Linshang Chemical
PRODUCTS
4-Chlorobenzene-1-Carboximidamidehcl
Linshang Chemical
|
HS Code |
473036 |
| Name | 4-Chlorobenzene-1-Carboximidamide hcl |
| Chemical Formula | C7H8Cl2N2 |
| Molar Mass | 191.057 g/mol |
| Appearance | Solid |
| Solubility In Water | Moderately soluble |
| Melting Point | Typically in a certain range (exact value depends on purity) |
| Pka Value | Specific value related to its acidic - basic properties |
| Density | Certain value (depends on physical state and conditions) |
| Odor | May have a characteristic odor |
As an accredited 4-Chlorobenzene-1-Carboximidamidehcl factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 4 - chlorobenzene - 1 - carboximidamide HCl in sealed, labeled plastic bags. |
| Storage | 4 - chlorobenzene - 1 - carboximidamide HCl should be stored in a cool, dry place away from direct sunlight. Keep it in a tightly - sealed container to prevent moisture absorption and potential reactions with air components. Store it separately from incompatible substances like strong oxidizers or bases to avoid chemical reactions. Ensure the storage area has good ventilation. |
| Shipping | 4 - chlorobenzene - 1 - carboximidamide HCl is shipped in well - sealed containers, compliant with chemical transportation regulations. Packaging ensures protection from moisture, physical damage, and is clearly labeled for safe handling during transit. |
Competitive 4-Chlorobenzene-1-Carboximidamidehcl prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 4-Chlorobenzene-1-Carboximidamidehcl in China?
As a trusted 4-Chlorobenzene-1-Carboximidamidehcl manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 4-Chlorobenzene-1-Carboximidamidehcl supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 4-chlorobenzene-1-carboximidamide HCL?
4-Chlorobenzene-1-carboximidamide + HCl is widely used in the chemical and pharmaceutical fields.
It is often a key intermediate in organic synthesis. It can be combined with various reagents through a specific reaction path to prepare other nitrogen-containing organic compounds. Such reactions can help chemists build diverse and complex molecular structures, which are essential for the creation of novel organic materials and fine chemicals.
In the field of medicine, its significance is extraordinary. Some studies show that the compound may have certain biological activity. Or it can be used as a lead compound for medical researchers to explore in depth. After structural modification and optimization, it is expected to derive new drugs with specific pharmacological effects. For example, in the development of antibacterial, anti-inflammatory and other drugs, the chemical structural properties of 4-chlorbenzamidine hydrochloride may provide ideas and bases for finding effective active ingredients.
Furthermore, in the field of materials science, this can be used as a raw material for specific processing processes, or materials with special properties can be prepared. For example, in the synthesis of some functional polymers, it may participate in reactions, endowing materials with different physical and chemical properties, such as improving material stability, solubility, etc., thereby broadening the application scenarios of materials.
It is often a key intermediate in organic synthesis. It can be combined with various reagents through a specific reaction path to prepare other nitrogen-containing organic compounds. Such reactions can help chemists build diverse and complex molecular structures, which are essential for the creation of novel organic materials and fine chemicals.
In the field of medicine, its significance is extraordinary. Some studies show that the compound may have certain biological activity. Or it can be used as a lead compound for medical researchers to explore in depth. After structural modification and optimization, it is expected to derive new drugs with specific pharmacological effects. For example, in the development of antibacterial, anti-inflammatory and other drugs, the chemical structural properties of 4-chlorbenzamidine hydrochloride may provide ideas and bases for finding effective active ingredients.
Furthermore, in the field of materials science, this can be used as a raw material for specific processing processes, or materials with special properties can be prepared. For example, in the synthesis of some functional polymers, it may participate in reactions, endowing materials with different physical and chemical properties, such as improving material stability, solubility, etc., thereby broadening the application scenarios of materials.
What are the physical properties of 4-chlorobenzene-1-carboximidamide HCL?
4-Chlorobenzamidine hydrochloride is one of the organic compounds. Its physical properties are quite unique.
Looking at its appearance, it is often in the state of white to light yellow crystalline powder, which is easy to observe and operate. When it comes to solubility, it is soluble in water. This property makes it well dispersed and involved in many chemical reactions or preparations involving the aqueous phase. Because it is soluble in water, it can be more evenly distributed in the aqueous solution, which is conducive to the full progress of related reactions.
As for the melting point, it also has a specific value. This value is of great significance for the identification of the substance, the determination of purity, and the consideration of stability under different temperature conditions. By accurately measuring the melting point, the purity of the substance can be preliminarily judged. If the melting point is consistent with the standard value and the melting range is narrow, it usually indicates high purity; conversely, if the melting point is deviated or the melting range is wide, there may be impurities.
In terms of stability, 4-chlorobenzamidine hydrochloride is relatively stable at room temperature and pressure. However, in case of extreme conditions such as high temperature, open flame, or contact with certain chemical substances, chemical reactions may be triggered, resulting in changes in its properties. Therefore, during storage and use, care should be taken to avoid such adverse situations to ensure the stability of its properties and the safety of use.
Furthermore, the odor of the substance is weak, although it does not produce a strong irritating odor to interfere with the experimental or production environment, but during the operation, it should still follow the specifications and take protective measures to prevent potential hazards.
Looking at its appearance, it is often in the state of white to light yellow crystalline powder, which is easy to observe and operate. When it comes to solubility, it is soluble in water. This property makes it well dispersed and involved in many chemical reactions or preparations involving the aqueous phase. Because it is soluble in water, it can be more evenly distributed in the aqueous solution, which is conducive to the full progress of related reactions.
As for the melting point, it also has a specific value. This value is of great significance for the identification of the substance, the determination of purity, and the consideration of stability under different temperature conditions. By accurately measuring the melting point, the purity of the substance can be preliminarily judged. If the melting point is consistent with the standard value and the melting range is narrow, it usually indicates high purity; conversely, if the melting point is deviated or the melting range is wide, there may be impurities.
In terms of stability, 4-chlorobenzamidine hydrochloride is relatively stable at room temperature and pressure. However, in case of extreme conditions such as high temperature, open flame, or contact with certain chemical substances, chemical reactions may be triggered, resulting in changes in its properties. Therefore, during storage and use, care should be taken to avoid such adverse situations to ensure the stability of its properties and the safety of use.
Furthermore, the odor of the substance is weak, although it does not produce a strong irritating odor to interfere with the experimental or production environment, but during the operation, it should still follow the specifications and take protective measures to prevent potential hazards.
4-chlorobenzene-1-carboximidamide the chemical properties of HCL
4-Chlorobenzamidine hydrochloride, this is an organic compound. Its chemical properties are quite unique and have many characteristics.
Looking at its physical properties, 4-chlorobenzamidine hydrochloride is often in the state of white to light yellow crystalline powder, which is quite stable at room temperature and pressure. Its solubility also has characteristics, and it can be soluble in polar solvents such as water and alcohol. This characteristic is due to the polar groups in its molecular structure, which can form strong interactions with polar solvents, such as hydrogen bonds, so that it is easily soluble in such solvents.
When it comes to chemical activity, the amidine group of this compound is a highly reactive site. Under suitable conditions, the nitrogen atom of the amidine group can be used as a nucleophilic reagent to react with electrophilic reagents, such as nucleophilic substitution reactions. For example, when it encounters electrophilic reagents such as acyl halide and acid anhydride, an acylation reaction can occur, and an acyl group is introduced on the amidine nitrogen atom to generate the corresponding amide derivative.
Furthermore, its hydrochloric acid salt form imparts a certain acidity to the compound. In aqueous solutions, hydrochloride ions can be partially dissociated, making the solution weakly acidic. This acidic property makes it play a unique role in certain acid-base related reactions, or participate in acid-base neutralization reactions, or act as an acidic catalyst to catalyze the progress of specific organic reactions.
In addition, the benzene ring structure of 4-chlorobenzamidine hydrochloride also affects its chemical properties. The benzene ring has a conjugated system, which makes the molecule stable. At the same time, the chlorine atoms on the benzene ring can participate in aromatic nucleophilic substitution reactions, etc., expanding the reaction path and application scope of the compound. In short, the chemical properties of 4-chlorobenzamidine hydrochloride are rich and diverse, and it may have important uses in organic synthesis and other fields.
Looking at its physical properties, 4-chlorobenzamidine hydrochloride is often in the state of white to light yellow crystalline powder, which is quite stable at room temperature and pressure. Its solubility also has characteristics, and it can be soluble in polar solvents such as water and alcohol. This characteristic is due to the polar groups in its molecular structure, which can form strong interactions with polar solvents, such as hydrogen bonds, so that it is easily soluble in such solvents.
When it comes to chemical activity, the amidine group of this compound is a highly reactive site. Under suitable conditions, the nitrogen atom of the amidine group can be used as a nucleophilic reagent to react with electrophilic reagents, such as nucleophilic substitution reactions. For example, when it encounters electrophilic reagents such as acyl halide and acid anhydride, an acylation reaction can occur, and an acyl group is introduced on the amidine nitrogen atom to generate the corresponding amide derivative.
Furthermore, its hydrochloric acid salt form imparts a certain acidity to the compound. In aqueous solutions, hydrochloride ions can be partially dissociated, making the solution weakly acidic. This acidic property makes it play a unique role in certain acid-base related reactions, or participate in acid-base neutralization reactions, or act as an acidic catalyst to catalyze the progress of specific organic reactions.
In addition, the benzene ring structure of 4-chlorobenzamidine hydrochloride also affects its chemical properties. The benzene ring has a conjugated system, which makes the molecule stable. At the same time, the chlorine atoms on the benzene ring can participate in aromatic nucleophilic substitution reactions, etc., expanding the reaction path and application scope of the compound. In short, the chemical properties of 4-chlorobenzamidine hydrochloride are rich and diverse, and it may have important uses in organic synthesis and other fields.
What is the production method of 4-chlorobenzene-1-carboximidamide HCL?
The preparation of 4-chlorobenzene-1-carboximidamide + HCl is an ancient method of multi-step chemical synthesis.
First, 4-chlorobenzene is often used as the starting material. 4-chlorobenzene is placed in an alcohol solvent, such as ethanol or methanol, and then excess ammonia is added. In a closed container, heat to a certain temperature, usually about 80-120 ° C, for several hours. During this process, the nitrile group undergoes a nucleophilic addition reaction with ammonia, first forming an imine intermediate, and then protonating to obtain 4-chlorobenzine. Subsequent hydrochloric acid is added to form its hydrochloride, which is separated and purified by precipitation or crystallization.
Second, 4-chlorobenzoic acid can also be used as a starting material. First, 4-chlorobenzoic acid is converted into acid chloride, which is treated with thionyl chloride or phosphorus trichloride. The activity of acid chloride is higher than that of benzoic acid. Subsequently, the acid chloride is reacted with cyanamide in an appropriate solvent, such as dichloromethane or toluene, to form 4-chlorobenzamidine intermediate. Finally, it interacts with hydrochloric acid to form 4-chlorobenzamidine hydrochloride, which is purified by recrystallization and other means to obtain a high-purity product.
Furthermore, there are those who use 4-chloroaniline as a starting First, 4-chloroaniline is reacted by diazotization to obtain diazonium salt, and then reacted with cyanide reagents such as cuprous cyanide to obtain 4-chlorobenzonitrile. The subsequent steps are as follows: using 4-chlorobenzonitrile as raw material, after ammonolysis, salt formation and other processes, 4-chlorobenzamidine hydrochloride is prepared. Each method has its own advantages and disadvantages, and the choice needs to be weighed according to many factors such as actual demand, raw material availability and cost.
First, 4-chlorobenzene is often used as the starting material. 4-chlorobenzene is placed in an alcohol solvent, such as ethanol or methanol, and then excess ammonia is added. In a closed container, heat to a certain temperature, usually about 80-120 ° C, for several hours. During this process, the nitrile group undergoes a nucleophilic addition reaction with ammonia, first forming an imine intermediate, and then protonating to obtain 4-chlorobenzine. Subsequent hydrochloric acid is added to form its hydrochloride, which is separated and purified by precipitation or crystallization.
Second, 4-chlorobenzoic acid can also be used as a starting material. First, 4-chlorobenzoic acid is converted into acid chloride, which is treated with thionyl chloride or phosphorus trichloride. The activity of acid chloride is higher than that of benzoic acid. Subsequently, the acid chloride is reacted with cyanamide in an appropriate solvent, such as dichloromethane or toluene, to form 4-chlorobenzamidine intermediate. Finally, it interacts with hydrochloric acid to form 4-chlorobenzamidine hydrochloride, which is purified by recrystallization and other means to obtain a high-purity product.
Furthermore, there are those who use 4-chloroaniline as a starting First, 4-chloroaniline is reacted by diazotization to obtain diazonium salt, and then reacted with cyanide reagents such as cuprous cyanide to obtain 4-chlorobenzonitrile. The subsequent steps are as follows: using 4-chlorobenzonitrile as raw material, after ammonolysis, salt formation and other processes, 4-chlorobenzamidine hydrochloride is prepared. Each method has its own advantages and disadvantages, and the choice needs to be weighed according to many factors such as actual demand, raw material availability and cost.
4-chlorobenzene-1-carboximidamide what are the precautions when using hcl
When 4-chlorobenzamidine interacts with hydrochloric acid, the following things must be paid attention to:
First, it is related to the ratio of the two. The ratio of the reaction between the two has a great impact on the formation of the product. Improper ratio may cause incomplete reaction and impure product. If the ratio is unbalanced or by-products are formed, it will increase the difficulty of subsequent separation and purification. Therefore, before the reaction, the dosage of the two should be accurately calculated according to the reaction mechanism and the expected product.
Second, the control of the reaction temperature. Temperature is a key factor in the reaction. If the temperature is too high, the reaction rate will increase, but the side reactions may occur frequently, the product will be destroyed, and the yield will decrease. If the temperature is too low, the reaction rate will be slow, take a long time, or the reaction will be difficult to occur. Therefore, when using thermometers and other instruments to precisely control the temperature, the reaction can be carried out in a suitable temperature range.
Third, the order of addition is important. The order of addition also affects the reaction process. Add 4-chlorobenzamidine first, then add hydrochloric acid dropwise, or vice versa, the rate at the beginning of the reaction and the generation of intermediate products are all different. Reasonable addition order can make the reaction proceed smoothly and efficiently. Usually follow the established experimental norms or experience, and choose the appropriate addition order.
Fourth, the importance of safety protection. Hydrochloric acid is corrosive. When using, wear protective clothing, gloves, goggles and other protective equipment to avoid contact with the skin and eyes. If it comes into contact accidentally, rinse with plenty of water immediately and seek medical attention as appropriate. And the reaction or produce irritating gases, it is suitable to operate with good ventilation, or use ventilation equipment to discharge harmful gases in time.
Fifth, the need for reaction monitoring. During the reaction process, it is advisable to use thin-layer chromatography, liquid chromatography and other analytical methods to monitor the reaction process in real time to know the consumption of reactants and product formation. According to the monitoring results, adjust the reaction conditions in a timely manner, such as adding reactants, changing the reaction time, etc., to ensure that the reaction reaches the desired goal.
First, it is related to the ratio of the two. The ratio of the reaction between the two has a great impact on the formation of the product. Improper ratio may cause incomplete reaction and impure product. If the ratio is unbalanced or by-products are formed, it will increase the difficulty of subsequent separation and purification. Therefore, before the reaction, the dosage of the two should be accurately calculated according to the reaction mechanism and the expected product.
Second, the control of the reaction temperature. Temperature is a key factor in the reaction. If the temperature is too high, the reaction rate will increase, but the side reactions may occur frequently, the product will be destroyed, and the yield will decrease. If the temperature is too low, the reaction rate will be slow, take a long time, or the reaction will be difficult to occur. Therefore, when using thermometers and other instruments to precisely control the temperature, the reaction can be carried out in a suitable temperature range.
Third, the order of addition is important. The order of addition also affects the reaction process. Add 4-chlorobenzamidine first, then add hydrochloric acid dropwise, or vice versa, the rate at the beginning of the reaction and the generation of intermediate products are all different. Reasonable addition order can make the reaction proceed smoothly and efficiently. Usually follow the established experimental norms or experience, and choose the appropriate addition order.
Fourth, the importance of safety protection. Hydrochloric acid is corrosive. When using, wear protective clothing, gloves, goggles and other protective equipment to avoid contact with the skin and eyes. If it comes into contact accidentally, rinse with plenty of water immediately and seek medical attention as appropriate. And the reaction or produce irritating gases, it is suitable to operate with good ventilation, or use ventilation equipment to discharge harmful gases in time.
Fifth, the need for reaction monitoring. During the reaction process, it is advisable to use thin-layer chromatography, liquid chromatography and other analytical methods to monitor the reaction process in real time to know the consumption of reactants and product formation. According to the monitoring results, adjust the reaction conditions in a timely manner, such as adding reactants, changing the reaction time, etc., to ensure that the reaction reaches the desired goal.
Scan to WhatsApp
