Linshang Chemical
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4-Chlorobenzenepropanoic Acid
Linshang Chemical
|
HS Code |
470719 |
| Chemical Formula | C9H9ClO2 |
| Molar Mass | 184.62 g/mol |
| Appearance | White to off - white solid |
| Odor | Typical carboxylic acid - like odor |
| Solubility In Water | Slightly soluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Melting Point | 97 - 101 °C |
| Boiling Point | Approximately 285 - 287 °C |
| Pka | Around 4.4 |
| Density | 1.305 g/cm³ (approximate) |
As an accredited 4-Chlorobenzenepropanoic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - chlorobenzenepropanoic Acid in a sealed, chemical - resistant plastic container. |
| Storage | 4 - Chlorobenzenepropanoic acid should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent moisture absorption and contact with air. Store it separately from oxidizing agents and bases, as it may react. Use a storage facility compliant with chemical safety regulations to ensure safe containment. |
| Shipping | 4 - Chlorobenzenepropanoic acid is shipped in tightly - sealed, corrosion - resistant containers. It follows strict regulations due to its chemical nature, ensuring safe transportation to prevent spills and environmental or safety hazards. |
Competitive 4-Chlorobenzenepropanoic Acid prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 4-Chlorobenzenepropanoic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 4-chlorobenzenepropanoic Acid?
4-Chlorophenylpropionic acid is an organic compound with unique properties and a variety of chemical characteristics.
This substance contains benzene ring, chlorine atom and carboxyl group, and its chemical activity is determined by these groups. The benzene ring is a stable conjugated system, which endows the molecule with certain aromaticity and stability. Chlorine atoms can affect the electron cloud distribution of the benzene ring due to electronegativity, causing changes in the electrophilic substitution activity of the benzene ring, and the ortho and para-sites are more susceptible to attack by electrophilic reagents. The carboxyl group is acidic and can be partially ionized in water, releasing hydrogen ions, which can neutralize with bases to form corresponding carboxylic salts and water.
4-Chlorophenylpropionic acid can participate in the esterification reaction. Under the catalysis of concentrated sulfuric acid and heating Due to its benzene ring, it can also carry out electrophilic substitution reactions such as halogenation, nitration, and sulfonation. In addition, α-hydrogen is affected by carboxyl groups and benzene rings, and has certain activity, which can undergo substitution or oxidation reactions.
In the field of organic synthesis, 4-chlorophenylpropionic acid is an important intermediate, which can construct complex organic molecules through various reactions and is used in the synthesis of drugs, pesticides and fine chemicals. Understanding its chemical properties is of great significance to organic synthesis and related fields.
This substance contains benzene ring, chlorine atom and carboxyl group, and its chemical activity is determined by these groups. The benzene ring is a stable conjugated system, which endows the molecule with certain aromaticity and stability. Chlorine atoms can affect the electron cloud distribution of the benzene ring due to electronegativity, causing changes in the electrophilic substitution activity of the benzene ring, and the ortho and para-sites are more susceptible to attack by electrophilic reagents. The carboxyl group is acidic and can be partially ionized in water, releasing hydrogen ions, which can neutralize with bases to form corresponding carboxylic salts and water.
4-Chlorophenylpropionic acid can participate in the esterification reaction. Under the catalysis of concentrated sulfuric acid and heating Due to its benzene ring, it can also carry out electrophilic substitution reactions such as halogenation, nitration, and sulfonation. In addition, α-hydrogen is affected by carboxyl groups and benzene rings, and has certain activity, which can undergo substitution or oxidation reactions.
In the field of organic synthesis, 4-chlorophenylpropionic acid is an important intermediate, which can construct complex organic molecules through various reactions and is used in the synthesis of drugs, pesticides and fine chemicals. Understanding its chemical properties is of great significance to organic synthesis and related fields.
What are the main uses of 4-chlorobenzenepropanoic Acid?
4-Chlorophenylpropionic acid, whose name is p-chlorophenylpropionic acid, has a wide range of uses and has its own impact in many fields.
In the field of pharmaceutical chemistry, it is an important organic synthesis intermediate. The special structure of the phenyl ring and the chlorine atom and carboxyl group endows it with unique chemical activity. Based on this, a variety of compounds with specific pharmacological activities can be synthesized. For example, some drugs used to regulate human physiology, 4-chlorophenylpropionic acid participates in its synthesis path, through a series of chemical reactions, or modifies its structure, or introduces key functional groups, in order to achieve the expected pharmacological effect, contributing greatly to human health.
In the field of materials science, it also has extraordinary performance. In the preparation of some polymer materials with special properties, 4-chlorophenylpropionic acid can participate in the polymerization reaction as a functional monomer. Its structure is integrated into the polymer chain, which can change the physical and chemical properties of the material, such as improving the stability of the material and improving its mechanical properties. In this way, the synthesized material can be used in different scenarios, such as the high performance requirements of materials in the aerospace field, and this material may meet.
In the preparation of agricultural chemicals, 4-chlorophenylpropionic acid is also indispensable. It can be used as a raw material for the synthesis of new pesticides. Due to the existence of chlorine atoms, it can endow the synthesized pesticides with specific biological activities, or enhance their impact on pests, stomach toxicity, or enhance their inhibitory effect on plant diseases and bacteria, thereby assisting agricultural pest control and ensuring crop yield and quality.
In addition, in the study of organic synthetic chemistry, 4-chlorophenylpropionic acid is a commonly used basic raw material, providing chemists with the possibility to explore new reaction paths and develop new synthesis methods. Due to its structural characteristics, it can trigger a variety of chemical reactions, help researchers expand the boundaries of organic synthesis, create more novel organic compounds, and promote the development of organic chemistry.
In the field of pharmaceutical chemistry, it is an important organic synthesis intermediate. The special structure of the phenyl ring and the chlorine atom and carboxyl group endows it with unique chemical activity. Based on this, a variety of compounds with specific pharmacological activities can be synthesized. For example, some drugs used to regulate human physiology, 4-chlorophenylpropionic acid participates in its synthesis path, through a series of chemical reactions, or modifies its structure, or introduces key functional groups, in order to achieve the expected pharmacological effect, contributing greatly to human health.
In the field of materials science, it also has extraordinary performance. In the preparation of some polymer materials with special properties, 4-chlorophenylpropionic acid can participate in the polymerization reaction as a functional monomer. Its structure is integrated into the polymer chain, which can change the physical and chemical properties of the material, such as improving the stability of the material and improving its mechanical properties. In this way, the synthesized material can be used in different scenarios, such as the high performance requirements of materials in the aerospace field, and this material may meet.
In the preparation of agricultural chemicals, 4-chlorophenylpropionic acid is also indispensable. It can be used as a raw material for the synthesis of new pesticides. Due to the existence of chlorine atoms, it can endow the synthesized pesticides with specific biological activities, or enhance their impact on pests, stomach toxicity, or enhance their inhibitory effect on plant diseases and bacteria, thereby assisting agricultural pest control and ensuring crop yield and quality.
In addition, in the study of organic synthetic chemistry, 4-chlorophenylpropionic acid is a commonly used basic raw material, providing chemists with the possibility to explore new reaction paths and develop new synthesis methods. Due to its structural characteristics, it can trigger a variety of chemical reactions, help researchers expand the boundaries of organic synthesis, create more novel organic compounds, and promote the development of organic chemistry.
What are the synthetic methods of 4-chlorobenzenepropanoic Acid?
There are various ways to synthesize 4-chlorophenylpropionic acid. One is to use phenylpropionic acid as the starting material and introduce chlorine atoms through a halogenation reaction. In this method, phenylpropionic acid can be placed in an appropriate reaction solvent, such as dichloromethane or chloroform, and then an appropriate amount of halogenating reagents, such as thionyl chloride, phosphorus trichloride or phosphorus pentachloride, can be added. At a suitable temperature and reaction time, the halogenated reagent undergoes a nucleophilic substitution reaction with phenylpropionic acid, so that chlorine atoms are introduced at specific positions on the benzene ring, thereby generating 4-chlorophenylpropionic acid. This reaction process requires careful control of the reaction conditions, such as temperature, reagent dosage ratio, etc., to ensure the
Second, we can start from 4-chlorobenzene. First, 4-chlorobenzene is oxidized by suitable means, such as potassium permanganate or osmium tetroxide, so that the double bond is oxidized and broken, and converted into the corresponding carboxylic acid, which is 4-chlorophenylpropionic acid. In this process, the control of the conditions of the oxidation reaction is quite critical. Excessive oxidation intensity may lead to excessive oxidation, generating unnecessary by-products, affecting the purity and yield of the target product.
Furthermore, the synthesis of 4-chlorophenylpropionic acid can also be achieved by condensation reaction with malonic acid and other reagents, followed by decarboxylation reaction. In the condensation reaction stage, suitable catalysts and reaction solvents should be selected to promote the reaction between 4-chlorobenzaldehyde and malonic acid. The decarboxylation reaction step needs to control the appropriate temperature and reaction time, so that the condensation product can be decarboxylated smoothly to generate 4-chlorophenylpropionic acid.
The above synthesis methods have their own advantages and disadvantages, and they need to be weighed according to actual needs, such as raw material availability, cost considerations, product purity requirements and other factors.
Second, we can start from 4-chlorobenzene. First, 4-chlorobenzene is oxidized by suitable means, such as potassium permanganate or osmium tetroxide, so that the double bond is oxidized and broken, and converted into the corresponding carboxylic acid, which is 4-chlorophenylpropionic acid. In this process, the control of the conditions of the oxidation reaction is quite critical. Excessive oxidation intensity may lead to excessive oxidation, generating unnecessary by-products, affecting the purity and yield of the target product.
Furthermore, the synthesis of 4-chlorophenylpropionic acid can also be achieved by condensation reaction with malonic acid and other reagents, followed by decarboxylation reaction. In the condensation reaction stage, suitable catalysts and reaction solvents should be selected to promote the reaction between 4-chlorobenzaldehyde and malonic acid. The decarboxylation reaction step needs to control the appropriate temperature and reaction time, so that the condensation product can be decarboxylated smoothly to generate 4-chlorophenylpropionic acid.
The above synthesis methods have their own advantages and disadvantages, and they need to be weighed according to actual needs, such as raw material availability, cost considerations, product purity requirements and other factors.
4-chlorobenzenepropanoic Acid during storage and transportation
4-Chlorophenylpropionic acid is an organic compound. During storage and transportation, the following things should be carefully noted:
First, the storage environment should be careful. This substance should be stored in a cool, dry and well-ventilated place. Avoid open flames and hot topics to prevent it from being decomposed by heat or triggering combustion. In a high temperature environment, 4-chlorophenylpropionic acid may undergo chemical changes that damage its quality and even cause safety accidents. If placed in the sun or near a heat source, it may cause accidents.
Second, the packaging must be tight. Use suitable packaging materials to ensure sealing and prevent its leakage. Because 4-chlorophenylpropionic acid has a certain chemical activity, it may react with surrounding substances after leakage, and it may be polluted to the environment. If the package is damaged, it will come into contact with air, moisture, or deteriorate and lose use.
Third, during transportation, it is necessary to pack and unload lightly. Avoid violent vibration and impact, otherwise the package will be easily damaged and leak. And the transportation tool should also be clean and dry, and there are no other substances that can react with it. Do not mix with oxidants, strong alkalis, etc., to prevent dangerous chemical reactions.
Fourth, the logo should be clearly marked. On the storage and transportation containers, clearly mark the name, characteristics, danger warning and other information of 4-chlorophenylpropionic acid. Make it clear to the contact at a glance, and dispose of it in an appropriate way. If the identification is unclear, it will be mistaken for other things, or cause disaster.
Fifth, special management is also important. Relevant personnel need professional training, familiar with the properties and safety precautions of 4-chlorophenylpropionic acid. During storage and transportation, regular inspection, timely handling of packaging damage, leakage and other problems, to ensure the safety of the process.
First, the storage environment should be careful. This substance should be stored in a cool, dry and well-ventilated place. Avoid open flames and hot topics to prevent it from being decomposed by heat or triggering combustion. In a high temperature environment, 4-chlorophenylpropionic acid may undergo chemical changes that damage its quality and even cause safety accidents. If placed in the sun or near a heat source, it may cause accidents.
Second, the packaging must be tight. Use suitable packaging materials to ensure sealing and prevent its leakage. Because 4-chlorophenylpropionic acid has a certain chemical activity, it may react with surrounding substances after leakage, and it may be polluted to the environment. If the package is damaged, it will come into contact with air, moisture, or deteriorate and lose use.
Third, during transportation, it is necessary to pack and unload lightly. Avoid violent vibration and impact, otherwise the package will be easily damaged and leak. And the transportation tool should also be clean and dry, and there are no other substances that can react with it. Do not mix with oxidants, strong alkalis, etc., to prevent dangerous chemical reactions.
Fourth, the logo should be clearly marked. On the storage and transportation containers, clearly mark the name, characteristics, danger warning and other information of 4-chlorophenylpropionic acid. Make it clear to the contact at a glance, and dispose of it in an appropriate way. If the identification is unclear, it will be mistaken for other things, or cause disaster.
Fifth, special management is also important. Relevant personnel need professional training, familiar with the properties and safety precautions of 4-chlorophenylpropionic acid. During storage and transportation, regular inspection, timely handling of packaging damage, leakage and other problems, to ensure the safety of the process.
4-chlorobenzenepropanoic impact of Acid on the environment and human health
4-Chlorophenylpropionic acid, the impact of this substance on the environment and human health needs to be carefully investigated.
At the environmental level, it may have multiple effects. If it flows into the water body, it may be harmful to aquatic organisms. Aquatic organisms have different tolerances to it, or are disturbed by physiological functions, such as growth retardation, decreased reproductive ability, etc. Because of this substance, it may interfere with the biochemical reaction path in the organism, affecting the hormone balance and enzyme activity. And its degradation rate in the water body is slow, resulting in long-term retention, which will affect the aquatic ecosystem and destroy the ecological balance.
As for the soil environment, if 4-chlorophenylpropionic acid remains in it, it may change the structure and function of the soil microbial community. Microorganisms are essential for soil material circulation and nutrient transformation. Their communities are destroyed, or soil fertility is reduced, affecting plant growth.
It is related to human health. Exposure to this substance through various channels may pose a hidden danger. If ingested orally, or irritating the digestive system, it may cause gastrointestinal discomfort, nausea, vomiting, etc. Long-term low-dose intake, or hidden chronic damage to human organs. Because it has a certain fat solubility, or accumulates in adipose tissue, it interferes with the endocrine system, affects hormone secretion and regulation, and is associated with many health problems, such as reproductive disorders, metabolic disorders, etc.
And skin contact is not worry-free, or causes skin allergies, inflammation and other reactions. Inhalation of aerosols containing this substance in the respiratory tract may damage the respiratory system, causing symptoms such as cough and asthma.
Therefore, 4-chlorophenylpropionic acid has complex effects on the environment and human health, and in-depth research is required to clarify its exact harm, and to provide a solid basis for the formulation of protection and control measures to protect the environment and human well-being.
At the environmental level, it may have multiple effects. If it flows into the water body, it may be harmful to aquatic organisms. Aquatic organisms have different tolerances to it, or are disturbed by physiological functions, such as growth retardation, decreased reproductive ability, etc. Because of this substance, it may interfere with the biochemical reaction path in the organism, affecting the hormone balance and enzyme activity. And its degradation rate in the water body is slow, resulting in long-term retention, which will affect the aquatic ecosystem and destroy the ecological balance.
As for the soil environment, if 4-chlorophenylpropionic acid remains in it, it may change the structure and function of the soil microbial community. Microorganisms are essential for soil material circulation and nutrient transformation. Their communities are destroyed, or soil fertility is reduced, affecting plant growth.
It is related to human health. Exposure to this substance through various channels may pose a hidden danger. If ingested orally, or irritating the digestive system, it may cause gastrointestinal discomfort, nausea, vomiting, etc. Long-term low-dose intake, or hidden chronic damage to human organs. Because it has a certain fat solubility, or accumulates in adipose tissue, it interferes with the endocrine system, affects hormone secretion and regulation, and is associated with many health problems, such as reproductive disorders, metabolic disorders, etc.
And skin contact is not worry-free, or causes skin allergies, inflammation and other reactions. Inhalation of aerosols containing this substance in the respiratory tract may damage the respiratory system, causing symptoms such as cough and asthma.
Therefore, 4-chlorophenylpropionic acid has complex effects on the environment and human health, and in-depth research is required to clarify its exact harm, and to provide a solid basis for the formulation of protection and control measures to protect the environment and human well-being.
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