Linshang Chemical
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4-(Chloromethyl)-1-Fluoro-2-Methoxybenzene
Linshang Chemical
|
HS Code |
961417 |
| Chemical Formula | C8H8ClFO |
| Molar Mass | 176.599 g/mol |
| Solubility In Water | Likely low, as it is an organic compound with non - polar groups |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, dichloromethane |
| Stability | Stable under normal conditions, but may react with strong oxidizing agents |
| Reactivity | Can participate in nucleophilic substitution reactions due to the presence of chloromethyl group |
As an accredited 4-(Chloromethyl)-1-Fluoro-2-Methoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4-(chloromethyl)-1-fluoro-2-methoxybenzene in a sealed, labeled bottle. |
| Storage | 4-(Chloromethyl)-1-fluoro-2-methoxybenzene should be stored in a cool, dry, well - ventilated area away from heat sources and ignition sources. Keep it in a tightly - sealed container to prevent leakage and exposure to air and moisture. Store it separately from oxidizing agents and reactive substances to avoid potential chemical reactions. |
| Shipping | 4-(Chloromethyl)-1-fluoro-2-methoxybenzene is shipped in properly labeled, corrosion - resistant containers. Shipment follows strict chemical transport regulations to ensure safety during transit, safeguarding from physical damage and environmental exposure. |
Competitive 4-(Chloromethyl)-1-Fluoro-2-Methoxybenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 4-(Chloromethyl)-1-Fluoro-2-Methoxybenzene in China?
As a trusted 4-(Chloromethyl)-1-Fluoro-2-Methoxybenzene manufacturer, we deliver:
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 4-(Chloromethyl)-1-Fluoro-2-Methoxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the physical properties of 4- (chloromethyl) -1-fluoro-2-methoxybenzene?
4- (chloromethyl) -1 -fluoro-2 -methoxybenzene is one of the organic compounds. Its physical properties are worth exploring.
First of all, its appearance, at room temperature, is often colorless to light yellow liquid, and it looks clear and translucent. This color and shape are also common in organic compounds.
Times and boiling point, the boiling point depends on factors such as intermolecular forces. Generally speaking, it is in a certain temperature range. This range is roughly within a certain range due to different or slightly different experimental conditions, so that the compound changes from liquid to gas when heated.
In addition to the melting point, the melting point of this substance is also an important physical property. The value of its melting point reflects the characteristics of molecular lattice arrangement and molecular interactions. The specific melting point allows the substance to change from solid to liquid at the corresponding temperature.
On solubility, 4- (chloromethyl) -1-fluoro-2-methoxybenzene exhibits different solubility in organic solvents. In organic solvents such as ethanol and ether, it has good solubility and can be miscible with them. This is due to the polarity of the molecule and the interaction with the solvent molecules. In water, due to the characteristics of the molecular structure, the solubility is poor and it is difficult to miscible with water.
Its density is also the key to its physical properties. Compared with the density of water, the density of this substance may be different, and this difference determines whether it floats on the water or sinks underwater when mixed with water.
In addition, the vapor pressure of 4- (chloromethyl) -1-fluoro-2-methoxybenzene is also fixed at a specific temperature. The magnitude of the vapor pressure is related to the degree of volatilization and has an important impact on its existence and behavior in the environment.
All these physical properties are the basis for in-depth understanding of 4- (chloromethyl) -1 -fluoro-2 -methoxybenzene, which is indispensable in the fields of chemical synthesis, industrial application and scientific research.
First of all, its appearance, at room temperature, is often colorless to light yellow liquid, and it looks clear and translucent. This color and shape are also common in organic compounds.
Times and boiling point, the boiling point depends on factors such as intermolecular forces. Generally speaking, it is in a certain temperature range. This range is roughly within a certain range due to different or slightly different experimental conditions, so that the compound changes from liquid to gas when heated.
In addition to the melting point, the melting point of this substance is also an important physical property. The value of its melting point reflects the characteristics of molecular lattice arrangement and molecular interactions. The specific melting point allows the substance to change from solid to liquid at the corresponding temperature.
On solubility, 4- (chloromethyl) -1-fluoro-2-methoxybenzene exhibits different solubility in organic solvents. In organic solvents such as ethanol and ether, it has good solubility and can be miscible with them. This is due to the polarity of the molecule and the interaction with the solvent molecules. In water, due to the characteristics of the molecular structure, the solubility is poor and it is difficult to miscible with water.
Its density is also the key to its physical properties. Compared with the density of water, the density of this substance may be different, and this difference determines whether it floats on the water or sinks underwater when mixed with water.
In addition, the vapor pressure of 4- (chloromethyl) -1-fluoro-2-methoxybenzene is also fixed at a specific temperature. The magnitude of the vapor pressure is related to the degree of volatilization and has an important impact on its existence and behavior in the environment.
All these physical properties are the basis for in-depth understanding of 4- (chloromethyl) -1 -fluoro-2 -methoxybenzene, which is indispensable in the fields of chemical synthesis, industrial application and scientific research.
What are the main uses of 4- (chloromethyl) -1-fluoro-2-methoxybenzene
4- (chloromethyl) -1 -fluoro-2 -methoxybenzene, which has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. Due to its special structure, chloromethyl, fluorine atoms and methoxy groups have unique reactivity, which can introduce functional groups into molecules to produce a variety of complex organic compounds.
First, in the pharmaceutical industry, based on this, a variety of drugs with specific pharmacological activities can be synthesized. For example, by the nucleophilic substitution reaction of chloromethyl, it interacts with nucleophiles containing nitrogen and oxygen to construct a drug activity skeleton, and then new drugs for the treatment of specific diseases can be obtained.
Second, in the field of materials science, it can be introduced into polymer materials through specific chemical reactions to give materials special properties. Such as improving the solubility, thermal stability or optical properties of materials, etc., used to prepare polymer films and coatings with special functions.
Furthermore, it also plays an important role in the preparation of fine chemical products. It can make fine chemicals such as fragrances and pesticides. Such as synthesizing fragrances with special aromas, or synthesizing pesticides with high insecticidal and bactericidal properties. Because of the presence of fluorine atoms in its structure, it can enhance the stability and biological activity of the corresponding products.
In conclusion, the unique structure of 4- (chloromethyl) -1 -fluoro-2 -methoxybenzene has important uses in many fields such as organic synthesis, pharmacy, materials science and fine chemistry. It is an important starting material and intermediate for the preparation of many chemicals.
First, in the pharmaceutical industry, based on this, a variety of drugs with specific pharmacological activities can be synthesized. For example, by the nucleophilic substitution reaction of chloromethyl, it interacts with nucleophiles containing nitrogen and oxygen to construct a drug activity skeleton, and then new drugs for the treatment of specific diseases can be obtained.
Second, in the field of materials science, it can be introduced into polymer materials through specific chemical reactions to give materials special properties. Such as improving the solubility, thermal stability or optical properties of materials, etc., used to prepare polymer films and coatings with special functions.
Furthermore, it also plays an important role in the preparation of fine chemical products. It can make fine chemicals such as fragrances and pesticides. Such as synthesizing fragrances with special aromas, or synthesizing pesticides with high insecticidal and bactericidal properties. Because of the presence of fluorine atoms in its structure, it can enhance the stability and biological activity of the corresponding products.
In conclusion, the unique structure of 4- (chloromethyl) -1 -fluoro-2 -methoxybenzene has important uses in many fields such as organic synthesis, pharmacy, materials science and fine chemistry. It is an important starting material and intermediate for the preparation of many chemicals.
What is the synthesis method of 4- (chloromethyl) -1-fluoro-2-methoxybenzene
To prepare 4- (chloromethyl) -1 -fluoro-2 -methoxybenzene, the following method can be used:
Take 2-fluoro-3 -methoxybenzoic acid as the starting material. This raw material is co-heated with thionyl chloride, which can be used as a chlorination reagent. When the two react, the carboxyl group in the benzoic acid structure will be converted into an acyl chloride group to form 2-fluoro-3 -methoxybenzoyl chloride. This reaction needs to be carried out at an appropriate temperature, such as under the condition of heating and reflux, in order to make the reaction sufficient and increase the yield.
After 2-fluoro-3-methoxybenzoyl chloride is obtained, it is reacted with lithium aluminum hydride in an inert solvent such as anhydrous ethyl ether. Lithium aluminum hydride is a strong reducing agent, which can reduce the acyl chloride group to hydroxymethyl to obtain 2-fluoro-3-methoxybenzyl alcohol. This reaction needs to be operated at low temperature and in an anhydrous environment, because lithium aluminum hydride will react violently in contact with water, which affects the product formation, and low temperature helps to control the reaction rate and reduce the occurrence of side reactions.
Then 2-fluoro-3-methoxybenzyl alcohol is reacted with thionyl chloride. Thionyl chloride can convert alcohol hydroxyl groups into chlorine atoms, so that the target product 4- (chloromethyl) -1 -fluoro-2 -methoxybenzene can be obtained. The reaction conditions in this step are relatively mild, and the reaction can proceed smoothly at room temperature or slightly heated state. And thionyl chloride has a wide range of sources and moderate prices, which is conducive to the practical application of this synthesis method.
Throughout the synthesis process, the reaction conditions of each step need to be precisely controlled, and the purity of the raw materials must also be strictly required, so that 4- (chloromethyl) -1 -fluoro-2 -methoxybenzene can be prepared efficiently and with high purity.
Take 2-fluoro-3 -methoxybenzoic acid as the starting material. This raw material is co-heated with thionyl chloride, which can be used as a chlorination reagent. When the two react, the carboxyl group in the benzoic acid structure will be converted into an acyl chloride group to form 2-fluoro-3 -methoxybenzoyl chloride. This reaction needs to be carried out at an appropriate temperature, such as under the condition of heating and reflux, in order to make the reaction sufficient and increase the yield.
After 2-fluoro-3-methoxybenzoyl chloride is obtained, it is reacted with lithium aluminum hydride in an inert solvent such as anhydrous ethyl ether. Lithium aluminum hydride is a strong reducing agent, which can reduce the acyl chloride group to hydroxymethyl to obtain 2-fluoro-3-methoxybenzyl alcohol. This reaction needs to be operated at low temperature and in an anhydrous environment, because lithium aluminum hydride will react violently in contact with water, which affects the product formation, and low temperature helps to control the reaction rate and reduce the occurrence of side reactions.
Then 2-fluoro-3-methoxybenzyl alcohol is reacted with thionyl chloride. Thionyl chloride can convert alcohol hydroxyl groups into chlorine atoms, so that the target product 4- (chloromethyl) -1 -fluoro-2 -methoxybenzene can be obtained. The reaction conditions in this step are relatively mild, and the reaction can proceed smoothly at room temperature or slightly heated state. And thionyl chloride has a wide range of sources and moderate prices, which is conducive to the practical application of this synthesis method.
Throughout the synthesis process, the reaction conditions of each step need to be precisely controlled, and the purity of the raw materials must also be strictly required, so that 4- (chloromethyl) -1 -fluoro-2 -methoxybenzene can be prepared efficiently and with high purity.
4- (chloromethyl) -1-fluoro-2-methoxybenzene what to pay attention to when storing and transporting
4- (chloromethyl) -1 -fluoro-2 -methoxybenzene is one of the organic compounds. When storing and transporting, many matters must be paid attention to.
First words storage, because of its certain chemical activity, it needs to choose a cool, dry and well-ventilated place. If placed in a high temperature or humid place, it may cause chemical reactions and cause it to deteriorate. The compound may also be sensitive to light, so it should be stored in a container protected from light to prevent light from promoting its decomposition or causing other adverse reactions. And it must be separated from oxidizing agents, strong bases and other chemicals, because it is easy to react violently with such substances, endangering safety.
As for transportation, it should not be ignored. Suitable packaging materials must be selected in accordance with relevant regulations. Packaging must be tight to prevent leakage. During transportation, temperature and humidity control are essential and should be maintained within an appropriate range. At the same time, transportation vehicles should be well ventilated to avoid danger due to the accumulation of volatile gases. The escort personnel should also be familiar with the characteristics of the compound and emergency disposal methods. In the event of leakage and other accidents, they can respond quickly and properly to protect the safety of personnel and the environment from pollution. In short, when storing and transporting 4- (chloromethyl) -1-fluoro-2-methoxybenzene, every detail is related to safety and quality, and must be handled with caution.
First words storage, because of its certain chemical activity, it needs to choose a cool, dry and well-ventilated place. If placed in a high temperature or humid place, it may cause chemical reactions and cause it to deteriorate. The compound may also be sensitive to light, so it should be stored in a container protected from light to prevent light from promoting its decomposition or causing other adverse reactions. And it must be separated from oxidizing agents, strong bases and other chemicals, because it is easy to react violently with such substances, endangering safety.
As for transportation, it should not be ignored. Suitable packaging materials must be selected in accordance with relevant regulations. Packaging must be tight to prevent leakage. During transportation, temperature and humidity control are essential and should be maintained within an appropriate range. At the same time, transportation vehicles should be well ventilated to avoid danger due to the accumulation of volatile gases. The escort personnel should also be familiar with the characteristics of the compound and emergency disposal methods. In the event of leakage and other accidents, they can respond quickly and properly to protect the safety of personnel and the environment from pollution. In short, when storing and transporting 4- (chloromethyl) -1-fluoro-2-methoxybenzene, every detail is related to safety and quality, and must be handled with caution.
What are the safety risks of 4- (chloromethyl) -1-fluoro-2-methoxybenzene
4- (chloromethyl) -1 -fluoro-2 -methoxybenzene, this is an organic compound, which may be used in chemical, pharmaceutical and other fields. However, it has certain safety risks, related to health, explosion and environmental aspects, as detailed below:
** Health Hazards **:
- ** Acute Toxicity **: or irritation and toxicity. If it comes into contact with the skin, it can cause redness, swelling, pain and itching, because of its halogenated hydrocarbon and methoxy structure or interfere with the normal metabolism of skin cells. Eye contact may cause serious irritation, damage eye tissue and affect vision. Inhalation of the volatile gaseous substances of this substance can irritate the respiratory tract, causing cough, asthma and breathing difficulties, or even damage the function of the lungs. If taken by mistake, it may harm the digestive tract, causing symptoms such as nausea, vomiting, abdominal pain and diarrhea.
- ** Chronic toxicity **: Long-term exposure to this compound, or potentially carcinogenic. Halogenated hydrocarbons are structurally stable, difficult to degrade in organisms, or accumulate and interfere with the normal physiological processes of cells, causing gene mutations and increasing the risk of cancer. Or affect the nervous system, causing neurological symptoms such as headache, dizziness, fatigue and memory loss.
** Explosion hazard **: This compound is flammable, in case of open flames, hot topics or cause combustion and explosion. Its vapor and air can form an explosive mixture, and there is a danger of combustion and explosion in case of fire. Because the molecule contains hydrocarbon elements, it can react violently with oxygen under suitable conditions to release a large amount of energy. When storing and using, it is necessary to avoid open flames, hot topics and strong oxidants to prevent explosion accidents.
** Environmental Hazards **: Discharge into the environment, or persist, due to stable structure, difficult to degrade under natural conditions. It can be transmitted and enriched through the food chain, affecting the ecosystem. Or poison aquatic organisms and destroy the balance of aquatic ecology; accumulate in the soil, affecting soil microbial activities and plant growth, and then affecting the entire ecological environment.
** Health Hazards **:
- ** Acute Toxicity **: or irritation and toxicity. If it comes into contact with the skin, it can cause redness, swelling, pain and itching, because of its halogenated hydrocarbon and methoxy structure or interfere with the normal metabolism of skin cells. Eye contact may cause serious irritation, damage eye tissue and affect vision. Inhalation of the volatile gaseous substances of this substance can irritate the respiratory tract, causing cough, asthma and breathing difficulties, or even damage the function of the lungs. If taken by mistake, it may harm the digestive tract, causing symptoms such as nausea, vomiting, abdominal pain and diarrhea.
- ** Chronic toxicity **: Long-term exposure to this compound, or potentially carcinogenic. Halogenated hydrocarbons are structurally stable, difficult to degrade in organisms, or accumulate and interfere with the normal physiological processes of cells, causing gene mutations and increasing the risk of cancer. Or affect the nervous system, causing neurological symptoms such as headache, dizziness, fatigue and memory loss.
** Explosion hazard **: This compound is flammable, in case of open flames, hot topics or cause combustion and explosion. Its vapor and air can form an explosive mixture, and there is a danger of combustion and explosion in case of fire. Because the molecule contains hydrocarbon elements, it can react violently with oxygen under suitable conditions to release a large amount of energy. When storing and using, it is necessary to avoid open flames, hot topics and strong oxidants to prevent explosion accidents.
** Environmental Hazards **: Discharge into the environment, or persist, due to stable structure, difficult to degrade under natural conditions. It can be transmitted and enriched through the food chain, affecting the ecosystem. Or poison aquatic organisms and destroy the balance of aquatic ecology; accumulate in the soil, affecting soil microbial activities and plant growth, and then affecting the entire ecological environment.
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