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4-Chlorobenzenesulfonyl Chloride
Linshang Chemical
|
HS Code |
544134 |
| Name | 4-Chlorobenzenesulfonyl Chloride |
| Chemical Formula | C6H4Cl2O2S |
| Molar Mass | 211.065 g/mol |
| Appearance | Colorless to pale yellow solid or liquid |
| Odor | Pungent odor |
| Density | 1.49 g/cm³ (20 °C) |
| Boiling Point | 156-158 °C (10 mmHg) |
| Melting Point | 41-45 °C |
| Solubility In Water | Reacts with water |
| Solubility In Organic Solvents | Soluble in many organic solvents like benzene, toluene |
| Cas Number | 98-60-2 |
| Flash Point | 132 °C |
As an accredited 4-Chlorobenzenesulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - kg bottle of 4 - chlorobenzenesulfonyl chloride, well - sealed for chemical storage. |
| Storage | 4 - Chlorobenzenesulfonyl chloride should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It must be stored in a tightly - sealed container to prevent contact with moisture, as it is reactive with water. Keep it separated from incompatible substances like bases, reducing agents, and amines. Store in a dedicated chemical storage area following safety regulations. |
| Shipping | 4 - Chlorobenzenesulfonyl Chloride is shipped in well - sealed, corrosion - resistant containers. It must be transported in accordance with hazardous chemical regulations, ensuring proper labeling and handling to prevent spills and exposure during transit. |
Competitive 4-Chlorobenzenesulfonyl Chloride prices that fit your budget—flexible terms and customized quotes for every order.
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Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 4-Chlorobenzenesulfonyl Chloride in China?
As a trusted 4-Chlorobenzenesulfonyl Chloride manufacturer, we deliver:
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 4-Chlorobenzenesulfonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 4-chlorobenzenesulfonyl Chloride?
4-Chlorobenzenesulfonyl chloride is also an important agent in organic synthesis. It has a wide range of uses and is widely used in the fields of medicine, pesticides, dyes and materials.
In the field of medicine, it is often the key intermediate for the creation of drugs. It can be combined with other compounds through specific chemical reactions to form molecules with special pharmacological activities. For example, when synthesizing some antibacterial and anti-inflammatory drugs, 4-chlorobenzenesulfonyl chloride can introduce a sulfonyl chloride group, which has a great impact on the activity, solubility and stability of drug molecules. It is related to whether the drug can accurately act on the target and exert the healing effect.
In the field of pesticides, it is also important. It is used to prepare high-efficiency pesticides, and by virtue of its chemical properties, it gives pesticides good insecticidal, bactericidal or herbicidal properties. After reacting with other organic raw materials, complex pesticide molecular structures are constructed to deal with the challenges of various crop diseases and insect pests, protect the flourishing of crops, and ensure the safety of harvests.
The synthesis of dyes also relies on 4-chlorobenzenesulfonyl chloride. It can add special functional groups to dye molecules, which in turn affect the key properties such as color, light and fastness of dyes. Make the dyed fabrics bright and lasting, and make great contributions to the textile printing and dyeing industry.
In the field of materials, its role cannot be underestimated. Or participate in the synthesis of high-performance polymer materials, endowing materials with special physical and chemical properties, such as improving heat resistance and mechanical properties of materials. Help materials meet the stringent requirements of high-end technology and industrial applications, and promote the progress of materials science.
In summary, 4-chlorobenzenesulfonyl chloride is indispensable in many industries, and its application promotes development and innovation in various fields, which is a treasure of organic synthetic chemistry.
In the field of medicine, it is often the key intermediate for the creation of drugs. It can be combined with other compounds through specific chemical reactions to form molecules with special pharmacological activities. For example, when synthesizing some antibacterial and anti-inflammatory drugs, 4-chlorobenzenesulfonyl chloride can introduce a sulfonyl chloride group, which has a great impact on the activity, solubility and stability of drug molecules. It is related to whether the drug can accurately act on the target and exert the healing effect.
In the field of pesticides, it is also important. It is used to prepare high-efficiency pesticides, and by virtue of its chemical properties, it gives pesticides good insecticidal, bactericidal or herbicidal properties. After reacting with other organic raw materials, complex pesticide molecular structures are constructed to deal with the challenges of various crop diseases and insect pests, protect the flourishing of crops, and ensure the safety of harvests.
The synthesis of dyes also relies on 4-chlorobenzenesulfonyl chloride. It can add special functional groups to dye molecules, which in turn affect the key properties such as color, light and fastness of dyes. Make the dyed fabrics bright and lasting, and make great contributions to the textile printing and dyeing industry.
In the field of materials, its role cannot be underestimated. Or participate in the synthesis of high-performance polymer materials, endowing materials with special physical and chemical properties, such as improving heat resistance and mechanical properties of materials. Help materials meet the stringent requirements of high-end technology and industrial applications, and promote the progress of materials science.
In summary, 4-chlorobenzenesulfonyl chloride is indispensable in many industries, and its application promotes development and innovation in various fields, which is a treasure of organic synthetic chemistry.
What are the physical properties of 4-chlorobenzenesulfonyl Chloride?
4-Chlorobenzenesulfonyl chloride, which is colorless to yellowish needle-like or flake-like crystalline. Its melting point is quite high, about 67-69 ° C, and its boiling point is 254 ° C. Under normal temperature, its solid state is stable, and it is flammable and explosive when exposed to heat, open flame or oxidants.
Looking at its solubility, 4-chlorobenzenesulfonyl chloride is insoluble in cold water, but soluble in organic solvents such as benzene, ether, and carbon disulfide. This property makes it suitable for organic synthesis and can participate in various reactions in specific organic solvent systems.
Furthermore, 4-chlorobenzenesulfonyl chloride is highly corrosive and has serious irritation to eyes, skin, and mucous membranes. If careless contact, light can cause local redness, pain, severe or damage to tissues and organs. Because of its high chemical activity, it is easy to hydrolyze in contact with water, generating 4-chlorobenzenesulfonic acid and hydrogen chloride gas, so when storing, it should be placed in a dry, cool and well-ventilated place to prevent water vapor from invading.
Looking at its solubility, 4-chlorobenzenesulfonyl chloride is insoluble in cold water, but soluble in organic solvents such as benzene, ether, and carbon disulfide. This property makes it suitable for organic synthesis and can participate in various reactions in specific organic solvent systems.
Furthermore, 4-chlorobenzenesulfonyl chloride is highly corrosive and has serious irritation to eyes, skin, and mucous membranes. If careless contact, light can cause local redness, pain, severe or damage to tissues and organs. Because of its high chemical activity, it is easy to hydrolyze in contact with water, generating 4-chlorobenzenesulfonic acid and hydrogen chloride gas, so when storing, it should be placed in a dry, cool and well-ventilated place to prevent water vapor from invading.
What are the chemical properties of 4-chlorobenzenesulfonyl Chloride?
4-Chlorobenzenesulfonyl chloride is a class of organic compounds with considerable characteristics. It is active and has a wide range of uses in the field of organic synthesis.
Looking at its chemical properties, the first thing to mention is its hydrolysis. In contact with water, it is easy to hydrolyze, producing 4-chlorobenzenesulfonic acid and hydrogen chloride. This reaction is as described in the text, that is, 4-chlorobenzenesulfonyl chloride encounters water, and the sulfonyl chloride group is replaced by a hydroxyl group, releasing hydrogen chloride gas. The mechanism of the reaction is that the sulfur atom in the sulfonyl chloride group has high positive electricity, which is easy to attack the oxygen atom in the water molecule, causing the C-S bond to break, and then forming a hydrolysis product.
Furthermore, 4-chlorobenzenesulfonyl chloride can also react with alcohols, which is the process of forming sulfonates. The hydroxyl oxygen in the alcohol attacks the sulfur atom of the sulfonyl chloride group with its lone pair electron nucleophilic, and then the chlorine atom leaves to obtain the corresponding sulfonate. This reaction is often used in organic synthesis as a way to prepare sulfonate compounds.
And it can also react with amine compounds. The nitrogen atom of amine has lone pairs of electrons and is a nucleophilic reagent. It attacks the sulfur atom of 4-chlorobenzenesulfonyl chloride, and the chlorine atom is separated to form a sulfonamide compound. This reaction is of great significance in many fields such as drug synthesis and material preparation, because many sulfonamides have unique biological activities and physicochemical properties.
4-chlorobenzenesulfonyl chloride still has the characteristics of halogenation reaction. Under certain conditions, the hydrogen atom on the benzene ring can be replaced by other halogen atoms, which is caused by the electron cloud distribution of the benzene ring and the localization effect of the sulfonyl chloride group. Sulfonyl chloride groups are meta-localized groups, which increase the density of the electron cloud in the benzene ring, so the halogenation reaction easily occurs in the meta-site. Due to its active chemical properties, 4-chlorobenzenesulfonyl chloride is an important intermediate in organic synthesis chemistry. It can construct various organic compounds with special structures and properties through various reaction paths, and has made significant contributions to the pharmaceutical, pesticide, materials and other industries.
Looking at its chemical properties, the first thing to mention is its hydrolysis. In contact with water, it is easy to hydrolyze, producing 4-chlorobenzenesulfonic acid and hydrogen chloride. This reaction is as described in the text, that is, 4-chlorobenzenesulfonyl chloride encounters water, and the sulfonyl chloride group is replaced by a hydroxyl group, releasing hydrogen chloride gas. The mechanism of the reaction is that the sulfur atom in the sulfonyl chloride group has high positive electricity, which is easy to attack the oxygen atom in the water molecule, causing the C-S bond to break, and then forming a hydrolysis product.
Furthermore, 4-chlorobenzenesulfonyl chloride can also react with alcohols, which is the process of forming sulfonates. The hydroxyl oxygen in the alcohol attacks the sulfur atom of the sulfonyl chloride group with its lone pair electron nucleophilic, and then the chlorine atom leaves to obtain the corresponding sulfonate. This reaction is often used in organic synthesis as a way to prepare sulfonate compounds.
And it can also react with amine compounds. The nitrogen atom of amine has lone pairs of electrons and is a nucleophilic reagent. It attacks the sulfur atom of 4-chlorobenzenesulfonyl chloride, and the chlorine atom is separated to form a sulfonamide compound. This reaction is of great significance in many fields such as drug synthesis and material preparation, because many sulfonamides have unique biological activities and physicochemical properties.
4-chlorobenzenesulfonyl chloride still has the characteristics of halogenation reaction. Under certain conditions, the hydrogen atom on the benzene ring can be replaced by other halogen atoms, which is caused by the electron cloud distribution of the benzene ring and the localization effect of the sulfonyl chloride group. Sulfonyl chloride groups are meta-localized groups, which increase the density of the electron cloud in the benzene ring, so the halogenation reaction easily occurs in the meta-site. Due to its active chemical properties, 4-chlorobenzenesulfonyl chloride is an important intermediate in organic synthesis chemistry. It can construct various organic compounds with special structures and properties through various reaction paths, and has made significant contributions to the pharmaceutical, pesticide, materials and other industries.
What to pay attention to when storing and transporting 4-chlorobenzenesulfonyl Chloride
4-Chlorobenzenesulfonyl chloride is a chemical substance, and many matters must be paid attention to during storage and transportation.
First, storage, this material is lively, corrosive, and should be stored in a cool, dry and well-ventilated warehouse. The temperature of the warehouse should not be too high to prevent it from changing due to heat, causing loss of stability, or causing dangerous reactions. And it needs to be kept away from fire and heat sources, because the source of fire can easily cause it to explode, endangering the safety of the warehouse and the surrounding area.
In addition, it must be stored separately from oxidants, alkalis, etc., and must not be mixed. Due to its chemical properties, the cover encounters with the oxidant, or causes a violent oxidation reaction; contact with alkalis can also cause chemical reactions, causing material deterioration, and even causing safety accidents.
The storage container is also very important. It must be well sealed to prevent it from volatilizing and escaping, polluting the environment, and avoiding reactions with substances in the air. At the same time, the storage environment and container should be checked regularly to check for leakage, deterioration, etc.
As for transportation, it is necessary to ensure that the packaging is complete and safely loaded before transportation. The materials used in the packaging must be able to withstand its corrosion to ensure that it will not be damaged or leaked during transportation. During transportation, the speed should not be too fast to avoid sudden braking to prevent package damage caused by collision.
Transport vehicles should also have good ventilation equipment. If there is a leak during transportation, drivers and passengers must quickly evacuate to a safe area and strictly follow the emergency handling procedures.
In short, the storage and transportation of 4-chlorobenzenesulfonyl chloride is related to safety, and it must be done with caution in accordance with the regulations to ensure safety.
First, storage, this material is lively, corrosive, and should be stored in a cool, dry and well-ventilated warehouse. The temperature of the warehouse should not be too high to prevent it from changing due to heat, causing loss of stability, or causing dangerous reactions. And it needs to be kept away from fire and heat sources, because the source of fire can easily cause it to explode, endangering the safety of the warehouse and the surrounding area.
In addition, it must be stored separately from oxidants, alkalis, etc., and must not be mixed. Due to its chemical properties, the cover encounters with the oxidant, or causes a violent oxidation reaction; contact with alkalis can also cause chemical reactions, causing material deterioration, and even causing safety accidents.
The storage container is also very important. It must be well sealed to prevent it from volatilizing and escaping, polluting the environment, and avoiding reactions with substances in the air. At the same time, the storage environment and container should be checked regularly to check for leakage, deterioration, etc.
As for transportation, it is necessary to ensure that the packaging is complete and safely loaded before transportation. The materials used in the packaging must be able to withstand its corrosion to ensure that it will not be damaged or leaked during transportation. During transportation, the speed should not be too fast to avoid sudden braking to prevent package damage caused by collision.
Transport vehicles should also have good ventilation equipment. If there is a leak during transportation, drivers and passengers must quickly evacuate to a safe area and strictly follow the emergency handling procedures.
In short, the storage and transportation of 4-chlorobenzenesulfonyl chloride is related to safety, and it must be done with caution in accordance with the regulations to ensure safety.
What are the synthesis methods of 4-chlorobenzenesulfonyl Chloride?
The synthesis method of 4-chlorobenzenesulfonyl chloride has been explored by many parties in the past, and each path has its own advantages.
One method starts with 4-chlorobenzenesulfonic acid and makes it co-heat with phosphorus pentachloride. The two are mixed in a certain proportion in a suitable vessel, slowly heated, and then react. Phosphorus pentachloride is highly chlorinated and can replace the hydroxyl group in the sulfonic acid group with a chlorine atom to form 4-chlorobenzenesulfonyl chloride. The reaction process must be controlled by temperature. If it is overheated, it is easy to produce side reactions, resulting in impure products; if it is too slow, the reaction will be slow and time-consuming. And after the reaction, the product needs to be properly separated to remove unreacted raw materials and by-products.
There is also 4-chlorobenzene as a group, which is first sulfonated to obtain 4-chlorobenzenesulfonic acid, and then treated with sulfoxide chloride. When sulfonating, choose an appropriate sulfonating agent, such as concentrated sulfuric acid or fuming sulfuric acid, according to its characteristics and interact with 4-chlorobenzene, introduce the sulfonic acid group. Then the sulfoxide chloride encounters it, and the sulfonic acid group is chlorinated and converted into a sulfonyl chloride group. In this path, the decision of the conditions of the sulfonation step is quite important, which is related to the position and degree of the introduction of the sulfonic acid group; the amount of sulfoxide chloride and the reaction conditions also need to be fine-tuned to ensure that the reaction is complete and the product is pure.
There are It is first reduced to 4-chloroaniline, and then through a series of steps such as diazotization and Sandmeier reaction, a sulfonic acid group is introduced and converted into sulfonyl chloride. Although this process is complicated, if each step is carefully operated, pure 4-chlorobenzenesulfonyl chloride can also be obtained. The reduction step requires the selection of an appropriate reducing agent. The diazotization reaction should pay attention to temperature, acidity and other conditions. The Sandmeier reaction has specific requirements for reagents and reaction environment.
All these synthesis methods have advantages and disadvantages. In practice, when making a careful choice according to the availability of raw materials, the availability of equipment, and the purity requirements of the product, the synthesis can be smooth and satisfactory results can be obtained.
One method starts with 4-chlorobenzenesulfonic acid and makes it co-heat with phosphorus pentachloride. The two are mixed in a certain proportion in a suitable vessel, slowly heated, and then react. Phosphorus pentachloride is highly chlorinated and can replace the hydroxyl group in the sulfonic acid group with a chlorine atom to form 4-chlorobenzenesulfonyl chloride. The reaction process must be controlled by temperature. If it is overheated, it is easy to produce side reactions, resulting in impure products; if it is too slow, the reaction will be slow and time-consuming. And after the reaction, the product needs to be properly separated to remove unreacted raw materials and by-products.
There is also 4-chlorobenzene as a group, which is first sulfonated to obtain 4-chlorobenzenesulfonic acid, and then treated with sulfoxide chloride. When sulfonating, choose an appropriate sulfonating agent, such as concentrated sulfuric acid or fuming sulfuric acid, according to its characteristics and interact with 4-chlorobenzene, introduce the sulfonic acid group. Then the sulfoxide chloride encounters it, and the sulfonic acid group is chlorinated and converted into a sulfonyl chloride group. In this path, the decision of the conditions of the sulfonation step is quite important, which is related to the position and degree of the introduction of the sulfonic acid group; the amount of sulfoxide chloride and the reaction conditions also need to be fine-tuned to ensure that the reaction is complete and the product is pure.
There are It is first reduced to 4-chloroaniline, and then through a series of steps such as diazotization and Sandmeier reaction, a sulfonic acid group is introduced and converted into sulfonyl chloride. Although this process is complicated, if each step is carefully operated, pure 4-chlorobenzenesulfonyl chloride can also be obtained. The reduction step requires the selection of an appropriate reducing agent. The diazotization reaction should pay attention to temperature, acidity and other conditions. The Sandmeier reaction has specific requirements for reagents and reaction environment.
All these synthesis methods have advantages and disadvantages. In practice, when making a careful choice according to the availability of raw materials, the availability of equipment, and the purity requirements of the product, the synthesis can be smooth and satisfactory results can be obtained.
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