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4-Chlorobenzeneacetyl Chloride
Linshang Chemical
|
HS Code |
950281 |
| Name | 4-Chlorobenzeneacetyl Chloride |
| Chemical Formula | C8H6Cl2O |
| Molar Mass | 189.04 g/mol |
| Appearance | Colorless to pale yellow liquid |
| Density | 1.325 g/cm³ |
| Boiling Point | 132 - 134 °C (15 mmHg) |
| Solubility In Water | Reacts with water |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene |
| Flash Point | 110 °C |
| Odor | Pungent, irritating odor |
As an accredited 4-Chlorobenzeneacetyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - chlorobenzeneacetyl Chloride packaged in a sealed, corrosion - resistant bottle. |
| Storage | 4 - chlorobenzeneacetyl chloride should be stored in a cool, dry, well - ventilated area away from heat, flames, and sources of ignition. Keep it in a tightly - sealed container, preferably made of corrosion - resistant materials. Store it separately from incompatible substances like oxidizing agents, bases, and water to prevent reactions. |
| Shipping | 4 - Chlorobenzeneacetyl Chloride is a hazardous chemical. Shipping requires proper packaging in accordance with regulations, like using corrosion - resistant containers. It must be clearly labeled for its hazardous nature and shipped with appropriate safety documentation. |
Competitive 4-Chlorobenzeneacetyl Chloride prices that fit your budget—flexible terms and customized quotes for every order.
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What are the main uses of 4-chlorobenzeneacetyl Chloride?
4-Chlorophenylacetyl chloride is an important intermediate in organic synthesis and has a wide range of uses.
First, it is very useful in the field of pharmaceutical synthesis. In the preparation of many drugs, 4-chlorophenylacetyl chloride is often used as the key raw material. For example, in the synthesis of some antibacterial drugs, it is used as the starting reactant through a series of delicate chemical reactions to construct the specific structure of drug molecules. Due to the unique activity of chlorine atoms and phenylacetyl groups, it can participate in many reactions such as nucleophilic substitution and acylation, laying the foundation for the synthesis of molecular structures with specific pharmacological activities.
Second, it is also indispensable in the creation of pesticides. It can react with other organic compounds to generate new pesticide active ingredients. Such as the preparation of high-efficiency, low-toxicity insecticides, fungicides, etc., with the help of their chemical activity, pesticide molecules can be precisely designed and constructed, giving pesticides the ability to kill specific pests or bacteria efficiently, while reducing the adverse effects on the environment and non-target organisms.
Third, it can also be seen in the field of dye synthesis. 4-Chlorophenylacetyl chloride participates in the reaction path of dye synthesis, which can introduce specific functional groups, thereby changing the color, stability and dyeing properties of dye molecules. Through rational design of reactions, various dyes with bright colors and excellent fastness can be prepared to meet the diverse needs of textile, printing and dyeing industries.
Fourth, it also has extraordinary performance in the synthesis of organic materials. It can be used as a structural unit to participate in the synthesis of polymer materials or functional organic materials. By polymerizing or reacting with other monomers, the material is endowed with unique physical and chemical properties, such as improving the solubility, thermal stability and mechanical properties of the material, providing an effective way for the development of new organic materials.
First, it is very useful in the field of pharmaceutical synthesis. In the preparation of many drugs, 4-chlorophenylacetyl chloride is often used as the key raw material. For example, in the synthesis of some antibacterial drugs, it is used as the starting reactant through a series of delicate chemical reactions to construct the specific structure of drug molecules. Due to the unique activity of chlorine atoms and phenylacetyl groups, it can participate in many reactions such as nucleophilic substitution and acylation, laying the foundation for the synthesis of molecular structures with specific pharmacological activities.
Second, it is also indispensable in the creation of pesticides. It can react with other organic compounds to generate new pesticide active ingredients. Such as the preparation of high-efficiency, low-toxicity insecticides, fungicides, etc., with the help of their chemical activity, pesticide molecules can be precisely designed and constructed, giving pesticides the ability to kill specific pests or bacteria efficiently, while reducing the adverse effects on the environment and non-target organisms.
Third, it can also be seen in the field of dye synthesis. 4-Chlorophenylacetyl chloride participates in the reaction path of dye synthesis, which can introduce specific functional groups, thereby changing the color, stability and dyeing properties of dye molecules. Through rational design of reactions, various dyes with bright colors and excellent fastness can be prepared to meet the diverse needs of textile, printing and dyeing industries.
Fourth, it also has extraordinary performance in the synthesis of organic materials. It can be used as a structural unit to participate in the synthesis of polymer materials or functional organic materials. By polymerizing or reacting with other monomers, the material is endowed with unique physical and chemical properties, such as improving the solubility, thermal stability and mechanical properties of the material, providing an effective way for the development of new organic materials.
What are the physical properties of 4-chlorobenzeneacetyl Chloride?
4-Chlorophenylacetyl chloride is an important raw material in organic synthesis. This substance has the following physical properties:
Looking at its shape, under room temperature and pressure, 4-chlorophenylacetyl chloride is a colorless to light yellow liquid. Its appearance is distinct, like a clear liquid flow, but it hides chemical activity.
Smell its odor, it emits a strong and irritating odor, which is sharp and pungent. Once inhaled, it can cause significant irritation to the respiratory tract, eyes and skin. If inhaled carelessly, it may cause severe consequences such as discomfort or cough, and severe cases may cause respiratory damage.
Measured its density, 4-chlorophenylacetyl chloride has a density greater than that of water, about [X] g/cm ³. When mixed with water, it will sink to the bottom of the water, and the two are distinct. This property is due to factors such as its molecular structure and relative molecular mass.
In terms of its solubility, 4-chlorophenylacetyl chloride is soluble in a variety of organic solvents, such as ether, benzene, chloroform, etc. In these organic solvents, it can be uniformly dispersed to form a uniform solution. This solubility facilitates its application in organic synthesis reactions, because many organic reactions are often carried out in organic solvent systems.
Explore its boiling point, the boiling point is about [X] ° C. When the external temperature rises to this boiling point, 4-chlorobenzene acetyl chloride will change from liquid to gaseous, and undergo a phase change. This boiling point value is of great significance for its separation, purification and reaction operation under specific temperature conditions.
Looking at its melting point, the melting point is about [X] ° C. Below this temperature, 4-chlorobenzene acetyl chloride will solidify from liquid to solid, showing a different physical form. Knowing the melting point helps to control its physical state at different temperatures, and then rationally plan storage and use conditions. The many physical properties of
4-chlorophenylacetyl chloride play a key role in the field of organic synthesis. Synthetic chemists need to carefully plan the reaction conditions according to their characteristics in order to achieve the desired synthesis goal.
Looking at its shape, under room temperature and pressure, 4-chlorophenylacetyl chloride is a colorless to light yellow liquid. Its appearance is distinct, like a clear liquid flow, but it hides chemical activity.
Smell its odor, it emits a strong and irritating odor, which is sharp and pungent. Once inhaled, it can cause significant irritation to the respiratory tract, eyes and skin. If inhaled carelessly, it may cause severe consequences such as discomfort or cough, and severe cases may cause respiratory damage.
Measured its density, 4-chlorophenylacetyl chloride has a density greater than that of water, about [X] g/cm ³. When mixed with water, it will sink to the bottom of the water, and the two are distinct. This property is due to factors such as its molecular structure and relative molecular mass.
In terms of its solubility, 4-chlorophenylacetyl chloride is soluble in a variety of organic solvents, such as ether, benzene, chloroform, etc. In these organic solvents, it can be uniformly dispersed to form a uniform solution. This solubility facilitates its application in organic synthesis reactions, because many organic reactions are often carried out in organic solvent systems.
Explore its boiling point, the boiling point is about [X] ° C. When the external temperature rises to this boiling point, 4-chlorobenzene acetyl chloride will change from liquid to gaseous, and undergo a phase change. This boiling point value is of great significance for its separation, purification and reaction operation under specific temperature conditions.
Looking at its melting point, the melting point is about [X] ° C. Below this temperature, 4-chlorobenzene acetyl chloride will solidify from liquid to solid, showing a different physical form. Knowing the melting point helps to control its physical state at different temperatures, and then rationally plan storage and use conditions. The many physical properties of
4-chlorophenylacetyl chloride play a key role in the field of organic synthesis. Synthetic chemists need to carefully plan the reaction conditions according to their characteristics in order to achieve the desired synthesis goal.
What are the chemical properties of 4-chlorobenzeneacetyl Chloride?
4-Chlorophenylacetyl chloride is a significant substance in the field of organic compounds. Its chemical properties are unique and rich, and I will describe them in detail.
First of all, it has significant acid chloride properties. Acyl chloride is an extremely active compound, and 4-chlorophenylacetyl chloride is no exception. It easily reacts with compounds containing active hydrogen, such as alcohols. When it encounters an alcohol, the two quickly acylate to form corresponding esters. This reaction process is that the hydroxyl oxygen atom of the alcohol launches a nucleophilic attack on the carbonyl carbon atom of the acyl chloride with its lone pair of electrons, and then the chloride ions leave to form esters. And this reaction is usually quite rapid. In organic synthesis, it is often used to prepare various ester derivatives, which are widely used in medicine, fragrance and other industries.
Furthermore, the reaction with amine compounds is also very typical. 4-Chlorophenylacetyl chloride and amine can undergo ammonolysis smoothly to form amides. During this process, the nitrogen atom of the amine acts as a nucleophile to attack the carbonyl carbon of the acid chloride, and the chloride ions are separated to form amide bonds. Amide compounds are widely present in many natural products and drug molecular structures, and this reaction provides a key path for the synthesis of such important compounds.
In addition, the chlorine atom in 4-chlorophenylacetyl chloride also exhibits specific activities. Although its activity is slightly inferior to the carbonyl moiety of acyl chloride, substitution reactions can still occur under appropriate conditions. For example, when nucleophiles exist and the reaction conditions are suitable, chlorine atoms can be replaced by other nucleophilic groups, and then more diverse compounds can be derived, which greatly expands the possibility of organic synthesis.
At the same time, 4-chlorophenylacetyl chloride can also participate in some benzene-based reactions due to the presence of benzene rings in its molecular structure. The benzene ring can undergo electrophilic substitution reaction. Although the presence of acid chloride groups will affect the electron cloud distribution of the benzene ring and change its reactivity and selectivity, other substituents can still be introduced at specific positions on the benzene ring under suitable electrophilic reagents and reaction conditions, which further enriches the derivatization pathway of the compound and lays the foundation for the synthesis of organic molecules with specific functions and structures.
First of all, it has significant acid chloride properties. Acyl chloride is an extremely active compound, and 4-chlorophenylacetyl chloride is no exception. It easily reacts with compounds containing active hydrogen, such as alcohols. When it encounters an alcohol, the two quickly acylate to form corresponding esters. This reaction process is that the hydroxyl oxygen atom of the alcohol launches a nucleophilic attack on the carbonyl carbon atom of the acyl chloride with its lone pair of electrons, and then the chloride ions leave to form esters. And this reaction is usually quite rapid. In organic synthesis, it is often used to prepare various ester derivatives, which are widely used in medicine, fragrance and other industries.
Furthermore, the reaction with amine compounds is also very typical. 4-Chlorophenylacetyl chloride and amine can undergo ammonolysis smoothly to form amides. During this process, the nitrogen atom of the amine acts as a nucleophile to attack the carbonyl carbon of the acid chloride, and the chloride ions are separated to form amide bonds. Amide compounds are widely present in many natural products and drug molecular structures, and this reaction provides a key path for the synthesis of such important compounds.
In addition, the chlorine atom in 4-chlorophenylacetyl chloride also exhibits specific activities. Although its activity is slightly inferior to the carbonyl moiety of acyl chloride, substitution reactions can still occur under appropriate conditions. For example, when nucleophiles exist and the reaction conditions are suitable, chlorine atoms can be replaced by other nucleophilic groups, and then more diverse compounds can be derived, which greatly expands the possibility of organic synthesis.
At the same time, 4-chlorophenylacetyl chloride can also participate in some benzene-based reactions due to the presence of benzene rings in its molecular structure. The benzene ring can undergo electrophilic substitution reaction. Although the presence of acid chloride groups will affect the electron cloud distribution of the benzene ring and change its reactivity and selectivity, other substituents can still be introduced at specific positions on the benzene ring under suitable electrophilic reagents and reaction conditions, which further enriches the derivatization pathway of the compound and lays the foundation for the synthesis of organic molecules with specific functions and structures.
What is the production method of 4-chlorobenzeneacetyl Chloride?
The preparation method of 4-chlorophenylacetyl chloride, although there is no specific description in "Tiangong Kaiwu", can be deduced according to the chemical process idea and common chemical principles.
This kind of acid chloride is usually prepared, and it is often obtained by reacting 4-chlorophenylacetic acid with a chlorination reagent. The chlorination reagent is mostly sulfoxide chloride (SOCl ²), because the by-product after the reaction is a gas, which is easy to separate and make the product pure. The reaction is roughly as follows: 4-chlorophenylacetic acid is co-heated with thionyl chloride, and the carboxyl group (-COOH) of 4-chlorophenylacetic acid interacts with thionyl chloride. After the substitution reaction, the hydroxyl group (-OH) is replaced by the chlorine atom (-Cl) to generate 4-chlorophenylacetyl chloride, and sulfur dioxide (SO 2) and hydrogen chloride (HCl) gas escape at the same time.
When operating, first place 4-chlorophenylacetic acid in the reaction vessel, slowly add sulfoxide chloride, and an appropriate amount of catalyst such as N, N-dimethylformamide (DMF) can speed up the reaction. Temperature control heating makes the reaction proceed smoothly, and the reaction is completed. Distillation and separation of pure 4-chlorophenylacetyl chloride Phosphorus trichloride (PCl) can also be used as a chlorination reagent. 4-chlorophenylacetic acid reacts with phosphorus trichloride, and the hydroxyl group of the carboxyl group is replaced by a chlorine atom to form 4-chlorophenylacetyl chloride and phosphoric acid (H 🥰 PO 🥰). However, compared with sulfoxide chloride, the separation of phosphite by-product of this reaction is more difficult, resulting in complicated product purification.
Preparation of 4-chlorophenylacetyl chloride, thionyl chloride method is more commonly used, because of its convenient operation, the product is easy to purify, which meets the requirements of chemical production to pursue high efficiency and purity.
This kind of acid chloride is usually prepared, and it is often obtained by reacting 4-chlorophenylacetic acid with a chlorination reagent. The chlorination reagent is mostly sulfoxide chloride (SOCl ²), because the by-product after the reaction is a gas, which is easy to separate and make the product pure. The reaction is roughly as follows: 4-chlorophenylacetic acid is co-heated with thionyl chloride, and the carboxyl group (-COOH) of 4-chlorophenylacetic acid interacts with thionyl chloride. After the substitution reaction, the hydroxyl group (-OH) is replaced by the chlorine atom (-Cl) to generate 4-chlorophenylacetyl chloride, and sulfur dioxide (SO 2) and hydrogen chloride (HCl) gas escape at the same time.
When operating, first place 4-chlorophenylacetic acid in the reaction vessel, slowly add sulfoxide chloride, and an appropriate amount of catalyst such as N, N-dimethylformamide (DMF) can speed up the reaction. Temperature control heating makes the reaction proceed smoothly, and the reaction is completed. Distillation and separation of pure 4-chlorophenylacetyl chloride Phosphorus trichloride (PCl) can also be used as a chlorination reagent. 4-chlorophenylacetic acid reacts with phosphorus trichloride, and the hydroxyl group of the carboxyl group is replaced by a chlorine atom to form 4-chlorophenylacetyl chloride and phosphoric acid (H 🥰 PO 🥰). However, compared with sulfoxide chloride, the separation of phosphite by-product of this reaction is more difficult, resulting in complicated product purification.
Preparation of 4-chlorophenylacetyl chloride, thionyl chloride method is more commonly used, because of its convenient operation, the product is easy to purify, which meets the requirements of chemical production to pursue high efficiency and purity.
4-chlorobenzeneacetyl the precautions when using Chloride
When using 4-chlorobenzene acetyl chloride, when expressed in ancient Chinese, pay attention to the following things.
First, this material is highly corrosive, such as "sharp blades are easy to hurt hands, and fire can burn the body". If it touches the skin and eyes, it will cause serious burns. Therefore, when using it, you should prepare protective gear, wear thick protective clothing, wear tough protective gloves on your hands, and wear eye goggles to protect the whole body.
Second, its smell is pungent and toxic, and it is essential to use it in ventilated places. Just like the need for windows and windows in the residence to ventilate, the operation site must be equipped with good ventilation devices. If conditions permit, it is especially good in the fume hood to prevent the retention of harmful gas and endanger human health.
Third, 4-chlorophenylacetyl chloride is chemically active and easy to react with many substances. If the ancients said "incompatible with water and fire", this reagent may come into contact with water, alcohols, etc., or cause severe reactions. Therefore, when storing and using, be sure to keep away from such substances, and properly seal and store them to prevent accidents caused by environmental factors.
Fourth, the operation process needs to be rigorous and fine. Weighing, transfer and other steps should follow precise procedures and should not be neglected. Such as the ancient method of processing medicinal pills, the slightest difference, or cause the whole plate to be wrong. A little carelessness, or cause the reagent to spill, causing safety risks.
Fifth, after use, the disposal of the remaining reagents and related equipment should not be ignored. The remaining reagents need to be properly stored or disposed of in accordance with regulations, and the utensils should be cleaned and sorted out in time for later use. These are all important items that should not be forgotten when using 4-chlorophenylacetyl chloride, and always be cautious to ensure safety.
First, this material is highly corrosive, such as "sharp blades are easy to hurt hands, and fire can burn the body". If it touches the skin and eyes, it will cause serious burns. Therefore, when using it, you should prepare protective gear, wear thick protective clothing, wear tough protective gloves on your hands, and wear eye goggles to protect the whole body.
Second, its smell is pungent and toxic, and it is essential to use it in ventilated places. Just like the need for windows and windows in the residence to ventilate, the operation site must be equipped with good ventilation devices. If conditions permit, it is especially good in the fume hood to prevent the retention of harmful gas and endanger human health.
Third, 4-chlorophenylacetyl chloride is chemically active and easy to react with many substances. If the ancients said "incompatible with water and fire", this reagent may come into contact with water, alcohols, etc., or cause severe reactions. Therefore, when storing and using, be sure to keep away from such substances, and properly seal and store them to prevent accidents caused by environmental factors.
Fourth, the operation process needs to be rigorous and fine. Weighing, transfer and other steps should follow precise procedures and should not be neglected. Such as the ancient method of processing medicinal pills, the slightest difference, or cause the whole plate to be wrong. A little carelessness, or cause the reagent to spill, causing safety risks.
Fifth, after use, the disposal of the remaining reagents and related equipment should not be ignored. The remaining reagents need to be properly stored or disposed of in accordance with regulations, and the utensils should be cleaned and sorted out in time for later use. These are all important items that should not be forgotten when using 4-chlorophenylacetyl chloride, and always be cautious to ensure safety.
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