4-Chlorofluorobenzene
Linshang Chemical
HS Code |
164210 |
Chemical Formula | C6H4ClF |
Molar Mass | 116.546 g/mol |
Appearance | Colorless liquid |
Odor | Characteristic aromatic odor |
Density | 1.22 g/cm³ at 20 °C |
Boiling Point | 117 - 118 °C |
Melting Point | -43 °C |
Solubility In Water | Insoluble |
Solubility In Organic Solvents | Soluble in many organic solvents like ethanol, ether |
Vapor Pressure | 2.67 kPa at 25 °C |
Flash Point | 20 °C |
As an accredited 4-Chlorofluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
Packing | 500 - gram bottles of 4 - chlorofluorobenzene, securely sealed for chemical storage. |
Storage | 4 - Chlorofluorobenzene should be stored in a cool, well - ventilated area, away from heat and ignition sources. Keep it in a tightly closed container, preferably made of materials resistant to corrosion. Store it separately from oxidizing agents and incompatible substances. This helps prevent reactions that could lead to spills, fires, or the release of harmful vapors. |
Shipping | 4 - Chlorofluorobenzene is shipped in tightly - sealed, corrosion - resistant containers. It's transported under regulated conditions, following hazardous chemical shipping guidelines to prevent spills and ensure safety during transit. |
Competitive 4-Chlorofluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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As a leading 4-Chlorofluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
First, it is an important raw material for pharmaceutical synthesis. When creating antibacterial and antiviral drugs, 4-chlorofluorobenzene often acts as a precursor. Due to its unique chemical structure, it can endow the synthesized drugs with specific pharmacological activities and molecular characteristics, which helps the drugs to accurately act on pathogens, or regulate human physiology, and then achieve the effect of treating diseases.
Second, it also plays a key role in the manufacture of pesticides. After chemical transformation, high-efficiency pesticides, fungicides and other pesticide products can be prepared. Its structural characteristics enable it to effectively act on the physiological processes of pests or pathogens, inhibit their growth and reproduction, protect crops from pests and diseases, and ensure agricultural harvests.
Third, in the field of materials science, 4-chlorofluorobenzene also contributes. In the synthesis of special polymer materials, it is often introduced to adjust the properties of materials. For example, to improve the heat resistance and chemical corrosion resistance of materials. Make the prepared materials suitable for high-precision fields such as aerospace and electronics industries, and meet their strict requirements for materials.
Fourth, used as an intermediate in organic synthesis. A variety of organic compounds can be derived through a series of chemical reactions. With the activity of chlorine and fluorine atoms, it has opened up many possibilities for organic synthesis, enabling chemists to construct complex and diverse organic molecular structures and promote the development of organic chemistry.
In summary, 4-chlorofluorobenzene plays an indispensable role in many fields such as medicine, pesticides, materials and organic synthesis, and has made significant contributions to the development of human society.
First of all, under normal temperature and pressure, 4-chlorofluorobenzene is a colorless and transparent liquid, clear like a mirror, and has a lot of texture. Its smell is also characteristic, emitting a special aroma, but this fragrance is not pleasant, inhaled too much, or disturbing human health.
As for its boiling point, it is between 128 ° C and 130 ° C. When the temperature rises to this value, 4-chlorofluorobenzene changes from liquid to gaseous state and turns into curling steam. Its melting point is relatively low, about -48 ° C. If the ambient temperature drops below that value, the substance condenses into a solid state, resembling ice crystals, but its texture is very different from that of ice crystals.
The density of 4-chlorofluorobenzene is greater than that of water, about 1.25g/cm ³. If it is placed in one place with water, it can be seen that it sinks to the bottom of the water, just like a pearl falling in a ditch. Its solubility is also considerable. It is slightly soluble in water, but it can be well miscible in most organic solvents, such as ethanol, ether, acetone, etc., as if a fish enters water and fuses together.
Furthermore, the vapor pressure of 4-chlorofluorobenzene is also one of its important physical properties. At a specific temperature, the magnitude of its vapor pressure depends on its degree of volatilization. The higher the vapor pressure, the easier it is to volatilize under the same conditions, and the faster it diffuses in the air.
In addition, the refractive index of 4-chlorofluorobenzene cannot be ignored. The refractive index reflects its ability to refract light. This value is specific and is of great significance for the identification and identification of this substance, as well as its application in optics-related fields.
In summary, the physical properties of 4-chlorofluorobenzene are diverse and intertwined, forming its unique physical "style". It is a key element in the research and application of organic chemistry and related fields.
In terms of reactivity, the halogen atom chlorine and fluorine are above the benzene ring, which affects the electron cloud density of the benzene ring. The fluorine atom has a strong electron-sucking induction effect, but its lone pair electrons have p-π conjugation with the benzene ring, which reduces the electron cloud density of the benzene ring as a whole, but the effect on the ortho and para-sites is slightly slower. The chlorine atom also has an electron-sucking induction effect, and the conjugation effect is weak. The synergistic effect of the two makes the electrophilic substitution of the benzene ring less active than that of benzene.
In the electrophilic substitution reaction, the localization effect of Taking the nitrification reaction as an example, when nitric acid and sulfuric acid interact together, the nitro cation is an electrophilic reagent, which tends to attack the ortho and para-sites of the benzene ring. This ortho and para-sites can form relatively stable carbon cation intermediates through resonance analysis. However, due to steric resistance factors, the proportion of ortho-substituted products may be slightly lower than the theoretical value.
4-chlorofluorobenzene can also participate in nucleophilic substitution reactions. Under specific conditions, such as strong alkaline environment and high temperature, fluorine atoms or chlorine atoms can be replaced by nucleophilic reagents. Fluorine atoms are slightly difficult to leave due to the high bond energy of C-F, but once the conditions are suitable, substitution can still occur.
In addition, 4-chlorofluorobenzene has certain chemical stability, can be dissolved in most organic solvents at room temperature and pressure, and is not easy to decompose spontaneously. In case of strong oxidizing agents, reducing agents or extreme conditions such as high temperature and light, its structure may change, causing various chemical reactions to occur.
One is the method of using fluorobenzene as the starting material. Under specific conditions, fluorobenzene and chlorine can undergo a substitution reaction to obtain 4-chlorofluorobenzene. This reaction requires specific catalysts, such as commonly used Lewis acid catalysts, such as ferric trichloride. In a suitable temperature and pressure environment, the hydrogen atom in the benzene ring of fluorobenzene can be replaced by the chlorine atom, and due to the positioning effect of the fluorine atom in the benzene ring, the chlorine atom is mostly replaced by the counterposition of the fluorine atom, thereby generating 4-chlorofluorobenzene. In this process, the regulation of reaction temperature is very critical. If the temperature is too high, it is easy to cause the formation of polychlorinated by-products; if the temperature is too low, the reaction rate is slow and the yield is not high. Therefore, the general reaction temperature is controlled at about tens of degrees Celsius to 100 degrees Celsius, depending on the specific reaction device and the concentration of the reactants and other factors.
Second, p-chloroaniline can also be used as a starting material. First, p-chloroaniline is converted into a diazo salt by diazotization reaction, and then treated with fluoroboronic acid to generate p-chlorobenzene diazo fluoroborate. This salt is decomposed by heating to obtain 4-chlorofluorobenzene. The diazotization reaction needs to be carried out in a low temperature environment, usually between 0 and 5 degrees Celsius, to prevent the decomposition The subsequent thermal decomposition steps also need to pay attention to the control of temperature. The temperature needs to reach a specific range in order to effectively promote the decomposition of diazofluoroborate to generate the target product 4-chlorofluorobenzene, and the thermal decomposition process should be in a suitable solvent system to ensure the smooth progress of the reaction and improve the purity and yield of the product.
In addition, there are also those who use other halogenated aromatics as starting materials to prepare 4-chlorofluorobenzene through halogen exchange reactions. However, these methods are relatively complicated, often require specific reaction conditions and reagents, and require high reaction equipment. In comparison, chlorination reactions using fluorobenzene as raw materials and diazotization-thermal decomposition methods using p-chloroaniline as raw materials are more commonly used. The various methods for preparing 4-chlorofluorobenzene have their own advantages and disadvantages. In actual production, it is necessary to comprehensively consider many factors such as the availability of raw materials, cost, and product purity requirements, and choose the most suitable preparation route.
The first word of storage is flammable, and it should be placed in a cool and ventilated warehouse. Keep away from fire and heat sources, and the storage temperature should not exceed 37 ° C. It should be stored separately from oxidants and food chemicals, and should not be mixed. The warehouse must be equipped with explosion-proof lighting and ventilation facilities, and it is forbidden to use machinery and tools that are prone to sparks. The storage area should be equipped with leakage emergency treatment equipment and suitable containment materials.
As for transportation, make sure that the container is sealed and loaded securely before transportation. The trough (tank) car used during transportation should have a grounding chain, and holes can be baffled in the trough to reduce shock and generate static electricity. It is strictly forbidden to mix with oxidants, edible chemicals, etc. During transportation, it is protected from exposure to the sun, rain, and high temperature. Stay away from fire, heat sources, and high temperature areas during stopovers. When traveling by road, follow the specified route, and do not stop in residential areas and densely populated areas. It is forbidden to slip during railway transportation.
In short, when storing and transporting 4-chlorofluorobenzene, all matters related to safety should be treated with caution to avoid disasters.
Looking at its appearance, under room temperature and pressure, it is mostly a colorless to light yellow transparent liquid, clear and shiny, like a quiet spring. Smell it, there is an aromatic smell, but this fragrance is not pleasant and rich, with a bit of irritation unique to chemicals. If you smell it, you will feel that the smell is unique, long-smelling or uncomfortable.
In terms of its boiling point, it is about 117-119 ° C. At this temperature, 4-chlorofluorobenzene gradually converts from liquid to gaseous state, like a mist rising, showing a wonderful change in the state of matter. Its melting point is about -35 ° C. When the temperature drops to this temperature, the liquid that originally flowed slowly solidifies, just like time freezes, and turns into a solid crystal block.
The density of 4-chlorofluorobenzene is about 1.298g/cm ³, which is heavier than water. If it is placed in one place with water, it can be seen that it is like gold falling to the bottom, quietly lying under the water layer. And it is insoluble in water, the two are like distinct strangers, and they are incompatible with each other. However, in the realm of organic solvents, such as ethanol, ether, acetone, etc., 4-chlorofluorobenzene can be closely blended with it, showing good solubility, just like a wanderer returning home and blending freely.
Its vapor pressure is also one of the important physical properties. In a specific temperature environment, the vapor pressure of 4-chlorofluorobenzene reflects its volatilization tendency. At moderate temperatures, although it is not very volatile, the steam still quietly escapes, disperses in the air, and gradually distributes its traces.
These physical properties are of key significance in many fields such as chemical industry and pharmaceutical synthesis. Because of its unique state, taste, melting boiling point, density and solubility, it provides the basic basis and conditions for the reaction process, separation and purification operations in related industries. It is a characteristic that cannot be ignored.
Chlorine and fluorodihalogen atoms are on the benzene ring, causing the electron cloud density of the benzene ring to change. The electron cloud density of the benzene ring is reduced due to the electron-absorbing induction effect of the halogen atom, so its electrophilic substitution reaction activity is slightly less than that of benzene.
In the electrophilic substitution reaction, the halogen atom is the ortho and para-site localization group. The localization effect of chlorine and fluorine is similar, and the newly introduced group is mostly into its ortho and para-site. However, due to the strong electronegativity of fluorine, the proportion
can also occur nucleophilic substitution reaction. Under suitable conditions, chlorine atoms can be replaced by nucleophilic reagents. Because the chlorine atom is connected to the benzene ring, the C-Cl bond has a certain polarity, and the nucleophilic reagent is easy to attack, causing the chlorine atom to leave and form a new compound.
Its chemical stability can also be observed. Under common conditions, it is not easy to react chemically. However, under extreme conditions such as high temperature and strong oxidants, benzene rings or halogen atoms can also participate in the reaction and cause structural changes.
And 4-chlorofluorobenzene can be used as a raw material or intermediate in organic synthesis. Through various reactions, such as substitution, addition, etc., a variety of organic compounds can be prepared, which are widely used in the fields of medicine, pesticides, and materials.
In the chemical industry, it is often used as a raw material and intermediate for the synthesis of other organic compounds. Due to its active chemical properties, it can be used for nucleophilic substitution, electrophilic substitution and other reactions to introduce other functional groups to obtain complex organic molecules. For example, by reacting with specific reagents, aromatic compounds with special structures can be synthesized, which is crucial in the preparation of fine chemical products such as dyes and fragrances.
In the field of medicine, 4-chlorofluorobenzene also makes significant contributions. As a key intermediate, it can be used in the synthesis of a variety of drugs. Due to the presence of chlorine and fluorine atoms, the physical and chemical properties and biological activities of compounds can be changed, such as regulating the lipid solubility, stability and affinity with biological targets of drugs. On this basis, drugs with antibacterial, anti-inflammatory, anti-tumor and other pharmacological activities can be prepared to help human health.
In the field of materials, 4-chlorofluorobenzene can participate in the synthesis of high-performance materials. For example, in the preparation of polymer materials, the introduction of its structural units can endow materials with special properties, such as improving the heat resistance, chemical corrosion resistance and mechanical properties of materials. This is of great significance in fields such as aerospace, electronics and electrical appliances that require strict material properties. For example, polymers obtained by polymerizing monomers containing 4-chlorofluorobenzene structures can be used to make parts inside aerospace vehicles to meet their high-performance material requirements.
In summary, although 4-chlorofluorobenzene is a small molecule compound, it plays an indispensable role in many fields such as chemical industry, medicine, materials, etc., and has outstanding effects on promoting the development of various fields.
One is to use fluorobenzene as the starting material and obtain it by chlorination. The fluorobenzene is placed in the reactor first, and iron powder or ferric trichloride is used as the catalyst to pass chlorine gas into it. On the benzene ring of fluorobenzene, the fluorine atom is the adjacent and para-locator, and the chlorine gas reacts with it, and the chlorine atom can be introduced into the para-position to obtain 4-chlorofluorobenzene. The reaction temperature should be controlled between 50 and 80 degrees Celsius, because the temperature is too low, the reaction is slow; if the temperature is too high, the side reactions will increase, and the yield will decrease and the product will After the reaction is completed, the pure 4-chlorofluorobenzene can be obtained by distillation, extraction and other methods.
Second, 4-chloroaniline is used as raw material, prepared by diazotization and Sandmeier reaction. First, 4-chloroaniline is reacted with hydrochloric acid and sodium nitrite at low temperature (zero to five degrees Celsius) to form a diazonium salt. This process requires strict temperature control to prevent the decomposition of diazonium salts. Later, the diazonium salt is mixed with fluoroborate acid to obtain fluoroborate precipitation. After separation, drying, heating and decomposition, 4-chlorofluorobenzene is obtained. Although there are many steps in this path, the selectivity is good and the product purity is quite high.
Third, p-chlorophenol is used as raw material and is prepared by halogenation and fluorination. First, p-chlorophenol is reacted with halogenating agents (such as phosphorus trichloride, phosphorus pentachloride, etc.) to obtain p-chlorohalobenzene. Then p-chlorohalobenzene and fluorinating agents (such as potassium fluoride, etc.) are reacted in polar aprotic solvents (such as dimethyl sulfoxide) at high temperature, and the halogen atoms are replaced by fluorine atoms to generate 4-chlorofluorobenzene. The raw materials used in this method are common and easy to obtain, but the first step of fluoridation requires specific reaction conditions and solvents to promote the smooth progress of the reaction.
In terms of the environment, 4-chlorofluorobenzene has certain stability and is difficult to degrade naturally. If it escapes in the atmosphere or migrates by air flow, it will affect the air quality of the area. Its solubility in water is limited, but it can adhere to suspended particles and settle to the bottom of the water, causing water body and sediment pollution. If aquatic organisms are exposed to it, they may have physiological abnormalities, such as stunted development and inhibited reproduction. In soil, 4-chlorofluorobenzene can be adsorbed by soil particles, interfering with the normal metabolism of soil microorganisms, destroying soil ecological balance, reducing soil fertility, and affecting plant growth.
As for the human body, 4-chlorofluorobenzene can be ingested into the human body through breathing, skin contact and diet. Inhaled through the respiratory tract, or irritate the mucosa of the respiratory tract, causing cough, asthma and other discomfort. Long-term inhalation may damage lung function and increase the risk of respiratory diseases. If exposed to the skin, it may cause skin allergies, itching, redness and swelling. Because of its fat solubility, it can enter the blood circulation through the skin barrier, which can damage the liver, kidneys and other organs. Accidentally ingesting substances containing 4-chlorofluorobenzene may irritate the gastrointestinal tract, causing nausea, vomiting, and abdominal pain. Long-term accumulation may affect the nervous system, causing dizziness, fatigue, insomnia, and even impairment of cognitive and
In summary, 4-chlorofluorobenzene is potentially harmful to the environment and people, and its production, use, and disposal should be strictly controlled to reduce its threat to the environment and human health.

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