Linshang Chemical
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4-Chlorobenzenemethanethiol
Linshang Chemical
|
HS Code |
117970 |
| Chemical Formula | C7H7ClS |
| Molar Mass | 158.65 g/mol |
| Appearance | Colorless to light yellow liquid |
| Odor | Strong, unpleasant odor |
| Density | 1.244 g/cm³ |
| Boiling Point | 234 - 236 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in many organic solvents |
| Flash Point | 101 °C |
| Stability | Stable under normal conditions |
| Hazard Class | Irritant |
As an accredited 4-Chlorobenzenemethanethiol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram vial of 4 - chlorobenzenemethanethiol, tightly sealed in chemical - resistant packaging. |
| Storage | 4 - chlorobenzenemethanethiol should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials, as it may react with some substances. Store it separately from oxidizing agents and bases to prevent chemical reactions. |
| Shipping | 4 - chlorobenzenemethanethiol is a chemical that may require special handling during shipping. It should be packaged in appropriate, leak - proof containers and shipped in accordance with hazardous material regulations to ensure safety during transit. |
Competitive 4-Chlorobenzenemethanethiol prices that fit your budget—flexible terms and customized quotes for every order.
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What is the chemistry of 4-chlorobenzenemethanethiol?
4-chlorobenzenemethanethiol, Chinese name 4-chlorobenzyl mercaptan. This is an organic compound with unique chemical properties.
Looking at its structure, it contains benzene ring, chlorine atom and methylthiol group. The benzene ring is a stable conjugated system, which makes the molecule have certain aromaticity. The chlorine atom has an electron-absorbing effect, which can affect the distribution and reactivity of the molecular electron cloud. The sulfur atom in the methylthiol group has moderate electronegativity and has a pair of lone pairs of electrons, which makes it easy to participate in the chemical reaction.
4-chlorobenzyl mercaptan has active chemical properties. Due to the electron-absorbing action of the chlorine atom, the electron cloud density of the benzene ring decreases, and the electro However, under certain conditions, electrophilic substitution can still occur, and the substitution check point is affected by the localization effect of chlorine atoms and methylthiol groups. The sulfur-hydrogen bond in methylthiol groups has a certain polarity, and the sulfur atom can act as a nucleophilic center to undergo nucleophilic substitution reaction with electrophilic reagents. For example, it can react with halogenated hydrocarbons to form thioethers.
4-chlorobenzyl mercaptan is also reductive, and the outer electrons of the sulfur atom are easily oxidized, which can be oxidized to sulfoxide or sulfone by mild oxidants. In addition, due to the sulfur content, sulfur dioxide gas with pungent od
In the field of organic synthesis, 4-chlorobenzyl mercaptan is an important intermediate. With its active reactivity, it can construct complex organic molecular structures through various reactions, making great contributions to the development of organic synthesis chemistry.
Looking at its structure, it contains benzene ring, chlorine atom and methylthiol group. The benzene ring is a stable conjugated system, which makes the molecule have certain aromaticity. The chlorine atom has an electron-absorbing effect, which can affect the distribution and reactivity of the molecular electron cloud. The sulfur atom in the methylthiol group has moderate electronegativity and has a pair of lone pairs of electrons, which makes it easy to participate in the chemical reaction.
4-chlorobenzyl mercaptan has active chemical properties. Due to the electron-absorbing action of the chlorine atom, the electron cloud density of the benzene ring decreases, and the electro However, under certain conditions, electrophilic substitution can still occur, and the substitution check point is affected by the localization effect of chlorine atoms and methylthiol groups. The sulfur-hydrogen bond in methylthiol groups has a certain polarity, and the sulfur atom can act as a nucleophilic center to undergo nucleophilic substitution reaction with electrophilic reagents. For example, it can react with halogenated hydrocarbons to form thioethers.
4-chlorobenzyl mercaptan is also reductive, and the outer electrons of the sulfur atom are easily oxidized, which can be oxidized to sulfoxide or sulfone by mild oxidants. In addition, due to the sulfur content, sulfur dioxide gas with pungent od
In the field of organic synthesis, 4-chlorobenzyl mercaptan is an important intermediate. With its active reactivity, it can construct complex organic molecular structures through various reactions, making great contributions to the development of organic synthesis chemistry.
What are the physical properties of 4-chlorobenzenemethanethiol?
4-Chlorobenzyl mercaptan, this is an organic compound. Its physical properties are as follows:
Looking at its appearance, at room temperature, it is mostly colorless to light yellow liquid, and seems to have a special mercaptan smell. The smell is strong and irritating, and it is easy to feel uncomfortable when smelling.
When it comes to solubility, it shows good solubility in organic solvents. Common organic solvents such as ethanol, ether, and acetone can be miscible with it, just like fish water. Due to the appropriate force between the two molecules, it can be miscible. However, its solubility in water is not good. Due to its molecular structure characteristics, it has strong hydrophobicity. Water is a polar solvent, and the polarity of the two is different. Therefore, it is difficult to miscible, just like the difficulty of mixing oil and water.
When talking about the boiling point, it is about a certain temperature range, and the specific value is affected by factors such as environmental pressure. Generally speaking, under standard atmospheric pressure, the boiling point is moderate, which is related to the intermolecular forces. There are Van der Waals forces and other effects between molecules, which maintain a certain state of aggregation, and a specific energy is required to make it boil into a gaseous state.
In terms of melting point, there is also a corresponding value, which is the critical temperature for the transformation of solid and liquid states. At this temperature, the substance is in a solid state, and the molecular arrangement is relatively orderly; at this temperature, the molecules are energized and begin to move disorderly, and the substance gradually melts into a liquid state.
The density of
is slightly higher than that of water. Placing it in the same container with water will sink to the bottom of the water, because its mass per unit volume is greater than that of water. The physical properties of
4-chlorobenzyl mercaptan are of great significance in organic synthesis, chemical industry and other fields. Its solubility can help the selection of reaction medium, and the properties of boiling point and melting point provide the basis for separation, purification and other operations, and are indispensable in chemical production process planning.
Looking at its appearance, at room temperature, it is mostly colorless to light yellow liquid, and seems to have a special mercaptan smell. The smell is strong and irritating, and it is easy to feel uncomfortable when smelling.
When it comes to solubility, it shows good solubility in organic solvents. Common organic solvents such as ethanol, ether, and acetone can be miscible with it, just like fish water. Due to the appropriate force between the two molecules, it can be miscible. However, its solubility in water is not good. Due to its molecular structure characteristics, it has strong hydrophobicity. Water is a polar solvent, and the polarity of the two is different. Therefore, it is difficult to miscible, just like the difficulty of mixing oil and water.
When talking about the boiling point, it is about a certain temperature range, and the specific value is affected by factors such as environmental pressure. Generally speaking, under standard atmospheric pressure, the boiling point is moderate, which is related to the intermolecular forces. There are Van der Waals forces and other effects between molecules, which maintain a certain state of aggregation, and a specific energy is required to make it boil into a gaseous state.
In terms of melting point, there is also a corresponding value, which is the critical temperature for the transformation of solid and liquid states. At this temperature, the substance is in a solid state, and the molecular arrangement is relatively orderly; at this temperature, the molecules are energized and begin to move disorderly, and the substance gradually melts into a liquid state.
The density of
is slightly higher than that of water. Placing it in the same container with water will sink to the bottom of the water, because its mass per unit volume is greater than that of water. The physical properties of
4-chlorobenzyl mercaptan are of great significance in organic synthesis, chemical industry and other fields. Its solubility can help the selection of reaction medium, and the properties of boiling point and melting point provide the basis for separation, purification and other operations, and are indispensable in chemical production process planning.
What are the main uses of 4-chlorobenzenemethanethiol?
4-Chlorobenzyl mercaptan is also an organic compound. It has a wide range of uses and has important applications in various fields of chemical industry.
In the field of organic synthesis, this compound is often used as a key intermediate. Because of its sulfur atoms and chlorine atoms, Gai gives it unique reactivity and can participate in many organic reactions. For example, nucleophilic substitution reactions, chlorine atoms can be replaced by other nucleophilic reagents, thus building the structure of various sulfur-containing organic compounds, assisting chemists in creating complex and functional organic molecules, which is of great significance in the field of drug synthesis.
In drug development, 4-chlorobenzyl mercaptan also plays an important role. The design and synthesis of some drug molecules rely on its special structure. Its thiol groups can interact specifically with targets in vivo, such as binding to the active check points of certain proteins, thereby regulating the function of proteins and thus exerting the effect of treating diseases. Medicinal chemists can explore new drug lead compounds by modifying their structures, opening up new avenues for disease treatment.
In the field of materials science, 4-chlorobenzethiol is also useful. It can be used to prepare materials with special properties, such as sulfur-containing polymers. Its participation in polymerization reactions can endow polymers with unique physical and chemical properties, such as improving material flexibility and oxidation resistance, which makes great contributions to the development of high-performance materials.
In addition, in the field of surface modification, 4-chlorobenzyl mercaptan can be adsorbed on the surface of certain materials, changing the chemical properties of the surface, and controlling the wettability and adhesion of the material surface. It has potential application value in micro-nano processing, sensors and other technical fields. In short, 4-chlorobenzyl mercaptan is an indispensable chemical raw material in many scientific and technological fields due to its unique structure and reactivity.
In the field of organic synthesis, this compound is often used as a key intermediate. Because of its sulfur atoms and chlorine atoms, Gai gives it unique reactivity and can participate in many organic reactions. For example, nucleophilic substitution reactions, chlorine atoms can be replaced by other nucleophilic reagents, thus building the structure of various sulfur-containing organic compounds, assisting chemists in creating complex and functional organic molecules, which is of great significance in the field of drug synthesis.
In drug development, 4-chlorobenzyl mercaptan also plays an important role. The design and synthesis of some drug molecules rely on its special structure. Its thiol groups can interact specifically with targets in vivo, such as binding to the active check points of certain proteins, thereby regulating the function of proteins and thus exerting the effect of treating diseases. Medicinal chemists can explore new drug lead compounds by modifying their structures, opening up new avenues for disease treatment.
In the field of materials science, 4-chlorobenzethiol is also useful. It can be used to prepare materials with special properties, such as sulfur-containing polymers. Its participation in polymerization reactions can endow polymers with unique physical and chemical properties, such as improving material flexibility and oxidation resistance, which makes great contributions to the development of high-performance materials.
In addition, in the field of surface modification, 4-chlorobenzyl mercaptan can be adsorbed on the surface of certain materials, changing the chemical properties of the surface, and controlling the wettability and adhesion of the material surface. It has potential application value in micro-nano processing, sensors and other technical fields. In short, 4-chlorobenzyl mercaptan is an indispensable chemical raw material in many scientific and technological fields due to its unique structure and reactivity.
What are the preparation methods of 4-chlorobenzenemethanethiol?
For 4-chlorobenzyl mercaptan, there are three ways to prepare it.
First, use 4-chlorobenzyl halide and sodium hydrosulfide as raw materials. Take an appropriate amount of 4-chlorobenzyl halide, such as 4-chlorobenzyl chloride, place it in a reactor, add an appropriate amount of alcohol solvent, such as ethanol, and stir well. Then slowly add the pre-prepared sodium hydrosulfide aqueous solution, and control the temperature between 40 and 60 degrees Celsius. If the temperature is too low, the reaction will be delayed, and if it is too high, the side reactions will increase. After stirring continuously for a few times, when the reaction is completed, pour the reaction liquid into the separation funnel, extract with an organic solvent, and then wash with water, dry, distillate and other steps to obtain 4-chlorobenzyl mercaptan.
Second, use 4-chlorobenzaldehyde as the starting material. First, 4-chlorobenzaldehyde and thioacetic acid react under acid catalysis. Place 4-chlorobenzaldehyde and thioacetic acid in the reaction vessel, add a little p-toluenesulfonic acid as the catalyst, heat it up to 70-90 ° C, and reflux for several times. After the reaction is completed, cool it, neutralize it with alkali, and then extract, separate and purify it, 4-chlorobenzyl mercaptan can be obtained. Among them, acid catalysis can accelerate the reaction process, but the amount of catalyst should be moderate, and too much will affect the purity of the product.
Third, 4-chlorobenzoyl chloride is used as the raw material. First, 4-chlorobenzoyl chloride is reacted with sulfur powder in the presence of an appropriate solvent and catalyst to generate 4-chlorobenzoyl sulfur chloride. Then it is reduced to 4-chlorobenzoyl mercaptan with a reducing agent. Take 4-chlorobenzoyl chloride, dissolve it in a solvent such as dichloromethane, add an appropriate amount of sulfur powder and a catalyst, such as DMF, and heat the reaction. After 4-chlorobenzoyl sulfuryl chloride is formed, zinc powder and hydrochloric acid are added to reduce the temperature, and the target product is obtained after subsequent separation and purification. In this process, the control of the reaction conditions at each step is very critical, which is related to the yield and purity of the product.
First, use 4-chlorobenzyl halide and sodium hydrosulfide as raw materials. Take an appropriate amount of 4-chlorobenzyl halide, such as 4-chlorobenzyl chloride, place it in a reactor, add an appropriate amount of alcohol solvent, such as ethanol, and stir well. Then slowly add the pre-prepared sodium hydrosulfide aqueous solution, and control the temperature between 40 and 60 degrees Celsius. If the temperature is too low, the reaction will be delayed, and if it is too high, the side reactions will increase. After stirring continuously for a few times, when the reaction is completed, pour the reaction liquid into the separation funnel, extract with an organic solvent, and then wash with water, dry, distillate and other steps to obtain 4-chlorobenzyl mercaptan.
Second, use 4-chlorobenzaldehyde as the starting material. First, 4-chlorobenzaldehyde and thioacetic acid react under acid catalysis. Place 4-chlorobenzaldehyde and thioacetic acid in the reaction vessel, add a little p-toluenesulfonic acid as the catalyst, heat it up to 70-90 ° C, and reflux for several times. After the reaction is completed, cool it, neutralize it with alkali, and then extract, separate and purify it, 4-chlorobenzyl mercaptan can be obtained. Among them, acid catalysis can accelerate the reaction process, but the amount of catalyst should be moderate, and too much will affect the purity of the product.
Third, 4-chlorobenzoyl chloride is used as the raw material. First, 4-chlorobenzoyl chloride is reacted with sulfur powder in the presence of an appropriate solvent and catalyst to generate 4-chlorobenzoyl sulfur chloride. Then it is reduced to 4-chlorobenzoyl mercaptan with a reducing agent. Take 4-chlorobenzoyl chloride, dissolve it in a solvent such as dichloromethane, add an appropriate amount of sulfur powder and a catalyst, such as DMF, and heat the reaction. After 4-chlorobenzoyl sulfuryl chloride is formed, zinc powder and hydrochloric acid are added to reduce the temperature, and the target product is obtained after subsequent separation and purification. In this process, the control of the reaction conditions at each step is very critical, which is related to the yield and purity of the product.
What are the precautions in storage and transportation of 4-chlorobenzenemethanethiol?
4-Chlorobenzyl mercaptan is an organic compound, and many things need to be paid attention to when storing and transporting.
First, it is related to storage. This substance should be placed in a cool and ventilated warehouse. Due to high temperature environment, it may cause internal molecular movement to intensify due to heat, increasing the possibility of volatilization and even dangerous reactions. And the humidity of the warehouse also needs to be strictly controlled, and it is recommended to keep it dry. Because of moisture or reaction with 4-chlorobenzyl mercaptan, it will deteriorate, affecting its quality and performance. At the same time, it should be stored separately from oxidants and acids, and should not be mixed. The edge oxidant has strong oxidizing properties, and the acid chemical properties are active. Both are prone to chemical reactions with 4-chlorobenzethiol, causing serious accidents such as fires and explosions.
Second, about transportation. When transporting, make sure that the container is well sealed. If the container is not well sealed, 4-chlorobenzethiol may leak, which not only pollutes the environment, but also poses a threat to the health of transporters. Transportation vehicles need to be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. In the event of an accident such as leakage on the way, measures can be taken in time to reduce the harm. And the transportation process should follow the specified route and do not stop in densely populated areas, residential areas, etc. This is because if 4-chlorobenzyl mercaptan accidentally leaks, it will cause more serious consequences in crowded places, endangering the safety of many lives and property.
First, it is related to storage. This substance should be placed in a cool and ventilated warehouse. Due to high temperature environment, it may cause internal molecular movement to intensify due to heat, increasing the possibility of volatilization and even dangerous reactions. And the humidity of the warehouse also needs to be strictly controlled, and it is recommended to keep it dry. Because of moisture or reaction with 4-chlorobenzyl mercaptan, it will deteriorate, affecting its quality and performance. At the same time, it should be stored separately from oxidants and acids, and should not be mixed. The edge oxidant has strong oxidizing properties, and the acid chemical properties are active. Both are prone to chemical reactions with 4-chlorobenzethiol, causing serious accidents such as fires and explosions.
Second, about transportation. When transporting, make sure that the container is well sealed. If the container is not well sealed, 4-chlorobenzethiol may leak, which not only pollutes the environment, but also poses a threat to the health of transporters. Transportation vehicles need to be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. In the event of an accident such as leakage on the way, measures can be taken in time to reduce the harm. And the transportation process should follow the specified route and do not stop in densely populated areas, residential areas, etc. This is because if 4-chlorobenzyl mercaptan accidentally leaks, it will cause more serious consequences in crowded places, endangering the safety of many lives and property.
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