Linshang Chemical
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4-Chlorobenzene-1-Sulfonyl Chloride
Linshang Chemical
|
HS Code |
785786 |
| Chemical Formula | C6H4Cl2O2S |
| Molar Mass | 211.06 g/mol |
| Appearance | Colorless to light yellow liquid |
| Odor | Pungent, irritating odor |
| Density | 1.486 g/cm³ |
| Boiling Point | 157 - 158 °C at 1.33 kPa |
| Solubility In Water | Reacts with water |
| Solubility In Organic Solvents | Soluble in common organic solvents like benzene, toluene |
| Hazard Class | Corrosive, harmful if swallowed, inhaled or in contact with skin |
As an accredited 4-Chlorobenzene-1-Sulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - chlorobenzene - 1 - sulfonyl chloride packaged in a sealed glass bottle. |
| Storage | 4 - chlorobenzene - 1 - sulfonyl chloride should be stored in a cool, dry, well - ventilated area. Keep it away from heat, flames, and sources of ignition. Store in a tightly closed container to prevent contact with moisture, which can cause hydrolysis. It should be separated from incompatible substances like bases, reducing agents, and reactive metals to avoid potential chemical reactions. |
| Shipping | 4 - chlorobenzene - 1 - sulfonyl chloride is shipped in tightly - sealed, corrosion - resistant containers. It's transported under conditions avoiding heat, moisture, and incompatible substances, following strict chemical shipping regulations. |
Competitive 4-Chlorobenzene-1-Sulfonyl Chloride prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 4-Chlorobenzene-1-Sulfonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemistry of 4-chlorobenzene-1-sulfonyl Chloride?
4-Chlorobenzene-1-sulfonyl chloride is strong and active, and is often an important angle in various chemical reactions. This substance is highly corrosive and can cause damage to the skin, eyes, etc. It should be used with caution.
Looking at its chemical properties, the sulfonyl chloride group is extremely active and easy to hydrolyze. React quickly in contact with water to produce 4-chlorobenzenesulfonic acid and hydrogen chloride. The speed of hydrolysis is derived from the activity of sulfur-chlorine bonds in sulfonyl chloride. If attacked by water, the bonds are easily broken.
It can react with alcohols to form sulfonates. In this reaction, the hydroxyl oxygen of the alcohol is nucleophilic and attacks the sulfur atom of the sulfonyl chloride, and the chlorine leaves to obtain a sulfonate product. This is a common method for preparing sulfonate esters.
It can also react quickly with amines to produce sulfonamides. The nitrogen atom of amines is nucleophilic, and the sulfur of the sulfonyl chloride is chlorinated to form sulfonamides. Sulfonamides are widely used in the fields of medicine and pesticides.
4-chlorobenzene-1-sulfonyl chloride has strong chlorination. It can chlorinate specific groups in some compounds and use them in organic synthesis to conduct chlorine atoms and expand the structure and properties of compounds.
Because of its liveliness and danger, when stored, it needs to be placed in a dry, cool and well-ventilated place, protected from water and all kinds of active substances. When using, it must follow strict safety procedures, wear protective equipment, and operate in a fume hood to prevent hazards and people and the environment.
Looking at its chemical properties, the sulfonyl chloride group is extremely active and easy to hydrolyze. React quickly in contact with water to produce 4-chlorobenzenesulfonic acid and hydrogen chloride. The speed of hydrolysis is derived from the activity of sulfur-chlorine bonds in sulfonyl chloride. If attacked by water, the bonds are easily broken.
It can react with alcohols to form sulfonates. In this reaction, the hydroxyl oxygen of the alcohol is nucleophilic and attacks the sulfur atom of the sulfonyl chloride, and the chlorine leaves to obtain a sulfonate product. This is a common method for preparing sulfonate esters.
It can also react quickly with amines to produce sulfonamides. The nitrogen atom of amines is nucleophilic, and the sulfur of the sulfonyl chloride is chlorinated to form sulfonamides. Sulfonamides are widely used in the fields of medicine and pesticides.
4-chlorobenzene-1-sulfonyl chloride has strong chlorination. It can chlorinate specific groups in some compounds and use them in organic synthesis to conduct chlorine atoms and expand the structure and properties of compounds.
Because of its liveliness and danger, when stored, it needs to be placed in a dry, cool and well-ventilated place, protected from water and all kinds of active substances. When using, it must follow strict safety procedures, wear protective equipment, and operate in a fume hood to prevent hazards and people and the environment.
What are the main uses of 4-chlorobenzene-1-sulfonyl Chloride?
4-Chlorobenzene-1-sulfonyl chloride, a crucial chemical reagent in the field of organic synthesis, has a wide range of uses and far-reaching influence.
First, in the process of drug synthesis, its role is crucial. It can act as a key intermediate and participate in the construction of many drug molecules. For example, in the synthesis process of some antibacterial drugs and cardiovascular drugs, 4-chlorobenzene-1-sulfonyl chloride can react ingeniously with other organic compounds with its unique chemical activity, accurately building the core structure of drug molecules, and then imparting specific pharmacological activity to drugs. Through a carefully designed reaction route, it interacts with compounds containing heteroatoms such as nitrogen and oxygen to generate complex and biologically active substances, providing rich possibilities for the development of new drugs.
Second, it is also indispensable in the field of materials science. In the preparation of high-performance polymer materials, 4-chlorobenzene-1-sulfonyl chloride can be used as a modifier to significantly optimize the properties of the material. It can react with polymer monomers to introduce specific functional groups into the polymer main chain or side chain, thereby enhancing the thermal stability, mechanical strength and chemical stability of the polymer. For example, in the synthesis of special engineering plastics, adding an appropriate amount of 4-chlorobenzene-1-sulfonyl chloride can make the plastic maintain good physical properties under harsh environments such as high temperature and high humidity, and broaden its application in high-end fields such as aerospace and electronics.
Third, in the field of dye synthesis, 4-chlorobenzene-1-sulfonyl chloride plays a key role. It can participate in the construction of dye molecules, giving dyes excellent dyeing performance and color fastness. By sulfonation and chlorination with various aromatic compounds, colorful and durable dyes can be synthesized. Whether it is the dyeing of natural fibers or synthetic fibers, such dyes prepared by 4-chlorobenzene-1-sulfonyl chloride can show excellent dyeing results and meet the demand for high-quality dyes in the textile printing and dyeing industry.
Fourth, in the field of pesticide synthesis, 4-chlorobenzene-1-sulfonyl chloride also plays an important role. As an important raw material for the synthesis of a variety of high-efficiency pesticides, it can react with other organic reagents to generate compounds with specific insecticidal, bactericidal or herbicidal activities. Its introduction into the molecular structure of pesticides helps to improve the biological activity and selectivity of pesticides, reduce the impact on the environment, and provide strong support for the sustainable development of modern agriculture.
First, in the process of drug synthesis, its role is crucial. It can act as a key intermediate and participate in the construction of many drug molecules. For example, in the synthesis process of some antibacterial drugs and cardiovascular drugs, 4-chlorobenzene-1-sulfonyl chloride can react ingeniously with other organic compounds with its unique chemical activity, accurately building the core structure of drug molecules, and then imparting specific pharmacological activity to drugs. Through a carefully designed reaction route, it interacts with compounds containing heteroatoms such as nitrogen and oxygen to generate complex and biologically active substances, providing rich possibilities for the development of new drugs.
Second, it is also indispensable in the field of materials science. In the preparation of high-performance polymer materials, 4-chlorobenzene-1-sulfonyl chloride can be used as a modifier to significantly optimize the properties of the material. It can react with polymer monomers to introduce specific functional groups into the polymer main chain or side chain, thereby enhancing the thermal stability, mechanical strength and chemical stability of the polymer. For example, in the synthesis of special engineering plastics, adding an appropriate amount of 4-chlorobenzene-1-sulfonyl chloride can make the plastic maintain good physical properties under harsh environments such as high temperature and high humidity, and broaden its application in high-end fields such as aerospace and electronics.
Third, in the field of dye synthesis, 4-chlorobenzene-1-sulfonyl chloride plays a key role. It can participate in the construction of dye molecules, giving dyes excellent dyeing performance and color fastness. By sulfonation and chlorination with various aromatic compounds, colorful and durable dyes can be synthesized. Whether it is the dyeing of natural fibers or synthetic fibers, such dyes prepared by 4-chlorobenzene-1-sulfonyl chloride can show excellent dyeing results and meet the demand for high-quality dyes in the textile printing and dyeing industry.
Fourth, in the field of pesticide synthesis, 4-chlorobenzene-1-sulfonyl chloride also plays an important role. As an important raw material for the synthesis of a variety of high-efficiency pesticides, it can react with other organic reagents to generate compounds with specific insecticidal, bactericidal or herbicidal activities. Its introduction into the molecular structure of pesticides helps to improve the biological activity and selectivity of pesticides, reduce the impact on the environment, and provide strong support for the sustainable development of modern agriculture.
What is the synthesis method of 4-chlorobenzene-1-sulfonyl Chloride?
The synthesis of 4-chlorobenzene-1-sulfonyl Chloride (4-chlorobenzene-1-sulfonyl Chloride) is an important topic in organic synthetic chemistry. The ancient combination of this compound followed the classical organic synthesis path.
The first method is to use 4-chlorobenzene sulfonic acid as the starting material. First, 4-chlorobenzene sulfonic acid is co-heated with phosphorus pentachloride (PCl), and the two are combined. The hydroxyl group (-OH) in the sulfonic acid group is replaced by the chlorine atom, and then 4-chlorobenzene-1-sulfonyl chloride is formed. The reaction formula is roughly as follows: 4-chlorobenzenesulfonic acid + PCl → 4-chlorobenzene-1-sulfonyl chloride + POCl 🥰 + HCl. This reaction needs to be carried out under the protection of appropriate temperature and inert gas to prevent the growth of side reactions. If the temperature is too high, it is easy to cause the product to decompose or produce other by-products; if it is too low, the reaction rate is slow and takes a long time.
There are also those who use 4-chlorobenzenesulfonic acid as raw material. Mix 4-chlorobenzenesulfonic acid with sulfoxide chloride (SOCl ²), heat and stir. The chlorine atom in the sulfoxide chloride is active and can replace the sodium atom in the sodium sulfonate At the time of the reaction, thionyl chloride is not only a chlorination reagent, but also can be used as a solvent to homogenize the reaction system and facilitate the reaction. The reaction can be recorded as: 4-sodium chlorobenzenesulfonate + SOCl ³ → 4-chlorobenzene-1-sulfonyl chloride + NaCl + SO ³. After the reaction, the product needs to be purified by distillation, extraction, etc. to remove unreacted raw materials and by-products.
Furthermore, benzene can be prepared by chlorosulfonation with benzene as the starting material. First, benzene and chlorine gas are used under the action of catalysts such as iron trichloride (FeCl 🥰) to obtain chlorobenzene. Then chlorobenzene is co-heated with fuming sulfuric acid and an appropriate amount of chlorosulfonic acid. After chlorosulfonation, a sulfonyl chloride group is introduced into the benzene ring chlorine atom para-position, and the final product is 4-chlorobenzene-1-sulfonyl chloride. This process step is slightly complicated, but the raw materials are easy to obtain, and the cost may be controllable. Each step requires precise control of the reaction conditions, such as temperature, reactant ratio, reaction time, etc., to obtain a product with higher yield and purity.
The first method is to use 4-chlorobenzene sulfonic acid as the starting material. First, 4-chlorobenzene sulfonic acid is co-heated with phosphorus pentachloride (PCl), and the two are combined. The hydroxyl group (-OH) in the sulfonic acid group is replaced by the chlorine atom, and then 4-chlorobenzene-1-sulfonyl chloride is formed. The reaction formula is roughly as follows: 4-chlorobenzenesulfonic acid + PCl → 4-chlorobenzene-1-sulfonyl chloride + POCl 🥰 + HCl. This reaction needs to be carried out under the protection of appropriate temperature and inert gas to prevent the growth of side reactions. If the temperature is too high, it is easy to cause the product to decompose or produce other by-products; if it is too low, the reaction rate is slow and takes a long time.
There are also those who use 4-chlorobenzenesulfonic acid as raw material. Mix 4-chlorobenzenesulfonic acid with sulfoxide chloride (SOCl ²), heat and stir. The chlorine atom in the sulfoxide chloride is active and can replace the sodium atom in the sodium sulfonate At the time of the reaction, thionyl chloride is not only a chlorination reagent, but also can be used as a solvent to homogenize the reaction system and facilitate the reaction. The reaction can be recorded as: 4-sodium chlorobenzenesulfonate + SOCl ³ → 4-chlorobenzene-1-sulfonyl chloride + NaCl + SO ³. After the reaction, the product needs to be purified by distillation, extraction, etc. to remove unreacted raw materials and by-products.
Furthermore, benzene can be prepared by chlorosulfonation with benzene as the starting material. First, benzene and chlorine gas are used under the action of catalysts such as iron trichloride (FeCl 🥰) to obtain chlorobenzene. Then chlorobenzene is co-heated with fuming sulfuric acid and an appropriate amount of chlorosulfonic acid. After chlorosulfonation, a sulfonyl chloride group is introduced into the benzene ring chlorine atom para-position, and the final product is 4-chlorobenzene-1-sulfonyl chloride. This process step is slightly complicated, but the raw materials are easy to obtain, and the cost may be controllable. Each step requires precise control of the reaction conditions, such as temperature, reactant ratio, reaction time, etc., to obtain a product with higher yield and purity.
4-chlorobenzene-1-sulfonyl Chloride in Storage and Transportation
4-Chlorobenzene-1-sulfonyl chloride, this is a very active chemical substance. When storing and transporting, many things need to be paid careful attention.
Be the first to bear the brunt. When storing, be sure to store in a cool, dry and well-ventilated place. Because it is sensitive to moisture and easily reacts with water, it should be kept away from water sources and humid places. If the storage environment humidity is high, the substance may hydrolyze and deteriorate, which will affect its quality and effectiveness.
Furthermore, this substance needs to be sealed and stored. Due to its strong volatility, if the seal is not good, it is easy to evaporate into the air, which will not only cause material loss, but also the volatile gas may be irritating and corrosive, posing a threat to the surrounding environment and human health.
During transportation, there are also many key points. It is necessary to choose suitable packaging materials to ensure that the packaging is strong and well sealed to prevent the packaging from being damaged due to bumps and collisions during transportation and cause leakage accidents. At the same time, the transportation vehicle needs to have corresponding protective measures, such as ventilation equipment, to disperse the gas that may leak. And the transportation personnel should be professionally trained to be familiar with the dangerous characteristics of the substance and emergency treatment methods. In the event of an accident such as a leak, it can be disposed of quickly and properly, thereby reducing the harm.
In addition, whether it is stored or transported, it must be strictly separated from oxidants, alkalis and other substances. Due to its active chemical properties, contact with these substances is likely to cause violent chemical reactions, and even lead to serious consequences such as combustion and explosion.
In short, for the storage and transportation of 4-chlorobenzene-1-sulfonyl chloride, a cautious and scientific attitude must be maintained, and relevant norms and standards must be strictly followed to ensure that the safety of personnel and the environment are not damaged, and the properties and functions of the substance are not affected.
Be the first to bear the brunt. When storing, be sure to store in a cool, dry and well-ventilated place. Because it is sensitive to moisture and easily reacts with water, it should be kept away from water sources and humid places. If the storage environment humidity is high, the substance may hydrolyze and deteriorate, which will affect its quality and effectiveness.
Furthermore, this substance needs to be sealed and stored. Due to its strong volatility, if the seal is not good, it is easy to evaporate into the air, which will not only cause material loss, but also the volatile gas may be irritating and corrosive, posing a threat to the surrounding environment and human health.
During transportation, there are also many key points. It is necessary to choose suitable packaging materials to ensure that the packaging is strong and well sealed to prevent the packaging from being damaged due to bumps and collisions during transportation and cause leakage accidents. At the same time, the transportation vehicle needs to have corresponding protective measures, such as ventilation equipment, to disperse the gas that may leak. And the transportation personnel should be professionally trained to be familiar with the dangerous characteristics of the substance and emergency treatment methods. In the event of an accident such as a leak, it can be disposed of quickly and properly, thereby reducing the harm.
In addition, whether it is stored or transported, it must be strictly separated from oxidants, alkalis and other substances. Due to its active chemical properties, contact with these substances is likely to cause violent chemical reactions, and even lead to serious consequences such as combustion and explosion.
In short, for the storage and transportation of 4-chlorobenzene-1-sulfonyl chloride, a cautious and scientific attitude must be maintained, and relevant norms and standards must be strictly followed to ensure that the safety of personnel and the environment are not damaged, and the properties and functions of the substance are not affected.
4-chlorobenzene-1-sulfonyl Chloride Effects on the Environment and Human Health
4-Chlorobenzene-1-sulfonyl chloride, this is a chemical substance. Its impact on the environment and human health should not be underestimated.
In terms of the environment, if this substance is released into nature, it may cause multiple hazards. If it flows into water bodies, it will be a source of sewage. Aquatic organisms bear the brunt, or due to physiological disturbances, they will be trapped in survival and reproduction. Its toxicity or cause diseases and death of fish, shellfish and other organisms, and destroy the water ecological balance. Entering the soil will change soil properties and inhibit plant growth. After plants absorb it, they may be stunted, resulting in reduced crop production and affecting the food chain. If it evaporates in the atmosphere, it becomes an air pollutant, participates in photochemical reactions, and aggravates environmental problems such as smog and acid rain.
As for human health, 4-chlorobenzene-1-sulfonyl chloride is significantly harmful. Corrosive, in contact with the skin, can cause burns, pain, redness, and blistering. Entering the eyes, damaging eye tissue, or even damaging vision. Inhalation of its volatile gases irritates the respiratory tract, causing cough, asthma, breathing difficulties, long-term exposure, or increasing the risk of respiratory diseases. Oral ingestion can damage the digestive system, causing nausea, vomiting, and abdominal pain, which is life-threatening in severe cases. And animal experiments or studies may show that long-term exposure to this substance may be potentially carcinogenic and increase the risk of cancer.
Therefore, 4-chlorobenzene-1-sulfonyl chloride should be treated with caution. The production and use links should be strictly operated in accordance with regulations, and protection and waste disposal should be done to reduce its harm to the environment and human health.
In terms of the environment, if this substance is released into nature, it may cause multiple hazards. If it flows into water bodies, it will be a source of sewage. Aquatic organisms bear the brunt, or due to physiological disturbances, they will be trapped in survival and reproduction. Its toxicity or cause diseases and death of fish, shellfish and other organisms, and destroy the water ecological balance. Entering the soil will change soil properties and inhibit plant growth. After plants absorb it, they may be stunted, resulting in reduced crop production and affecting the food chain. If it evaporates in the atmosphere, it becomes an air pollutant, participates in photochemical reactions, and aggravates environmental problems such as smog and acid rain.
As for human health, 4-chlorobenzene-1-sulfonyl chloride is significantly harmful. Corrosive, in contact with the skin, can cause burns, pain, redness, and blistering. Entering the eyes, damaging eye tissue, or even damaging vision. Inhalation of its volatile gases irritates the respiratory tract, causing cough, asthma, breathing difficulties, long-term exposure, or increasing the risk of respiratory diseases. Oral ingestion can damage the digestive system, causing nausea, vomiting, and abdominal pain, which is life-threatening in severe cases. And animal experiments or studies may show that long-term exposure to this substance may be potentially carcinogenic and increase the risk of cancer.
Therefore, 4-chlorobenzene-1-sulfonyl chloride should be treated with caution. The production and use links should be strictly operated in accordance with regulations, and protection and waste disposal should be done to reduce its harm to the environment and human health.
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