Linshang Chemical
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4-Chloroisocyanatobenzene
Linshang Chemical
|
HS Code |
558738 |
| Name | 4-Chloroisocyanatobenzene |
| Chemical Formula | C7H4ClNO |
| Molar Mass | 153.565 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 205 - 206 °C |
| Melting Point | 12 - 14 °C |
| Density | 1.252 g/mL at 25 °C |
| Solubility | Insoluble in water, soluble in organic solvents like benzene, toluene |
| Vapor Pressure | 0.11 mmHg at 25 °C |
| Flash Point | 86 °C |
| Hazard | Corrosive, causes burns to skin and eyes, harmful if inhaled or swallowed |
As an accredited 4-Chloroisocyanatobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 kg of 4 - chloroisocyanatobenzene packaged in a sealed, corrosion - resistant drum. |
| Storage | 4 - chloroisocyanatobenzene should be stored in a cool, dry, well - ventilated area, away from sources of heat, ignition, and moisture. It should be kept in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from incompatible substances like amines, alcohols, and strong acids to prevent dangerous reactions. Regularly check storage conditions and containers for integrity. |
| Shipping | 4 - Chloroisocyanatobenzene is a chemical that requires careful shipping. It should be packaged in sealed, corrosion - resistant containers. Shipments must comply with hazardous chemical regulations, ensuring proper labeling and transport in well - ventilated vehicles. |
Competitive 4-Chloroisocyanatobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 4-Chloroisocyanatobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 4-chloroisocyanatobenzene?
4-Phenyl chloroisocyanate is an important raw material for organic synthesis and has a wide range of uses.
First, in the field of pharmaceutical synthesis, it plays a significant role. It is indispensable for the construction of many drug molecules. For example, when developing antimicrobial drugs with specific structures, 4-chloroisocyanate can be used as a key intermediate to react with other compounds containing specific functional groups. Through carefully designed reaction steps, complex drug molecular structures with antibacterial activity can be ingeniously constructed. By adjusting the types of compounds and reaction conditions that react with it, the properties and activities of the synthesized drugs can be precisely regulated to meet the needs of different disease treatments.
Second, it is also indispensable in pesticide synthesis. For example, in the preparation of highly efficient and environmentally friendly insecticides, 4-chlorophenyl isocyanate can participate in the formation of active ingredients with specific insecticidal functions. It reacts with different types of organic compounds containing nitrogen and sulfur to generate a series of compounds with unique insecticidal mechanisms. These compounds have high selectivity and strong lethality to specific pests, and at the same time have relatively few residues in the environment, which meets the current requirements for pesticides in the development of green agriculture.
Third, in the field of materials science, 4-chlorophenyl isocyanate can also play an important role. For example, in the preparation of special polymer materials, it can participate in the polymerization reaction as a functional monomer. By copolymerizing with other monomers with complementary functional groups, polymer materials can be endowed with special properties, such as excellent heat resistance, chemical corrosion resistance, etc. These special polymer materials are widely used in high-end fields such as aerospace and electronics, and can meet the strict requirements for high performance in these fields.
First, in the field of pharmaceutical synthesis, it plays a significant role. It is indispensable for the construction of many drug molecules. For example, when developing antimicrobial drugs with specific structures, 4-chloroisocyanate can be used as a key intermediate to react with other compounds containing specific functional groups. Through carefully designed reaction steps, complex drug molecular structures with antibacterial activity can be ingeniously constructed. By adjusting the types of compounds and reaction conditions that react with it, the properties and activities of the synthesized drugs can be precisely regulated to meet the needs of different disease treatments.
Second, it is also indispensable in pesticide synthesis. For example, in the preparation of highly efficient and environmentally friendly insecticides, 4-chlorophenyl isocyanate can participate in the formation of active ingredients with specific insecticidal functions. It reacts with different types of organic compounds containing nitrogen and sulfur to generate a series of compounds with unique insecticidal mechanisms. These compounds have high selectivity and strong lethality to specific pests, and at the same time have relatively few residues in the environment, which meets the current requirements for pesticides in the development of green agriculture.
Third, in the field of materials science, 4-chlorophenyl isocyanate can also play an important role. For example, in the preparation of special polymer materials, it can participate in the polymerization reaction as a functional monomer. By copolymerizing with other monomers with complementary functional groups, polymer materials can be endowed with special properties, such as excellent heat resistance, chemical corrosion resistance, etc. These special polymer materials are widely used in high-end fields such as aerospace and electronics, and can meet the strict requirements for high performance in these fields.
What are the physical properties of 4-chloroisocyanatobenzene?
4-Phenyl chloroisocyanate, the physical properties of this substance are quite important, and it is related to many chemical matters. At room temperature, it is a colorless to light yellow liquid, and it has a specific color, which is intuitively recognizable.
When it comes to odor, 4-chloroisocyanate emits a pungent and strongly irritating odor, which is uncomfortable to smell. This odor characteristic is also one of its significant physical properties.
Furthermore, its boiling point has a fixed number, about 203-204 ° C. When the temperature reaches this point, the substance changes from liquid to gas state. This boiling point characteristic is of great significance in chemical operations such as distillation and separation, and is related to the temperature control of the operation.
In terms of melting point, 4-chloroisocyanate phenyl ester is about -6 ° C, the temperature drops below the melting point, and its morphology changes from liquid to solid. This melting point data is a key reference for storage and transportation conditions.
Density is also a physical property that cannot be ignored, about 1.27g/cm ³. This density value is crucial for judging its distribution in the system in the process of mixing and delamination of substances.
In addition, 4-chloroisocyanate phenyl ester is insoluble in water, but soluble in organic solvents such as toluene and dichloromethane. This difference in solubility is a core consideration in the extraction and reaction medium selection of the chemical industry, which determines the direction and effect of the process.
When it comes to odor, 4-chloroisocyanate emits a pungent and strongly irritating odor, which is uncomfortable to smell. This odor characteristic is also one of its significant physical properties.
Furthermore, its boiling point has a fixed number, about 203-204 ° C. When the temperature reaches this point, the substance changes from liquid to gas state. This boiling point characteristic is of great significance in chemical operations such as distillation and separation, and is related to the temperature control of the operation.
In terms of melting point, 4-chloroisocyanate phenyl ester is about -6 ° C, the temperature drops below the melting point, and its morphology changes from liquid to solid. This melting point data is a key reference for storage and transportation conditions.
Density is also a physical property that cannot be ignored, about 1.27g/cm ³. This density value is crucial for judging its distribution in the system in the process of mixing and delamination of substances.
In addition, 4-chloroisocyanate phenyl ester is insoluble in water, but soluble in organic solvents such as toluene and dichloromethane. This difference in solubility is a core consideration in the extraction and reaction medium selection of the chemical industry, which determines the direction and effect of the process.
What is the chemistry of 4-chloroisocyanatobenzene?
4-Phenyl chloroisocyanate, an organic compound with unique chemical properties, is widely used in the field of organic synthesis.
Looking at its reactivity, the isocyanate group (-N = C = O) is very active. When exposed to water, a hydrolysis reaction occurs immediately to generate carbon dioxide, amines and corresponding acids. The mechanism of its hydrolysis reaction is due to the high reactivity of the carbon-nitrogen and carbon-oxygen double bonds in the isocyanate group. The hydroxyl groups in the water molecule attack the carbon atoms of the isocyanate group, which triggers a series of changes. This hydrolysis reaction is quite violent. When storing and using 4-chloroisocyanate phenyl ester, care must be taken to isolate water vapor.
Furthermore, 4-chloroisocyanate phenyl ester can also react with alcohols to form urethane. In this reaction process, the hydroxyl oxygen atom of the alcohol conducts a nucleophilic attack on the carbon atom of the isocyanate group, and then goes through steps such as rearrangement to finally form the urethane product. This reaction is of great significance in the preparation of various polymer materials with special structures and properties, pharmaceutical intermediates, etc.
4-chloroisocyanate phenyl ester reacts with amines to obtain urea compounds. The nitrogen atom of the amine launches a nucleophilic attack on the carbon atom of the isocyanate group with its lone pair electron, and undergoes a series of transformations to form urea substances. This reaction is often used in organic synthesis to construct compounds containing urea structures, and many biologically active drugs and functional materials are prepared by such reactions.
In terms of chemical stability, although 4-chloroisocyanate phenyl ester can exist relatively stably under specific conditions such as anhydrous and inactive hydrogen compounds, it is not suitable for long-term exposure to air or coexistence with active substances such as water, alcohol, and amine, otherwise it is prone to uncontrollable reactions that affect its quality and use effect.
In addition, the presence of chlorine atoms in 4-chloroisocyanate phenyl ester also gives it certain characteristics. Chlorine atoms can participate in reactions such as nucleophilic substitution. Under suitable reaction conditions and reagents, chlorine atoms can be replaced by other groups, thereby modifying the molecular structure and creating possibilities for the synthesis of more derivatives with different properties and uses.
The chemical properties of phenyl chloroisocyanate are active, and various reactions caused by its isocyanate group and chlorine atoms provide many opportunities for organic synthesis chemistry. However, when operating and using, it is necessary to strictly control the reaction conditions and storage environment according to its characteristics.
Looking at its reactivity, the isocyanate group (-N = C = O) is very active. When exposed to water, a hydrolysis reaction occurs immediately to generate carbon dioxide, amines and corresponding acids. The mechanism of its hydrolysis reaction is due to the high reactivity of the carbon-nitrogen and carbon-oxygen double bonds in the isocyanate group. The hydroxyl groups in the water molecule attack the carbon atoms of the isocyanate group, which triggers a series of changes. This hydrolysis reaction is quite violent. When storing and using 4-chloroisocyanate phenyl ester, care must be taken to isolate water vapor.
Furthermore, 4-chloroisocyanate phenyl ester can also react with alcohols to form urethane. In this reaction process, the hydroxyl oxygen atom of the alcohol conducts a nucleophilic attack on the carbon atom of the isocyanate group, and then goes through steps such as rearrangement to finally form the urethane product. This reaction is of great significance in the preparation of various polymer materials with special structures and properties, pharmaceutical intermediates, etc.
4-chloroisocyanate phenyl ester reacts with amines to obtain urea compounds. The nitrogen atom of the amine launches a nucleophilic attack on the carbon atom of the isocyanate group with its lone pair electron, and undergoes a series of transformations to form urea substances. This reaction is often used in organic synthesis to construct compounds containing urea structures, and many biologically active drugs and functional materials are prepared by such reactions.
In terms of chemical stability, although 4-chloroisocyanate phenyl ester can exist relatively stably under specific conditions such as anhydrous and inactive hydrogen compounds, it is not suitable for long-term exposure to air or coexistence with active substances such as water, alcohol, and amine, otherwise it is prone to uncontrollable reactions that affect its quality and use effect.
In addition, the presence of chlorine atoms in 4-chloroisocyanate phenyl ester also gives it certain characteristics. Chlorine atoms can participate in reactions such as nucleophilic substitution. Under suitable reaction conditions and reagents, chlorine atoms can be replaced by other groups, thereby modifying the molecular structure and creating possibilities for the synthesis of more derivatives with different properties and uses.
The chemical properties of phenyl chloroisocyanate are active, and various reactions caused by its isocyanate group and chlorine atoms provide many opportunities for organic synthesis chemistry. However, when operating and using, it is necessary to strictly control the reaction conditions and storage environment according to its characteristics.
What are 4-chloroisocyanatobenzene synthesis methods?
The synthesis method of 4-chloroisocyanate phenyl ester has been known for a long time, and is described in detail as follows.
First, 4-chloroaniline is used as the starting material. This substance reacts with phosgene to obtain 4-chloroisocyanate phenyl ester. Phosgene is very toxic, and caution is required when operating. In the reaction system, 4-chloroaniline is dissolved in a suitable organic solvent, such as toluene, and phosgene is slowly introduced at low temperature. Phosgene interacts with the amino group in 4-chloroaniline to form a carbamyl chloride intermediate first, and then dehydrochlorinated to obtain 4-chloroisocyanate phenyl ester. In this process, the temperature and the rate of phosgene entry need to be precisely controlled, otherwise the yield and product purity will be affected.
Second, 4-chlorobenzoic acid is used as the starting material. First, it is converted into 4-chlorobenzoyl chloride, and chlorination reagents such as dichlorosulfoxide are commonly used. The reaction of the two can obtain 4-chlorobenzoyl chloride. Then 4-chlorobenzoyl chloride reacts with urea under the action of a catalyst, and after a series of conversions, 4-chlorobenzoyl isocyanate can also be obtained. This path is relatively safe, but the steps are slightly complicated, and the reaction conditions need to be finely adjusted to obtain the ideal result.
Third, 4-chloronitrobenzene is used as the starting material. After the reduction reaction, the nitro group is converted into an amino group to obtain 4-chloroaniline, and the subsequent steps are the same as the method using 4-chloroaniline as the starting material. In the reduction process, suitable reducing agents, such as iron filings and hydrochloric acid systems, can be selected. The raw materials in this way are easy to obtain, but the reduction step may require more post-processing operations to remove impurities.
First, 4-chloroaniline is used as the starting material. This substance reacts with phosgene to obtain 4-chloroisocyanate phenyl ester. Phosgene is very toxic, and caution is required when operating. In the reaction system, 4-chloroaniline is dissolved in a suitable organic solvent, such as toluene, and phosgene is slowly introduced at low temperature. Phosgene interacts with the amino group in 4-chloroaniline to form a carbamyl chloride intermediate first, and then dehydrochlorinated to obtain 4-chloroisocyanate phenyl ester. In this process, the temperature and the rate of phosgene entry need to be precisely controlled, otherwise the yield and product purity will be affected.
Second, 4-chlorobenzoic acid is used as the starting material. First, it is converted into 4-chlorobenzoyl chloride, and chlorination reagents such as dichlorosulfoxide are commonly used. The reaction of the two can obtain 4-chlorobenzoyl chloride. Then 4-chlorobenzoyl chloride reacts with urea under the action of a catalyst, and after a series of conversions, 4-chlorobenzoyl isocyanate can also be obtained. This path is relatively safe, but the steps are slightly complicated, and the reaction conditions need to be finely adjusted to obtain the ideal result.
Third, 4-chloronitrobenzene is used as the starting material. After the reduction reaction, the nitro group is converted into an amino group to obtain 4-chloroaniline, and the subsequent steps are the same as the method using 4-chloroaniline as the starting material. In the reduction process, suitable reducing agents, such as iron filings and hydrochloric acid systems, can be selected. The raw materials in this way are easy to obtain, but the reduction step may require more post-processing operations to remove impurities.
4-chloroisocyanatobenzene need to pay attention to when storing and transporting
4-Phenyl chloroisocyanate is an organic compound. When storing and transporting it, you must be careful and take care of many things.
It is active and reacts violently in contact with water. Therefore, the storage place must be kept dry and must not allow water vapor to invade. The warehouse should be selected in a high dry place, well ventilated, and should be away from water sources and moisture. When transporting, the utensils used must also be dry and water-free.
4-Phenyl chloroisocyanate is quite sensitive to heat, and it is easy to decompose when heated, and even risk explosion. Therefore, the temperature of the storage place should be controlled in a lower range, generally not exceeding 30 ° C. During transportation, it is also necessary to avoid direct sunlight and heat sources. It can be transported in a cool time. If it is in summer, special attention should be paid to heatstroke prevention and cooling.
This compound is toxic and irritating, and is very harmful to the human body. Storage should be strictly separated from living areas and office areas, with obvious warning signs. During transportation, operators must wear professional protective equipment, such as gas masks, protective clothing, etc., to prevent contact and inhalation. In case of leakage, quickly evacuate unrelated personnel, and emergency responders need to be well protected before disposal.
Furthermore, 4-chlorophenyl isocyanate is flammable, and it is easy to burn in case of open flames and hot topics. When storing and transporting, it is essential to keep away from fire and heat sources, and fire should be banned in warehouses and transportation vehicles. At the same time, the choice of fire extinguishing materials is also critical. Fire extinguishing agents such as carbon dioxide and dry powder should be used, and water must not be used.
Storage and transportation of 4-chloroisocyanate phenyl ester must strictly follow the specifications in terms of drying, temperature, protection, and fire protection. A little negligence can lead to disaster. This is a heavy responsibility for chemical safety.
It is active and reacts violently in contact with water. Therefore, the storage place must be kept dry and must not allow water vapor to invade. The warehouse should be selected in a high dry place, well ventilated, and should be away from water sources and moisture. When transporting, the utensils used must also be dry and water-free.
4-Phenyl chloroisocyanate is quite sensitive to heat, and it is easy to decompose when heated, and even risk explosion. Therefore, the temperature of the storage place should be controlled in a lower range, generally not exceeding 30 ° C. During transportation, it is also necessary to avoid direct sunlight and heat sources. It can be transported in a cool time. If it is in summer, special attention should be paid to heatstroke prevention and cooling.
This compound is toxic and irritating, and is very harmful to the human body. Storage should be strictly separated from living areas and office areas, with obvious warning signs. During transportation, operators must wear professional protective equipment, such as gas masks, protective clothing, etc., to prevent contact and inhalation. In case of leakage, quickly evacuate unrelated personnel, and emergency responders need to be well protected before disposal.
Furthermore, 4-chlorophenyl isocyanate is flammable, and it is easy to burn in case of open flames and hot topics. When storing and transporting, it is essential to keep away from fire and heat sources, and fire should be banned in warehouses and transportation vehicles. At the same time, the choice of fire extinguishing materials is also critical. Fire extinguishing agents such as carbon dioxide and dry powder should be used, and water must not be used.
Storage and transportation of 4-chloroisocyanate phenyl ester must strictly follow the specifications in terms of drying, temperature, protection, and fire protection. A little negligence can lead to disaster. This is a heavy responsibility for chemical safety.
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