Linshang Chemical
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4-Chloroiodobenzene
Linshang Chemical
|
HS Code |
469776 |
| Chemical Formula | C6H4ClI |
| Molar Mass | 238.45 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 217 - 219 °C |
| Melting Point | 19 - 21 °C |
| Density | 1.994 g/cm³ at 25 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Flash Point | 99 °C |
| Cas Number | 637-87-6 |
| Refractive Index | 1.648 - 1.650 |
As an accredited 4-Chloroiodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - chloroiodobenzene packaged in a sealed, corrosion - resistant bottle. |
| Storage | 4 - chloroiodobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition sources. Keep it in a tightly sealed container to prevent vapor leakage. As it is a chemical, store it separately from oxidizing agents and incompatible substances to avoid potential reactions. This helps maintain its stability and safety during storage. |
| Shipping | 4 - chloroiodobenzene is shipped in well - sealed containers, compliant with hazardous chemical regulations. Packaging ensures protection from breakage. Shipment is via approved carriers with proper handling to prevent spills during transit. |
Competitive 4-Chloroiodobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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What are the main uses of 4-chloroiodobenzene?
4-Chloroiodobenzene (4-chloroiodobenzene) has a wide range of main uses. In the field of organic synthesis, this is a crucial intermediate. With its unique chemical structure, it can participate in many types of chemical reactions, such as coupling reactions. In such reactions, 4-chloroiodobenzene can be combined with various organometallic reagents to form carbon-carbon bonds, which can assist in the synthesis of many complex organic compounds, such as drug molecules, natural products, and key structural fragments of functional materials.
Taking medicinal chemistry as an example, when developing new drugs, 4-chloroiodobenzene can undergo a series of chemical transformations to introduce specific functional groups to meet the needs of precise combination of drugs and targets, thereby optimizing the activity, selectivity and pharmacokinetic properties of drugs. For example, in the field of materials science, when synthesizing materials with special photoelectric properties, 4-chloroiodobenzene can be used as a starting material to prepare organic semiconductor materials with unique electrical and optical properties through cleverly designed reaction routes, which are used in frontier fields such as organic Light Emitting Diode (OLED) and organic solar cells.
In addition, in the process of studying new catalysts or catalytic systems, 4-chloroiodobenzene can also be used as a reactant to explore novel catalytic reaction pathways and mechanisms, and to promote the sustainable development and innovation of organic synthetic chemistry. Due to the difference in the activity of chlorine atoms and iodine atoms, it provides rich possibilities for the diversity and controllability of chemical reactions, and therefore plays an indispensable role in many fields of organic synthetic chemistry.
Taking medicinal chemistry as an example, when developing new drugs, 4-chloroiodobenzene can undergo a series of chemical transformations to introduce specific functional groups to meet the needs of precise combination of drugs and targets, thereby optimizing the activity, selectivity and pharmacokinetic properties of drugs. For example, in the field of materials science, when synthesizing materials with special photoelectric properties, 4-chloroiodobenzene can be used as a starting material to prepare organic semiconductor materials with unique electrical and optical properties through cleverly designed reaction routes, which are used in frontier fields such as organic Light Emitting Diode (OLED) and organic solar cells.
In addition, in the process of studying new catalysts or catalytic systems, 4-chloroiodobenzene can also be used as a reactant to explore novel catalytic reaction pathways and mechanisms, and to promote the sustainable development and innovation of organic synthetic chemistry. Due to the difference in the activity of chlorine atoms and iodine atoms, it provides rich possibilities for the diversity and controllability of chemical reactions, and therefore plays an indispensable role in many fields of organic synthetic chemistry.
What are the physical properties of 4-chloroiodobenzene?
4-Chloroiodobenzene is also an organic compound. Its physical properties are quite impressive.
Looking at its appearance, under room temperature and pressure, it is often solid, dense and has a specific crystal shape. The formation of this crystal shape is closely related to the interaction between molecules. The crystal shape is regular and the molecules are arranged in an orderly manner, so that the substance has a certain stability.
When it comes to color, it is mostly white to slightly yellow, pure and uniform in color. This color characteristic may be caused by the interaction of electron cloud distribution and light in the molecular structure. Under light, electrons transition, absorb and reflect light of specific wavelengths, and then show this color.
As for the melting point, it is about 43-45 ° C. When the temperature gradually rises to the melting point, the thermal motion of the molecule intensifies, which is enough to overcome the lattice energy, the lattice structure disintegrates, and the substance gradually melts from the solid state to the liquid state. The value of this melting point is closely related to the intermolecular forces, including van der Waals forces, weak interactions between halogen atoms, etc.
The boiling point is about 245-247 ° C. At this temperature, the kinetic energy of the liquid molecule increases greatly, which is enough to overcome the attractive force between the liquid molecules, escape from the liquid surface, and transform into a gaseous state. The boiling point is higher, due to the strong intermolecular forces, the presence of chlorine and iodine atoms increases the molecular polarity and enhances the intermolecular forces, so higher energy is required to achieve the gas-liquid phase transition.
In terms of solubility, 4-chloroiodobenzene is insoluble in water. Water is a strong polar solvent, and although the molecule of this compound contains a halogen atom with a certain polarity, the overall structure is still mainly non-polar. According to the principle of "similar miscibility", it is difficult to dissolve in water. However, in organic solvents such as ethanol, ether, benzene, etc., the solubility is quite good. Organic solvents are mostly weakly polar or non-polar, and are compatible with the intermolecular force of 4-chloroiodobenzene. They can be miscible with each other, and the molecules can be uniformly dispersed in them.
In addition, its density is also an important physical property. Compared with water, the density is higher, so in the coexistence system of water and this substance, 4-chloroiodo The density depends on the molecular weight and the degree of molecular accumulation. The relative atomic weight of chlorine and iodine atoms is relatively large, resulting in an increase in molecular weight and a tight arrangement of molecules, resulting in a considerable density.
Looking at its appearance, under room temperature and pressure, it is often solid, dense and has a specific crystal shape. The formation of this crystal shape is closely related to the interaction between molecules. The crystal shape is regular and the molecules are arranged in an orderly manner, so that the substance has a certain stability.
When it comes to color, it is mostly white to slightly yellow, pure and uniform in color. This color characteristic may be caused by the interaction of electron cloud distribution and light in the molecular structure. Under light, electrons transition, absorb and reflect light of specific wavelengths, and then show this color.
As for the melting point, it is about 43-45 ° C. When the temperature gradually rises to the melting point, the thermal motion of the molecule intensifies, which is enough to overcome the lattice energy, the lattice structure disintegrates, and the substance gradually melts from the solid state to the liquid state. The value of this melting point is closely related to the intermolecular forces, including van der Waals forces, weak interactions between halogen atoms, etc.
The boiling point is about 245-247 ° C. At this temperature, the kinetic energy of the liquid molecule increases greatly, which is enough to overcome the attractive force between the liquid molecules, escape from the liquid surface, and transform into a gaseous state. The boiling point is higher, due to the strong intermolecular forces, the presence of chlorine and iodine atoms increases the molecular polarity and enhances the intermolecular forces, so higher energy is required to achieve the gas-liquid phase transition.
In terms of solubility, 4-chloroiodobenzene is insoluble in water. Water is a strong polar solvent, and although the molecule of this compound contains a halogen atom with a certain polarity, the overall structure is still mainly non-polar. According to the principle of "similar miscibility", it is difficult to dissolve in water. However, in organic solvents such as ethanol, ether, benzene, etc., the solubility is quite good. Organic solvents are mostly weakly polar or non-polar, and are compatible with the intermolecular force of 4-chloroiodobenzene. They can be miscible with each other, and the molecules can be uniformly dispersed in them.
In addition, its density is also an important physical property. Compared with water, the density is higher, so in the coexistence system of water and this substance, 4-chloroiodo The density depends on the molecular weight and the degree of molecular accumulation. The relative atomic weight of chlorine and iodine atoms is relatively large, resulting in an increase in molecular weight and a tight arrangement of molecules, resulting in a considerable density.
What are the chemical properties of 4-chloroiodobenzene?
4-Chloroiodobenzene is an organic compound. Its molecular structure contains chlorine atoms and iodine atoms attached to the benzene ring. The chemical properties of this substance are worthy of in-depth study.
Let's talk about its substitution reaction first. Because the benzene ring has electron cloud density, the presence of chlorine and iodine atoms causes the electron cloud distribution of the benzene ring to change. Chlorine and iodine are electron-withdrawing groups, so that the electron cloud density of the benzene ring is relatively low, and the electron cloud density of the meta-site is slightly higher. Therefore, during the electrophilic substitution reaction, the electrophilic reagents tend to attack the meta-site. However, due to the conjugation effect of chlorine and iodine atoms, the electrophilic substitution activity is slightly lower than that of benzene. For example, when nitric acid and sulfuric acid are
Re-discussion on the reaction of its halogen atom. Although the electronegativity of chlorine atom is greater than that of iodine, the activity of iodine atom is higher because the C-I bond energy is less than that of C-Cl bond. In the nucleophilic substitution reaction, the iodine atom is more easily replaced by nucleophilic reagents. If reacted with sodium alcohol under appropriate conditions, the iodine atom can be replaced by an alkoxy group to generate 4-alkoxy chlorobenzene.
4-chloroiodobenzene has a wide range of uses in the field of organic synthesis. Because halogen atoms can participate in various reactions, they can be used as intermedi For example, through palladium-catalyzed coupling reaction, it can react with alkenyl, aryl-containing halides or boric acids to form carbon-carbon bonds, and realize the expansion and modification of molecular skeletons.
In terms of stability, it is relatively stable under normal conditions. In case of high temperature, strong light or specific catalysts, the intramolecular chemical bonds can be activated and the reaction can be initiated. Store away from high temperature and strong light. It should be placed in a cool and dry place to prevent deterioration.
To sum up, 4-chloroiodobenzene is of great significance in organic synthesis due to its unique structure and diverse chemical properties. The study of its properties and reactions has made great contributions to the development of organic chemistry.
Let's talk about its substitution reaction first. Because the benzene ring has electron cloud density, the presence of chlorine and iodine atoms causes the electron cloud distribution of the benzene ring to change. Chlorine and iodine are electron-withdrawing groups, so that the electron cloud density of the benzene ring is relatively low, and the electron cloud density of the meta-site is slightly higher. Therefore, during the electrophilic substitution reaction, the electrophilic reagents tend to attack the meta-site. However, due to the conjugation effect of chlorine and iodine atoms, the electrophilic substitution activity is slightly lower than that of benzene. For example, when nitric acid and sulfuric acid are
Re-discussion on the reaction of its halogen atom. Although the electronegativity of chlorine atom is greater than that of iodine, the activity of iodine atom is higher because the C-I bond energy is less than that of C-Cl bond. In the nucleophilic substitution reaction, the iodine atom is more easily replaced by nucleophilic reagents. If reacted with sodium alcohol under appropriate conditions, the iodine atom can be replaced by an alkoxy group to generate 4-alkoxy chlorobenzene.
4-chloroiodobenzene has a wide range of uses in the field of organic synthesis. Because halogen atoms can participate in various reactions, they can be used as intermedi For example, through palladium-catalyzed coupling reaction, it can react with alkenyl, aryl-containing halides or boric acids to form carbon-carbon bonds, and realize the expansion and modification of molecular skeletons.
In terms of stability, it is relatively stable under normal conditions. In case of high temperature, strong light or specific catalysts, the intramolecular chemical bonds can be activated and the reaction can be initiated. Store away from high temperature and strong light. It should be placed in a cool and dry place to prevent deterioration.
To sum up, 4-chloroiodobenzene is of great significance in organic synthesis due to its unique structure and diverse chemical properties. The study of its properties and reactions has made great contributions to the development of organic chemistry.
What are the synthesis methods of 4-chloroiodobenzene?
4-Chloroiodobenzene is also a commonly used intermediate in organic synthesis. The synthesis methods are many different, and this is what you described today.
First, it is obtained by halogenation reaction. Take benzene as the initial raw material, first chlorine reagents, such as chlorine gas and ferric chloride, are used to chlorinate benzene to obtain chlorobenzene. Then, chlorobenzene reacts with iodine reagents, such as iodine elementals, and appropriate oxidants (such as nitric acid, etc.), through electrophilic substitution mechanism, 4-chloroiodobenzene can be obtained. In this process, during chlorination, the chlorine atom enters the benzene ring and is affected by the localization effect, mainly forming ortho and para-products, which are then separated and purified to obtain a single chlorobenzene In the iodine substitution reaction, attention should be paid to the amount of oxidant and the reaction conditions to ensure that the iodine atoms mainly enter the counterposition of the chlorine atoms.
Second, it is prepared by metal-catalyzed cross-coupling reaction. First, the chlorobenzene is lithiated, such as reacting with n-butyl lithium to form a lithium chlorobenzene intermediate. Then it is cross-coupled with iodine substitutes (such as iodomethane, etc.) under the action of metal catalysts (such as palladium catalyst). This method has high selectivity and can effectively synthesize 4-chloroiodobenzene. And the metal-catalyzed reaction conditions are relatively mild and the yield is considerable. However, metal catalysts are expensive, and post-treatment needs to pay attention to separation and recovery to reduce costs.
Or, the reaction synthesis with the participation of arylboronic acid derivatives. The corresponding arylboronic acid is prepared from chlorobenzene through a multi-step reaction, and then reacted with an iodine substitution reagent in the presence of a base and a metal catalyst. This approach takes advantage of the characteristics of arylboronic acid. Under suitable conditions, iodine atoms can be selectively introduced into chlorobenzene pairs to obtain 4-chloroiodobenzene. This method is easier to operate and environmentally friendly, but the steps are slightly complicated, and the reaction conditions of each step need to be carefully controlled to ensure the purity and yield of the product.
First, it is obtained by halogenation reaction. Take benzene as the initial raw material, first chlorine reagents, such as chlorine gas and ferric chloride, are used to chlorinate benzene to obtain chlorobenzene. Then, chlorobenzene reacts with iodine reagents, such as iodine elementals, and appropriate oxidants (such as nitric acid, etc.), through electrophilic substitution mechanism, 4-chloroiodobenzene can be obtained. In this process, during chlorination, the chlorine atom enters the benzene ring and is affected by the localization effect, mainly forming ortho and para-products, which are then separated and purified to obtain a single chlorobenzene In the iodine substitution reaction, attention should be paid to the amount of oxidant and the reaction conditions to ensure that the iodine atoms mainly enter the counterposition of the chlorine atoms.
Second, it is prepared by metal-catalyzed cross-coupling reaction. First, the chlorobenzene is lithiated, such as reacting with n-butyl lithium to form a lithium chlorobenzene intermediate. Then it is cross-coupled with iodine substitutes (such as iodomethane, etc.) under the action of metal catalysts (such as palladium catalyst). This method has high selectivity and can effectively synthesize 4-chloroiodobenzene. And the metal-catalyzed reaction conditions are relatively mild and the yield is considerable. However, metal catalysts are expensive, and post-treatment needs to pay attention to separation and recovery to reduce costs.
Or, the reaction synthesis with the participation of arylboronic acid derivatives. The corresponding arylboronic acid is prepared from chlorobenzene through a multi-step reaction, and then reacted with an iodine substitution reagent in the presence of a base and a metal catalyst. This approach takes advantage of the characteristics of arylboronic acid. Under suitable conditions, iodine atoms can be selectively introduced into chlorobenzene pairs to obtain 4-chloroiodobenzene. This method is easier to operate and environmentally friendly, but the steps are slightly complicated, and the reaction conditions of each step need to be carefully controlled to ensure the purity and yield of the product.
What are the precautions for 4-chloroiodobenzene during storage and transportation?
For 4-chloroiodobenzene, it is also the first quality in the chemical process. In all matters of storage and transportation, be careful.
First words storage. This substance should be placed in a cool, dry and well ventilated place. Because it may be sensitive to temperature and humidity, in a humid and hot environment, it may cause deterioration. If stored in a tidal place, it is easy for water vapor to react with things, or change their properties; high temperatures can also promote their transformation and damage their quality. And it must be stored separately with oxidants and strong bases. Those with this number are strong in nature, and when it encounters 4-chloroiodobenzene, it is easy to respond to the drama and cause danger.
Times and transportation. When handling, be careful not to cause shock damage. Because it is a chemical, the bottle is broken and leaked, or causes pollution, and is harmful to the surroundings. The utensils used for transportation must be tightly sealed to prevent them from escaping. The vehicles used should also be clean and clean, free from other filth mixed with it. If the transportation journey is long, it is necessary to check its condition regularly to prevent leakage. In addition, the transporter must know its nature, know the emergency method, and deal with it quickly in case of danger, so as to ensure safety. In this way, the storage and transportation of 4-chloroiodobenzene can be safe and avoid accidents.
First words storage. This substance should be placed in a cool, dry and well ventilated place. Because it may be sensitive to temperature and humidity, in a humid and hot environment, it may cause deterioration. If stored in a tidal place, it is easy for water vapor to react with things, or change their properties; high temperatures can also promote their transformation and damage their quality. And it must be stored separately with oxidants and strong bases. Those with this number are strong in nature, and when it encounters 4-chloroiodobenzene, it is easy to respond to the drama and cause danger.
Times and transportation. When handling, be careful not to cause shock damage. Because it is a chemical, the bottle is broken and leaked, or causes pollution, and is harmful to the surroundings. The utensils used for transportation must be tightly sealed to prevent them from escaping. The vehicles used should also be clean and clean, free from other filth mixed with it. If the transportation journey is long, it is necessary to check its condition regularly to prevent leakage. In addition, the transporter must know its nature, know the emergency method, and deal with it quickly in case of danger, so as to ensure safety. In this way, the storage and transportation of 4-chloroiodobenzene can be safe and avoid accidents.
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