable halogenating reagents, such as chlorine gas or chlorination reagents. By controlling the reaction conditions, such as temperature, catalyst and proportion of reactants, chlorine atoms can be selectively substituted in the opposite position of trifluoromethoxy to obtain the target product 4-chloro (trifluoromethoxy) benzene.
Each synthesis method has its advantages and disadvantages. The cost of raw materials, the difficulty of reaction conditions, the yield and the number of side reactions are all factors to consider. The appropriate synthesis path needs to be selected according to the actual situation.
First, 4-chlorophenol is used as the starting material. First, 4-chlorophenol is mixed with alkaline substances such as sodium hydroxide to form a phenate. This phenate can react with trifluoromethylating reagents such as trifluoromethylsulfonic anhydride or sodium trifluoromethylsulfonate. Under suitable reaction conditions, such as in an organic solvent, at a specific temperature range, after a nucleophilic substitution reaction, the oxygen atom of the phenate attacks the trifluoromethylating reagent, forming a carbon-oxygen bond, thereby generating 4-chloro (trifluoromethoxy) benzene.
Second, it can start from halogenated aromatic hydrocarbons. Take 4-chlorobromobenzene as an example, in the presence of a catalyst, such as a palladium catalyst, with a trifluoromethoxy source, such as sodium trifluoromethoxide or potassium trifluoromethoxy, in a suitable solvent, through metal-catalyzed coupling reaction. The palladium catalyst activates the carbon-halogen bond of halogenated aromatics, and the oxygen-negative ion of the trifluoromethoxy source attacks nucleophilic attack, realizes the construction of carbon-oxygen bonds, and achieves the synthesis of 4-chloro (trifluoromethoxy) benzene.
Third, uses trifluoromethoxy benzene as a raw material. It is first halogenated, and chlorine atoms are introduced at specific positions in the benzene ring under the action of suitable halogenating reagents, such as chlorine gas or chlorination reagents. By controlling the reaction conditions, such as temperature, catalyst and proportion of reactants, chlorine atoms can be selectively substituted in the opposite position of trifluoromethoxy to obtain the target product 4-chloro (trifluoromethoxy) benzene.
Each synthesis method has its advantages and disadvantages. The cost of raw materials, the difficulty of reaction conditions, the yield and the number of side reactions are all factors to consider. The appropriate synthesis path needs to be selected according to the actual situation.
What are the precautions for 4-chloro (trifluoromethoxy) benzene during storage and transportation?
4-Chloro (trifluoromethoxy) benzene is also a chemical product. During storage and transportation, all matters should not be careless.
The head and storage must be in a cool and dry place, away from fire and pyrogens. It may be dangerous to cover this product when it is heated. And it should be placed in a well-ventilated place to prevent gas accumulation. Its utensils should also be carefully selected. It is advisable to be made of corrosion-resistant materials such as steel and aluminum, and it should be tightly sealed to prevent it from leaking out.
As for transportation, make sure that the packaging is intact and the loading is secure. The person handling, in front of protective equipment, such as anti-virus equipment, eye protection glasses, anti-chemical clothing, do not let the skin and eyes touch it. When driving, drive slowly and steadily to avoid its jolting and prevent package damage. And do not mix with oxidants, alkalis, etc., to prevent reactions and accidents.
Furthermore, in the storage and transportation site, corresponding emergency equipment and materials must be set up. If there is a leak, establish an emergency plan, evacuate everyone, and prohibit fire. Small leaks can be sucked up by sand, vermiculite, etc.; large leaks, embankment containment, and wait for professional people to deal with it properly.
All these things should be paid attention to when storing and transporting 4-chloro (trifluoromethoxy) benzene.
The head and storage must be in a cool and dry place, away from fire and pyrogens. It may be dangerous to cover this product when it is heated. And it should be placed in a well-ventilated place to prevent gas accumulation. Its utensils should also be carefully selected. It is advisable to be made of corrosion-resistant materials such as steel and aluminum, and it should be tightly sealed to prevent it from leaking out.
As for transportation, make sure that the packaging is intact and the loading is secure. The person handling, in front of protective equipment, such as anti-virus equipment, eye protection glasses, anti-chemical clothing, do not let the skin and eyes touch it. When driving, drive slowly and steadily to avoid its jolting and prevent package damage. And do not mix with oxidants, alkalis, etc., to prevent reactions and accidents.
Furthermore, in the storage and transportation site, corresponding emergency equipment and materials must be set up. If there is a leak, establish an emergency plan, evacuate everyone, and prohibit fire. Small leaks can be sucked up by sand, vermiculite, etc.; large leaks, embankment containment, and wait for professional people to deal with it properly.
All these things should be paid attention to when storing and transporting 4-chloro (trifluoromethoxy) benzene.
What are the effects of 4-chloro (trifluoromethoxy) benzene on the environment?
4-Chloro (trifluoromethoxy) benzene has a critical impact on the environment. This compound contains chlorine and trifluoromethoxy groups, and has unique properties. It may have multiple effects in the environment.
The first to bear the brunt is related to its persistence. Because of its structure containing fluorine and chlorine atoms, it has good stability and is slow to degrade in the natural environment. It can be retained in soil or water bodies for a long time, accumulating and not dispersing, gradually changing the chemical composition of the environment and affecting the ecological balance.
Furthermore, on biological accumulation. Because of its lipophilicity, it is easily ingested by organisms and accumulated in organisms. Starting from the bottom of the food chain, it is passed through the layers, and the concentration in high-trophic organisms rises gradually, which may cause toxicity to individual organisms and even populations. Birds, mammals, etc. or ingest food containing this compound, causing physiological disorders, reproduction disorders, and health damage.
In addition, 4-chloro (trifluoromethoxy) benzene may affect the microbial community. Soil and water microorganisms are crucial to the material cycle and energy conversion of ecosystems. The existence of this compound may inhibit the growth and metabolism of some microorganisms, destroy the structure and function of microbial communities, and then affect the material cycle process of the entire ecosystem.
And it may be potentially volatile. In the atmosphere, or through photochemical reactions, other harmful secondary pollutants are generated, which affect air quality and threaten the health of human and biological respiratory systems.
In summary, 4-chloro (trifluoromethoxy) benzene has a wide and far-reaching impact on the environment, and poses a potential threat to ecosystem stability and biological health. Close attention and in-depth research are required to find countermeasures and reduce its harm to the environment.
The first to bear the brunt is related to its persistence. Because of its structure containing fluorine and chlorine atoms, it has good stability and is slow to degrade in the natural environment. It can be retained in soil or water bodies for a long time, accumulating and not dispersing, gradually changing the chemical composition of the environment and affecting the ecological balance.
Furthermore, on biological accumulation. Because of its lipophilicity, it is easily ingested by organisms and accumulated in organisms. Starting from the bottom of the food chain, it is passed through the layers, and the concentration in high-trophic organisms rises gradually, which may cause toxicity to individual organisms and even populations. Birds, mammals, etc. or ingest food containing this compound, causing physiological disorders, reproduction disorders, and health damage.
In addition, 4-chloro (trifluoromethoxy) benzene may affect the microbial community. Soil and water microorganisms are crucial to the material cycle and energy conversion of ecosystems. The existence of this compound may inhibit the growth and metabolism of some microorganisms, destroy the structure and function of microbial communities, and then affect the material cycle process of the entire ecosystem.
And it may be potentially volatile. In the atmosphere, or through photochemical reactions, other harmful secondary pollutants are generated, which affect air quality and threaten the health of human and biological respiratory systems.
In summary, 4-chloro (trifluoromethoxy) benzene has a wide and far-reaching impact on the environment, and poses a potential threat to ecosystem stability and biological health. Close attention and in-depth research are required to find countermeasures and reduce its harm to the environment.
Scan to WhatsApp
