Linshang Chemical
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4-Chlorobenzenethiolate
Linshang Chemical
|
HS Code |
153978 |
| Chemical Formula | C6H4ClS- |
| Molecular Weight | 145.61 g/mol |
| Appearance | Solid (usually as a salt) |
| Solubility In Water | Soluble as a salt |
| Odor | Typical thiolate - strong, unpleasant sulfur - like |
| Acidity Basicity | Basic due to the negative charge on sulfur |
| Stability | Stable under normal conditions, but reactive towards electrophiles |
| Reactivity | Reacts with alkyl halides to form thioethers |
| Hazard Class | Irritant, harmful if swallowed |
| Melting Point | Varies depending on the counter - ion |
As an accredited 4-Chlorobenzenethiolate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 4 - chlorobenzenethiolate packaged in a sealed, chemical - resistant bottle. |
| Storage | 4 - Chlorobenzenethiolate should be stored in a cool, dry place away from heat sources and open flames. Keep it in a tightly - sealed container to prevent exposure to air and moisture, which could lead to decomposition or reaction. Store it separately from oxidizing agents and incompatible substances. Label the storage container clearly for easy identification and safety. |
| Shipping | 4 - Chlorobenzenethiolate is a chemical that may require special handling during shipping. It should be packaged securely in corrosion - resistant containers, following all relevant regulations for hazardous chemicals to ensure safe transit. |
Competitive 4-Chlorobenzenethiolate prices that fit your budget—flexible terms and customized quotes for every order.
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What is the chemical structure of 4-chlorobenzenethiolate?
4-chlorobenzenethiolate is one of the organic compounds. In its chemical structure, the benzene ring is the base, the chlorine atom is connected to the fourth position of the benzene ring, the thiol base is connected to the benzene ring, and the sulfur atom is negatively charged, forming a salt structure with the cation.
Looking at its structure, the benzene ring has a conjugated system with a six-membered ring, and six carbon atoms are bonded with sp ² hybrid orbitals to form a plane regular hexagon. The chlorine atom is covalently bonded to the benzene ring, and its electron cloud interacts with the benzene ring conjugated system. The thiol group (-SH) deprotons to form a thiol anion (-S), and the lone pair electrons of this anion can participate in the conjugation effect, which affects the electron distribution and chemical activity of the molecule.
When 4-chlorobenzenethiolate is formed, the negative charge of thiol anion gives the compound nucleophilicity and can react with electrophilic reagents. Its structural characteristics determine that it can participate in many chemical reactions such as substitution reactions as a nucleophilic reagent in the field of organic synthesis, and play an important role in the construction of organosulfur compounds. The chemical structure of this compound is the fundamental determinant of its physicochemical properties and chemical reactivity, and is a key content of organic chemistry research.
Looking at its structure, the benzene ring has a conjugated system with a six-membered ring, and six carbon atoms are bonded with sp ² hybrid orbitals to form a plane regular hexagon. The chlorine atom is covalently bonded to the benzene ring, and its electron cloud interacts with the benzene ring conjugated system. The thiol group (-SH) deprotons to form a thiol anion (-S), and the lone pair electrons of this anion can participate in the conjugation effect, which affects the electron distribution and chemical activity of the molecule.
When 4-chlorobenzenethiolate is formed, the negative charge of thiol anion gives the compound nucleophilicity and can react with electrophilic reagents. Its structural characteristics determine that it can participate in many chemical reactions such as substitution reactions as a nucleophilic reagent in the field of organic synthesis, and play an important role in the construction of organosulfur compounds. The chemical structure of this compound is the fundamental determinant of its physicochemical properties and chemical reactivity, and is a key content of organic chemistry research.
What are the main uses of 4-chlorobenzenethiolate?
4-chlorobenzenethiolate (4-chlorothiophenol) is an important compound in organic chemistry and has important uses in many fields.
First, in the field of organic synthesis, 4-chlorothiophenol is often used as a nucleophilic reagent. Because its sulfur atom has lone pair electrons, it has strong nucleophilicity and can undergo nucleophilic substitution reactions with various electrophilic reagents such as halogenated hydrocarbons and acyl halides. From this, many sulfur-containing organic compounds can be constructed, such as thioethers, thioesters, etc. Such reactions are of great significance in the construction of complex organic molecular structures. In the synthesis of many drugs and natural products, the nucleophilic substitution step participated by 4-chlorothiophenol salts is used to introduce key sulfur-containing structural fragments, and then achieve the construction of target molecules.
Second, in the field of materials science, 4-chlorothiophenol salts also have extraordinary performance. Because its sulfur-containing groups can form stable chemical bonds with metal surfaces, they are often used to prepare self-assembled monolayers. When its solution is contacted with a metal substrate, the molecules of 4-chlorothiophenol salts will spontaneously arrange and closely adsorb on the metal surface, forming an ordered monolayer structure. The self-assembled monolayer can effectively regulate the properties of the metal surface, such as changing the wettability and electrical properties of the surface. In sensors, electronic devices, etc., the metal surface modified by 4-chlorothiophenol salt can improve the performance and sensitivity of the device.
Furthermore, in the field of coordination chemistry, 4-chlorothiophenol salt can be used as a ligand to coordinate with metal ions. Its sulfur atoms can provide electron pairs to metal ions, form coordination bonds, and form metal complexes. These metal complexes often have unique structures and properties, and have potential applications in catalysis, optical materials, and other fields. For example, the metal complexes formed by part 4-chlorothiophenol salt can be used as efficient catalysts to accelerate specific organic reactions, and have good selectivity and catalytic activity.
First, in the field of organic synthesis, 4-chlorothiophenol is often used as a nucleophilic reagent. Because its sulfur atom has lone pair electrons, it has strong nucleophilicity and can undergo nucleophilic substitution reactions with various electrophilic reagents such as halogenated hydrocarbons and acyl halides. From this, many sulfur-containing organic compounds can be constructed, such as thioethers, thioesters, etc. Such reactions are of great significance in the construction of complex organic molecular structures. In the synthesis of many drugs and natural products, the nucleophilic substitution step participated by 4-chlorothiophenol salts is used to introduce key sulfur-containing structural fragments, and then achieve the construction of target molecules.
Second, in the field of materials science, 4-chlorothiophenol salts also have extraordinary performance. Because its sulfur-containing groups can form stable chemical bonds with metal surfaces, they are often used to prepare self-assembled monolayers. When its solution is contacted with a metal substrate, the molecules of 4-chlorothiophenol salts will spontaneously arrange and closely adsorb on the metal surface, forming an ordered monolayer structure. The self-assembled monolayer can effectively regulate the properties of the metal surface, such as changing the wettability and electrical properties of the surface. In sensors, electronic devices, etc., the metal surface modified by 4-chlorothiophenol salt can improve the performance and sensitivity of the device.
Furthermore, in the field of coordination chemistry, 4-chlorothiophenol salt can be used as a ligand to coordinate with metal ions. Its sulfur atoms can provide electron pairs to metal ions, form coordination bonds, and form metal complexes. These metal complexes often have unique structures and properties, and have potential applications in catalysis, optical materials, and other fields. For example, the metal complexes formed by part 4-chlorothiophenol salt can be used as efficient catalysts to accelerate specific organic reactions, and have good selectivity and catalytic activity.
What are the physical properties of 4-chlorobenzenethiolate?
4 - chlorobenzenethiolate is one of the organic compounds. Its physical properties are interesting, and I will tell you in detail.
Looking at its shape, under room temperature and pressure, it is mostly in a solid state, which is due to the intermolecular force. The chlorine atoms in the molecule interact with the benzene ring and sulfur atoms, causing the molecular arrangement to be relatively regular, so it becomes a solid state.
When it comes to color, it is usually white or off-white. The pure one is white in color. If it contains some impurities, it may be slightly yellow. The formation of this color is related to the absorption and reflection characteristics of the molecular structure to light. The electron transition energy level in its molecular structure corresponds to the absorption of light of a specific wavelength, and the light of other wavelengths is reflected into the human eye, so this color is seen.
Its melting point is also an important physical property. The melting point of 4-chlorobenzenethiolate is within a certain range, and this value is closely related to the intermolecular forces. There are interactions such as van der Waals forces and hydrogen bonds between molecules. In order to convert it from a solid state to a liquid state, it needs to provide enough energy to overcome these forces, so it has a specific melting point.
In terms of solubility, it has a certain solubility in organic solvents, such as ethanol, ether, etc. Due to the principle of similarity and miscibility, the structure of its organic molecules is similar to that of organic solvents, and the molecules can form interactions and dissolve. However, the solubility in water is very small, and water is a highly polar solvent. Although 4-chlorobenzenethiolate contains polar groups, the whole is still mainly non-polar structure, and the interaction with water is weak, so it is difficult to dissolve in water.
In addition, its density also has characteristics. Compared with water, the density may be slightly larger or smaller, which is determined by the molecular weight and the degree of molecular accumulation. If the molecular mass is large and the accumulation is tight, the density is relatively large; otherwise, it is small.
In summary, the physical properties of 4-chlorobenzenethiolate are determined by their molecular structure, and the properties of morphology, color, melting point, solubility, density, etc. are interrelated, which together constitute the unique physical properties of this compound.
Looking at its shape, under room temperature and pressure, it is mostly in a solid state, which is due to the intermolecular force. The chlorine atoms in the molecule interact with the benzene ring and sulfur atoms, causing the molecular arrangement to be relatively regular, so it becomes a solid state.
When it comes to color, it is usually white or off-white. The pure one is white in color. If it contains some impurities, it may be slightly yellow. The formation of this color is related to the absorption and reflection characteristics of the molecular structure to light. The electron transition energy level in its molecular structure corresponds to the absorption of light of a specific wavelength, and the light of other wavelengths is reflected into the human eye, so this color is seen.
Its melting point is also an important physical property. The melting point of 4-chlorobenzenethiolate is within a certain range, and this value is closely related to the intermolecular forces. There are interactions such as van der Waals forces and hydrogen bonds between molecules. In order to convert it from a solid state to a liquid state, it needs to provide enough energy to overcome these forces, so it has a specific melting point.
In terms of solubility, it has a certain solubility in organic solvents, such as ethanol, ether, etc. Due to the principle of similarity and miscibility, the structure of its organic molecules is similar to that of organic solvents, and the molecules can form interactions and dissolve. However, the solubility in water is very small, and water is a highly polar solvent. Although 4-chlorobenzenethiolate contains polar groups, the whole is still mainly non-polar structure, and the interaction with water is weak, so it is difficult to dissolve in water.
In addition, its density also has characteristics. Compared with water, the density may be slightly larger or smaller, which is determined by the molecular weight and the degree of molecular accumulation. If the molecular mass is large and the accumulation is tight, the density is relatively large; otherwise, it is small.
In summary, the physical properties of 4-chlorobenzenethiolate are determined by their molecular structure, and the properties of morphology, color, melting point, solubility, density, etc. are interrelated, which together constitute the unique physical properties of this compound.
What are 4-chlorobenzenethiolate synthesis methods?
The synthesis method of 4-chlorobromothiophenol often involves several paths. One is to start with 4-chlorobromobenzene and sodium hydrosulfide, heat and stir them in an appropriate solvent such as N, N-dimethylformamide (DMF). In this process, the bromine atom in 4-chlorobromobenzene has good activity, and it is easy to be replaced by hydrogen sulfide ions to form 4-chlorobenzothiophenol, which is then reacted with alkali to obtain 4-chlorobenzothiophenol.
Furthermore, 4-chloro-nitrobenzene can be used as the starting material, and the nitro group can be converted into an amino group through a reduction reaction to obtain 4-chloroaniline. Afterwards, it reacts with thiocyanate to form 4-chlorophenylthiourea, and then hydrolyzes to obtain 4-chlorophenylthiophenol, which can then be formed into salt.
Or take 4-chlorobenzenesulfonyl chloride as raw material and treat it with a reducing agent such as zinc powder. 4-chlorophenylthiophenol is obtained first, and then the target product is prepared by conventional salt forming methods.
During synthesis, the selection of solvent, the control of reaction temperature and time, and the preparation of the proportion of reactants are all crucial. Proper selection of solvent can promote the dissolution and mass transfer of reactants; precise control of temperature and time can ensure sufficient reaction and few side reactions; reasonable preparation ratio can improve product yield. All kinds of synthetic methods have their own advantages and disadvantages, and they need to be carefully selected according to the actual situation, such as the availability of raw materials, cost considerations, and product purity requirements.
Furthermore, 4-chloro-nitrobenzene can be used as the starting material, and the nitro group can be converted into an amino group through a reduction reaction to obtain 4-chloroaniline. Afterwards, it reacts with thiocyanate to form 4-chlorophenylthiourea, and then hydrolyzes to obtain 4-chlorophenylthiophenol, which can then be formed into salt.
Or take 4-chlorobenzenesulfonyl chloride as raw material and treat it with a reducing agent such as zinc powder. 4-chlorophenylthiophenol is obtained first, and then the target product is prepared by conventional salt forming methods.
During synthesis, the selection of solvent, the control of reaction temperature and time, and the preparation of the proportion of reactants are all crucial. Proper selection of solvent can promote the dissolution and mass transfer of reactants; precise control of temperature and time can ensure sufficient reaction and few side reactions; reasonable preparation ratio can improve product yield. All kinds of synthetic methods have their own advantages and disadvantages, and they need to be carefully selected according to the actual situation, such as the availability of raw materials, cost considerations, and product purity requirements.
4-chlorobenzenethiolate what are the precautions in storage and transportation?
4-Chlorothiophenol is a chemical substance, and various precautions are essential when storing and transporting it.
First word storage. Because of its specific chemical properties, it should be placed in a cool, dry and well-ventilated place. Avoid hot topics or open flames, which may cause chemical reactions due to heat and cause danger. In humid environments, moisture may react with 4-chlorothiophenol, causing it to deteriorate and damage its chemical purity and properties. In addition, it should be stored separately from oxidizing agents and acids. All of these can react violently with 4-chlorothiophenol, such as oxidation reaction, acid-base neutralization, etc., or produce harmful gases, or cause combustion and explosion.
Times and transportation. During transportation, the packaging must be tight and firm. Choose suitable packaging materials to prevent leakage. If it is road transportation, drive according to the specified route and avoid densely populated areas. Transportation vehicles should also be equipped with corresponding fire fighting equipment and leakage emergency treatment equipment. And transportation personnel need to be professionally trained and familiar with the characteristics of 4-chlorothiophenol and emergency response methods. When loading and unloading, the operation should be gentle, so as not to damage the packaging and cause material leakage.
In short, the storage and transportation of 4-chlorothiophenol salts must adhere to chemical substance management practices, from environmental selection, item isolation, packaging protection to personnel operation, all of which are meticulous to ensure safety and avoid accidents.
First word storage. Because of its specific chemical properties, it should be placed in a cool, dry and well-ventilated place. Avoid hot topics or open flames, which may cause chemical reactions due to heat and cause danger. In humid environments, moisture may react with 4-chlorothiophenol, causing it to deteriorate and damage its chemical purity and properties. In addition, it should be stored separately from oxidizing agents and acids. All of these can react violently with 4-chlorothiophenol, such as oxidation reaction, acid-base neutralization, etc., or produce harmful gases, or cause combustion and explosion.
Times and transportation. During transportation, the packaging must be tight and firm. Choose suitable packaging materials to prevent leakage. If it is road transportation, drive according to the specified route and avoid densely populated areas. Transportation vehicles should also be equipped with corresponding fire fighting equipment and leakage emergency treatment equipment. And transportation personnel need to be professionally trained and familiar with the characteristics of 4-chlorothiophenol and emergency response methods. When loading and unloading, the operation should be gentle, so as not to damage the packaging and cause material leakage.
In short, the storage and transportation of 4-chlorothiophenol salts must adhere to chemical substance management practices, from environmental selection, item isolation, packaging protection to personnel operation, all of which are meticulous to ensure safety and avoid accidents.
What is the chemical structure of 4-chlorobenzenethiolate?
4 - chlorobenzenethiolate, the chemical substance is also specific to its molecules. This is due to the fact that a benzene group has a chlorine atom and a thiol atom on it. For benzene, it is a six-membered carbon atom, and its carbon-carbon atom is between the two, showing a special characteristics. The chlorine atom is related to a certain carbon atom of benzene. The chlorine atom has the properties of benzene, which can affect the distribution of molecules in the molecule, so that the density of benzene is reduced. The thiol radical (-S -) is also related to another carbon atom of benzene. The sulphur atom has six atoms, and its benzene phase is different. Due to the distribution of the sulphur atom's cloud and the shape of the sulphur atom, the whole molecule exhibits a specific chemical property. The solitary of the sulphur atom can be transformed into a reaction, or influence the action of the molecule. In addition, the 4-chlorobenzenethiolate chemical property is formed by the interaction of benzene, chlorine atom and thiol root. This property determines its physical chemical properties and exhibits its special properties in the reaction of polymers and the interaction of matter.
What are the main uses of 4-chlorobenzenethiolate?
4 - chlorobenzenethiolate is an important compound in organic chemistry. It has a wide range of uses and has important applications in many fields.
First, in the field of organic synthesis, 4 - chlorobenzenethiolate is often a key reagent. It can participate in many organic reactions, such as nucleophilic substitution reactions. With its nucleophilic properties of sulfur atoms, it can react with substrates such as halogenated hydrocarbons to form new carbon-sulfur bonds, and then synthesize a series of sulfur-containing organic compounds. These reactions provide an important way for organic synthesis chemists to prepare organic molecules with specific structures and functions, and play an indispensable role in related organic synthesis branches such as medicinal chemistry and materials science.
Second, in the field of materials science, 4-chlorobenzenethiolate also contributes. It can be used to modify the surface of materials. By reacting with specific groups on the surface of the material, the chemical and physical properties of the material surface can be changed. For example, it can enhance the hydrophilicity of the material surface and improve the biocompatibility of the material. In the preparation of functional coatings, self-assembled monolayers, etc., 4-chlorobenzenethiolate shows unique advantages, laying the foundation for the development of high-performance materials.
Furthermore, in some catalytic reaction systems, 4-chlorobenzenethiolate can be used as a ligand. After coordinating with metal ions, the formed complexes may have unique catalytic activities. It can catalyze specific organic reactions and improve the selectivity and efficiency of reactions. This provides new strategies and approaches for optimizing catalytic processes and reducing side reactions in the development of green chemistry and sustainable chemistry.
In summary, 4-chlorobenzenethiolate has significant applications in many important fields such as organic synthesis, materials science and catalytic reactions, and plays an important role in promoting the progress of related science and technology.
First, in the field of organic synthesis, 4 - chlorobenzenethiolate is often a key reagent. It can participate in many organic reactions, such as nucleophilic substitution reactions. With its nucleophilic properties of sulfur atoms, it can react with substrates such as halogenated hydrocarbons to form new carbon-sulfur bonds, and then synthesize a series of sulfur-containing organic compounds. These reactions provide an important way for organic synthesis chemists to prepare organic molecules with specific structures and functions, and play an indispensable role in related organic synthesis branches such as medicinal chemistry and materials science.
Second, in the field of materials science, 4-chlorobenzenethiolate also contributes. It can be used to modify the surface of materials. By reacting with specific groups on the surface of the material, the chemical and physical properties of the material surface can be changed. For example, it can enhance the hydrophilicity of the material surface and improve the biocompatibility of the material. In the preparation of functional coatings, self-assembled monolayers, etc., 4-chlorobenzenethiolate shows unique advantages, laying the foundation for the development of high-performance materials.
Furthermore, in some catalytic reaction systems, 4-chlorobenzenethiolate can be used as a ligand. After coordinating with metal ions, the formed complexes may have unique catalytic activities. It can catalyze specific organic reactions and improve the selectivity and efficiency of reactions. This provides new strategies and approaches for optimizing catalytic processes and reducing side reactions in the development of green chemistry and sustainable chemistry.
In summary, 4-chlorobenzenethiolate has significant applications in many important fields such as organic synthesis, materials science and catalytic reactions, and plays an important role in promoting the progress of related science and technology.
What are the physical properties of 4-chlorobenzenethiolate?
4 - chlorobenzenethiolate, it is an organic compound containing sulfur. Its physical properties are quite impressive.
In terms of its appearance, it is mostly solid at room temperature. Its texture is either powder or crystalline, fine and regular, and its structure can be seen in an orderly state.
As for the melting point, it has a specific value due to the intermolecular force. The chlorine atom interacts with the benzene ring and sulfur atom, so that the molecule is tightly packed, so the melting point is within a certain range, and the specific value varies depending on the purity and measurement conditions.
In terms of solubility, it shows different performance in organic solvents. Because its molecules have a certain polarity, they have good solubility in polar organic solvents such as ethanol and acetone. This is due to the principle of similar miscibility, polar molecules and polar solvents attract each other, and the molecules can be uniformly dispersed. However, in water, its solubility is poor, because the polarity of water molecules is quite different from that of the compound, and the benzene ring part of the compound is a hydrophobic group, which hinders its interaction with water.
Furthermore, its density is also an important physical property. Due to the fact that the molecular composition contains chlorine atoms, the relative atomic mass is large, resulting in a slightly higher density than that of ordinary organic compounds. When participating in reactions or practical applications, density factors affect their distribution and behavior in the system.
Its volatility is relatively low, and the intermolecular force makes it difficult for the molecule to break away from the condensed phase and enter the gas phase. This property makes it easier to maintain stability during storage and use, and it is not easy to be lost due to volatilization.
In summary, the physical properties of 4-chlorobenzenethiolate, such as appearance, melting point, solubility, density and volatility, are interrelated and jointly determine their behavior and characteristics in the chemical field and related applications.
In terms of its appearance, it is mostly solid at room temperature. Its texture is either powder or crystalline, fine and regular, and its structure can be seen in an orderly state.
As for the melting point, it has a specific value due to the intermolecular force. The chlorine atom interacts with the benzene ring and sulfur atom, so that the molecule is tightly packed, so the melting point is within a certain range, and the specific value varies depending on the purity and measurement conditions.
In terms of solubility, it shows different performance in organic solvents. Because its molecules have a certain polarity, they have good solubility in polar organic solvents such as ethanol and acetone. This is due to the principle of similar miscibility, polar molecules and polar solvents attract each other, and the molecules can be uniformly dispersed. However, in water, its solubility is poor, because the polarity of water molecules is quite different from that of the compound, and the benzene ring part of the compound is a hydrophobic group, which hinders its interaction with water.
Furthermore, its density is also an important physical property. Due to the fact that the molecular composition contains chlorine atoms, the relative atomic mass is large, resulting in a slightly higher density than that of ordinary organic compounds. When participating in reactions or practical applications, density factors affect their distribution and behavior in the system.
Its volatility is relatively low, and the intermolecular force makes it difficult for the molecule to break away from the condensed phase and enter the gas phase. This property makes it easier to maintain stability during storage and use, and it is not easy to be lost due to volatilization.
In summary, the physical properties of 4-chlorobenzenethiolate, such as appearance, melting point, solubility, density and volatility, are interrelated and jointly determine their behavior and characteristics in the chemical field and related applications.
What are 4-chlorobenzenethiolate synthesis methods?
The synthesis method of 4-chlorobromobenzene thiophenate is an important topic in the field of organic synthesis. There are probably several synthetic methods as follows.
One can be obtained by reacting 4-chlorobromobenzene with thiourea. First take an appropriate amount of 4-chlorobromobenzene, place it in a reactor, add an appropriate amount of thiourea, use ethanol as a solvent, and heat it back. At this time, the bromine atom in 4-chlorobromobenzene is active, and the sulfur atom in thiourea is nucleophilic, and the two undergo nucleophilic substitution reaction. After several times of reaction, the intermediate is obtained, and then treated with sodium hydroxide solution to hydrolyze the intermediate to obtain 4-chlorobromothiophenate. This process requires attention to the control of reaction temperature and time. If the temperature is too high or the time is too long, it may cause side reactions to occur and affect the yield.
Second, 4-chloronitrobenzene is used as the starting material. First, 4-chloronitrobenzene and sodium sulfide are mixed in water to heat the reaction. In this step, sulfur ions in sodium sulfide undergo nucleophilic substitution with 4-chloronitrobenzene, and the nitro group is converted into a sulfhydryl group to obtain 4-chloronitrothiophenol. Then neutralize with alkali solution to obtain 4-chloronitrothiophenol salt. The raw materials used in this method are common, but the reaction conditions need to be precisely regulated. The amount of sodium sulfide, the reaction temperature and the pH value all have a
Third, 4-chlorobenzenesulfonic acid can also be prepared by reduction and alkalization of 4-chlorobenzenesulfonic acid. First, 4-chlorobenzenesulfonic acid is reduced to 4-chlorobenzenesulfonic acid with a suitable reducing agent, such as zinc powder and hydrochloric acid mixture. This reduction process needs to be carried out slowly at low temperature to prevent excessive reduction. After the reduction is completed, the pH value of 4-chlorobenzenesulfonic acid is adjusted with sodium hydroxide solution to convert 4-chlorobenzenesulfonic acid into 4-chlorobenzenesulfonic salt. This approach is slightly complicated, but if it is operated properly, a higher yield
The above synthetic methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider factors such as raw material availability, cost, yield and product purity, and choose the appropriate one.
One can be obtained by reacting 4-chlorobromobenzene with thiourea. First take an appropriate amount of 4-chlorobromobenzene, place it in a reactor, add an appropriate amount of thiourea, use ethanol as a solvent, and heat it back. At this time, the bromine atom in 4-chlorobromobenzene is active, and the sulfur atom in thiourea is nucleophilic, and the two undergo nucleophilic substitution reaction. After several times of reaction, the intermediate is obtained, and then treated with sodium hydroxide solution to hydrolyze the intermediate to obtain 4-chlorobromothiophenate. This process requires attention to the control of reaction temperature and time. If the temperature is too high or the time is too long, it may cause side reactions to occur and affect the yield.
Second, 4-chloronitrobenzene is used as the starting material. First, 4-chloronitrobenzene and sodium sulfide are mixed in water to heat the reaction. In this step, sulfur ions in sodium sulfide undergo nucleophilic substitution with 4-chloronitrobenzene, and the nitro group is converted into a sulfhydryl group to obtain 4-chloronitrothiophenol. Then neutralize with alkali solution to obtain 4-chloronitrothiophenol salt. The raw materials used in this method are common, but the reaction conditions need to be precisely regulated. The amount of sodium sulfide, the reaction temperature and the pH value all have a
Third, 4-chlorobenzenesulfonic acid can also be prepared by reduction and alkalization of 4-chlorobenzenesulfonic acid. First, 4-chlorobenzenesulfonic acid is reduced to 4-chlorobenzenesulfonic acid with a suitable reducing agent, such as zinc powder and hydrochloric acid mixture. This reduction process needs to be carried out slowly at low temperature to prevent excessive reduction. After the reduction is completed, the pH value of 4-chlorobenzenesulfonic acid is adjusted with sodium hydroxide solution to convert 4-chlorobenzenesulfonic acid into 4-chlorobenzenesulfonic salt. This approach is slightly complicated, but if it is operated properly, a higher yield
The above synthetic methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider factors such as raw material availability, cost, yield and product purity, and choose the appropriate one.
4-chlorobenzenethiolate what are the precautions during use
4-Chlorothiophenol salt, when using, all the precautions should not be ignored.
The first safety protection. This substance may be irritating and toxic, and it may hurt the skin when touched. Therefore, use gloves to protect your hands and wear protective clothing to avoid direct contact with the body. If it accidentally touches the skin, rinse with a lot of water as soon as possible. It is recommended to seek medical attention immediately.
Furthermore, it is related to ventilation conditions. When using it, make sure that the place is well ventilated. Because it is in the operation room or scattered in the air, if inhaled, it will damage the respiratory system and cause discomfort. If the ventilation is good, the harmful gas can be dissipated in time to protect the safety of the person.
In addition, access and storage are also key. When taking it, use an accurate device and measure it correctly to avoid the risk of waste and excess. When storing, it must be placed in a cool, dry and ventilated place, away from fire and heat sources to prevent its deterioration or accidents. And it must be stored separately with oxidants, acids and other substances to avoid mutual reaction and harm.
When used, wash and dry the utensils for later use. And do not dispose of the utensils used at will to prevent residual materials from polluting the environment.
Furthermore, the operator must undergo special training, be familiar with its nature, and understand the method of use before acting. When operating, be attentive, follow the procedures, and must not be negligent.
All of these are the things that should be paid attention to when using 4-chlorothiophenol salt. Be careful to ensure safety and everything goes well.
The first safety protection. This substance may be irritating and toxic, and it may hurt the skin when touched. Therefore, use gloves to protect your hands and wear protective clothing to avoid direct contact with the body. If it accidentally touches the skin, rinse with a lot of water as soon as possible. It is recommended to seek medical attention immediately.
Furthermore, it is related to ventilation conditions. When using it, make sure that the place is well ventilated. Because it is in the operation room or scattered in the air, if inhaled, it will damage the respiratory system and cause discomfort. If the ventilation is good, the harmful gas can be dissipated in time to protect the safety of the person.
In addition, access and storage are also key. When taking it, use an accurate device and measure it correctly to avoid the risk of waste and excess. When storing, it must be placed in a cool, dry and ventilated place, away from fire and heat sources to prevent its deterioration or accidents. And it must be stored separately with oxidants, acids and other substances to avoid mutual reaction and harm.
When used, wash and dry the utensils for later use. And do not dispose of the utensils used at will to prevent residual materials from polluting the environment.
Furthermore, the operator must undergo special training, be familiar with its nature, and understand the method of use before acting. When operating, be attentive, follow the procedures, and must not be negligent.
All of these are the things that should be paid attention to when using 4-chlorothiophenol salt. Be careful to ensure safety and everything goes well.
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