4-Chlorobenzene-1,3-Diol

Linshang Chemical

Specifications

HS Code

754545

Name 4-Chlorobenzene-1,3-Diol
Molecular Formula C6H5ClO2
Molecular Weight 144.555 g/mol
Appearance White to off - white solid
Boiling Point Approximately 264 - 266 °C
Melting Point 136 - 138 °C
Solubility In Water Slightly soluble
Solubility In Organic Solvents Soluble in ethanol, ether
Odor May have a faint phenolic odor
Cas Number 95 - 88 - 5

As an accredited 4-Chlorobenzene-1,3-Diol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500g of 4 - chlorobenzene - 1,3 - diol packaged in a sealed chemical - grade plastic bottle.
Storage 4 - chlorobenzene - 1,3 - diol should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent moisture absorption and evaporation. Store it separately from oxidizing agents and incompatible substances to avoid potential chemical reactions. Ensure proper labeling for easy identification and safety compliance.
Shipping 4 - chlorobenzene - 1,3 - diol is shipped in well - sealed containers, often within a climate - controlled environment to prevent degradation. Special handling procedures are followed due to its chemical nature to ensure safe transportation.
Free Quote

Competitive 4-Chlorobenzene-1,3-Diol prices that fit your budget—flexible terms and customized quotes for every order.

For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.

We will respond to you as soon as possible.

Tel: +8615365006308

Email: info@alchemist-chem.com

4-Chlorobenzene-1,3-Diol 4-Chlorobenzene-1,3-Diol
General Information
Where to Buy 4-Chlorobenzene-1,3-Diol in China?
As a trusted 4-Chlorobenzene-1,3-Diol manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 4-Chlorobenzene-1,3-Diol supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the chemical properties of 4-chlorobenzene-1,3-diol?
4-Chlorobenzene-1,3-diol (4-chlorobenzene-1,3-diol), which is one of the organic compounds. This substance has specific chemical properties.
Looking at its structure, the chlorine-containing atom and two hydroxyl groups are connected to the benzene ring. Hydroxyl groups are groups with active chemical properties and can participate in a variety of chemical reactions. First, esterification can occur. Due to the activity of hydroxyl groups, they can be dehydrated and condensed with acids under appropriate conditions to form ester compounds. This reaction is quite common in organic synthesis and can be used to prepare ester products with specific functions.
Furthermore, the hydroxyl groups in this compound are easily oxidized. In the presence of strong oxidizing agents, hydroxyl groups can be oxidized to carbonyl groups or oxygen-containing functional groups with higher valence states, and this oxidation reaction has a great impact on the transformation of their chemical properties.
Chlorine atoms also have unique effects on the benzene ring. Due to its large electronegativity, the electron cloud density distribution of the benzene ring can be changed, which affects the activity and selectivity of the electrophilic substitution reaction of the benzene ring. For example, in the electrophilic substitution reaction, the chlorine atom is an adjacent and para-site group, which makes the subsequent substitution reaction more likely to occur in the ortho and para-sites of the benzene ring.
In addition, 4-chlorobenzene-1,3-diol has a certain solubility in water because of its hydroxyl group, which can form hydrogen bonds with water molecules. This physical property is also closely related to its chemical environment, which affects its behavior and reactivity in different solvent systems. Its chemical properties are complex and diverse, and it has important research and application value in many fields of organic chemistry.
What are the main uses of 4-chlorobenzene-1,3-diol?
4-Chlorobenzene-1,3-diol, also known as 4-chloro-resorcinol, is widely used.
In the field of medicine, it can be used as a raw material to produce antibacterial and anti-inflammatory drugs. Because it has a certain antibacterial effect, it can resist specific bacteria from invading the human body, help relieve inflammatory symptoms, and relieve pain for patients. For example, some external anti-inflammatory ointments, 4-chlorobenzene-1,3-diol or as an important ingredient, are applied to the affected area to exert antibacterial and anti-inflammatory properties.
In the dye industry, it is a key intermediate for the synthesis of special dyes. With its unique chemical structure, it participates in the dye synthesis reaction, giving the dye special color and properties, such as improving the light resistance and washable properties of the dye. The dyes synthesized by it can be used for fabric dyeing to make the fabric color more vivid and lasting.
In the cosmetic industry, 4-chlorobenzene-1,3-diol is often used as a hair dye ingredient. It can bind to keratin in the hair to achieve the purpose of hair dyeing, and it is relatively less damaging to the hair. However, when used, the dose needs to be controlled to prevent adverse reactions such as allergies.
In addition, in the field of organic synthesis, it is used as an organic synthesizer to participate in many complex organic compound synthesis reactions, providing important raw material support for organic chemistry research and industrial production, and promoting the continuous development of organic synthesis chemistry.
What is the production method of 4-chlorobenzene-1,3-diol?
4-Chlorobenzene-1,3-diol, its preparation method is mostly based on chemical synthesis in the past. First, it can be started from the corresponding benzene derivative. Based on benzene, chlorine atoms are introduced into the benzene ring by halogenation to obtain chlorobenzene. When halogenating, choose the appropriate halogenating agent and reaction conditions. For example, chlorine gas is used as the halogenating agent, and the chlorine atom can be selected to replace the hydrogen of the benzene ring in the system under light or catalyst to obtain chlorobenzene.
Second, the reaction of phenylation of chlorobenzene is carried out. There are various methods of phenylation. Chlorobenzene and alkali metal hydroxides are often used in the environment of high temperature and pressure, and a phase transfer catalyst is added to help the chlorine atom be replaced by hydroxyl groups to obtain hydroxyl-containing chlorobenzene derivatives. In this process, the concentration of alkali, reaction temperature and time all have a great impact on the yield and purity of the product. Fine regulation of these factors can obtain the desired intermediate.
Furthermore, for the obtained hydroxyl-containing chlorobenzene derivatives, another hydroxyl group is introduced at a specific position in the benzene ring by oxidation or other functional group transformation. This step also requires careful selection of reaction reagents and conditions to ensure that the position of hydroxyl group introduction is accurate. During the oxidation process, suitable oxidants, such as certain metal oxides or peroxides, should be selected. In a mild reaction environment, hydrogen at a specific position on the benzene ring is replaced by hydroxyl groups, and 4-chlorobenzene-1,3-diol is finally obtained.
However, this method may have the disadvantages of cumbersome steps, many side reactions, and low yield. In today's world, there are also those who explore biosynthetic methods. By leveraging the catalytic properties of microorganisms or enzymes, the synthesis is completed under mild reaction conditions. It is expected to avoid the shortcomings of traditional chemical methods. However, it is still in the stage of research and development. If it is to be used maturely, it will take time to improve.
What should be paid attention to when storing and transporting 4-chlorobenzene-1,3-diol?
4-Chlorobenzene-1,3-diol is a chemical substance. When storing and transporting, many matters must be paid attention to.
First words storage. This substance should be placed in a cool, dry and well-ventilated place. Because of its fear of heat, if it is placed in a high temperature place, it may cause changes in properties and even cause dangerous reactions. Therefore, the temperature of the warehouse should be controlled at a suitable degree, and it should not be fumigated by heat. And because of its requirements for humidity, humid places are prone to moisture, which affects the purity and quality of the substance, so it is necessary to keep it dry. Furthermore, it should be stored separately from oxidants, acids, bases and other substances. All of these may react chemically with 4-chlorobenzene-1,3-diol, causing accidents and cannot be ignored. And the storage place must be clearly marked, indicating the name of the substance, characteristics and precautions for use and management.
Second talk about transportation. When transporting, the packaging must be tight and sturdy. To prevent damage to the container and leakage of substances during the bumpy road. The packaging materials used must be able to withstand the erosion of this substance and not react with it. The transportation vehicle should also be clean and free of other chemicals that may interfere with it. And during transportation, avoid sun and rain, and must not be exposed to bad weather conditions. The escort must also be familiar with the characteristics of this substance and emergency treatment methods. In case of leakage and other incidents, they can be dealt with in time to avoid major disasters.
All of these, in the storage and transportation of 4-chlorobenzene-1,3-diol, are the key, must not be negligent, and must be done with caution to ensure safety.
What are the effects of 4-chlorobenzene-1,3-diol on the environment and human body?
4-Chlorobenzene-1,3-diol, the impact of this substance on the environment and human body is quite critical, let me explain in detail.
In terms of the environment, if this compound is released in nature, it may have many effects. First, it may be toxic to aquatic organisms. If it flows into rivers, lakes and seas, it may cause physiological disorders such as fish, shrimp, and plankton in the water, affecting their reproduction, growth, and even death, thereby destroying the balance of aquatic ecosystems. Second, in the soil environment, or change the soil microbial community structure. Due to its chemical properties, it may inhibit the growth of some beneficial microorganisms, affect soil nutrient cycling and material transformation, and have indirect adverse effects on vegetation growth. Third, in the atmosphere, although it is volatile or not high, if it is complicated by atmospheric chemical reactions or converted into more harmful substances, it will affect the air quality.
As for the impact on the human body, it cannot be ignored. Inhalation through the respiratory tract, or irritation of the respiratory mucosa, causes cough, asthma and other uncomfortable symptoms, long-term exposure, or aggravates respiratory diseases. If it is exposed to the skin, or causes skin allergies, redness, swelling, itching and other phenomena, because it is corrosive, or damages the skin tissue. More serious cases, if accidentally ingested, or affect the function of internal organs of the human body. In the digestive system, or cause gastrointestinal discomfort, vomiting, diarrhea, etc.; in the nervous system, or interfere with nerve conduction, making people feel dizzy and weak. Long-term ingestion may cause damage to important organs such as the liver and kidneys, affecting their normal metabolism and detoxification functions.
In short, 4-chlorobenzene-1,3-diol is potentially harmful to the environment and the human body. When producing, using and handling this substance, it is necessary to exercise caution and take proper protection and handling measures to reduce its adverse effects on the environment and the human body.
What are the chemical properties of 4-chlorobenzene-1,3-diol?
4-Chlorobenzene-1,3-diol, that is, 4-chloro-1,3-catechol, has the following chemical properties:
This substance has the general properties of phenols and is active. Phenolic hydroxyl groups are weakly acidic and can react with bases, just like weak acids meet bases to form corresponding phenolic salts. It reacts with sodium hydroxide to obtain sodium phenol and water.
Because its structure contains phenyl rings and phenolic hydroxyl groups, it has certain nucleophilicity and is prone to electrophilic substitution reactions with electrophilic reagents. The electron cloud density on the phenolic ring increases due to the electron-giving conjugation effect of phenolic hydroxyl groups, which enhances its electrophilic substitution reaction activity. Under appropriate conditions, it can interact with electrophilic reagents such as halogenating agents and nitrifying agents. If it encounters bromine water, the hydrogen atoms of the phenolic hydroxyl group are active and easily replaced by bromine atoms to form brominated products.
The phenyl ring of 4-chloro-1,3-catechol can undergo hydrogenation and reduction reaction. Under suitable catalysts and conditions, the phenyl ring can be partially or completely hydrogenated to form corresponding cycloalkanol derivatives. At the same time, the phenolic hydroxyl group is reductive and easy to be oxidized. In case of strong oxidizing agents, the phenolic hydroxyl group can be oxidized to quinones and other products; even if it is oxygen in the air, it can be slowly oxidized under certain conditions, resulting in darker color. And because it contains chlorine atoms, under certain conditions, chlorine atoms can undergo transformations such as substitution reactions.
Where is 4-chlorobenzene-1,3-diol used?
4-Chlorobenzene-1,3-diol, also known as 4-chloro-resorcinol, is useful in many fields.
In the field of medicine, it is quite valuable. It can be used as a raw material for pharmaceutical synthesis and participates in the preparation process of many drugs. Because it has specific chemical properties, it can cleverly react with other compounds to generate substances with therapeutic effects. For example, in the synthesis of some antibacterial drugs, 4-chlorobenzene-1,3-diol can fill the body and react carefully with other reagents to construct drug components that have inhibitory or killing effects on specific bacteria, contributing to human resistance to diseases.
In the cosmetics industry, 4-chlorobenzene-1,3-diol also has a place. It can be used as a key ingredient in hair dyes. Because it can combine with keratin in the hair, it can change the hair color with the help of a specific chemical reaction, and can maintain a certain degree of durability and stability. At the same time, under the premise of considering its safety, appropriate use can meet people's needs for hairdressing, making hair color more diverse.
Furthermore, in the chemical industry, it is also an important intermediate. The synthesis of many fine chemicals is inseparable from it. For example, in the preparation of certain high-performance plastic additives and special coating additives, 4-chlorobenzene-1,3-diol can participate in complex chemical reaction pathways, providing products with excellent characteristics such as better stability and weather resistance, thus improving the quality and performance of chemical products and meeting the requirements of different industrial scenarios.
What are the preparation methods of 4-chlorobenzene-1,3-diol?
4-Chlorobenzene-1,3-diol, also known as 4-chloro-resorcinol, is prepared by the following methods.
First, resorcinol is used as the starting material to react with chlorine-containing reagents. Chlorinated reagents such as thionyl chloride, phosphorus oxychloride, etc. can be selected. Taking thionyl chloride as an example, in a suitable solvent such as dichloromethane, in the presence of a suitable temperature and catalyst, resorcinol reacts with thionyl chloride. In this process, the chlorine atom of thionyl chloride replaces the hydrogen atom at a specific position on the phenyl ring of resorcinol. After reaction, separation, purification and other steps, 4-chlorobenzene-1,3-diol can be obtained. The key to this method lies in the precise control of the reaction conditions. If the temperature is too high or too low, it can affect the yield and purity of the product.
Second, it can be started from other benzene compounds. For example, select a suitable benzene ring derivative, first perform functional group transformation to construct a suitable substituent distribution, and then introduce chlorine atoms through halogenation reaction, and then adjust the functional group through a series of reactions to achieve the purpose of generating 4-chlorobenzene-1,3-diol. This approach requires a multi-step reaction, and the steps are relatively complicated. However, if the reaction conditions of each step are properly optimized, the target product can also be obtained. It is necessary to pay attention to the connection between the reactions of each step and the purification of the intermediate product to prevent the accumulation of impurities from affecting the quality of the final product.
Third, by means of the catalytic reaction method. Appropriate catalysts, such as metal catalysts or enzyme catalysts, are used to promote the reaction in the direction of generating 4-chlorobenzene-1,3-diol. Metal catalysts can activate the reactant molecules and reduce the activation energy of the reaction; enzyme catalysts are highly selective and can precisely catalyze specific reactions. However, when selecting a catalyst, factors such as its activity, selectivity, cost, and recycling need to be considered in order to make the method practical.
What is the market price of 4-chlorobenzene-1,3-diol?
The market price of 4-chlorobenzene-1,3-diol is volatile due to a variety of factors.
In the market, the price of 4-chlorobenzene-1,3-diol is often caused by the interaction of various factors. The first one to bear the brunt is the balance between supply and demand. If the demand for emerging industries, such as medicine, dyes, etc., increases sharply, and the supply fails to follow in time, the price will rise. On the contrary, if there is a small demand and the output is full, the price will inevitably fall.
Furthermore, the price of raw materials also plays a crucial role. The preparation of 4-chloro-resorcinol requires specific raw materials. If the price of these raw materials fluctuates due to disasters in the production area or policy changes, the price of 4-chloro-resorcinol will also fluctuate. For example, if the production of raw materials is reduced due to unfavorable weather, the price of 4-chloro-resorcinol will soar, and the cost of 4-chloro-resorcinol will increase sharply, and its price in the market will also rise.
The technology and cost of production also affect the price. If the new technology comes out, the production efficiency can be greatly increased and the cost can be greatly reduced, the price may be reduced. However, if the production process is complicated, expensive equipment and reagents are required, and the cost remains high, the price will not be greatly reduced.
Regional differences also make prices different. In places with convenient transportation and prosperous markets, supply and demand circulate smoothly, and prices may stabilize; while in remote and remote soils, transportation is difficult, costs are accumulated, and prices may be high.
In addition, the competitive situation of the market also has an impact. If there are many competitors in the same industry, they may compete for market share, or there may be price reduction promotions; if there is a unique company, there is no semicolon, and the pricing power depends on their hands, and the price may be high.
Therefore, in order to know the exact market price of 4-chlororesorcinol, an approximate value can be obtained by studying many factors such as market supply and demand, raw material prices, production conditions, regional differences, and competition in real time.
What are the environmental effects of 4-chlorobenzene-1,3-diol?
4-Chlorobenzene-1,3-diol, the impact of this substance on the environment is particularly important and cannot be ignored.
Its effect on the environment is the first to involve ecological balance. If released in nature or into water bodies, aquatic organisms may suffer from it. Because 4-chlorobenzene-1,3-diol has chemical activity, or breaks the cell structure of aquatic organisms, disturbing their physiological functions. Such as algae, photosynthesis or inhibition, resulting in poor growth, which in turn disrupts the bottom foundation of the food chain, affects the survival and reproduction of many organisms upstream and downstream, and endangers the stability of aquatic ecosystems.
In the soil environment, if its residues accumulate, or change the soil microbial community structure and function. Microorganisms are crucial for soil material recycling and nutrient transformation. 4-chlorobenzene-1,3-diol may inhibit the growth of beneficial microorganisms, break the soil ecological balance, reduce soil fertility, and affect plant growth.
In the atmospheric environment, although its volatilization may be limited, it may generate harmful secondary pollutants through photochemical reactions. And its odor may cause air quality to deteriorate, affecting the lives and health of surrounding residents.
Furthermore, the degradability of 4-chlorobenzene-1,3-diol is also related to the environment. If it is difficult to degrade, it will exist in the environment for a long time, continue to accumulate, and be more harmful. And its degradation products may have different environmental effects, or be more toxic and lasting, and need to be investigated in detail.
In conclusion, the environmental impact of 4-chlorobenzene-1,3-diol is multi-faceted and complex, and it is related to various elements of the ecosystem. It needs to be treated with caution and studied in detail to clarify its nature and protect the safety of the ecological environment.