Linshang Chemical
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4-Chlorobenzenesulfonyl Fluoride
Linshang Chemical
|
HS Code |
325703 |
| Chemical Formula | C6H4ClFO2S |
| Molecular Weight | 194.61 |
| Appearance | Colorless to light yellow liquid |
| Odor | Pungent odor |
| Density | 1.48 g/cm³ (approximate) |
| Boiling Point | 246 - 248 °C |
| Solubility | Slightly soluble in water, soluble in organic solvents |
| Vapor Pressure | Low vapor pressure |
| Flash Point | 120 °C (approximate) |
As an accredited 4-Chlorobenzenesulfonyl Fluoride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - chlorobenzenesulfonyl fluoride in a sealed, corrosion - resistant bottle. |
| Storage | 4 - Chlorobenzenesulfonyl Fluoride should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container to prevent leakage. It is best stored in a dedicated chemical storage cabinet, separated from incompatible substances, to ensure safety and prevent degradation. |
| Shipping | 4 - chlorobenzenesulfonyl fluoride, a hazardous chemical, is shipped in well - sealed, corrosion - resistant containers. Transport follows strict regulations, with appropriate labeling for its dangerous nature, ensuring safety during transit. |
Competitive 4-Chlorobenzenesulfonyl Fluoride prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 4-Chlorobenzenesulfonyl Fluoride in China?
As a trusted 4-Chlorobenzenesulfonyl Fluoride manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 4-Chlorobenzenesulfonyl Fluoride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 4-chlorobenzenesulfonyl Fluoride?
4-Chlorobenzenesulfonyl fluoride has a wide range of uses. In the field of organic synthesis, it is often used as a key reagent. Because of its active sulfonyl fluoride group, it can react with many nucleophiles to form carbon-sulfur bonds or other heteroatom-sulfur bonds. This property is of great significance in the creation of complex organic compounds.
It also plays an important role in the field of medicinal chemistry. With its chemical activity, it can modify drug molecules and improve drug formation, such as improving drug solubility, stability and bioavailability. At the same time, when developing new antibacterial and antiviral drugs, the reaction of 4-chlorobenzenesulfonyl fluoride can introduce special functional groups and endow the drug with unique pharmacological activity.
In the field of materials science, 4-chlorobenzenesulfonyl fluoride can be used to prepare special polymer materials. By polymerizing with monomers containing active groups, sulfonyl fluoride groups can be introduced into the polymer chain, thereby giving the material special properties such as chemical resistance and surface activity. It has potential applications in coatings, plastics and other fields.
In addition, in agricultural chemistry, it may be used to synthesize new pesticides. With its unique chemical structure and reactivity, high-efficiency, low-toxicity and environmentally friendly pesticides have been created, which contribute to crop protection. In short, 4-chlorobenzenesulfonyl fluoride, with its active chemical properties, plays an important role in many fields and promotes technological and product innovation in various fields.
It also plays an important role in the field of medicinal chemistry. With its chemical activity, it can modify drug molecules and improve drug formation, such as improving drug solubility, stability and bioavailability. At the same time, when developing new antibacterial and antiviral drugs, the reaction of 4-chlorobenzenesulfonyl fluoride can introduce special functional groups and endow the drug with unique pharmacological activity.
In the field of materials science, 4-chlorobenzenesulfonyl fluoride can be used to prepare special polymer materials. By polymerizing with monomers containing active groups, sulfonyl fluoride groups can be introduced into the polymer chain, thereby giving the material special properties such as chemical resistance and surface activity. It has potential applications in coatings, plastics and other fields.
In addition, in agricultural chemistry, it may be used to synthesize new pesticides. With its unique chemical structure and reactivity, high-efficiency, low-toxicity and environmentally friendly pesticides have been created, which contribute to crop protection. In short, 4-chlorobenzenesulfonyl fluoride, with its active chemical properties, plays an important role in many fields and promotes technological and product innovation in various fields.
What are the physical properties of 4-chlorobenzenesulfonyl Fluoride?
4-Chlorobenzenesulfonyl fluoride is one of the organic compounds. Its physical properties are particularly important and relevant to its many applications.
Looking at its properties, 4-chlorobenzenesulfonyl fluoride is often colorless to light yellow liquid at room temperature and pressure. The characterization of this color state is one of the key bases for identifying the substance in actual operation and observation. It has a specific odor. Although the text is difficult to know its exact taste, in the experimental environment, its unique smell can be identified by olfaction, which is also the characteristic identification of the substance.
When it comes to the melting point, the data of the melting point is of great significance for determining the limit of its physical state change. Unfortunately, the exact melting point is not detailed, but the information about the boiling point can be used as a research reference. At standard atmospheric pressure, the value of the boiling point is an important parameter that defines its transition from liquid to gaseous state, and can provide accurate guidance for operations involving heating and distillation of the substance.
The density of 4-chlorobenzenesulfonyl fluoride is a physical quantity to measure the relationship between its mass and volume. Under the given conditions, its density is stable, and it is indispensable for accurate measurement of the substance in the measurement of chemical reactions and many practical application scenarios. The characteristics of density are also related to its fluctuation and distribution in different media, which has a profound impact on the design of related experiments and industrial processes.
In terms of solubility, 4-chlorobenzenesulfonyl fluoride exhibits good solubility in organic solvents such as ether and dichloromethane. This property makes it easy to participate in various reactions in the field of organic synthesis, because organic solvents can effectively disperse the substance, promoting contact and collision between reaction molecules, thereby accelerating the reaction process. However, in water, its solubility is not good, and this difference needs to be taken into account in separation, purification and wastewater treatment.
Volatility is also an important physical property of 4-chlorobenzenesulfonyl fluoride. Because of its certain volatility, it needs to be properly sealed during storage and use to prevent it from escaping into the environment. Volatility not only affects its concentration stability in the reaction system, but also affects the safety and health of the operating environment.
In summary, the physical properties of 4-chlorobenzenesulfonyl fluoride, such as color state, melting boiling point, density, solubility and volatility, are interrelated and affect its application and treatment in chemical industry, scientific research and other fields. The accurate grasp of these properties lays a solid foundation for the rational use of this substance.
Looking at its properties, 4-chlorobenzenesulfonyl fluoride is often colorless to light yellow liquid at room temperature and pressure. The characterization of this color state is one of the key bases for identifying the substance in actual operation and observation. It has a specific odor. Although the text is difficult to know its exact taste, in the experimental environment, its unique smell can be identified by olfaction, which is also the characteristic identification of the substance.
When it comes to the melting point, the data of the melting point is of great significance for determining the limit of its physical state change. Unfortunately, the exact melting point is not detailed, but the information about the boiling point can be used as a research reference. At standard atmospheric pressure, the value of the boiling point is an important parameter that defines its transition from liquid to gaseous state, and can provide accurate guidance for operations involving heating and distillation of the substance.
The density of 4-chlorobenzenesulfonyl fluoride is a physical quantity to measure the relationship between its mass and volume. Under the given conditions, its density is stable, and it is indispensable for accurate measurement of the substance in the measurement of chemical reactions and many practical application scenarios. The characteristics of density are also related to its fluctuation and distribution in different media, which has a profound impact on the design of related experiments and industrial processes.
In terms of solubility, 4-chlorobenzenesulfonyl fluoride exhibits good solubility in organic solvents such as ether and dichloromethane. This property makes it easy to participate in various reactions in the field of organic synthesis, because organic solvents can effectively disperse the substance, promoting contact and collision between reaction molecules, thereby accelerating the reaction process. However, in water, its solubility is not good, and this difference needs to be taken into account in separation, purification and wastewater treatment.
Volatility is also an important physical property of 4-chlorobenzenesulfonyl fluoride. Because of its certain volatility, it needs to be properly sealed during storage and use to prevent it from escaping into the environment. Volatility not only affects its concentration stability in the reaction system, but also affects the safety and health of the operating environment.
In summary, the physical properties of 4-chlorobenzenesulfonyl fluoride, such as color state, melting boiling point, density, solubility and volatility, are interrelated and affect its application and treatment in chemical industry, scientific research and other fields. The accurate grasp of these properties lays a solid foundation for the rational use of this substance.
4-chlorobenzenesulfonyl is Fluoride chemically stable?
The chemical properties of 4-chlorobenzenesulfonyl fluoride are not very stable.
Looking at its structure, it contains a sulfonyl fluoro group and a chlorine atom. The sulfonyl fluoro group has high activity and is easy to react with many nucleophilic reagents. In case of water, the sulfonyl fluoro group is easy to hydrolyze, and the sulfonic acid is initially formed, and then there may be further changes. The hydrolysis reaction may be fast or slow, but eventually its chemical form can be changed.
On the chlorine atom, although the activity of the sulfonyl fluoro group is slightly less than that of the sulfonyl fluoro group, it can also participate in reactions such as nucleophilic substitution under suitable conditions. For example, if a suitable nucleophilic reagent exists and the conditions
If it is stored from a storage point of view, it needs to be done with caution. Because it is sensitive to water and air, it is suitable for storage in a dry and air-isolated environment. Otherwise, it is easy to deteriorate due to the above-mentioned hydrolysis and other reactions, and lose its original chemical properties. Therefore, the chemical properties of 4-chlorobenzenesulfonyl fluoride are not stable. It is necessary to pay attention to its activity characteristics in use, storage and other links to prevent it from mutating due to environmental factors.
Looking at its structure, it contains a sulfonyl fluoro group and a chlorine atom. The sulfonyl fluoro group has high activity and is easy to react with many nucleophilic reagents. In case of water, the sulfonyl fluoro group is easy to hydrolyze, and the sulfonic acid is initially formed, and then there may be further changes. The hydrolysis reaction may be fast or slow, but eventually its chemical form can be changed.
On the chlorine atom, although the activity of the sulfonyl fluoro group is slightly less than that of the sulfonyl fluoro group, it can also participate in reactions such as nucleophilic substitution under suitable conditions. For example, if a suitable nucleophilic reagent exists and the conditions
If it is stored from a storage point of view, it needs to be done with caution. Because it is sensitive to water and air, it is suitable for storage in a dry and air-isolated environment. Otherwise, it is easy to deteriorate due to the above-mentioned hydrolysis and other reactions, and lose its original chemical properties. Therefore, the chemical properties of 4-chlorobenzenesulfonyl fluoride are not stable. It is necessary to pay attention to its activity characteristics in use, storage and other links to prevent it from mutating due to environmental factors.
What is the synthesis method of 4-chlorobenzenesulfonyl Fluoride?
To prepare 4-chlorobenzenesulfonyl fluoride, the method is as follows:
Take 4-chlorobenzenesulfonate first, which is the starting material. 4-chlorobenzenesulfonate is often started with sodium salt of 4-chlorobenzenesulfonate, and 4-chlorobenzenesulfonate can be obtained by acidification. Place 4-chlorobenzenesulfonate in an appropriate reaction vessel and add an appropriate amount of chlorinated reagent, such as phosphorus pentachloride ($PCl_ {5} $) or thionyl chloride ($SOCl_ {2} $). If phosphorus pentachloride is used, its reaction with 4-chlorobenzenesulfonate can cause the hydroxyl group on the sulfonate group to be replaced by a chlorine atom to form 4-chlorobenesulfon This reaction needs to be carried out at an appropriate temperature and reaction time. Usually in a heated and anhydrous environment, the reaction is relatively smooth.
After 4-chlorobenzenesulfonyl chloride is formed, it is reacted with a fluorinating reagent. Commonly used fluorinating reagents are anhydrous hydrogen fluoride ($HF $) or metal fluorides, such as potassium fluoride ($KF $). Taking potassium fluoride as an example, in an aprotic solvent, such as dimethylformamide ($DMF $), 4-chlorobenzenesulfonyl chloride undergoes a nucleophilic substitution reaction with potassium fluoride, in which the chlorine atom is replaced by a fluorine atom, and 4-chlorobenzenesulfonyl fluoride is obtained.
During the reaction process, attention should be paid to the control of the reaction conditions If the temperature is too high or too low, it may affect the rate and yield of the reaction. And the anhydrous requirement of the reaction environment is very critical, because the existence of water may cause side reactions to occur and affect the purity of the product. At the same time, after the reaction is completed, the product needs to be separated and purified before high-purity 4-chlorobenzenesulfonyl fluoride can be obtained. Generally, 4-chlorobenzenesulfonyl fluoride can be separated and purified by distillation, recrystallization or column chromatography. In this way, according to the above steps and conditions, 4-chlorobenzenesulfonyl fluoride can be prepared.
Take 4-chlorobenzenesulfonate first, which is the starting material. 4-chlorobenzenesulfonate is often started with sodium salt of 4-chlorobenzenesulfonate, and 4-chlorobenzenesulfonate can be obtained by acidification. Place 4-chlorobenzenesulfonate in an appropriate reaction vessel and add an appropriate amount of chlorinated reagent, such as phosphorus pentachloride ($PCl_ {5} $) or thionyl chloride ($SOCl_ {2} $). If phosphorus pentachloride is used, its reaction with 4-chlorobenzenesulfonate can cause the hydroxyl group on the sulfonate group to be replaced by a chlorine atom to form 4-chlorobenesulfon This reaction needs to be carried out at an appropriate temperature and reaction time. Usually in a heated and anhydrous environment, the reaction is relatively smooth.
After 4-chlorobenzenesulfonyl chloride is formed, it is reacted with a fluorinating reagent. Commonly used fluorinating reagents are anhydrous hydrogen fluoride ($HF $) or metal fluorides, such as potassium fluoride ($KF $). Taking potassium fluoride as an example, in an aprotic solvent, such as dimethylformamide ($DMF $), 4-chlorobenzenesulfonyl chloride undergoes a nucleophilic substitution reaction with potassium fluoride, in which the chlorine atom is replaced by a fluorine atom, and 4-chlorobenzenesulfonyl fluoride is obtained.
During the reaction process, attention should be paid to the control of the reaction conditions If the temperature is too high or too low, it may affect the rate and yield of the reaction. And the anhydrous requirement of the reaction environment is very critical, because the existence of water may cause side reactions to occur and affect the purity of the product. At the same time, after the reaction is completed, the product needs to be separated and purified before high-purity 4-chlorobenzenesulfonyl fluoride can be obtained. Generally, 4-chlorobenzenesulfonyl fluoride can be separated and purified by distillation, recrystallization or column chromatography. In this way, according to the above steps and conditions, 4-chlorobenzenesulfonyl fluoride can be prepared.
What are the precautions for 4-chlorobenzenesulfonyl Fluoride during use?
4 - Chlorobenzenesulfonyl fluoride, when using, many matters should be paid attention to. This is a chemical substance, which is more active and dangerous.
First safety protection. Users must wear appropriate protective equipment, such as gas masks, protective gloves and protective clothing. Because it may invade the human body through the respiratory tract and skin, causing health hazards. If you accidentally touch it, or cause burns to the skin and eyes. Therefore, before and after operation, check carefully whether the protective equipment is damaged.
Furthermore, operate in a well-ventilated place. 4 - Chlorobenzenesulfonyl fluoride may evaporate harmful gases. Good ventilation can reduce its concentration in the air and reduce the risk of human inhalation. If it is used in a confined space, poisonous gas will accumulate and it is easy to cause poisoning.
Also, its storage is also exquisite. It should be stored in a cool, dry and ventilated place, away from fire and heat sources. And it must be stored separately with oxidants and alkalis to prevent mutual reaction and danger.
When operating, the action should be steady and fine. Because of its high chemical activity, improper operation or severe reaction. The amount taken must be accurate, according to the needs of the experiment or production.
In waste disposal, it should not be neglected. It must be in accordance with relevant regulations, properly disposed of, and cannot be dumped at will to avoid polluting the environment.
In short, when using 4-chlorobenzenesulfonyl fluoride, safety protection, ventilation, storage, operation, and waste disposal must be taken with care to ensure personal safety and the environment.
First safety protection. Users must wear appropriate protective equipment, such as gas masks, protective gloves and protective clothing. Because it may invade the human body through the respiratory tract and skin, causing health hazards. If you accidentally touch it, or cause burns to the skin and eyes. Therefore, before and after operation, check carefully whether the protective equipment is damaged.
Furthermore, operate in a well-ventilated place. 4 - Chlorobenzenesulfonyl fluoride may evaporate harmful gases. Good ventilation can reduce its concentration in the air and reduce the risk of human inhalation. If it is used in a confined space, poisonous gas will accumulate and it is easy to cause poisoning.
Also, its storage is also exquisite. It should be stored in a cool, dry and ventilated place, away from fire and heat sources. And it must be stored separately with oxidants and alkalis to prevent mutual reaction and danger.
When operating, the action should be steady and fine. Because of its high chemical activity, improper operation or severe reaction. The amount taken must be accurate, according to the needs of the experiment or production.
In waste disposal, it should not be neglected. It must be in accordance with relevant regulations, properly disposed of, and cannot be dumped at will to avoid polluting the environment.
In short, when using 4-chlorobenzenesulfonyl fluoride, safety protection, ventilation, storage, operation, and waste disposal must be taken with care to ensure personal safety and the environment.
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