4-Chlorobenzenesulfonyl Chloride (Pcsc)

Linshang Chemical

Specifications

HS Code

651757

Chemical Formula C6H4Cl2O2S
Molar Mass 211.065 g/mol
Appearance Colorless to light - yellow liquid
Odor Pungent odor
Density 1.498 g/cm³ (at 20 °C)
Boiling Point 254 - 256 °C
Melting Point −15 °C
Solubility In Water Reacts with water
Solubility In Organic Solvents Soluble in common organic solvents like benzene, toluene
Flash Point 110 °C
Vapor Pressure Low vapor pressure

As an accredited 4-Chlorobenzenesulfonyl Chloride (Pcsc) factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 1 - kg bottle of 4 - chlorobenzenesulfonyl Chloride (PCSC) with secure chemical - resistant packaging.
Storage 4 - Chlorobenzenesulfonyl chloride (PCSC) should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It should be kept in a tightly sealed container to prevent moisture absorption and contact with air, as it can react with water. Store it separately from incompatible substances like bases and reactive metals to avoid potential chemical reactions.
Shipping 4 - Chlorobenzenesulfonyl Chloride (PCSC) is shipped in well - sealed, corrosion - resistant containers. Special care is taken to prevent exposure to moisture and heat during transit as it is reactive. Shipment adheres to strict chemical transportation regulations.
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4-Chlorobenzenesulfonyl Chloride (Pcsc) 4-Chlorobenzenesulfonyl Chloride (Pcsc)
General Information
Where to Buy 4-Chlorobenzenesulfonyl Chloride (Pcsc) in China?
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Frequently Asked Questions

As a leading 4-Chlorobenzenesulfonyl Chloride (Pcsc) supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 4-chlorobenzenesulfonyl Chloride (PCSC)?
4-Chlorobenzenesulfonyl chloride (PCSC) has a wide range of uses. In the field of organic synthesis, it is often used as a key reagent.
First, it can be used to prepare sulfonamides. The sulfonyl group of benzenesulfonyl chloride has active chemical properties and can react with amino-containing compounds, such as amines, under suitable conditions, through nucleophilic substitution to form sulfonamides. This sulfonamide substance has many applications in the field of medicine, and some have antibacterial and anti-inflammatory effects. It can provide an important intermediate for the creation of new drugs.
Second, it can be used to synthesize sulfonyl esters. After reacting with alcohols, PCSC can obtain sulfonyl esters. Such compounds may have unique properties in materials science. For example, some sulfonyl esters can be used as additives for special functional materials to improve the properties of materials, such as improving the stability and flexibility of materials.
Third, it is also useful in the dye industry. By reacting with specific compounds, sulfonyl chloride groups can be introduced to modify the molecular structure of dyes, thereby changing the color and dyeing properties of dyes. It can enhance the affinity of dyes to specific fiber materials, improve dyeing fastness, and broaden the application range of dyes.
Fourth, in the preparation of surfactants, 4-chlorobenzenesulfonyl chloride can also play a role. Through a series of reactions, it is introduced into the molecular structure of the surfactant, which can adjust the hydrophilic-lipophilic balance value (HLB) of the surfactant, optimize its surface activity, and make it exhibit better performance in emulsification, dispersion, solubilization, etc. It is widely used in daily chemical, oil extraction and other industries.
What are the physical properties of 4-chlorobenzenesulfonyl Chloride (PCSC)?
4-Chlorobenzenesulfonyl chloride (PCSC) is a commonly used reagent in organic synthesis. Its physical properties are quite characteristic, let me describe them in detail for you.
Looking at its appearance, 4-chlorobenzenesulfonyl chloride is colorless to light yellow liquid at room temperature. This state is in many organic reactions, easy to operate and mix, and conducive to the development of reactions.
When it comes to odor, this substance has a pungent and unpleasant smell. This smell warns everyone to be cautious during use. Because it may be irritating to the human respiratory tract and sensory parts such as eyes and nose, appropriate protective measures must be taken when using it to ensure safety.
The boiling point of 4-chlorobenzenesulfonyl chloride is about 145 ° C (2.0 kPa), and the boiling point value is of great significance in organic synthesis operations. Knowing the boiling point can accurately control the temperature in separation steps such as distillation, so that 4-chlorobenzenesulfonyl chloride can be effectively separated from other substances to ensure the purity of the product.
Its melting point is about 14 ° C, and the characteristics of the melting point also affect its storage and use conditions. At lower temperatures, 4-chlorobenzenesulfonyl chloride may be in a solid state, and it needs to be properly heated to liquefy it before it can be used in the reaction.
In terms of density, it is about 1.49g/cm ³. This density data is crucial in the measurement operation. Accurate measurement of the volume of 4-chlorobenzenesulfonyl chloride, combined with the density, can accurately know its quality and provide a basis for accurate feeding of the reaction.
In addition, 4-chlorobenzenesulfonyl chloride has poor solubility in water, but it can be soluble in most organic solvents, such as benzene, toluene, dichloromethane, etc. This solubility characteristic makes it possible to select suitable organic solvents according to the reaction requirements when building an organic synthesis reaction system to promote the reaction and improve the reaction efficiency and yield.
4-chlorobenzenesulfonyl the chemistry of Chloride (PCSC)
4-Chlorobenzenesulfonyl chloride (PCSC) is an important reagent in organic synthesis. It is active and plays a key role in many chemical reactions.
Looking at its physical properties, 4-chlorobenzenesulfonyl chloride is often colorless to slightly yellow at room temperature, with a pungent odor. Its boiling point is quite high, about 255 ° C, due to the strong interaction force between molecules. The density is greater than that of water, about 1.49 g/cm ³, so it will sink in water.
On its chemical properties, its hydrolysis characteristics are first discussed. 4-chlorobenzenesulfonyl chloride is highly prone to hydrolysis in contact with water, resulting in 4-chlorobenzenesulfonic acid and hydrogen chloride. This reaction is rapid, and the activity of the sulfonyl chloride group is very high. The reaction formula is as follows: C H ClSO ² Cl + H ² O → C H ClSO 😉 H + HCl.
There is a nucleophilic substitution reaction. This is an important reaction type of 4-chlorobenzenesulfonyl chloride. Because the chlorine atom in the sulfonyl chloride group has good departure properties, it is easily replaced by various nucleophilic reagents. If it encounters an alcohol, the oxygen atom of the alcohol acts as a nucleophilic center, attacking the sulfur atom of the sulfonyl chloride group, and the chlorine atom leaves to form a sulfonate. If it reacts with ethanol, ethyl 4-chlorobenzenesulfonate can be obtained. The reaction formula is: C H ClSO ² Cl + C ² H OH → C H ClSO ³ OC ³ H + HCl.
When reacting with amines, the nitrogen atom of the amine attacks the sulfur atom nucleophilically, and the chlorine leaves to form a sulfonamide. This reaction is widely used in drug synthesis and other fields, and can construct a variety of nitrogen-containing compound structures.
In addition, 4-chlorobenzenesulfonyl chloride can participate in the Foux-gram reaction. Under the action of appropriate catalysts, it can react with aromatic hydrocarbons and introduce sulfonyl groups into aromatic hydrocarbon rings, so as to realize the functional modification of aromatic hydrocarbons and expand the structural diversity of compounds.
In short, 4-chlorobenzenesulfonyl chloride plays an important role in many aspects of organic synthesis due to its active chemical properties, providing an important way and method for the preparation of many compounds.
What is the preparation method of 4-chlorobenzenesulfonyl Chloride (pcsc)?
The method of preparing 4-chlorobenzenesulfonyl chloride (PCSC) has been known for a long time. If you want to make this substance, you can get it by interacting 4-chlorobenzenesulfonate with a chlorinating agent.
Common chlorinating agent is phosphorus pentachloride ($PCl_ {5} $). Put 4-chlorobenzenesulfonate and an appropriate amount of phosphorus pentachloride in a suitable reaction vessel at room temperature, and the two will react chemically. The reaction formula is as follows: $C_ {6} H_ {4} ClSO_ {3} H + PCl_ {5}\ longrightarrow C_ {6} H_ {4} ClSO_ {2} Cl + POCl_ {3} + HCl $. At the time of the reaction, the phosphorus atom of phosphorus pentachloride attacks the sulfonic acid oxygen atom of 4-chlorobenzenesulfonic acid electrophilically, and then a series of group transfer and elimination reactions occur, resulting in 4-chlorobenzenesulfonyl chloride. At the same time, by-products of phosphorus oxychloride ($POCl_ {3} $) and hydrogen chloride ($HCl $) gas.
Sulfite chloride ($SOCl_ {2} $) can also be used as a chlorination agent. Take 4-chlorobenzenesulfonic acid and sulfite chloride and place them in a reactor, and heat them moderately to promote the reaction. The chemical equation for this reaction is: $C_ {6} H_ {4} ClSO_ {3} H + SOCl_ {2}\ longrightarrow C_ {6} H_ {4} ClSO_ {2} Cl + SO_ {2}\ uparrow + HCl\ uparrow $. When thionyl chloride reacts with 4-chlorobenzenesulfonic acid, the chlorine atom in the thionyl chloride replaces the hydroxyl group of the sulfonic acid group to form 4-chlorobenzenesulfonic chloride, and sulfur dioxide ($SO_ {2} $) and hydrogen chloride gas escape.
After the reaction is completed, the product may contain impurities such as unreacted raw materials and by-products. To obtain pure 4-chlorobenzenesulfonic chloride, distillation can be applied. Using the difference between the boiling point of 4-chlorobenzenesulfonyl chloride and the impurity, the mixture is heated, and the 4-chlorobenzenesulfonyl chloride is gasified and condensed to remove impurities and obtain a pure product.
What are the precautions for 4-chlorobenzenesulfonyl Chloride (pcsc) in storage and transportation?
4-Chlorobenzenesulfonyl chloride (PCSC) is a chemical substance, and many things must be paid attention to when storing and transporting it.
First storage, this substance should be placed in a cool, dry and well-ventilated place. Because of its active nature, it is easy to react chemically when heated or wet, resulting in quality variation, so it is important to avoid heat and moisture. It needs to be stored in a sealed container to prevent oxidation and other reactions from coming into contact with air. And it should be kept away from fire and heat sources. Because of its flammability and reactivity, it is at risk of exposure to open flames, hot topics or combustion and explosion. Furthermore, it should be stored separately from oxidants and alkalis, and should not be mixed. It is easy to react violently with them.
As for transportation, it must be handled lightly and unloaded, and must not be operated brutally to avoid damage to the container and leakage of materials. Transportation vehicles should be equipped with corresponding types and quantities of fire-fighting equipment and leakage emergency treatment equipment. During driving, it should be protected from exposure to the sun, rain and high temperature. When road transportation, it should be driven according to the prescribed route, and do not stop in residential areas and densely populated areas. If rail transportation is used, it must also be strictly handled in accordance with regulations to ensure safe transportation.
All of these are for the storage and transportation of 4-chlorobenzenesulfonyl chloride (PCSC), so as to ensure its safety and avoid disasters.