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4-Chlorobenzenesulphonyl Chloride
Linshang Chemical
|
HS Code |
857295 |
| Chemical Formula | C6H4Cl2O2S |
| Molar Mass | 211.065 g/mol |
| Appearance | Colorless to pale yellow liquid |
| Density | 1.499 g/cm³ |
| Boiling Point | 145 - 148 °C at 13 mmHg |
| Melting Point | 12 - 13 °C |
| Solubility In Water | Reacts with water |
| Solubility In Organic Solvents | Soluble in common organic solvents like benzene, toluene |
| Odor | Pungent, irritating odor |
| Flash Point | 110 °C |
| Hazard | Corrosive, causes burns to skin, eyes, and respiratory tract |
As an accredited 4-Chlorobenzenesulphonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - chlorobenzenesulphonyl chloride in a tightly - sealed glass bottle. |
| Storage | 4 - Chlorobenzenesulphonyl chloride should be stored in a cool, dry, well - ventilated area away from sources of heat, ignition, and direct sunlight. It should be kept in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from incompatible substances like bases, water - reactive materials, and reducing agents to prevent dangerous reactions. |
| Shipping | 4 - Chlorobenzenesulphonyl Chloride is a hazardous chemical. It must be shipped in accordance with strict regulations. Use appropriate, tightly - sealed containers. Label clearly for proper handling and transport to avoid spills and ensure safety during transit. |
Competitive 4-Chlorobenzenesulphonyl Chloride prices that fit your budget—flexible terms and customized quotes for every order.
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Where to Buy 4-Chlorobenzenesulphonyl Chloride in China?
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As a leading 4-Chlorobenzenesulphonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 4-chlorobenzenesulphonyl Chloride?
4-Chlorobenzenesulfonyl chloride has a wide range of uses. In the field of organic synthesis, it can be called a key reagent.
Because of its active chemical properties, it can react with many compounds to obtain various compounds containing sulfonyl groups. First, it often meets with alcohols and chemically reacts to generate sulfonyl esters. In organic synthesis, this sulfonyl ester is often used as an electrophilic reagent to introduce sulfonyl groups, which is an important step in the construction of complex organic molecular structures.
Furthermore, 4-chlorobenzenesulfonyl chloride meets amines and can form sulfonamides. Sulfonamides have a significant position in the field of pharmaceutical chemistry. In the molecular structure of many drugs, sulfonamide groups are contained, and these compounds may have antibacterial, anti-inflammatory, diuretic and other pharmacological activities, which have contributed greatly to the development of the pharmaceutical industry.
And in the field of materials science, 4-chlorobenzenesulfonyl chloride is involved in the synthesis of polymers, or has special physical and chemical properties. For example, some sulfonyl-containing polymers have good heat resistance, mechanical properties and chemical stability, and can be used to make high-performance engineering plastics, fibers and other materials. They are widely used in high-end fields such as aerospace and electronics.
In the field of dye chemistry, it can provide key intermediates for the synthesis of dyes with specific structures through a series of reactions, so that dyes have better dyeing properties and color fastness, and meet the diverse needs of textile, printing and dyeing industries.
From this perspective, 4-chlorobenzenesulfonyl chloride plays a pivotal role in organic synthesis, medicine, materials, dyes and other fields, and has a profound impact on the progress and development of various industries.
Because of its active chemical properties, it can react with many compounds to obtain various compounds containing sulfonyl groups. First, it often meets with alcohols and chemically reacts to generate sulfonyl esters. In organic synthesis, this sulfonyl ester is often used as an electrophilic reagent to introduce sulfonyl groups, which is an important step in the construction of complex organic molecular structures.
Furthermore, 4-chlorobenzenesulfonyl chloride meets amines and can form sulfonamides. Sulfonamides have a significant position in the field of pharmaceutical chemistry. In the molecular structure of many drugs, sulfonamide groups are contained, and these compounds may have antibacterial, anti-inflammatory, diuretic and other pharmacological activities, which have contributed greatly to the development of the pharmaceutical industry.
And in the field of materials science, 4-chlorobenzenesulfonyl chloride is involved in the synthesis of polymers, or has special physical and chemical properties. For example, some sulfonyl-containing polymers have good heat resistance, mechanical properties and chemical stability, and can be used to make high-performance engineering plastics, fibers and other materials. They are widely used in high-end fields such as aerospace and electronics.
In the field of dye chemistry, it can provide key intermediates for the synthesis of dyes with specific structures through a series of reactions, so that dyes have better dyeing properties and color fastness, and meet the diverse needs of textile, printing and dyeing industries.
From this perspective, 4-chlorobenzenesulfonyl chloride plays a pivotal role in organic synthesis, medicine, materials, dyes and other fields, and has a profound impact on the progress and development of various industries.
What are the physical properties of 4-chlorobenzenesulphonyl Chloride?
4-Chlorobenzenesulfonyl chloride, its physical properties are as follows:
This substance is colorless to slightly yellow needle-like crystal or liquid at room temperature, with a pungent odor. The melting point is about 67-69 ° C. Under this temperature, it is a solid state with a needle-like crystal appearance. The texture is relatively hard and brittle, and it has a certain regular shape. When the temperature rises above the melting point, it melts into a liquid with better fluidity.
The boiling point is about 145-148 ° C (2.0kPa). When it reaches the boiling point, the liquid is violently vaporized and converted into a gaseous state. Its density is relatively large, about 1.496g/cm ³. Compared with water, it will sink in water.
4-Chlorobenzenesulfonyl chloride is insoluble in water. When mixed with water, there will be stratification. Because its density is greater than that of water, it is in the lower layer. But it is soluble in most organic solvents, such as benzene, ether, chloroform, etc., and can be evenly dispersed in these organic solvents to form a uniform solution system. Because it is volatile, it will evaporate slowly in the air, and the evaporated gas is irritating and irritating to the eyes, respiratory tract, etc., so it needs to be operated in a well-ventilated place when used.
This substance is colorless to slightly yellow needle-like crystal or liquid at room temperature, with a pungent odor. The melting point is about 67-69 ° C. Under this temperature, it is a solid state with a needle-like crystal appearance. The texture is relatively hard and brittle, and it has a certain regular shape. When the temperature rises above the melting point, it melts into a liquid with better fluidity.
The boiling point is about 145-148 ° C (2.0kPa). When it reaches the boiling point, the liquid is violently vaporized and converted into a gaseous state. Its density is relatively large, about 1.496g/cm ³. Compared with water, it will sink in water.
4-Chlorobenzenesulfonyl chloride is insoluble in water. When mixed with water, there will be stratification. Because its density is greater than that of water, it is in the lower layer. But it is soluble in most organic solvents, such as benzene, ether, chloroform, etc., and can be evenly dispersed in these organic solvents to form a uniform solution system. Because it is volatile, it will evaporate slowly in the air, and the evaporated gas is irritating and irritating to the eyes, respiratory tract, etc., so it needs to be operated in a well-ventilated place when used.
What are the chemical properties of 4-chlorobenzenesulphonyl Chloride?
The chemical properties of 4-chlorobenzenesulfonyl chloride are particularly important, so let me tell you one by one.
This compound has strong reactivity. First, the hydrolysis is significant. In contact with water, it is easy to cause hydrolysis reaction. When water touches 4-chlorobenzenesulfonyl chloride, the sulfonyl chloride group (-SO ² Cl) will gradually change to the sulfonic acid group (-SO ² H), and hydrogen chloride gas will be released at the same time. This process is like a subtle chemical change, just like the ancient alchemy. The raw materials are refined by water and fire to produce new substances.
Second, the ability of alcoholysis should not be underestimated. If it encounters alcohols, an alcoholysis reaction will occur. The hydroxyl group (-OH) in the alcohol interacts with the sulfonyl chloride group of 4-chlorobenzenesulfonyl chloride to form sulfonate compounds, and hydrogen chloride escapes at the same time. This reaction is like the alcohol and 4-chlorobenzenesulfonyl chloride dancing hand in hand to deduce a new material form on the stage of chemistry.
Third, the aminolysis reaction is also one of its important chemical properties. When 4-chlorobenzenesulfonyl chloride meets ammonia or amines, the sulfonyl chloride group will be replaced by an amino group (-NH2O) or a substituted amino group to form sulfonamides. This reaction is like a clever replacement between different chemical components, such as the ancient art of war, each in its place, to achieve a new chemical structure.
Fourth, 4-chlorobenzenesulfonyl chloride also exhibits the characteristics of halogenation reaction. Under specific conditions, the hydrogen atom on the benzene ring can be replaced by other halogen atoms, thereby preparing different halogenated benzenesulfonyl chloride derivatives. This process is like fine carving on the chemical structure of the benzene ring, and different halogen atoms are embedded according to different needs to shape diverse chemical products.
In short, 4-chlorobenzenesulfonyl chloride, with its rich chemical properties, is like a delicate key in the field of organic synthesis, which can open the door to the preparation of many compounds and occupy an important position in the vast world of chemistry.
This compound has strong reactivity. First, the hydrolysis is significant. In contact with water, it is easy to cause hydrolysis reaction. When water touches 4-chlorobenzenesulfonyl chloride, the sulfonyl chloride group (-SO ² Cl) will gradually change to the sulfonic acid group (-SO ² H), and hydrogen chloride gas will be released at the same time. This process is like a subtle chemical change, just like the ancient alchemy. The raw materials are refined by water and fire to produce new substances.
Second, the ability of alcoholysis should not be underestimated. If it encounters alcohols, an alcoholysis reaction will occur. The hydroxyl group (-OH) in the alcohol interacts with the sulfonyl chloride group of 4-chlorobenzenesulfonyl chloride to form sulfonate compounds, and hydrogen chloride escapes at the same time. This reaction is like the alcohol and 4-chlorobenzenesulfonyl chloride dancing hand in hand to deduce a new material form on the stage of chemistry.
Third, the aminolysis reaction is also one of its important chemical properties. When 4-chlorobenzenesulfonyl chloride meets ammonia or amines, the sulfonyl chloride group will be replaced by an amino group (-NH2O) or a substituted amino group to form sulfonamides. This reaction is like a clever replacement between different chemical components, such as the ancient art of war, each in its place, to achieve a new chemical structure.
Fourth, 4-chlorobenzenesulfonyl chloride also exhibits the characteristics of halogenation reaction. Under specific conditions, the hydrogen atom on the benzene ring can be replaced by other halogen atoms, thereby preparing different halogenated benzenesulfonyl chloride derivatives. This process is like fine carving on the chemical structure of the benzene ring, and different halogen atoms are embedded according to different needs to shape diverse chemical products.
In short, 4-chlorobenzenesulfonyl chloride, with its rich chemical properties, is like a delicate key in the field of organic synthesis, which can open the door to the preparation of many compounds and occupy an important position in the vast world of chemistry.
What is the preparation method of 4-chlorobenzenesulphonyl Chloride?
4-Chlorobenzenesulfonyl chloride, the method of preparation, has been known since ancient times. The method depends on the characteristics of the material and the reaction mechanism.
First, 4-chlorobenzenesulfonic acid is used as the raw material and reacts with the chlorinating agent. The chlorinating agent is often phosphorus pentachloride, sulfinyl chloride, etc. If phosphorus pentachloride is used, it meets 4-chlorobenzenesulfonic acid and starts a replacement reaction. The chlorine atom in phosphorus pentachloride is active and can replace the hydroxyl group in the sulfonic acid group. During the reaction, the temperature must be controlled moderately and not overly dramatic. Usually it starts in a low temperature environment In this process, phosphorus pentachloride is mixed with 4-chlorobenzenesulfonic acid in an appropriate proportion. Generally speaking, phosphorus pentachloride is slightly excessive to promote the reaction in the direction of generating 4-chlorobenzenesulfonyl chloride. After the reaction is completed, the product is purified by distillation, extraction and other methods.
If sulfuryl chloride is used as a chlorinating agent, there is also a method. Sulfuryl chloride is mixed with 4-chlorobenzenesulfonic acid to heat and stimulate the reaction. Sulfuryl chloride decomposes sulfur dioxide and hydrogen chloride gas. In this process, the sulfonic acid group is hydroxylated into a chlorine atom, and 4-chlorobenzenesulfonyl chloride is obtained. The reaction system needs to be protected by inert gas to prevent impur The reaction temperature also needs to be fine-tuned to make the reaction sufficient and avoid side reactions. After the reaction, the excess sulfinyl chloride is removed, and the pure 4-chlorobenzenesulfonyl chloride can be obtained by means of reduced pressure distillation.
Furthermore, 4-chloroaniline can be used as the starting material. First, 4-chloroaniline is diazotized to obtain diazonium salt. Then the diazonium salt reacts with sodium bisulfite to form 4-chlorobenzenesulfonic acid, and then treated with a chlorination agent as described above to obtain 4-chlorobenzenesulfonyl chloride. This path step is slightly complicated, but the raw material is easy to obtain. If properly controlled, it can also be prepared efficiently.
Preparation of 4-chlorobenzenesulfonyl chloride requires finesse in material ratio, temperature control, and reaction environment maintenance to obtain high-purity products.
First, 4-chlorobenzenesulfonic acid is used as the raw material and reacts with the chlorinating agent. The chlorinating agent is often phosphorus pentachloride, sulfinyl chloride, etc. If phosphorus pentachloride is used, it meets 4-chlorobenzenesulfonic acid and starts a replacement reaction. The chlorine atom in phosphorus pentachloride is active and can replace the hydroxyl group in the sulfonic acid group. During the reaction, the temperature must be controlled moderately and not overly dramatic. Usually it starts in a low temperature environment In this process, phosphorus pentachloride is mixed with 4-chlorobenzenesulfonic acid in an appropriate proportion. Generally speaking, phosphorus pentachloride is slightly excessive to promote the reaction in the direction of generating 4-chlorobenzenesulfonyl chloride. After the reaction is completed, the product is purified by distillation, extraction and other methods.
If sulfuryl chloride is used as a chlorinating agent, there is also a method. Sulfuryl chloride is mixed with 4-chlorobenzenesulfonic acid to heat and stimulate the reaction. Sulfuryl chloride decomposes sulfur dioxide and hydrogen chloride gas. In this process, the sulfonic acid group is hydroxylated into a chlorine atom, and 4-chlorobenzenesulfonyl chloride is obtained. The reaction system needs to be protected by inert gas to prevent impur The reaction temperature also needs to be fine-tuned to make the reaction sufficient and avoid side reactions. After the reaction, the excess sulfinyl chloride is removed, and the pure 4-chlorobenzenesulfonyl chloride can be obtained by means of reduced pressure distillation.
Furthermore, 4-chloroaniline can be used as the starting material. First, 4-chloroaniline is diazotized to obtain diazonium salt. Then the diazonium salt reacts with sodium bisulfite to form 4-chlorobenzenesulfonic acid, and then treated with a chlorination agent as described above to obtain 4-chlorobenzenesulfonyl chloride. This path step is slightly complicated, but the raw material is easy to obtain. If properly controlled, it can also be prepared efficiently.
Preparation of 4-chlorobenzenesulfonyl chloride requires finesse in material ratio, temperature control, and reaction environment maintenance to obtain high-purity products.
What are the precautions for 4-chlorobenzenesulphonyl Chloride during use?
For 4-chlorobenzenesulfonyl chloride, there are several ends that should be paid attention to when using it.
The first way to protect. This substance is corrosive and can cause serious injury if it touches the skin, eyes or inhales its vapor. Therefore, when performing the operation, it is necessary to wear appropriate protective equipment, such as protective clothing, gloves, goggles and gas masks, to ensure that all parts of the body are fully protected from its harm.
The second is about the operating environment. It is best to handle it in a well-ventilated place, and it is best to handle it in a fume hood, so that harmful gases can dissipate quickly, so as not to accumulate and endanger the person. At the same time, the operating place should be far away from fire and heat sources. If it encounters hot topics or open flames, it may be dangerous.
Furthermore, it is related to the method of storage. When stored in a cool, dry and well-ventilated place, away from fire and heat sources, and separated from oxidants and alkalis, do not mix storage to prevent violent reactions. The storage container must be well sealed to prevent it from leaking.
Also, during use, the operation must be fine and slow. When taking it, do not spill it; if it is accidentally spilled, it should be cleaned immediately according to a proper method. First cover it with inert materials such as sand and vermiculite, collect it in a closed container, and then follow up. Do not let it spread.
And when taking, transferring, etc., the utensils used must be clean and dry to avoid impurities from mixing in, affecting its quality, and preventing accidental reactions.
In addition, operators should be professionally trained to be familiar with its nature, hazards and emergency treatment methods. In the event of an accident such as leakage or contact with the human body, the correct measures can be taken immediately to reduce damage.
The first way to protect. This substance is corrosive and can cause serious injury if it touches the skin, eyes or inhales its vapor. Therefore, when performing the operation, it is necessary to wear appropriate protective equipment, such as protective clothing, gloves, goggles and gas masks, to ensure that all parts of the body are fully protected from its harm.
The second is about the operating environment. It is best to handle it in a well-ventilated place, and it is best to handle it in a fume hood, so that harmful gases can dissipate quickly, so as not to accumulate and endanger the person. At the same time, the operating place should be far away from fire and heat sources. If it encounters hot topics or open flames, it may be dangerous.
Furthermore, it is related to the method of storage. When stored in a cool, dry and well-ventilated place, away from fire and heat sources, and separated from oxidants and alkalis, do not mix storage to prevent violent reactions. The storage container must be well sealed to prevent it from leaking.
Also, during use, the operation must be fine and slow. When taking it, do not spill it; if it is accidentally spilled, it should be cleaned immediately according to a proper method. First cover it with inert materials such as sand and vermiculite, collect it in a closed container, and then follow up. Do not let it spread.
And when taking, transferring, etc., the utensils used must be clean and dry to avoid impurities from mixing in, affecting its quality, and preventing accidental reactions.
In addition, operators should be professionally trained to be familiar with its nature, hazards and emergency treatment methods. In the event of an accident such as leakage or contact with the human body, the correct measures can be taken immediately to reduce damage.
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