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4-Chlorobenzene-1-Carboximidamide Hydrochloride
Linshang Chemical
|
HS Code |
166062 |
| Chemical Formula | C7H8Cl2N2 |
| Molar Mass | 191.057 g/mol |
| Appearance | Solid |
| Solubility In Water | Moderate |
| Boiling Point | Decomposes before boiling |
| Melting Point | 238 - 242 °C |
| Odor | Typically pungent, characteristic of imidamide - like compounds |
| Ph Aqueous Solution | Acidic due to the hydrochloride part |
| Stability | Stable under normal conditions but may react with strong oxidizing agents |
As an accredited 4-Chlorobenzene-1-Carboximidamide Hydrochloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - chlorobenzene - 1 - carboximidamide Hydrochloride in a sealed plastic bag. |
| Storage | 4 - chlorobenzene - 1 - carboximidamide Hydrochloride should be stored in a cool, dry place away from direct sunlight. Keep it in a tightly sealed container to prevent moisture absorption and exposure to air. Store it separately from incompatible substances to avoid potential chemical reactions. Ensure the storage area is well - ventilated to minimize the risk of harmful fumes accumulation. |
| Shipping | 4 - chlorobenzene - 1 - carboximidamide Hydrochloride is shipped in well - sealed containers, following strict chemical transportation regulations. Special care is taken to prevent exposure, with proper labeling for hazard identification during transit. |
Competitive 4-Chlorobenzene-1-Carboximidamide Hydrochloride prices that fit your budget—flexible terms and customized quotes for every order.
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4-chlorobenzene-1-carboximidamide chemical structure of hydrochloride
4 - chlorobenzene - 1 - carboximidamide Hydrochloride is 4 - chlorobenzene hydrochloride. Its chemical structure is as follows.
This compound is composed of a benzene ring as the core structure, and is connected to a formamidine group (-C (= NH) NH 2) at position 1 of the benzene ring, and a chlorine atom (-Cl) at position 4. The overall structure is planar. The carbon atom in the formamidine group is connected to the benzene ring by a single carbon-carbon bond, and the carbon atom is connected to two nitrogen atoms by double bonds and single bonds to form a special amidine structure. The lone pair of electrons on the nitrogen atom makes the formamidine group have a certain alkalinity. The chlorine atom at position 4 is a substituent with strong electronegativity, and its existence will affect the electron cloud distribution of the benzene ring, resulting in a relatively low electron cloud density of the benzene ring.
When hydrochloride is formed, the nitrogen atom in the formamidine group combines with the hydrogen ion (H 🥰) in hydrochloric acid with its lone pair electrons to form a positively charged ionic structure, while the chloride ion (Cl) acts as a counterion to balance the charge, thereby forming a stable ionic compound 4-chlorobenzamidine hydrochloride. This structure endows the compound with good solubility in water and other physical and chemical properties.
This compound is composed of a benzene ring as the core structure, and is connected to a formamidine group (-C (= NH) NH 2) at position 1 of the benzene ring, and a chlorine atom (-Cl) at position 4. The overall structure is planar. The carbon atom in the formamidine group is connected to the benzene ring by a single carbon-carbon bond, and the carbon atom is connected to two nitrogen atoms by double bonds and single bonds to form a special amidine structure. The lone pair of electrons on the nitrogen atom makes the formamidine group have a certain alkalinity. The chlorine atom at position 4 is a substituent with strong electronegativity, and its existence will affect the electron cloud distribution of the benzene ring, resulting in a relatively low electron cloud density of the benzene ring.
When hydrochloride is formed, the nitrogen atom in the formamidine group combines with the hydrogen ion (H 🥰) in hydrochloric acid with its lone pair electrons to form a positively charged ionic structure, while the chloride ion (Cl) acts as a counterion to balance the charge, thereby forming a stable ionic compound 4-chlorobenzamidine hydrochloride. This structure endows the compound with good solubility in water and other physical and chemical properties.
What are the physical properties of 4-chlorobenzene-1-carboximidamide Hydrochloride?
4-Chlorobenzamidine hydrochloride is an organic compound. Its physical properties are quite important and are related to many fields of application.
This compound is mostly in the state of white crystalline powder under normal conditions, which is easy to store and transport, and is also conducive to subsequent processing. Its melting point is quite high, about 240-245 ° C. The higher melting point indicates that the intermolecular force is strong, the structure is relatively stable, and it can maintain its own shape and properties in high temperature environments. In some chemical reactions or industrial processes that require high temperature treatment, this property is of great significance.
4-Chlorobenzamidine hydrochloride has a certain solubility in water. It can be dissolved in water to form a uniform solution, and this property is significant in the fields of drug preparation, chemical analysis, etc. Because in these processes, it is often necessary to dissolve the compound in a solvent to achieve reaction or detection. However, its solubility in organic solvents varies depending on the type of solvent. It has better solubility in polar organic solvents such as methanol and ethanol, and poor solubility in non-polar organic solvents such as benzene and toluene. This difference in solubility provides a basis for the separation, purification and selection of specific reaction environments for compounds.
Furthermore, 4-chlorobenzamidine hydrochloride has hygroscopicity. It is easy to absorb moisture in the air in a humid environment, which requires that attention be paid to moisture-proof during storage to prevent the properties of the compound from changing due to moisture absorption and affecting its use effect.
In addition, its appearance is clean, free of obvious impurities and odors, which is essential for some application scenarios that require strict purity and quality, such as medicine, food additives and other fields.
In short, the white crystalline powder morphology, high melting point, specific solubility and hygroscopicity of 4-chlorobenzamidine hydrochloride play a decisive role in its application in chemical industry, medicine, agriculture and many other fields. Only by understanding and controlling these properties can its effectiveness be better exerted.
This compound is mostly in the state of white crystalline powder under normal conditions, which is easy to store and transport, and is also conducive to subsequent processing. Its melting point is quite high, about 240-245 ° C. The higher melting point indicates that the intermolecular force is strong, the structure is relatively stable, and it can maintain its own shape and properties in high temperature environments. In some chemical reactions or industrial processes that require high temperature treatment, this property is of great significance.
4-Chlorobenzamidine hydrochloride has a certain solubility in water. It can be dissolved in water to form a uniform solution, and this property is significant in the fields of drug preparation, chemical analysis, etc. Because in these processes, it is often necessary to dissolve the compound in a solvent to achieve reaction or detection. However, its solubility in organic solvents varies depending on the type of solvent. It has better solubility in polar organic solvents such as methanol and ethanol, and poor solubility in non-polar organic solvents such as benzene and toluene. This difference in solubility provides a basis for the separation, purification and selection of specific reaction environments for compounds.
Furthermore, 4-chlorobenzamidine hydrochloride has hygroscopicity. It is easy to absorb moisture in the air in a humid environment, which requires that attention be paid to moisture-proof during storage to prevent the properties of the compound from changing due to moisture absorption and affecting its use effect.
In addition, its appearance is clean, free of obvious impurities and odors, which is essential for some application scenarios that require strict purity and quality, such as medicine, food additives and other fields.
In short, the white crystalline powder morphology, high melting point, specific solubility and hygroscopicity of 4-chlorobenzamidine hydrochloride play a decisive role in its application in chemical industry, medicine, agriculture and many other fields. Only by understanding and controlling these properties can its effectiveness be better exerted.
What are the main uses of 4-chlorobenzene-1-carboximidamide hydrochloride?
4-Chlorobenzamidine hydrochloride is an organic compound. It has a wide range of uses and is often used as a key intermediate in the field of pharmaceutical synthesis. Because it can participate in the construction of many drug molecules, through chemical reactions, it interacts with other compounds to generate drugs with specific pharmacological activities.
In the field of pesticide creation, it also plays an important role. It can be used as a raw material for the synthesis of new pesticides. The synthesized pesticides may have efficient killing or inhibitory effects on pests, adding to the control of agricultural pests.
In the field of material science, some of its properties may enable it to be used to synthesize materials with specific functions. For example, it may be possible to participate in the preparation of materials with special adsorption or electrical properties, which can be used in fields such as separation membrane materials or electronic device materials.
In summary, 4-chlorobenzamidine hydrochloride has important applications in many fields such as medicine, pesticides and materials science due to its unique chemical structure, and has made great contributions to the development of related fields.
In the field of pesticide creation, it also plays an important role. It can be used as a raw material for the synthesis of new pesticides. The synthesized pesticides may have efficient killing or inhibitory effects on pests, adding to the control of agricultural pests.
In the field of material science, some of its properties may enable it to be used to synthesize materials with specific functions. For example, it may be possible to participate in the preparation of materials with special adsorption or electrical properties, which can be used in fields such as separation membrane materials or electronic device materials.
In summary, 4-chlorobenzamidine hydrochloride has important applications in many fields such as medicine, pesticides and materials science due to its unique chemical structure, and has made great contributions to the development of related fields.
What are the synthetic methods of 4-chlorobenzene-1-carboximidamide Hydrochloride?
There are many different ways to synthesize 4-chlorobenzamidine hydrochloride. The most common one is to use 4-chlorobenzonitrile as the starting material. In the reactor, an appropriate amount of alcohol solvent, such as ethanol or methanol, is first added, and then 4-chlorobenzonitrile is added. Then ammonia is slowly added, and it is fully reacted at a specific temperature and pressure. This process requires precise temperature control. The temperature should be maintained between 30 ° C and 50 ° C, and the pressure is about 0.5 MPa to 1.5 MPa. When the reaction continues, the content of 4-chlorobenzonitrile in the reaction solution is reduced to a very low level before the reaction is completed. After that, it is neutralized with dilute hydrochloric acid, the solvent is removed by reduced pressure distillation, and then recrystallized with an appropriate amount of organic solvent to obtain pure 4-chlorobenzamidine hydrochloride.
There is also another method, which is to use 4-chlorobenzoic acid as the starting material. First, 4-chlorobenzoic acid is co-heated with dichlorosulfoxide, and an acylation reaction occurs to obtain 4-chlorobenzoyl chloride. This step of the reaction temperature is quite high, about 70 ° C to 90 ° C, and needs to be carried out under the protection of inert gas. After the acylation reaction is completed, the reaction liquid is cooled, and then at a low temperature, such as 0 ° C to 10 ° C, ammonia water is added dropwise to Subsequently, 4-chlorobenzamidine hydrochloride can be obtained by acidification with hydrochloric acid, extraction, drying, recrystallization and other series operations.
Another method is to use 4-chloronitrobenzene as the starting material. First, 4-chloronitrobenzene is reduced to 4-chloroaniline, often with iron powder and hydrochloric acid as the reducing agent. After obtaining 4-chloroaniline, it is reacted with cyanamide under specific conditions, such as heating in an appropriate solvent in the presence of an alkaline catalyst. After the reaction is completed, the purpose of synthesizing 4-chlorobenzamidine hydrochloride can also be achieved through acidification, separation and purification.
There is also another method, which is to use 4-chlorobenzoic acid as the starting material. First, 4-chlorobenzoic acid is co-heated with dichlorosulfoxide, and an acylation reaction occurs to obtain 4-chlorobenzoyl chloride. This step of the reaction temperature is quite high, about 70 ° C to 90 ° C, and needs to be carried out under the protection of inert gas. After the acylation reaction is completed, the reaction liquid is cooled, and then at a low temperature, such as 0 ° C to 10 ° C, ammonia water is added dropwise to Subsequently, 4-chlorobenzamidine hydrochloride can be obtained by acidification with hydrochloric acid, extraction, drying, recrystallization and other series operations.
Another method is to use 4-chloronitrobenzene as the starting material. First, 4-chloronitrobenzene is reduced to 4-chloroaniline, often with iron powder and hydrochloric acid as the reducing agent. After obtaining 4-chloroaniline, it is reacted with cyanamide under specific conditions, such as heating in an appropriate solvent in the presence of an alkaline catalyst. After the reaction is completed, the purpose of synthesizing 4-chlorobenzamidine hydrochloride can also be achieved through acidification, separation and purification.
4-chlorobenzene-1-carboximidamide Hydrochloride in storage and transportation
4-Chlorobenzamidine hydrochloride is a chemical substance. When storing and transporting, there are several important items to pay attention to.
First words storage, this substance should be stored in a cool, dry and well-ventilated place. Because it may be sensitive to temperature and humidity, if it is placed in a high temperature and humid place, it may cause deterioration. Therefore, the temperature of the warehouse should be controlled within a suitable range, not too high, and the humidity should also be maintained at a low level to prevent moisture dissolution and other conditions. Furthermore, it needs to be stored in isolation from oxidants, acids, alkalis, etc. Due to the chemical properties of 4-chlorobenzamidine hydrochloride, contact with them can easily cause chemical reactions, or cause fire, explosion and other risks. And the storage place should be equipped with suitable materials to contain leaks in case of leakage, which can be properly handled in time.
As for transportation, it should not be underestimated. Before transportation, it is necessary to ensure that the packaging is complete, and the packaging material must be able to resist vibration, collision and friction to prevent material leakage due to package damage. During transportation, the vehicle should drive smoothly to avoid bumps and sudden braking. Transport personnel should also be familiar with the characteristics of this substance and emergency treatment methods. If there is a leak on the way, they can deal with it quickly and properly. And the transportation vehicles should not be mixed with the above-mentioned taboo substances, so as not to cause disasters due to interaction during transportation. In short, whether storing or transporting 4-chlorobenzamidine hydrochloride, it is necessary to adhere to its chemical properties and adhere to specifications to ensure safety.
First words storage, this substance should be stored in a cool, dry and well-ventilated place. Because it may be sensitive to temperature and humidity, if it is placed in a high temperature and humid place, it may cause deterioration. Therefore, the temperature of the warehouse should be controlled within a suitable range, not too high, and the humidity should also be maintained at a low level to prevent moisture dissolution and other conditions. Furthermore, it needs to be stored in isolation from oxidants, acids, alkalis, etc. Due to the chemical properties of 4-chlorobenzamidine hydrochloride, contact with them can easily cause chemical reactions, or cause fire, explosion and other risks. And the storage place should be equipped with suitable materials to contain leaks in case of leakage, which can be properly handled in time.
As for transportation, it should not be underestimated. Before transportation, it is necessary to ensure that the packaging is complete, and the packaging material must be able to resist vibration, collision and friction to prevent material leakage due to package damage. During transportation, the vehicle should drive smoothly to avoid bumps and sudden braking. Transport personnel should also be familiar with the characteristics of this substance and emergency treatment methods. If there is a leak on the way, they can deal with it quickly and properly. And the transportation vehicles should not be mixed with the above-mentioned taboo substances, so as not to cause disasters due to interaction during transportation. In short, whether storing or transporting 4-chlorobenzamidine hydrochloride, it is necessary to adhere to its chemical properties and adhere to specifications to ensure safety.
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