Linshang Chemical
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4-(Chloromethyl)-1,2-Difluorobenzene
Linshang Chemical
|
HS Code |
603235 |
| Chemical Formula | C7H5ClF2 |
| Molecular Weight | 162.56 |
| Appearance | Liquid (usually) |
| Boiling Point | Data needed |
| Melting Point | Data needed |
| Density | Data needed |
| Solubility In Water | Low (hydrophobic) |
| Solubility In Organic Solvents | Good solubility in many organic solvents |
| Flash Point | Data needed |
| Vapor Pressure | Data needed |
| Odor | Characteristic aromatic odor (推测) |
As an accredited 4-(Chloromethyl)-1,2-Difluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 mL of 4-(chloromethyl)-1,2 -difluorobenzene in a tightly - sealed glass bottle. |
| Storage | 4-(Chloromethyl)-1,2 -difluorobenzene should be stored in a cool, dry, well - ventilated area away from sources of ignition. Keep it in a tightly sealed container made of materials compatible with the chemical, such as corrosion - resistant metals or specific plastics. Store it separately from oxidizing agents and reactive chemicals to prevent potential hazardous reactions. |
| Shipping | 4-(Chloromethyl)-1,2 -difluorobenzene is shipped in accordance with strict chemical transportation regulations. It's typically packed in specialized containers to prevent leakage, ensuring safe transit to the destination. |
Competitive 4-(Chloromethyl)-1,2-Difluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 4-(Chloromethyl)-1,2-Difluorobenzene in China?
As a trusted 4-(Chloromethyl)-1,2-Difluorobenzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 4-(Chloromethyl)-1,2-Difluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 4- (chloromethyl) -1,2-difluorobenzene?
4- (chloromethyl) -1,2-difluorobenzene is also an organic compound. Its main uses are quite extensive and useful in various fields.
First, in the field of pharmaceutical synthesis, this compound is often a key intermediate. In terms of creating new drugs, its unique chemical structure can be introduced into drug molecules through specific chemical reactions, giving drugs specific biological activities and pharmacological properties. For example, it may help to construct drugs with unique targets, open up new avenues for the treatment of diseases, and play an important role in the process of drug development against difficult diseases.
Second, in the field of materials science, 4- (chloromethyl) -1,2-difluorobenzene can also be used. It can be used to prepare special polymer materials by polymerizing with other monomers to generate polymers with special properties. Such polymers may have excellent heat resistance, chemical corrosion resistance, or unique electrical properties, so they are used in aerospace, electronics and other fields that require strict material properties.
Furthermore, in the field of pesticide synthesis, it is also indispensable. As an important raw material for the synthesis of new pesticides, many efficient, low-toxic and environmentally friendly pesticide varieties can be derived. These pesticides have significant control effects on crop pests, can effectively ensure the yield and quality of crops, and contribute to the sustainable development of agriculture.
In summary, 4- (chloromethyl) -1,2-difluorobenzene has shown important application value in the fields of medicine, materials, pesticides, etc., promoting technological progress and industrial development in various related fields.
First, in the field of pharmaceutical synthesis, this compound is often a key intermediate. In terms of creating new drugs, its unique chemical structure can be introduced into drug molecules through specific chemical reactions, giving drugs specific biological activities and pharmacological properties. For example, it may help to construct drugs with unique targets, open up new avenues for the treatment of diseases, and play an important role in the process of drug development against difficult diseases.
Second, in the field of materials science, 4- (chloromethyl) -1,2-difluorobenzene can also be used. It can be used to prepare special polymer materials by polymerizing with other monomers to generate polymers with special properties. Such polymers may have excellent heat resistance, chemical corrosion resistance, or unique electrical properties, so they are used in aerospace, electronics and other fields that require strict material properties.
Furthermore, in the field of pesticide synthesis, it is also indispensable. As an important raw material for the synthesis of new pesticides, many efficient, low-toxic and environmentally friendly pesticide varieties can be derived. These pesticides have significant control effects on crop pests, can effectively ensure the yield and quality of crops, and contribute to the sustainable development of agriculture.
In summary, 4- (chloromethyl) -1,2-difluorobenzene has shown important application value in the fields of medicine, materials, pesticides, etc., promoting technological progress and industrial development in various related fields.
What are the physical properties of 4- (chloromethyl) -1,2-difluorobenzene
4- (chloromethyl) -1,2-difluorobenzene is one of the organic compounds. Its physical properties are quite important and are related to many practical applications.
First of all, its appearance is often colorless to light yellow liquid, clear in appearance, without much variegation. This appearance feature is an important basis for preliminary identification and observation of its state.
Second, its odor has a special aromatic smell. Although it is not rich and pungent, it is also clearly identifiable. This odor property is of great significance for sensory cognition and evaluation of related operating environments.
Furthermore, boiling point is one of the key physical properties. Its boiling point is about a certain range, and this value determines the temperature conditions for it to change from liquid to gaseous during heating. The exact value of the boiling point allows those who handle this substance to follow the appropriate temperature for distillation, separation, etc. The
melting point cannot be ignored. The specific melting point indicates the critical temperature for its conversion from solid to liquid. Knowing its melting point has guiding value in storage and specific preparation processes.
Density is also an important property. 4- (chloromethyl) -1,2-difluorobenzene has a certain density. This value is related to its distribution and space occupied when mixed with other substances. It is indispensable for chemical synthesis and related experimental deployment.
In terms of solubility, it has good solubility in organic solvents such as ethanol and ether, and can dissolve with them. However, in water, the solubility is poor, and this property is a key consideration when separating, purifying and selecting the reaction environment.
In summary, the physical properties of 4- (chloromethyl) -1,2-difluorobenzene, such as appearance, odor, boiling point, melting point, density and solubility, are of crucial significance in many fields such as chemical industry and scientific research, and are the cornerstone of their rational application and research.
First of all, its appearance is often colorless to light yellow liquid, clear in appearance, without much variegation. This appearance feature is an important basis for preliminary identification and observation of its state.
Second, its odor has a special aromatic smell. Although it is not rich and pungent, it is also clearly identifiable. This odor property is of great significance for sensory cognition and evaluation of related operating environments.
Furthermore, boiling point is one of the key physical properties. Its boiling point is about a certain range, and this value determines the temperature conditions for it to change from liquid to gaseous during heating. The exact value of the boiling point allows those who handle this substance to follow the appropriate temperature for distillation, separation, etc. The
melting point cannot be ignored. The specific melting point indicates the critical temperature for its conversion from solid to liquid. Knowing its melting point has guiding value in storage and specific preparation processes.
Density is also an important property. 4- (chloromethyl) -1,2-difluorobenzene has a certain density. This value is related to its distribution and space occupied when mixed with other substances. It is indispensable for chemical synthesis and related experimental deployment.
In terms of solubility, it has good solubility in organic solvents such as ethanol and ether, and can dissolve with them. However, in water, the solubility is poor, and this property is a key consideration when separating, purifying and selecting the reaction environment.
In summary, the physical properties of 4- (chloromethyl) -1,2-difluorobenzene, such as appearance, odor, boiling point, melting point, density and solubility, are of crucial significance in many fields such as chemical industry and scientific research, and are the cornerstone of their rational application and research.
What are the synthesis methods of 4- (chloromethyl) -1,2-difluorobenzene?
There are several common methods for the synthesis of 4- (chloromethyl) -1,2-difluorobenzene.
First, 1,2-difluorobenzene is used as the starting material. First, it is chloromethylated with paraformaldehyde and hydrogen chloride gas in the presence of specific catalysts such as anhydrous zinc chloride. This reaction requires attention to the control of reaction temperature, raw material ratio and catalyst dosage. If the temperature is too high, or side reactions increase, it will affect the purity and yield of the product; if the raw material ratio is improper, the reaction will be incomplete and the amount of product will be reduced. The amount of catalyst also has a significant impact on the reaction rate and selectivity.
Second, it can be started from 4-methyl-1,2-difluorobenzene. First, a suitable chlorinating agent, such as N-chlorosuccinimide (NCS), is carried out in the presence of an initiator such as benzoyl peroxide. Radical substitution reaction is carried out to chlorinate methyl to produce 4- (chloromethyl) -1,2-difluorobenzene. In this process, the amount of initiator, reaction time and temperature are extremely critical. Too little initiator makes it difficult to start the reaction; too much may lead to runaway reaction. If the reaction time is too long or too short, it will affect the yield and purity of the product. Improper temperature can also trigger side reactions, such as the formation of polychlorinated products.
Third, if the corresponding halogenated aromatics are used as raw materials, they can also be synthesized through halogen exchange reaction. For example, select suitable chlorine-containing and fluorohalogenated benzene derivatives, and carry out halogen exchange under the action of specific solvents and catalysts to achieve the purpose of generating 4- (chloromethyl) -1,2-difluorobenzene. However, this method requires precise control of the reaction conditions. The polarity of the solvent and the activity of the catalyst will play an important role in the reaction process and results. If the polarity of the solvent is not suitable, the solubility of the reactants will be affected, and the reaction will be difficult to proceed smoothly. The catalyst activity is poor, the reaction rate is slow, or the target product cannot be obtained.
First, 1,2-difluorobenzene is used as the starting material. First, it is chloromethylated with paraformaldehyde and hydrogen chloride gas in the presence of specific catalysts such as anhydrous zinc chloride. This reaction requires attention to the control of reaction temperature, raw material ratio and catalyst dosage. If the temperature is too high, or side reactions increase, it will affect the purity and yield of the product; if the raw material ratio is improper, the reaction will be incomplete and the amount of product will be reduced. The amount of catalyst also has a significant impact on the reaction rate and selectivity.
Second, it can be started from 4-methyl-1,2-difluorobenzene. First, a suitable chlorinating agent, such as N-chlorosuccinimide (NCS), is carried out in the presence of an initiator such as benzoyl peroxide. Radical substitution reaction is carried out to chlorinate methyl to produce 4- (chloromethyl) -1,2-difluorobenzene. In this process, the amount of initiator, reaction time and temperature are extremely critical. Too little initiator makes it difficult to start the reaction; too much may lead to runaway reaction. If the reaction time is too long or too short, it will affect the yield and purity of the product. Improper temperature can also trigger side reactions, such as the formation of polychlorinated products.
Third, if the corresponding halogenated aromatics are used as raw materials, they can also be synthesized through halogen exchange reaction. For example, select suitable chlorine-containing and fluorohalogenated benzene derivatives, and carry out halogen exchange under the action of specific solvents and catalysts to achieve the purpose of generating 4- (chloromethyl) -1,2-difluorobenzene. However, this method requires precise control of the reaction conditions. The polarity of the solvent and the activity of the catalyst will play an important role in the reaction process and results. If the polarity of the solvent is not suitable, the solubility of the reactants will be affected, and the reaction will be difficult to proceed smoothly. The catalyst activity is poor, the reaction rate is slow, or the target product cannot be obtained.
What are the precautions for 4- (chloromethyl) -1,2-difluorobenzene in storage and transportation?
4 - (chloromethyl) - 1,2 - difluorobenzene is an organic chemical, and many things need to be paid attention to when storing and transporting.
First, because of its chemical activity, it should be found in a cool, dry and well-ventilated place. This substance may be sensitive to heat. If it is exposed to high temperature environment, or a chemical reaction occurs, it will cause danger. Therefore, the temperature should be controlled within a specific range to avoid deterioration. Furthermore, it is necessary to keep away from fire and heat sources to prevent the risk of explosion. Because of its flammability, it may encounter open flames, hot topics, or cause fires, endangering safety.
And because of its corrosion and toxicity, the storage place must be isolated from oxidants, acids, alkalis, etc., so as not to interact and cause accidents. And the storage container must be firmly sealed to prevent leakage. If it leaks, it will emit gaseous substances or pollute the environment, endangering the health of the surrounding people.
As for transportation, it should not be ignored. Transportation vehicles should be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment. During transportation, ensure that the container does not leak, collapse, fall, or damage. When driving, follow the specified route and do not stop in densely populated areas and residential areas. When loading and unloading, the operator should wear suitable protective equipment and unload it lightly. It is strictly forbidden to drop, heavy pressure and friction to avoid packaging damage and material leakage.
In short, the storage and transportation of 4- (chloromethyl) -1,2-difluorobenzene is related to safety and the environment. All links must be handled with caution and operated according to specifications to ensure safety.
First, because of its chemical activity, it should be found in a cool, dry and well-ventilated place. This substance may be sensitive to heat. If it is exposed to high temperature environment, or a chemical reaction occurs, it will cause danger. Therefore, the temperature should be controlled within a specific range to avoid deterioration. Furthermore, it is necessary to keep away from fire and heat sources to prevent the risk of explosion. Because of its flammability, it may encounter open flames, hot topics, or cause fires, endangering safety.
And because of its corrosion and toxicity, the storage place must be isolated from oxidants, acids, alkalis, etc., so as not to interact and cause accidents. And the storage container must be firmly sealed to prevent leakage. If it leaks, it will emit gaseous substances or pollute the environment, endangering the health of the surrounding people.
As for transportation, it should not be ignored. Transportation vehicles should be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment. During transportation, ensure that the container does not leak, collapse, fall, or damage. When driving, follow the specified route and do not stop in densely populated areas and residential areas. When loading and unloading, the operator should wear suitable protective equipment and unload it lightly. It is strictly forbidden to drop, heavy pressure and friction to avoid packaging damage and material leakage.
In short, the storage and transportation of 4- (chloromethyl) -1,2-difluorobenzene is related to safety and the environment. All links must be handled with caution and operated according to specifications to ensure safety.
What are the effects of 4- (chloromethyl) -1,2-difluorobenzene on the environment and human health?
4- (chloromethyl) -1,2-difluorobenzene is an organic compound. Its impact on the environment and human health cannot be ignored.
In terms of the environment, if this compound is released in nature, it may pose many hazards. It has certain chemical stability and is difficult to degrade, so it can be retained in the environment for a long time. If it flows into water bodies, or causes water pollution, it will affect the survival and reproduction of aquatic organisms. After aquatic organisms ingest this substance, it may cause damage to physiological functions, stunted growth and development, and even death. If it enters the soil, or changes the chemical properties of the soil, affects the activity and community structure of soil microorganisms, and then has adverse effects on plant growth, or allows plants to absorb this harmful substance and pass through the food chain, endangering higher trophic organisms.
As for human health, 4- (chloromethyl) -1,2-difluorobenzene also has latent risk. Inhalation through the respiratory tract, or irritation of respiratory mucosa, causing cough, asthma and other symptoms. Long-term exposure to this environment may damage lung function. It can also penetrate into the human body through skin contact, causing irritation and corrosion to the skin, causing skin inflammation, redness, swelling, itching and other discomfort. More seriously, this compound may have certain carcinogenicity, teratogenicity and mutagenicity, long-term exposure or increase the probability of cancer and other diseases, affect the reproductive system, cause abnormal fetal development, and may damage genetic material and cause gene mutation.
From this point of view, 4- (chloromethyl) -1,2-difluorobenzene poses a potential threat to the environment and human health. During its production, use and disposal, strict prevention and control measures should be taken to reduce its harm to the environment and human body.
In terms of the environment, if this compound is released in nature, it may pose many hazards. It has certain chemical stability and is difficult to degrade, so it can be retained in the environment for a long time. If it flows into water bodies, or causes water pollution, it will affect the survival and reproduction of aquatic organisms. After aquatic organisms ingest this substance, it may cause damage to physiological functions, stunted growth and development, and even death. If it enters the soil, or changes the chemical properties of the soil, affects the activity and community structure of soil microorganisms, and then has adverse effects on plant growth, or allows plants to absorb this harmful substance and pass through the food chain, endangering higher trophic organisms.
As for human health, 4- (chloromethyl) -1,2-difluorobenzene also has latent risk. Inhalation through the respiratory tract, or irritation of respiratory mucosa, causing cough, asthma and other symptoms. Long-term exposure to this environment may damage lung function. It can also penetrate into the human body through skin contact, causing irritation and corrosion to the skin, causing skin inflammation, redness, swelling, itching and other discomfort. More seriously, this compound may have certain carcinogenicity, teratogenicity and mutagenicity, long-term exposure or increase the probability of cancer and other diseases, affect the reproductive system, cause abnormal fetal development, and may damage genetic material and cause gene mutation.
From this point of view, 4- (chloromethyl) -1,2-difluorobenzene poses a potential threat to the environment and human health. During its production, use and disposal, strict prevention and control measures should be taken to reduce its harm to the environment and human body.
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