Linshang Chemical
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4-Chloroacetyl-1-Fluoro Benzene
Linshang Chemical
|
HS Code |
193043 |
| Chemical Formula | C8H6ClFO |
| Molar Mass | 174.583 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Around 210 - 212 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene |
| Vapor Pressure | Low at room temperature |
As an accredited 4-Chloroacetyl-1-Fluoro Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - chloroacetyl - 1 - fluoro benzene in sealed, corrosion - resistant container. |
| Storage | 4 - chloroacetyl - 1 - fluoro benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent leakage and exposure to air and moisture. Store it separately from oxidizing agents, bases, and other incompatible substances to avoid potential chemical reactions. |
| Shipping | 4 - chloroacetyl - 1 - fluoro benzene is a chemical. Shipping requires proper packaging in accordance with hazardous material regulations. It must be labeled clearly, transported by approved carriers, and handled with care to prevent spills and ensure safety. |
Competitive 4-Chloroacetyl-1-Fluoro Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the main uses of 4-chloroacetyl-1-fluoro Benzene?
4-Chloroacetyl-1-fluorobenzene is one of the organic compounds. Its main uses are quite extensive, and it plays an important role in the field of organic synthesis.
First, it is often used as an intermediate to prepare various drugs. Because it contains specific functional groups, it can be chemically reacted to construct structures with biological activity. For example, in the synthesis of some antibacterial drugs, by chemically modifying it, specific groups can be introduced to give the drug better antibacterial properties, act on key bacterial targets, and inhibit bacterial growth and reproduction.
Second, it is also used in the field of materials science. It can participate in polymer synthesis and give materials unique properties. For example, when synthesizing functional polymer materials, introducing them as monomers or modifiers can change the electrical, optical or mechanical properties of the materials, and prepare materials suitable for specific purposes, such as photoelectric materials, to meet the needs of electronic equipment for special materials.
Third, it also plays an important role in pesticide synthesis. It can be used as a key raw material for the synthesis of new pesticides. Through chemical transformation, pesticide products with high-efficiency killing or repelling effects on pests can be created. Such pesticides may have low toxicity, high efficiency, and environmentally friendly characteristics. They can precisely act on specific physiological processes of pests, reduce environmental impact and harm to non-target organisms, ensure crop growth, and improve agricultural production efficiency.
First, it is often used as an intermediate to prepare various drugs. Because it contains specific functional groups, it can be chemically reacted to construct structures with biological activity. For example, in the synthesis of some antibacterial drugs, by chemically modifying it, specific groups can be introduced to give the drug better antibacterial properties, act on key bacterial targets, and inhibit bacterial growth and reproduction.
Second, it is also used in the field of materials science. It can participate in polymer synthesis and give materials unique properties. For example, when synthesizing functional polymer materials, introducing them as monomers or modifiers can change the electrical, optical or mechanical properties of the materials, and prepare materials suitable for specific purposes, such as photoelectric materials, to meet the needs of electronic equipment for special materials.
Third, it also plays an important role in pesticide synthesis. It can be used as a key raw material for the synthesis of new pesticides. Through chemical transformation, pesticide products with high-efficiency killing or repelling effects on pests can be created. Such pesticides may have low toxicity, high efficiency, and environmentally friendly characteristics. They can precisely act on specific physiological processes of pests, reduce environmental impact and harm to non-target organisms, ensure crop growth, and improve agricultural production efficiency.
4-chloroacetyl-1-fluoro the physical properties of Benzene
4-Chloroacetyl-1-fluorobenzene is also an organic compound. Its physical properties are particularly important, and it is related to the application of many chemical processes and research.
First of all, its appearance, under room temperature and pressure, 4-chloroacetyl-1-fluorobenzene is mostly colorless to light yellow liquid. The view is clear and has a slightly special smell. Although this smell is not strong and pungent, it also has its unique taste, and the smell can sense its chemical characteristics.
As for the melting point, it is about - [X] ° C, a very low melting point, which makes it easy to maintain a liquid state at room temperature. The boiling point is around [X] ° C, indicating that the corresponding heat needs to be applied to vaporize it. Such melting boiling point characteristics are key factors to consider in the separation, purification and control of reaction conditions.
Its density is heavier than water, about [X] g/cm ³. If it is juxtaposed with water, it will sink underwater. This property is quite instructive in operations such as liquid-liquid separation.
In terms of solubility, 4-chloroacetyl-1-fluorobenzene exhibits good solubility in organic solvents such as ethanol, ether, dichloromethane, etc., and can be miscible with various organic solvents. This property makes it possible to choose a suitable solvent in organic synthesis reactions to promote the smooth progress of the reaction. However, in water, its solubility is very small, and only a very small amount can be dissolved, due to the hydrophobicity of the molecular structure of the compound.
In addition, the vapor pressure of 4-chloroacetyl-1-fluorobenzene also has its value at a specific temperature, which is related to its tendency to escape in the gas phase. It needs to be carefully considered in the ventilation design and storage conditions of chemical production. And its refractive index is also a specific constant. This physical quantity can be a powerful criterion in the fields of optical detection and purity analysis.
First of all, its appearance, under room temperature and pressure, 4-chloroacetyl-1-fluorobenzene is mostly colorless to light yellow liquid. The view is clear and has a slightly special smell. Although this smell is not strong and pungent, it also has its unique taste, and the smell can sense its chemical characteristics.
As for the melting point, it is about - [X] ° C, a very low melting point, which makes it easy to maintain a liquid state at room temperature. The boiling point is around [X] ° C, indicating that the corresponding heat needs to be applied to vaporize it. Such melting boiling point characteristics are key factors to consider in the separation, purification and control of reaction conditions.
Its density is heavier than water, about [X] g/cm ³. If it is juxtaposed with water, it will sink underwater. This property is quite instructive in operations such as liquid-liquid separation.
In terms of solubility, 4-chloroacetyl-1-fluorobenzene exhibits good solubility in organic solvents such as ethanol, ether, dichloromethane, etc., and can be miscible with various organic solvents. This property makes it possible to choose a suitable solvent in organic synthesis reactions to promote the smooth progress of the reaction. However, in water, its solubility is very small, and only a very small amount can be dissolved, due to the hydrophobicity of the molecular structure of the compound.
In addition, the vapor pressure of 4-chloroacetyl-1-fluorobenzene also has its value at a specific temperature, which is related to its tendency to escape in the gas phase. It needs to be carefully considered in the ventilation design and storage conditions of chemical production. And its refractive index is also a specific constant. This physical quantity can be a powerful criterion in the fields of optical detection and purity analysis.
4-chloroacetyl-1-fluoro the chemistry of Benzene
4-Chloroacetyl-1-fluorobenzene, an organic compound, has unique chemical properties and contains specific reactivity and characteristics.
Let's talk about its structural characteristics first. On the benzene ring, the chloroacetyl group and the fluorine atom are on one side. Fluorine atoms have strong electronegativity, which affects the distribution of the electron cloud of the benzene ring, reducing the density of the electron cloud of the benzene ring, causing its electrophilic substitution activity to weaken. For example, during the halogenation reaction, it is more difficult to react with halogenated reagents than benzene, because the electron cloud of the benzene ring is weakened by the electron-absorbing effect of the fluorine atom, which is not conducive to the attack of the electrophilic reagents.
In the chloroacetyl group, the chlorine atom is active and In this reaction, if you encounter nucleophiles, such as alcohols, amines, etc., chlorine atoms are easily replaced by nucleophiles. For example, under the catalysis of alkali with ethanol, chlorine atoms will be replaced by ethoxy groups to form corresponding ether compounds. This is because the chlorine atom acts as a leaving group, and the nucleophile provides electrons to attack the carbon atoms connected to it, promoting the substitution reaction.
Moreover, the carbonyl group (C = O) in this compound can participate in a variety of reactions. For example, it can undergo addition reactions with nucleophiles. Taking Grignard's reagent as an example, the negatively charged alkyl group in Grignard's reagent will attack the carbonyl carbon atom, and then hydrolyze it to form an alcohol compound. This is an important method for building carbon-carbon bonds and preparing alcohols in organic synthesis.
Furthermore, the stability of this compound is influenced by structural factors. The electronic effect of fluorine atoms and chloroacetyl groups and the steric hindrance effect jointly determine its stability. Under certain conditions, rearrangement reactions or decomposition reactions may occur, but the specific conditions depend on the reaction conditions. For example, in high temperature or strong acid-base environments, intramolecular rearrangements may occur, resulting in structural changes and the formation of different products. In conclusion, 4-chloroacetyl-1-fluorobenzene has important applications in the field of organic synthesis due to its special structure and diverse chemical properties. It can be used as a key intermediate to prepare many valuable organic compounds through various reactions.
Let's talk about its structural characteristics first. On the benzene ring, the chloroacetyl group and the fluorine atom are on one side. Fluorine atoms have strong electronegativity, which affects the distribution of the electron cloud of the benzene ring, reducing the density of the electron cloud of the benzene ring, causing its electrophilic substitution activity to weaken. For example, during the halogenation reaction, it is more difficult to react with halogenated reagents than benzene, because the electron cloud of the benzene ring is weakened by the electron-absorbing effect of the fluorine atom, which is not conducive to the attack of the electrophilic reagents.
In the chloroacetyl group, the chlorine atom is active and In this reaction, if you encounter nucleophiles, such as alcohols, amines, etc., chlorine atoms are easily replaced by nucleophiles. For example, under the catalysis of alkali with ethanol, chlorine atoms will be replaced by ethoxy groups to form corresponding ether compounds. This is because the chlorine atom acts as a leaving group, and the nucleophile provides electrons to attack the carbon atoms connected to it, promoting the substitution reaction.
Moreover, the carbonyl group (C = O) in this compound can participate in a variety of reactions. For example, it can undergo addition reactions with nucleophiles. Taking Grignard's reagent as an example, the negatively charged alkyl group in Grignard's reagent will attack the carbonyl carbon atom, and then hydrolyze it to form an alcohol compound. This is an important method for building carbon-carbon bonds and preparing alcohols in organic synthesis.
Furthermore, the stability of this compound is influenced by structural factors. The electronic effect of fluorine atoms and chloroacetyl groups and the steric hindrance effect jointly determine its stability. Under certain conditions, rearrangement reactions or decomposition reactions may occur, but the specific conditions depend on the reaction conditions. For example, in high temperature or strong acid-base environments, intramolecular rearrangements may occur, resulting in structural changes and the formation of different products. In conclusion, 4-chloroacetyl-1-fluorobenzene has important applications in the field of organic synthesis due to its special structure and diverse chemical properties. It can be used as a key intermediate to prepare many valuable organic compounds through various reactions.
What are the synthesis methods of 4-chloroacetyl-1-fluoro Benzene
There are several ways to prepare 4-chloroacetyl-1-fluorobenzene. First, it can be prepared by the reaction of 1-fluorobenzene with chloroacetyl chloride through Foucault acylation. In this reaction, Lewis acids such as anhydrous aluminum trichloride are used as catalysts and reacted in suitable solvents such as dichloromethane at low temperature to room temperature. The benzene ring of 1-fluorobenzene is nucleophilic. After the acyl part of chloroacetyl chloride is catalyzed by Lewis acid, its carbonyl carbon is more electrophilic, and the two undergo an electrophilic substitution reaction, resulting in the formation of the target product 4-chloroacetyl-1-fluorobenzene.
In addition, 1-fluorobenzene can be used to make the corresponding Grignard reagent first, and then reacted with chloroacetyl chloride or chloroacetyl derivatives. The Grignard reagent is prepared by reacting 1-fluorobenzene with magnesium chips in anhydrous ether or tetrahydrofuran and other solvents. The reagent has high activity and meets chloroacetyl compounds, which can undergo nucleophilic addition reaction, and then synthesize 4-chloroacetyl-1-fluorobenzene.
Another way can be started from benzene derivatives containing suitable substituents and converted through a multi-step reaction. For example, fluorine atoms are introduced at specific positions in the benzene ring first, and then through a series of reactions, such as acylation, halogenation, etc., the structure of 4-chloroacetyl-1-fluorobenzene is gradually constructed. This multi-step reaction requires fine control of reaction conditions and sequence to ensure the yield and selectivity of each step.
Different methods have advantages and disadvantages. The Foucault acylation method is relatively simple, but the choice of catalyst and the control of reaction conditions have a great impact on the yield. Although the Grignard reagent method has high activity, the preparation of Grignard reagents requires anhydrous and anaerobic conditions, and the operation requirements are strict. Although the multi-step synthesis method is complex, it can flexibly adjust the reaction route to meet different needs. In actual synthesis, it is necessary to comprehensively consider factors such as raw material availability, cost, yield and purity requirements to select an appropriate method.
In addition, 1-fluorobenzene can be used to make the corresponding Grignard reagent first, and then reacted with chloroacetyl chloride or chloroacetyl derivatives. The Grignard reagent is prepared by reacting 1-fluorobenzene with magnesium chips in anhydrous ether or tetrahydrofuran and other solvents. The reagent has high activity and meets chloroacetyl compounds, which can undergo nucleophilic addition reaction, and then synthesize 4-chloroacetyl-1-fluorobenzene.
Another way can be started from benzene derivatives containing suitable substituents and converted through a multi-step reaction. For example, fluorine atoms are introduced at specific positions in the benzene ring first, and then through a series of reactions, such as acylation, halogenation, etc., the structure of 4-chloroacetyl-1-fluorobenzene is gradually constructed. This multi-step reaction requires fine control of reaction conditions and sequence to ensure the yield and selectivity of each step.
Different methods have advantages and disadvantages. The Foucault acylation method is relatively simple, but the choice of catalyst and the control of reaction conditions have a great impact on the yield. Although the Grignard reagent method has high activity, the preparation of Grignard reagents requires anhydrous and anaerobic conditions, and the operation requirements are strict. Although the multi-step synthesis method is complex, it can flexibly adjust the reaction route to meet different needs. In actual synthesis, it is necessary to comprehensively consider factors such as raw material availability, cost, yield and purity requirements to select an appropriate method.
4-chloroacetyl-1-fluoro Benzene to pay attention to when storing and transporting
4-Chloroacetyl-1-fluorobenzene is an organic compound. When storing and transporting, many key things need to be paid attention to.
First safety protection. Because of its certain chemical activity and potential danger, contacts must wear appropriate protective equipment, such as protective clothing, gloves, goggles and gas masks, to prevent skin contact, inhalation or accidental ingestion, to avoid harm to the body such as skin irritation, damage to the respiratory tract and other hazards.
Secondary storage conditions. It should be placed in a cool, dry and well-ventilated place, away from fire and heat sources, because it is exposed to heat or open flames, or there is a risk of combustion or even explosion. It needs to be stored separately from oxidizing agents, strong alkalis and other chemicals to prevent violent chemical reactions. The storage container should also be well sealed to prevent leakage, and the container should be checked regularly for damage.
Then there is the transportation link. Before transportation, ensure that the packaging is complete and sealed, follow relevant transportation regulations, and choose suitable transportation tools. Avoid vibration, collision and high temperature during transportation to prevent material leakage caused by package damage. If leakage unfortunately occurs, emergency measures should be taken quickly to evacuate the surrounding people, isolate the leakage area, and be properly handled by professionals according to their chemical characteristics.
In short, the storage and transportation of 4-chloroacetyl-1-fluorobenzene should be safe, strictly follow regulations, and do a good job of protection and management to avoid accidents and ensure the safety of personnel and the environment.
First safety protection. Because of its certain chemical activity and potential danger, contacts must wear appropriate protective equipment, such as protective clothing, gloves, goggles and gas masks, to prevent skin contact, inhalation or accidental ingestion, to avoid harm to the body such as skin irritation, damage to the respiratory tract and other hazards.
Secondary storage conditions. It should be placed in a cool, dry and well-ventilated place, away from fire and heat sources, because it is exposed to heat or open flames, or there is a risk of combustion or even explosion. It needs to be stored separately from oxidizing agents, strong alkalis and other chemicals to prevent violent chemical reactions. The storage container should also be well sealed to prevent leakage, and the container should be checked regularly for damage.
Then there is the transportation link. Before transportation, ensure that the packaging is complete and sealed, follow relevant transportation regulations, and choose suitable transportation tools. Avoid vibration, collision and high temperature during transportation to prevent material leakage caused by package damage. If leakage unfortunately occurs, emergency measures should be taken quickly to evacuate the surrounding people, isolate the leakage area, and be properly handled by professionals according to their chemical characteristics.
In short, the storage and transportation of 4-chloroacetyl-1-fluorobenzene should be safe, strictly follow regulations, and do a good job of protection and management to avoid accidents and ensure the safety of personnel and the environment.
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