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4-(Chloromethyl)-1-Cyclopentyl-2-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
322769 |
| Chemical Formula | C13H14ClF3 |
| Molecular Weight | 264.7 |
| Appearance | Typically a colorless to light - colored liquid |
| Boiling Point | Approximately [specific value] °C (experimental determination needed) |
| Melting Point | Approximately [specific value] °C (experimental determination needed) |
| Density | Approximately [specific value] g/cm³ (experimental determination needed) |
| Solubility In Water | Low solubility, likely insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene |
| Flash Point | Approximately [specific value] °C (experimental determination needed) |
| Vapor Pressure | Low vapor pressure at room temperature |
As an accredited 4-(Chloromethyl)-1-Cyclopentyl-2-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4-(chloromethyl)-1 - cyclopentyl - 2-(trifluoromethyl)benzene in sealed chemical - grade bottles. |
| Storage | 4-(Chloromethyl)-1-cyclopentyl-2-(trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area away from sources of ignition and heat. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, reducing agents, and reactive chemicals to prevent potential reactions. |
| Shipping | 4-(Chloromethyl)-1-cyclopentyl-2-(trifluoromethyl)benzene is shipped in accordance with strict chemical transportation regulations. It's typically in sealed, appropriate containers to prevent leakage and ensure safe transit. |
Competitive 4-(Chloromethyl)-1-Cyclopentyl-2-(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the main uses of 4- (chloromethyl) -1-cyclopentyl-2- (trifluoromethyl) benzene?
4- (cyanomethyl) -1 -cyclopentyl-2- (trifluoromethyl) pyridine has important uses in many fields.
In the field of medicinal chemistry, it acts as a key intermediate to help create new drugs. Take the development of drugs to treat specific diseases as an example, with its unique chemical structure, it can precisely fit with specific targets in organisms. Like some targeted drugs targeting abnormal signaling pathways in tumor cells, the structural properties of this compound allow it to embed into the activity check points of related proteins, interfering with the proliferation and survival signaling of tumor cells, thereby demonstrating potential anti-cancer activity.
In the field of materials science, it has made significant contributions to the development of high-performance materials. For example, it is used to prepare organic materials with special optical and electrical properties. Because of the special groups it contains, it can regulate the distribution of electron clouds and intermolecular forces inside the material. Introducing it into polymer materials can change the conductivity and fluorescence emission characteristics of the material, providing the possibility for the manufacture of new optoelectronic devices, such as organic Light Emitting Diode (OLED) and field effect transistor (FET).
In agricultural chemistry, it can be used as an important raw material for the synthesis of high-efficiency and low-toxicity pesticides. With its chemical properties, pesticides with high selective toxicity to pests and friendly to the environment and non-target organisms can be designed and synthesized. For example, for specific crop pests, the structure of the compound can be modified to act precisely on the specific physiological processes of the pests, such as nervous system conduction or energy metabolism pathways, so as to effectively control pests and ensure the yield and quality of crops.
In the field of medicinal chemistry, it acts as a key intermediate to help create new drugs. Take the development of drugs to treat specific diseases as an example, with its unique chemical structure, it can precisely fit with specific targets in organisms. Like some targeted drugs targeting abnormal signaling pathways in tumor cells, the structural properties of this compound allow it to embed into the activity check points of related proteins, interfering with the proliferation and survival signaling of tumor cells, thereby demonstrating potential anti-cancer activity.
In the field of materials science, it has made significant contributions to the development of high-performance materials. For example, it is used to prepare organic materials with special optical and electrical properties. Because of the special groups it contains, it can regulate the distribution of electron clouds and intermolecular forces inside the material. Introducing it into polymer materials can change the conductivity and fluorescence emission characteristics of the material, providing the possibility for the manufacture of new optoelectronic devices, such as organic Light Emitting Diode (OLED) and field effect transistor (FET).
In agricultural chemistry, it can be used as an important raw material for the synthesis of high-efficiency and low-toxicity pesticides. With its chemical properties, pesticides with high selective toxicity to pests and friendly to the environment and non-target organisms can be designed and synthesized. For example, for specific crop pests, the structure of the compound can be modified to act precisely on the specific physiological processes of the pests, such as nervous system conduction or energy metabolism pathways, so as to effectively control pests and ensure the yield and quality of crops.
What are the synthesis methods of 4- (chloromethyl) -1-cyclopentyl-2- (trifluoromethyl) benzene?
To prepare 4- (cyanomethyl) -1 -cyclopentyl-2- (trifluoromethyl) pyridine, there are many methods for its synthesis, which are described in detail below.
First, it can be started by halogenation reaction. First, take a suitable substrate containing cyclopentyl and pyridine structures, make it react with halogenated reagents such as N-bromosuccinimide (NBS) under suitable conditions, and introduce a halogen atom at a specific position in the pyridine ring. Then, the cyanomethyl reagent, such as sodium cyanide, reacts with halogenated pyridine, and the cyanomethyl is connected by nucleophilic substitution. Finally, trifluoromethyl is introduced at the target check point of the pyridine ring with the help of trifluoromethyl-containing reagents, such as trifluoromethylation reagents. This process requires careful regulation of reaction conditions, such as temperature, solvent, catalyst, etc., to achieve good yield and selectivity.
Second, take metal catalytic coupling reaction as the main path. First prepare halides or borate derivatives containing cyclopentyl, cyanomethyl, and trifluoromethyl groups, respectively. For example, prepare cyclopentyl borate esters, halogenated cyanomethane, and trifluoromethyl halides. Then, in the presence of metal catalysts and ligands such as palladium and nickel, the coupling reactions are carried out in a specific order. For example, the cyclopentyl borate is first Suzuki coupled to the halogenated pyridine, and then the cyanomethyl group is connected to the obtained product through nucleophilic substitution, and finally the trifluoromethyl group is introduced through metal catalysis. This approach requires strict reaction conditions, and the choice of metal catalysts and ligands is also crucial.
Third, the construction of pyridine rings can also be started. Using suitable raw materials containing cyclopentyl groups, cyanomethyl groups, and trifluoromethyl groups, pyridine rings are constructed through multi-step reactions. For example, the pyridine ring skeleton is constructed by condensation and cyclization of compounds containing functional groups such as carbonyl and amino groups. At the same time, cyclopentyl, cyanomethyl, trifluoromethyl and other substituents are gradually introduced. This process involves many organic reaction mechanisms, and the reaction steps are complicated. It is necessary to precisely control the reaction conditions.
Synthesis of 4- (cyanomethyl) -1 -cyclopentyl-2- (trifluoromethyl) pyridine has its own advantages and disadvantages. It is necessary to comprehensively consider factors such as raw material availability, cost, yield, and selectivity to choose the optimal path to achieve efficient synthesis.
First, it can be started by halogenation reaction. First, take a suitable substrate containing cyclopentyl and pyridine structures, make it react with halogenated reagents such as N-bromosuccinimide (NBS) under suitable conditions, and introduce a halogen atom at a specific position in the pyridine ring. Then, the cyanomethyl reagent, such as sodium cyanide, reacts with halogenated pyridine, and the cyanomethyl is connected by nucleophilic substitution. Finally, trifluoromethyl is introduced at the target check point of the pyridine ring with the help of trifluoromethyl-containing reagents, such as trifluoromethylation reagents. This process requires careful regulation of reaction conditions, such as temperature, solvent, catalyst, etc., to achieve good yield and selectivity.
Second, take metal catalytic coupling reaction as the main path. First prepare halides or borate derivatives containing cyclopentyl, cyanomethyl, and trifluoromethyl groups, respectively. For example, prepare cyclopentyl borate esters, halogenated cyanomethane, and trifluoromethyl halides. Then, in the presence of metal catalysts and ligands such as palladium and nickel, the coupling reactions are carried out in a specific order. For example, the cyclopentyl borate is first Suzuki coupled to the halogenated pyridine, and then the cyanomethyl group is connected to the obtained product through nucleophilic substitution, and finally the trifluoromethyl group is introduced through metal catalysis. This approach requires strict reaction conditions, and the choice of metal catalysts and ligands is also crucial.
Third, the construction of pyridine rings can also be started. Using suitable raw materials containing cyclopentyl groups, cyanomethyl groups, and trifluoromethyl groups, pyridine rings are constructed through multi-step reactions. For example, the pyridine ring skeleton is constructed by condensation and cyclization of compounds containing functional groups such as carbonyl and amino groups. At the same time, cyclopentyl, cyanomethyl, trifluoromethyl and other substituents are gradually introduced. This process involves many organic reaction mechanisms, and the reaction steps are complicated. It is necessary to precisely control the reaction conditions.
Synthesis of 4- (cyanomethyl) -1 -cyclopentyl-2- (trifluoromethyl) pyridine has its own advantages and disadvantages. It is necessary to comprehensively consider factors such as raw material availability, cost, yield, and selectivity to choose the optimal path to achieve efficient synthesis.
What are the physical properties of 4- (chloromethyl) -1-cyclopentyl-2- (trifluoromethyl) benzene?
(Chloromethyl) -1-cyclopentyl-2- (trifluoromethyl) pyridine is a class of compounds with a specific structure in the field of organic chemistry. Its physical properties are quite critical, and will be described in detail below.
In this compound, due to the presence of trifluoromethyl, the group has strong electron-absorbing properties, which significantly affects the electron cloud distribution of molecules, and then has many effects on physical properties.
From the appearance point of view, it is usually a colorless to light yellow liquid or solid, and the specific state varies according to the intermolecular force and the ambient temperature and pressure. If the intermolecular force is strong, such as the presence of hydrogen bonds, van der Waals forces, etc., it is more likely to assume a solid form at room temperature and pressure; on the contrary, if the intermolecular force is weak, it is mostly in the form of liquid.
Discussing the melting point and boiling point, the introduction of trifluoromethyl enhances the polarity of molecules and enhances the intermolecular force, resulting in relatively high melting points and boiling points. Compared with compounds with similar structures but no trifluoromethyl, it requires higher energy to overcome the intermolecular force and achieve phase transition.
In terms of solubility, the compound has both lipophilic and hydrophilic properties. The lipophilicity originates from the non-polar structural parts such as cyclopentyl and pyridine rings, which make them have good solubility in organic solvents such as dichloromethane, chloroform, toluene, etc. The existence of chloromethyl and trifluoromethyl gives the molecule a certain polarity, and it also has a certain solubility in some polar organic solvents such as acetonitrile, N, N-dimethylformamide (DMF). However, because the whole is not a strongly polar compound, the solubility in water is relatively low.
On the density, the density of the molecule is usually greater than that of water due to the fact that it contains atoms with relatively large atomic mass such as chlorine and fluorine. In related experimental operations or industrial applications, this characteristic affects its stratification in liquid systems.
In terms of volatility, it is relatively low in volatility. This is due to the existence of various forces between molecules, and the high energy required for molecules to break away from the liquid phase and enter the gas phase, which makes the compound evaporate more slowly at room temperature and pressure.
The above is the common physical properties of (chloromethyl) -1-cyclopentyl-2 - (trifluoromethyl) pyridine, which is of great significance in chemical synthesis, drug development, and materials science.
In this compound, due to the presence of trifluoromethyl, the group has strong electron-absorbing properties, which significantly affects the electron cloud distribution of molecules, and then has many effects on physical properties.
From the appearance point of view, it is usually a colorless to light yellow liquid or solid, and the specific state varies according to the intermolecular force and the ambient temperature and pressure. If the intermolecular force is strong, such as the presence of hydrogen bonds, van der Waals forces, etc., it is more likely to assume a solid form at room temperature and pressure; on the contrary, if the intermolecular force is weak, it is mostly in the form of liquid.
Discussing the melting point and boiling point, the introduction of trifluoromethyl enhances the polarity of molecules and enhances the intermolecular force, resulting in relatively high melting points and boiling points. Compared with compounds with similar structures but no trifluoromethyl, it requires higher energy to overcome the intermolecular force and achieve phase transition.
In terms of solubility, the compound has both lipophilic and hydrophilic properties. The lipophilicity originates from the non-polar structural parts such as cyclopentyl and pyridine rings, which make them have good solubility in organic solvents such as dichloromethane, chloroform, toluene, etc. The existence of chloromethyl and trifluoromethyl gives the molecule a certain polarity, and it also has a certain solubility in some polar organic solvents such as acetonitrile, N, N-dimethylformamide (DMF). However, because the whole is not a strongly polar compound, the solubility in water is relatively low.
On the density, the density of the molecule is usually greater than that of water due to the fact that it contains atoms with relatively large atomic mass such as chlorine and fluorine. In related experimental operations or industrial applications, this characteristic affects its stratification in liquid systems.
In terms of volatility, it is relatively low in volatility. This is due to the existence of various forces between molecules, and the high energy required for molecules to break away from the liquid phase and enter the gas phase, which makes the compound evaporate more slowly at room temperature and pressure.
The above is the common physical properties of (chloromethyl) -1-cyclopentyl-2 - (trifluoromethyl) pyridine, which is of great significance in chemical synthesis, drug development, and materials science.
What are the precautions for storing and transporting 4- (chloromethyl) -1-cyclopentyl-2- (trifluoromethyl) benzene?
4- (cyanomethyl) -1 -cyclopentyl-2- (trifluoromethyl) pyridine should pay attention to the following matters during storage and transportation:
First, the storage place must be dry and cool. This substance may undergo chemical reactions such as hydrolysis in contact with water or in a humid environment, which will change its chemical properties and affect its quality. And high temperature will also accelerate its chemical changes, or cause reactions such as decomposition and polymerization to occur. Therefore, a place with suitable temperature and controllable humidity should be selected, such as a warehouse equipped with air conditioning and dehumidification equipment.
Second, keep away from fire sources and oxidants. The substance may be flammable. If it encounters an open flame or hot topic, it may cause combustion or even explosion. Oxidants can react violently with it, which will also pose a safety hazard. In the warehouse, fireworks are strictly prohibited and should be stored separately from oxidizers.
Third, ensure that the packaging is intact during transportation. If the packaging is damaged, the substance leaks, which will not only pollute the environment, but also pose a threat to the health of transporters. It is necessary to choose packaging materials that meet the standards, such as well-sealed steel drums or plastic drums, and properly fix them to prevent packaging damage caused by collisions during transportation.
Fourth, transportation and storage personnel need professional training. They should be familiar with the characteristics, hazards and emergency treatment methods of this substance. In the event of leakage, fire and other unexpected situations, it can respond quickly and correctly to avoid the expansion of harm.
Fifth, make corresponding warning signs. Storage containers and transportation vehicles should be clearly marked with warning signs, such as "flammable" and "toxic", so that relevant personnel can see at a glance, be vigilant, and prevent accidents. In this way, the safety of 4- (cyanomethyl) -1-cyclopentyl-2- (trifluoromethyl) pyridine during storage and transportation can be ensured.
First, the storage place must be dry and cool. This substance may undergo chemical reactions such as hydrolysis in contact with water or in a humid environment, which will change its chemical properties and affect its quality. And high temperature will also accelerate its chemical changes, or cause reactions such as decomposition and polymerization to occur. Therefore, a place with suitable temperature and controllable humidity should be selected, such as a warehouse equipped with air conditioning and dehumidification equipment.
Second, keep away from fire sources and oxidants. The substance may be flammable. If it encounters an open flame or hot topic, it may cause combustion or even explosion. Oxidants can react violently with it, which will also pose a safety hazard. In the warehouse, fireworks are strictly prohibited and should be stored separately from oxidizers.
Third, ensure that the packaging is intact during transportation. If the packaging is damaged, the substance leaks, which will not only pollute the environment, but also pose a threat to the health of transporters. It is necessary to choose packaging materials that meet the standards, such as well-sealed steel drums or plastic drums, and properly fix them to prevent packaging damage caused by collisions during transportation.
Fourth, transportation and storage personnel need professional training. They should be familiar with the characteristics, hazards and emergency treatment methods of this substance. In the event of leakage, fire and other unexpected situations, it can respond quickly and correctly to avoid the expansion of harm.
Fifth, make corresponding warning signs. Storage containers and transportation vehicles should be clearly marked with warning signs, such as "flammable" and "toxic", so that relevant personnel can see at a glance, be vigilant, and prevent accidents. In this way, the safety of 4- (cyanomethyl) -1-cyclopentyl-2- (trifluoromethyl) pyridine during storage and transportation can be ensured.
What are the environmental effects of 4- (chloromethyl) -1-cyclopentyl-2- (trifluoromethyl) benzene?
F (4- (cyanomethyl) -1 -cyclopentyl-2- (trifluoromethyl) pyridine) This substance is very important in the environment.
Its molecules contain cyanomethyl and cyanyl groups, which have high chemical activity. In the natural environment, cyanyl groups easily react with surrounding substances. It may come into contact with water, through the process of hydrolysis, raw hydrogen cyanide and other substances. Hydrogen cyanide is highly toxic. If it escapes in the atmosphere, it will cause harm to humans and animals, and damage the respiratory and nervous systems. If it enters the water body, aquatic organisms are endangered, causing population changes and ecological imbalance.
also contains trifluoromethyl, and the fluorine atom has high electronegativity, which makes the group have strong electron-absorbing properties. As a result, the chemical stability of this compound is increased, and it is difficult to degrade in the environment. It may be transmitted through the food chain and enriched in organisms. After biological enrichment, it affects the physiological functions of organisms, such as interfering with endocrine, causing biological reproduction and growth obstruction. And it is in the soil environment, or affects the soil microbial community. Soil microorganisms are the key to soil ecology, and their community changes are implicated in soil nutrient cycling and organic matter decomposition, hindering plant growth and disturbing the balance of terrestrial ecosystems.
Furthermore, the existence of cyclopentyl groups affects the spatial configuration and physical properties of molecules. The distribution coefficient changes between different media, such as water-soil and water-air distribution, resulting in different distribution in the environment, affecting the scope and degree of ecological effects.
Its molecules contain cyanomethyl and cyanyl groups, which have high chemical activity. In the natural environment, cyanyl groups easily react with surrounding substances. It may come into contact with water, through the process of hydrolysis, raw hydrogen cyanide and other substances. Hydrogen cyanide is highly toxic. If it escapes in the atmosphere, it will cause harm to humans and animals, and damage the respiratory and nervous systems. If it enters the water body, aquatic organisms are endangered, causing population changes and ecological imbalance.
also contains trifluoromethyl, and the fluorine atom has high electronegativity, which makes the group have strong electron-absorbing properties. As a result, the chemical stability of this compound is increased, and it is difficult to degrade in the environment. It may be transmitted through the food chain and enriched in organisms. After biological enrichment, it affects the physiological functions of organisms, such as interfering with endocrine, causing biological reproduction and growth obstruction. And it is in the soil environment, or affects the soil microbial community. Soil microorganisms are the key to soil ecology, and their community changes are implicated in soil nutrient cycling and organic matter decomposition, hindering plant growth and disturbing the balance of terrestrial ecosystems.
Furthermore, the existence of cyclopentyl groups affects the spatial configuration and physical properties of molecules. The distribution coefficient changes between different media, such as water-soil and water-air distribution, resulting in different distribution in the environment, affecting the scope and degree of ecological effects.
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