Linshang Chemical
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4-Chlorobenzene-1,2-Dicarboxylate
Linshang Chemical
|
HS Code |
290633 |
| Chemical Formula | C8H4ClO4 |
| Molar Mass | 214.57 g/mol |
| Appearance | Solid (usually white or off - white) |
| Solubility In Water | Low solubility |
| Solubility In Organic Solvents | Soluble in some organic solvents like ethanol, acetone |
| Melting Point | Typically in a certain temperature range (specific value may vary depending on purity) |
| Boiling Point | Higher boiling point due to intermolecular forces |
| Density | A specific density value (depending on conditions) |
| Stability | Stable under normal conditions, may decompose under high heat or in contact with strong oxidizing agents |
| Odor | May have a faint, characteristic odor |
As an accredited 4-Chlorobenzene-1,2-Dicarboxylate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 kg of 4 - chlorobenzene - 1,2 - dicarboxylate in sealed chemical - grade bags. |
| Storage | 4 - chlorobenzene - 1,2 - dicarboxylate should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and incompatible substances like strong oxidizing agents. Store in tightly - sealed containers to prevent moisture absorption and potential leakage, ensuring its stability and safety during storage. |
| Shipping | 4 - chlorobenzene - 1,2 - dicarboxylate is shipped in sealed, corrosion - resistant containers. Transport follows strict chemical safety regulations, ensuring protection from environmental factors and preventing leakage during transit. |
Competitive 4-Chlorobenzene-1,2-Dicarboxylate prices that fit your budget—flexible terms and customized quotes for every order.
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Tel: +8615365006308
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What are the chemical properties of 4-chlorobenzene-1,2-dicarboxylate?
4-Bromo-1,2-dichlorobenzophenone is an organic compound with the following chemical properties:
First, nucleophilic substitution reactivity. The halogen atom (bromine and chlorine) in its molecule is highly electronegative due to the high electronegativity of the halogen atom, which is connected to the benzene ring and causes the C-X bond (X is bromine or chlorine) to be polar. The carbon is partially positively charged and vulnerable to attack by nucleophiles. In case of nucleophiles such as hydroxyl negative ions (OH), halogen atoms can be replaced to form compounds containing new functional groups such as hydroxyl groups. This reaction mechanism usually provides an electron pair for the nucleophilic reagent to attack the partially positively charged carbon atom, and the halogen atom leaves with a pair of electrons.
Second, a reduction reaction can Its carbonyl group (C = O) can be reduced. Using metal hydrides such as lithium aluminum hydride (LiAlH) or sodium borohydride (NaBH) as reducing agents, the carbonyl group will be reduced to alcohol hydroxyl groups to generate 4-bromo-1,2-dichlorobenzyl alcohol. LiAlHhas strong reduction ability and can completely reduce the carbonyl group to alcohol; NaBHis relatively mild and selectively reduces the carbonyl group.
Third, the characteristic reaction of aromatic rings. The compound contains benzene rings and has the typical electrophilic substitution reaction properties of aromatic rings. The electron cloud density of the benzene ring is high, which is vulnerable to the attack of electrophilic reagents. If under the action of appropriate catalysts (such as Lewis acids such as FeBr, etc.), bromination reaction can occur with brominating agents, and new bromine atoms can be introduced into the benzene ring. The specific substitution position is affected by the localization effect of the original substituent. The original bromine, chlorine and carbonyl groups are all electron-absorbing groups, which belong to the meta-position locator, and the new substituent mainly enters the meta-position.
Fourth, the difference in the activity of halogen atoms. Although both bromine and chlorine can undergo nucleophilic substitution, the activity of bromine atoms is relatively higher. Because the bond energy of C-Br bond is smaller than that of C-Cl bond, in the nucleophilic substitution reaction, the C-Br bond is more prone to fracture and the reactivity is stronger.
First, nucleophilic substitution reactivity. The halogen atom (bromine and chlorine) in its molecule is highly electronegative due to the high electronegativity of the halogen atom, which is connected to the benzene ring and causes the C-X bond (X is bromine or chlorine) to be polar. The carbon is partially positively charged and vulnerable to attack by nucleophiles. In case of nucleophiles such as hydroxyl negative ions (OH), halogen atoms can be replaced to form compounds containing new functional groups such as hydroxyl groups. This reaction mechanism usually provides an electron pair for the nucleophilic reagent to attack the partially positively charged carbon atom, and the halogen atom leaves with a pair of electrons.
Second, a reduction reaction can Its carbonyl group (C = O) can be reduced. Using metal hydrides such as lithium aluminum hydride (LiAlH) or sodium borohydride (NaBH) as reducing agents, the carbonyl group will be reduced to alcohol hydroxyl groups to generate 4-bromo-1,2-dichlorobenzyl alcohol. LiAlHhas strong reduction ability and can completely reduce the carbonyl group to alcohol; NaBHis relatively mild and selectively reduces the carbonyl group.
Third, the characteristic reaction of aromatic rings. The compound contains benzene rings and has the typical electrophilic substitution reaction properties of aromatic rings. The electron cloud density of the benzene ring is high, which is vulnerable to the attack of electrophilic reagents. If under the action of appropriate catalysts (such as Lewis acids such as FeBr, etc.), bromination reaction can occur with brominating agents, and new bromine atoms can be introduced into the benzene ring. The specific substitution position is affected by the localization effect of the original substituent. The original bromine, chlorine and carbonyl groups are all electron-absorbing groups, which belong to the meta-position locator, and the new substituent mainly enters the meta-position.
Fourth, the difference in the activity of halogen atoms. Although both bromine and chlorine can undergo nucleophilic substitution, the activity of bromine atoms is relatively higher. Because the bond energy of C-Br bond is smaller than that of C-Cl bond, in the nucleophilic substitution reaction, the C-Br bond is more prone to fracture and the reactivity is stronger.
What are the common application fields of 4-chlorobenzene-1,2-dicarboxylate?
4-Bromo-1,2-dichlorobenzene is an organic compound, and its common application fields are as follows:
One is the synthesis of medicine. In many drug preparation processes, 4-bromo-1,2-dichlorobenzene can be used as a key intermediate. For example, when synthesizing specific antibacterial drugs, molecular structures with antibacterial activity can be constructed by chemical reaction of bromine and chlorine atoms. Because the halogen atoms in the structure can participate in reactions such as nucleophilic substitution to introduce the required functional groups into drug molecules, it occupies an important position in the field of pharmaceutical chemistry.
The second is in the field of pesticides. It can be used as a raw material for the synthesis of a variety of pesticides. For example, through a series of chemical transformations, insecticides with efficient pest control effects can be prepared. Its structural characteristics enable the derived pesticides to effectively act on the physiological system of pests, or interfere with the normal growth and development process of pests, or affect the nervous system conduction of pests, thereby achieving the purpose of pest control.
The third is used in dye synthesis. 4-Bromo-1,2-dichlorobenzene can help build dye molecules with specific colors and properties. Halogen atoms in it can regulate the electron cloud distribution of dye molecules, thereby affecting the absorption and emission characteristics of dyes to light, ultimately giving dyes unique colors and good dyeing fastness and other properties, playing an important role in textile printing and dyeing industries.
The fourth is in the field of organic synthesis. As an important starting material, it lays the foundation for the construction of more complex organic compounds. Due to the difference in reactivity between two chlorine atoms and one bromine atom, different types of chemical reactions can be carried out in sequence to achieve the precise construction of complex organic molecules, providing a variety of possibilities for the study of organic synthetic chemistry.
One is the synthesis of medicine. In many drug preparation processes, 4-bromo-1,2-dichlorobenzene can be used as a key intermediate. For example, when synthesizing specific antibacterial drugs, molecular structures with antibacterial activity can be constructed by chemical reaction of bromine and chlorine atoms. Because the halogen atoms in the structure can participate in reactions such as nucleophilic substitution to introduce the required functional groups into drug molecules, it occupies an important position in the field of pharmaceutical chemistry.
The second is in the field of pesticides. It can be used as a raw material for the synthesis of a variety of pesticides. For example, through a series of chemical transformations, insecticides with efficient pest control effects can be prepared. Its structural characteristics enable the derived pesticides to effectively act on the physiological system of pests, or interfere with the normal growth and development process of pests, or affect the nervous system conduction of pests, thereby achieving the purpose of pest control.
The third is used in dye synthesis. 4-Bromo-1,2-dichlorobenzene can help build dye molecules with specific colors and properties. Halogen atoms in it can regulate the electron cloud distribution of dye molecules, thereby affecting the absorption and emission characteristics of dyes to light, ultimately giving dyes unique colors and good dyeing fastness and other properties, playing an important role in textile printing and dyeing industries.
The fourth is in the field of organic synthesis. As an important starting material, it lays the foundation for the construction of more complex organic compounds. Due to the difference in reactivity between two chlorine atoms and one bromine atom, different types of chemical reactions can be carried out in sequence to achieve the precise construction of complex organic molecules, providing a variety of possibilities for the study of organic synthetic chemistry.
What is the preparation method of 4-chlorobenzene-1,2-dicarboxylate?
To prepare 4-bromo-1,2-dichlorobenzophenone, you can do it as follows.
First take an appropriate amount of o-dichlorobenzene, place it in the reactor, and use it as the substrate. Slowly add an appropriate amount of catalyst to the kettle, such as anhydrous aluminum trichloride, which is a common catalyst for Fu-gram reaction, which can effectively promote the subsequent reaction.
Then, bromoacetyl bromide is introduced into the reaction system. This process needs to be carefully controlled and maintained at a specific temperature range. Generally, the reaction is started at a low temperature, such as about 0 ° C, to prevent the reaction from being too violent and out of control. As the reaction progresses, the temperature is gradually raised to 30-50 ° C to allow the reaction to proceed fully. During this period, bromoacetyl bromide and o-dichlorobenzene undergo a Fu-gram acylation reaction under the action of the catalyst, and the bromoacetyl group can be attached to the benzene ring to form an intermediate product.
After the reaction is basically completed, the reaction mixture needs to be treated. Pour it into a container containing an appropriate amount of ice water and stir it evenly to dissolve the catalyst and other impurities in the aqueous phase. At this time, the product is mostly retained in the organic phase. The organic phase is separated by liquid separation.
Next, the organic phase is washed with sodium bicarbonate solution to remove the remaining acidic substances; then washed with distilled water to remove the remaining sodium bicarbonate and other water-soluble impurities. The washed organic phase is dried with anhydrous sodium sulfate to remove the remaining moisture.
Finally, the dried organic phase is distilled. First, the solvent and impurities with low boiling point are removed by atmospheric distillation, and then the fraction with a specific boiling point range is collected by reduced pressure distillation. This fraction is 4-bromo-1,2-dichlorobenzophenone. Through the above steps, the target product can be prepared more effectively.
First take an appropriate amount of o-dichlorobenzene, place it in the reactor, and use it as the substrate. Slowly add an appropriate amount of catalyst to the kettle, such as anhydrous aluminum trichloride, which is a common catalyst for Fu-gram reaction, which can effectively promote the subsequent reaction.
Then, bromoacetyl bromide is introduced into the reaction system. This process needs to be carefully controlled and maintained at a specific temperature range. Generally, the reaction is started at a low temperature, such as about 0 ° C, to prevent the reaction from being too violent and out of control. As the reaction progresses, the temperature is gradually raised to 30-50 ° C to allow the reaction to proceed fully. During this period, bromoacetyl bromide and o-dichlorobenzene undergo a Fu-gram acylation reaction under the action of the catalyst, and the bromoacetyl group can be attached to the benzene ring to form an intermediate product.
After the reaction is basically completed, the reaction mixture needs to be treated. Pour it into a container containing an appropriate amount of ice water and stir it evenly to dissolve the catalyst and other impurities in the aqueous phase. At this time, the product is mostly retained in the organic phase. The organic phase is separated by liquid separation.
Next, the organic phase is washed with sodium bicarbonate solution to remove the remaining acidic substances; then washed with distilled water to remove the remaining sodium bicarbonate and other water-soluble impurities. The washed organic phase is dried with anhydrous sodium sulfate to remove the remaining moisture.
Finally, the dried organic phase is distilled. First, the solvent and impurities with low boiling point are removed by atmospheric distillation, and then the fraction with a specific boiling point range is collected by reduced pressure distillation. This fraction is 4-bromo-1,2-dichlorobenzophenone. Through the above steps, the target product can be prepared more effectively.
What are the environmental effects of 4-chlorobenzene-1,2-dicarboxylate?
4-Chloro-1,2-dicarboxylic anhydride is a key intermediate in organic synthesis, and its impact on the environment should not be underestimated.
The degradation process of 4-chloro-1,2-dicarboxylic anhydride in the environment is relatively slow. Because its structure contains chlorine atoms, the covalent bond between chlorine atoms and carbon atoms is quite stable. Under normal natural conditions, it is not easy to fracture it. This allows it to persist in environmental media such as soil and water for a long time, gradually accumulating, and then affecting the structure and function of ecosystems in the environment.
Secondly, this substance has certain biological toxicity. Once it enters the organism, it may interfere with the normal physiological and biochemical processes of the organism. For example, it may be able to react with biological macromolecules such as proteins and nucleic acids in the organism, changing the structure and function of these macromolecules, thereby causing adverse effects on the growth, development and reproduction of the organism. If the organism is exposed to the environment containing 4-chloro-1,2-dicarboxylic anhydride for a long time, it may have genetic mutations, cytopathies and other conditions, and even cause the organism to die in severe cases.
Furthermore, the impact of 4-chloro-1,2-dicarboxylic anhydride on aquatic ecosystems is particularly significant. If it accidentally enters the water body, it will pose a threat to the survival of aquatic organisms. Phytoplankton are extremely sensitive to environmental changes. 4-chloro-1,2-dicarboxylic anhydride may inhibit the growth and reproduction of plankton, thereby destroying the balance of the entire aquatic food chain. Aquatic animals such as fish may cause damage to internal organs and physiological disorders due to ingestion of food containing this substance, or direct respiration and infiltration in contaminated water bodies.
In addition, in the process of production and use of 4-chloro-1,2-dicarboxylic anhydride, if the relevant wastes are not properly treated, the waste gas, wastewater and waste residue containing this substance may be discharged into the environment, which may cause all-round pollution to environmental factors such as the atmosphere, soil and water bodies. This substance in the atmosphere may enter the human body through respiration, causing harm to human health; after the soil is polluted, it may affect the absorption of nutrients by plants, hinder plant growth, and reduce crop yield and quality.
The degradation process of 4-chloro-1,2-dicarboxylic anhydride in the environment is relatively slow. Because its structure contains chlorine atoms, the covalent bond between chlorine atoms and carbon atoms is quite stable. Under normal natural conditions, it is not easy to fracture it. This allows it to persist in environmental media such as soil and water for a long time, gradually accumulating, and then affecting the structure and function of ecosystems in the environment.
Secondly, this substance has certain biological toxicity. Once it enters the organism, it may interfere with the normal physiological and biochemical processes of the organism. For example, it may be able to react with biological macromolecules such as proteins and nucleic acids in the organism, changing the structure and function of these macromolecules, thereby causing adverse effects on the growth, development and reproduction of the organism. If the organism is exposed to the environment containing 4-chloro-1,2-dicarboxylic anhydride for a long time, it may have genetic mutations, cytopathies and other conditions, and even cause the organism to die in severe cases.
Furthermore, the impact of 4-chloro-1,2-dicarboxylic anhydride on aquatic ecosystems is particularly significant. If it accidentally enters the water body, it will pose a threat to the survival of aquatic organisms. Phytoplankton are extremely sensitive to environmental changes. 4-chloro-1,2-dicarboxylic anhydride may inhibit the growth and reproduction of plankton, thereby destroying the balance of the entire aquatic food chain. Aquatic animals such as fish may cause damage to internal organs and physiological disorders due to ingestion of food containing this substance, or direct respiration and infiltration in contaminated water bodies.
In addition, in the process of production and use of 4-chloro-1,2-dicarboxylic anhydride, if the relevant wastes are not properly treated, the waste gas, wastewater and waste residue containing this substance may be discharged into the environment, which may cause all-round pollution to environmental factors such as the atmosphere, soil and water bodies. This substance in the atmosphere may enter the human body through respiration, causing harm to human health; after the soil is polluted, it may affect the absorption of nutrients by plants, hinder plant growth, and reduce crop yield and quality.
What are the precautions for 4-chlorobenzene-1,2-dicarboxylate during storage and transportation?
When storing and transporting 4-chloro-1,2-dichloroanisole, there are several matters to be paid attention to.
First, this material is toxic and irritating, and contact can cause human damage. Therefore, during the handling process, be sure to take good protection. Porters should wear protective clothing, protective gloves and goggles, and beware of skin and eye contact. If you come into contact accidentally, you need to rinse with plenty of water immediately. If it is serious, seek medical attention immediately.
Second, it is a chemical dangerous substance and should be stored in a cool, well-ventilated place away from fire and heat sources. At the same time, it should be stored separately from oxidants, acids, alkalis, etc., and should not be mixed to prevent chemical reactions and cause danger. The storage area should be equipped with suitable containment materials to deal with possible leaks.
Third, when transporting, be sure to abide by relevant laws and regulations. Transportation vehicles must have corresponding qualifications and be equipped with necessary emergency treatment equipment and protective supplies. During transportation, ensure that the container does not leak, collapse, fall, or damage, and prevent the leakage of items. If a leak occurs during transportation, emergency measures should be taken quickly to evacuate the surrounding people and properly dispose of the leak.
Fourth, this substance may be harmful to the environment and should be avoided from entering the environment. Whether it is storage or transportation, anti-leakage measures must be taken. Once a leak occurs, it needs to be cleaned up in time to prevent pollution to soil, water, etc. In short, for the storage and transportation of 4-chloro-1,2-dichloroanisole, all details need to be strictly treated to ensure the safety of personnel, the environment is not polluted and the transportation process is smooth.
First, this material is toxic and irritating, and contact can cause human damage. Therefore, during the handling process, be sure to take good protection. Porters should wear protective clothing, protective gloves and goggles, and beware of skin and eye contact. If you come into contact accidentally, you need to rinse with plenty of water immediately. If it is serious, seek medical attention immediately.
Second, it is a chemical dangerous substance and should be stored in a cool, well-ventilated place away from fire and heat sources. At the same time, it should be stored separately from oxidants, acids, alkalis, etc., and should not be mixed to prevent chemical reactions and cause danger. The storage area should be equipped with suitable containment materials to deal with possible leaks.
Third, when transporting, be sure to abide by relevant laws and regulations. Transportation vehicles must have corresponding qualifications and be equipped with necessary emergency treatment equipment and protective supplies. During transportation, ensure that the container does not leak, collapse, fall, or damage, and prevent the leakage of items. If a leak occurs during transportation, emergency measures should be taken quickly to evacuate the surrounding people and properly dispose of the leak.
Fourth, this substance may be harmful to the environment and should be avoided from entering the environment. Whether it is storage or transportation, anti-leakage measures must be taken. Once a leak occurs, it needs to be cleaned up in time to prevent pollution to soil, water, etc. In short, for the storage and transportation of 4-chloro-1,2-dichloroanisole, all details need to be strictly treated to ensure the safety of personnel, the environment is not polluted and the transportation process is smooth.
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