Linshang Chemical
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4-(Chloromethyl)-1-Fluoro-2-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
691563 |
| Chemical Formula | C8H5ClF4 |
| Molecular Weight | 214.57 |
As an accredited 4-(Chloromethyl)-1-Fluoro-2-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4-(chloromethyl)-1-fluoro-2-(trifluoromethyl)benzene in sealed, chemical - resistant bottle. |
| Storage | 4-(Chloromethyl)-1-fluoro-2-(trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents and incompatible substances to avoid potential chemical reactions. Use appropriate storage cabinets designed for hazardous chemicals. |
| Shipping | 4-(Chloromethyl)-1-fluoro-2-(trifluoromethyl)benzene is shipped in specialized, well - sealed containers. It adheres to strict chemical shipping regulations, ensuring safe transport to prevent leakage and environmental or safety hazards. |
Competitive 4-(Chloromethyl)-1-Fluoro-2-(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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What is the main use of 4- (chloromethyl) -1-fluoro-2- (trifluoromethyl) benzene?
4- (chloromethyl) -1 -fluoro-2- (trifluoromethyl) benzene is also an organic compound. Its main uses are quite extensive, and in the field of organic synthesis, this compound is often a key intermediate. Because its molecular structure contains functional groups such as chloromethyl, fluorine atoms and trifluoromethyl, it gives it unique chemical activity and reaction characteristics. It can introduce other functional groups through various chemical reactions to build more complex organic molecular structures to synthesize specific compounds required in the fields of medicine, pesticides, materials, etc.
In the way of pharmaceutical research and development, the lead compound with specific biological activity can be created by structural modification and derivatization of 4- (chloromethyl) -1 -fluoromethyl-2- (trifluoromethyl) benzene. The presence of fluorine atoms and trifluoromethyl can change the lipophilicity, metabolic stability and interaction with biological targets of the compound, and help to develop new drugs, such as antibacterial, antiviral, antitumor and other drugs.
In the process of pesticide creation, this compound can be used as an important starting material. Through chemical synthesis, pesticide molecules with high insecticidal, bactericidal or herbicidal activities are constructed. Due to its special functional group structure, it may enhance the activity and selectivity of pesticides to target organisms, and improve their environmental compatibility and sustainability.
In the field of materials science, 4- (chloromethyl) -1 -fluoro-2- (trifluoromethyl) benzene also has its uses. Through polymerization or other chemical transformations, it can be introduced into the main chain or side chain of polymer materials to give materials special properties, such as improving the material's weather resistance, chemical corrosion resistance, electrical properties, etc., to prepare high-performance functional materials for use in electronics, aerospace and other fields.
In the way of pharmaceutical research and development, the lead compound with specific biological activity can be created by structural modification and derivatization of 4- (chloromethyl) -1 -fluoromethyl-2- (trifluoromethyl) benzene. The presence of fluorine atoms and trifluoromethyl can change the lipophilicity, metabolic stability and interaction with biological targets of the compound, and help to develop new drugs, such as antibacterial, antiviral, antitumor and other drugs.
In the process of pesticide creation, this compound can be used as an important starting material. Through chemical synthesis, pesticide molecules with high insecticidal, bactericidal or herbicidal activities are constructed. Due to its special functional group structure, it may enhance the activity and selectivity of pesticides to target organisms, and improve their environmental compatibility and sustainability.
In the field of materials science, 4- (chloromethyl) -1 -fluoro-2- (trifluoromethyl) benzene also has its uses. Through polymerization or other chemical transformations, it can be introduced into the main chain or side chain of polymer materials to give materials special properties, such as improving the material's weather resistance, chemical corrosion resistance, electrical properties, etc., to prepare high-performance functional materials for use in electronics, aerospace and other fields.
What are the physical properties of 4- (chloromethyl) -1-fluoro-2- (trifluoromethyl) benzene
4- (chloromethyl) -1 -fluoro-2- (trifluoromethyl) benzene is one of the organic compounds. Its physical properties are quite important and are related to many practical applications.
First of all, its phase and odor. Under normal temperature and pressure, this substance may be in a liquid state and has a certain volatility, and it may smell a special smell in the air. However, this smell may be different due to personal differences in smell.
Describe its melting point and boiling point. The melting point is the temperature at which the substance changes from a solid state to a liquid state. The melting point of 4- (chloromethyl) -1 -fluoro-2- (trifluoromethyl) benzene is within a certain range, but the exact value needs to be determined by precise experiments. The boiling point is the temperature at which a substance changes from a liquid state to a gaseous state. The boiling point of this compound is also related to factors such as intermolecular forces. Generally speaking, halogen atoms such as fluorine and chlorine are contained, and the intermolecular forces change, causing their boiling points to be different from ordinary hydrocarbon compounds.
Furthermore, when it comes to solubility. Because its molecular structure contains fluorine, chlorine and methyl groups, it has good solubility in organic solvents. Organic solvents such as common ether and dichloromethane may be miscible with them. However, in water, the solubility in water is poor due to the difference between the polarity of water molecules and the molecular polarity of the compound, and there is no significant hydrophilic group.
Density is also one of its important physical properties. The density of 4- (chloromethyl) -1-fluoro-2- (trifluoromethyl) benzene may be different from that of water, or greater than or less than that of water, which also needs to be accurately determined by experiments.
In addition, the volatility and vapor pressure of the compound are also worthy of attention. Volatility is related to its diffusion rate in air, and vapor pressure is reflected at a certain temperature, which is an equilibrium relationship between the gas phase and the liquid phase. The two are also closely related to the molecular structure. The fluorine and chlorine atoms change the intermolecular forces, which in turn affect volatility and vapor pressure.
In summary, the physical properties of 4- (chloromethyl) -1 -fluoro-2- (trifluoromethyl) benzene are of great significance in the fields of organic synthesis and chemical production, and need to be further studied and understood.
First of all, its phase and odor. Under normal temperature and pressure, this substance may be in a liquid state and has a certain volatility, and it may smell a special smell in the air. However, this smell may be different due to personal differences in smell.
Describe its melting point and boiling point. The melting point is the temperature at which the substance changes from a solid state to a liquid state. The melting point of 4- (chloromethyl) -1 -fluoro-2- (trifluoromethyl) benzene is within a certain range, but the exact value needs to be determined by precise experiments. The boiling point is the temperature at which a substance changes from a liquid state to a gaseous state. The boiling point of this compound is also related to factors such as intermolecular forces. Generally speaking, halogen atoms such as fluorine and chlorine are contained, and the intermolecular forces change, causing their boiling points to be different from ordinary hydrocarbon compounds.
Furthermore, when it comes to solubility. Because its molecular structure contains fluorine, chlorine and methyl groups, it has good solubility in organic solvents. Organic solvents such as common ether and dichloromethane may be miscible with them. However, in water, the solubility in water is poor due to the difference between the polarity of water molecules and the molecular polarity of the compound, and there is no significant hydrophilic group.
Density is also one of its important physical properties. The density of 4- (chloromethyl) -1-fluoro-2- (trifluoromethyl) benzene may be different from that of water, or greater than or less than that of water, which also needs to be accurately determined by experiments.
In addition, the volatility and vapor pressure of the compound are also worthy of attention. Volatility is related to its diffusion rate in air, and vapor pressure is reflected at a certain temperature, which is an equilibrium relationship between the gas phase and the liquid phase. The two are also closely related to the molecular structure. The fluorine and chlorine atoms change the intermolecular forces, which in turn affect volatility and vapor pressure.
In summary, the physical properties of 4- (chloromethyl) -1 -fluoro-2- (trifluoromethyl) benzene are of great significance in the fields of organic synthesis and chemical production, and need to be further studied and understood.
What are the synthesis methods of 4- (chloromethyl) -1-fluoro-2- (trifluoromethyl) benzene
The synthesis method of 4- (chloromethyl) -1 -fluoro-2- (trifluoromethyl) benzene is now your way.
First, the benzene derivative containing the corresponding substituent can be started. Take the benzene containing fluorine and trifluoromethyl first, and let it react with the chloromethylation reagent. For example, polyformaldehyde and hydrogen chloride gas are used as chloromethylation reagents, and the reaction is carried out by heating in the presence of a suitable catalyst. The commonly used catalyst is anhydrous zinc chloride, which can promote the progress of the reaction. This reaction requires attention to the control of the reaction temperature. If it is too high, the side reactions will increase, and if it is too low, the reaction rate will be slow. Usually the reaction temperature can be controlled between 50-80 ° C, and the reaction time is several hours. The specific process depends on the monitoring of the reaction process. The reaction process can be monitored by means of thin layer chromatography.
Second, halogenated aromatics can also be used as raw materials. If a suitable halogenated (fluorinated or chlorinated) benzene containing trifluoromethyl is obtained, it can be coupled with a chloromethylated reagent through metal catalysis. For example, a palladium catalyst, such as tetra (triphenylphosphine) palladium, is used as a catalyst to react with a chloromethyl source (such as chloromethylborate, etc.) in an alkaline environment. The alkaline conditions can be maintained by potassium carbonate, sodium carbonate and other bases. This reaction requires high anhydrous and oxygen-free reaction system, otherwise the catalyst activity is easily affected, resulting in a decrease in the reaction yield. The reaction temperature is generally 80-100 ° C, carried out in a nitrogen or argon protective atmosphere, which lasts for several hours to ten hours. Close monitoring of the reaction is required to achieve the best effect.
Third, the benzene ring construction can also be started from the perspective of benzene ring construction. The benzene ring structure containing fluorine and trifluoromethyl is constructed first, and then chloromethyl is introduced later. For example, through a multi-step reaction, the aryl intermediate containing fluorine and trifluoromethyl is synthesized first, and then the nucleophilic substitution or electrophilic substitution reaction is used to introduce chlor There are many steps in this pathway, and each step needs to be carefully planned and the reaction conditions controlled to ensure the yield and selectivity of each step, and finally the synthesis of 4- (chloromethyl) -1 -fluoro-2- (trifluoromethyl) benzene is achieved.
First, the benzene derivative containing the corresponding substituent can be started. Take the benzene containing fluorine and trifluoromethyl first, and let it react with the chloromethylation reagent. For example, polyformaldehyde and hydrogen chloride gas are used as chloromethylation reagents, and the reaction is carried out by heating in the presence of a suitable catalyst. The commonly used catalyst is anhydrous zinc chloride, which can promote the progress of the reaction. This reaction requires attention to the control of the reaction temperature. If it is too high, the side reactions will increase, and if it is too low, the reaction rate will be slow. Usually the reaction temperature can be controlled between 50-80 ° C, and the reaction time is several hours. The specific process depends on the monitoring of the reaction process. The reaction process can be monitored by means of thin layer chromatography.
Second, halogenated aromatics can also be used as raw materials. If a suitable halogenated (fluorinated or chlorinated) benzene containing trifluoromethyl is obtained, it can be coupled with a chloromethylated reagent through metal catalysis. For example, a palladium catalyst, such as tetra (triphenylphosphine) palladium, is used as a catalyst to react with a chloromethyl source (such as chloromethylborate, etc.) in an alkaline environment. The alkaline conditions can be maintained by potassium carbonate, sodium carbonate and other bases. This reaction requires high anhydrous and oxygen-free reaction system, otherwise the catalyst activity is easily affected, resulting in a decrease in the reaction yield. The reaction temperature is generally 80-100 ° C, carried out in a nitrogen or argon protective atmosphere, which lasts for several hours to ten hours. Close monitoring of the reaction is required to achieve the best effect.
Third, the benzene ring construction can also be started from the perspective of benzene ring construction. The benzene ring structure containing fluorine and trifluoromethyl is constructed first, and then chloromethyl is introduced later. For example, through a multi-step reaction, the aryl intermediate containing fluorine and trifluoromethyl is synthesized first, and then the nucleophilic substitution or electrophilic substitution reaction is used to introduce chlor There are many steps in this pathway, and each step needs to be carefully planned and the reaction conditions controlled to ensure the yield and selectivity of each step, and finally the synthesis of 4- (chloromethyl) -1 -fluoro-2- (trifluoromethyl) benzene is achieved.
What are the precautions for 4- (chloromethyl) -1-fluoro-2- (trifluoromethyl) benzene in storage and transportation?
4- (chloromethyl) -1 -fluoro-2- (trifluoromethyl) benzene is also an organic compound. During storage and transportation, many matters need to be paid attention to.
Bear the brunt, the storage place must be cool and dry. This compound is active, and it is easy to react when wet or high temperature, damage its quality, or even risk safety. If it is placed in a humid place, the moisture may react with it, destroying its structure; under high temperature, or accelerate its decomposition, it is necessary to choose a cool and dry place.
Furthermore, storage and transportation need to avoid open flames and hot topic sources. Because of its flammability, in case of open flames and hot topics, it is very easy to explode and endanger the safety of the surroundings. Fireworks are strictly prohibited at the place of operation, and heat sources should be properly isolated.
This compound is also toxic to a certain extent, and protection must be taken during storage and transportation. Practitioners should wear appropriate protective equipment, such as gas masks, protective gloves and protective clothing, to avoid contact or inhalation and damage to health.
Packaging should also not be ignored. A sealed and corrosion-resistant container must be used to prevent leakage. Packaging materials must be able to withstand certain pressure and temperature changes to ensure that there is no leakage during transportation.
During the handling process, the action should be slow and stable. Avoid violent vibration and collision to prevent leakage caused by damage to the container. If there is a leak, emergency measures should be taken immediately, evacuate personnel, isolate the site, and dispose of it properly according to the characteristics of the chemical.
In short, the storage and transportation of 4- (chloromethyl) -1 -fluoro-2- (trifluoromethyl) benzene is related to safety and quality. All links must be carefully handled and strictly followed to ensure safety.
Bear the brunt, the storage place must be cool and dry. This compound is active, and it is easy to react when wet or high temperature, damage its quality, or even risk safety. If it is placed in a humid place, the moisture may react with it, destroying its structure; under high temperature, or accelerate its decomposition, it is necessary to choose a cool and dry place.
Furthermore, storage and transportation need to avoid open flames and hot topic sources. Because of its flammability, in case of open flames and hot topics, it is very easy to explode and endanger the safety of the surroundings. Fireworks are strictly prohibited at the place of operation, and heat sources should be properly isolated.
This compound is also toxic to a certain extent, and protection must be taken during storage and transportation. Practitioners should wear appropriate protective equipment, such as gas masks, protective gloves and protective clothing, to avoid contact or inhalation and damage to health.
Packaging should also not be ignored. A sealed and corrosion-resistant container must be used to prevent leakage. Packaging materials must be able to withstand certain pressure and temperature changes to ensure that there is no leakage during transportation.
During the handling process, the action should be slow and stable. Avoid violent vibration and collision to prevent leakage caused by damage to the container. If there is a leak, emergency measures should be taken immediately, evacuate personnel, isolate the site, and dispose of it properly according to the characteristics of the chemical.
In short, the storage and transportation of 4- (chloromethyl) -1 -fluoro-2- (trifluoromethyl) benzene is related to safety and quality. All links must be carefully handled and strictly followed to ensure safety.
What are the effects of 4- (chloromethyl) -1-fluoro-2- (trifluoromethyl) benzene on the environment and human health?
4- (chloromethyl) -1 -fluoro-2- (trifluoromethyl) benzene, this is an organic compound. The impact on the environment and human health, let me explain in detail for you.
First talk about its impact on the environment. If this compound is released in nature, its chemical structure contains fluorine, chlorine and other halogen elements, and its stability is quite high, and it is not easy to be decomposed by microorganisms. In the soil, it may accumulate, change the physical and chemical properties of the soil, hinder the absorption of nutrients and moisture by plant roots, cause plant growth inhibition, or even wither. Inflow into the water body, because of its hydrophobicity, it may be adsorbed on suspended particles and settle to the bottom of the water, affecting the underwater ecosystem and posing a threat to aquatic organisms. It migrates and transforms in the environment, or travels long distances through atmospheric circulation, expanding the scope of pollution.
Re-discuss its impact on human health. If people inhale this compound through the respiratory tract, or through skin contact, digestive tract ingestion, it may endanger health. Because of its fat solubility, it is easy to penetrate biofilms and enter human tissues and cells. It may interfere with the human endocrine system, affect the normal secretion and regulation of hormones, such as thyroid hormones, sex hormones, etc., and then affect human growth and development, reproductive function. It may also damage the nervous system, causing symptoms such as headache, dizziness, fatigue, and memory loss. Long-term exposure may increase the risk of cancer, because the haloalkyl groups in the structure may be mutagenic and carcinogenic. Therefore, such compounds should be treated with caution and their production, use, and emissions should be strictly controlled to protect the environment and human health.
First talk about its impact on the environment. If this compound is released in nature, its chemical structure contains fluorine, chlorine and other halogen elements, and its stability is quite high, and it is not easy to be decomposed by microorganisms. In the soil, it may accumulate, change the physical and chemical properties of the soil, hinder the absorption of nutrients and moisture by plant roots, cause plant growth inhibition, or even wither. Inflow into the water body, because of its hydrophobicity, it may be adsorbed on suspended particles and settle to the bottom of the water, affecting the underwater ecosystem and posing a threat to aquatic organisms. It migrates and transforms in the environment, or travels long distances through atmospheric circulation, expanding the scope of pollution.
Re-discuss its impact on human health. If people inhale this compound through the respiratory tract, or through skin contact, digestive tract ingestion, it may endanger health. Because of its fat solubility, it is easy to penetrate biofilms and enter human tissues and cells. It may interfere with the human endocrine system, affect the normal secretion and regulation of hormones, such as thyroid hormones, sex hormones, etc., and then affect human growth and development, reproductive function. It may also damage the nervous system, causing symptoms such as headache, dizziness, fatigue, and memory loss. Long-term exposure may increase the risk of cancer, because the haloalkyl groups in the structure may be mutagenic and carcinogenic. Therefore, such compounds should be treated with caution and their production, use, and emissions should be strictly controlled to protect the environment and human health.
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