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4-(Chloromethyl)-1-Methyl-2-Nitrobenzene
Linshang Chemical
|
HS Code |
993060 |
| Chemical Formula | C8H8ClNO2 |
| Molar Mass | 185.61 g/mol |
| Appearance | Solid (presumed, common for aromatic nitro - halides) |
| Physical State At Room Temp | Solid |
| Solubility In Water | Low (due to non - polar aromatic and hydrophobic groups) |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene (aromatic - aromatic interactions) |
| Odor | Pungent (common for nitro - containing aromatic compounds) |
| Vapor Pressure | Low (due to its solid state and relatively high molar mass) |
As an accredited 4-(Chloromethyl)-1-Methyl-2-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4-(chloromethyl)-1 -methyl-2 -nitrobenzene packaged in a sealed, chemical - resistant bottle. |
| Storage | 4-(Chloromethyl)-1-methyl-2-nitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition points. Keep it in a tightly - sealed container to prevent leakage and exposure to air or moisture. Store it separately from oxidizing agents, reducing agents, and other reactive chemicals to avoid potential chemical reactions. |
| Shipping | 4-(Chloromethyl)-1 -methyl-2 -nitrobenzene is a chemical. Shipping requires proper packaging in accordance with hazardous material regulations, likely in sealed, corrosion - resistant containers, and with clear hazard labels for safe transportation. |
Competitive 4-(Chloromethyl)-1-Methyl-2-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 4-(Chloromethyl)-1-Methyl-2-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 4- (chloromethyl) -1-methyl-2-nitrobenzene?
4- (chloromethyl) -1-methyl-2-nitrobenzene is a kind of organic compound. Its main uses are generally as follows.
The first in the field of organic synthesis. This compound can be used as a key intermediate for the preparation of other complex organic compounds. In the synthesis of medicine, it may lay the foundation for the preparation of drug molecules with specific structures. The structure of its chloromethyl, methyl and nitro groups can be converted into other functional groups by chemical means through various reactions such as substitution reaction, reduction reaction, etc., and then construct compounds with specific physiological activities.
Furthermore, it can also be used in materials science. After being modified by specific chemical reactions, it can participate in the synthesis of polymer materials, giving the materials unique properties such as special solubility and thermal stability. For example, it can be polymerized with monomers containing active hydrogen and introduce its structural units to affect the microstructure and macroscopic properties of the material.
In addition, in the field of dye synthesis, 4- (chloromethyl) -1-methyl-2-nitrobenzene may play an important role. Because of the functional groups it contains, or compounds with chromophore structure can be constructed through a series of reactions, it can be used to synthesize dyes with unique color and excellent performance, and can be used in textile printing and dyeing and other industries.
In summary, 4- (chloromethyl) -1 -methyl-2 -nitrobenzene has important uses in organic synthesis, materials science, dye synthesis and other fields due to its special structure, and is an indispensable part of the development of the chemical industry.
The first in the field of organic synthesis. This compound can be used as a key intermediate for the preparation of other complex organic compounds. In the synthesis of medicine, it may lay the foundation for the preparation of drug molecules with specific structures. The structure of its chloromethyl, methyl and nitro groups can be converted into other functional groups by chemical means through various reactions such as substitution reaction, reduction reaction, etc., and then construct compounds with specific physiological activities.
Furthermore, it can also be used in materials science. After being modified by specific chemical reactions, it can participate in the synthesis of polymer materials, giving the materials unique properties such as special solubility and thermal stability. For example, it can be polymerized with monomers containing active hydrogen and introduce its structural units to affect the microstructure and macroscopic properties of the material.
In addition, in the field of dye synthesis, 4- (chloromethyl) -1-methyl-2-nitrobenzene may play an important role. Because of the functional groups it contains, or compounds with chromophore structure can be constructed through a series of reactions, it can be used to synthesize dyes with unique color and excellent performance, and can be used in textile printing and dyeing and other industries.
In summary, 4- (chloromethyl) -1 -methyl-2 -nitrobenzene has important uses in organic synthesis, materials science, dye synthesis and other fields due to its special structure, and is an indispensable part of the development of the chemical industry.
What are the physical properties of 4- (chloromethyl) -1-methyl-2-nitrobenzene
4- (chloromethyl) -1-methyl-2-nitrobenzene is one of the organic compounds. Its physical properties are worth studying in detail.
First of all, its appearance, at room temperature, is often a light yellow to brown liquid, with a specific color and luster, which can be identified by visual inspection. Its odor is also characteristic, emitting a pungent and irritating odor, which can be keenly perceived by the sniffer.
As for the melting point, it is about -13 ° C. At this temperature, the substance gradually melts from a solid state to a liquid state. The boiling point is in the range of 265-267 ° C. When the temperature rises to Si, the liquid 4- (chloromethyl) -1-methyl-2-nitrobenzene will be converted into a gaseous state.
Its density is about 1.29g/cm ³, which is slightly higher than that of water. Therefore, when placed in water, it will sink to the bottom. In terms of solubility, this substance is insoluble in water, but soluble in organic solvents such as ethanol, ether, and benzene. This property is similar to that of many organic compounds.
Because its molecular structure contains functional groups such as chloromethyl, methyl, and nitro, its physical properties are unique. The presence of nitro groups enhances the polarity of molecules, which affects their melting point, solubility and other properties. The characteristics of chloromethyl groups also play an important role in their reactivity and physical properties.
First of all, its appearance, at room temperature, is often a light yellow to brown liquid, with a specific color and luster, which can be identified by visual inspection. Its odor is also characteristic, emitting a pungent and irritating odor, which can be keenly perceived by the sniffer.
As for the melting point, it is about -13 ° C. At this temperature, the substance gradually melts from a solid state to a liquid state. The boiling point is in the range of 265-267 ° C. When the temperature rises to Si, the liquid 4- (chloromethyl) -1-methyl-2-nitrobenzene will be converted into a gaseous state.
Its density is about 1.29g/cm ³, which is slightly higher than that of water. Therefore, when placed in water, it will sink to the bottom. In terms of solubility, this substance is insoluble in water, but soluble in organic solvents such as ethanol, ether, and benzene. This property is similar to that of many organic compounds.
Because its molecular structure contains functional groups such as chloromethyl, methyl, and nitro, its physical properties are unique. The presence of nitro groups enhances the polarity of molecules, which affects their melting point, solubility and other properties. The characteristics of chloromethyl groups also play an important role in their reactivity and physical properties.
What are the chemical properties of 4- (chloromethyl) -1-methyl-2-nitrobenzene
4- (chloromethyl) -1-methyl-2-nitrobenzene is also an organic compound. Its molecular structure contains chloromethyl, methyl and nitro groups, and these groups give their unique chemical properties.
In terms of its reactivity, chloromethyl is active and can initiate many reactions. Due to the strong electronegativity of chlorine atoms, the carbon atoms of chloromethyl groups are positively charged and vulnerable to attack by nucleophiles. For example, under basic conditions with alcohols, nucleophilic substitution reactions can occur, and the chlorine atoms are replaced by alcoholoxy groups to form corresponding ether compounds. This reaction mechanism is that the electron-rich part of the nucleophile attacks the carbon atoms of chloromethyl groups, and the chlorine atoms leave with a pair of electrons. The electron cloud density of the benzene ring can be increased by methyl group as the donator group, but its donator effect is weak. In contrast, the nitro group is a strong electron-absorbing group, which greatly reduces the electron cloud density of the benzene ring, especially at the ortho and para-positions of the nitro group. Therefore, the electrophilic substitution reactivity of the benzene ring is reduced, and the reaction check point is mostly in the ortho and para-position of the methyl group. Due to the methyl donator, the electron cloud density of the ortho and para-position is relatively high.
In addition to its stability, due to the strong electron absorption of the nitro group, the charge distribution in the molecule is uneven, resulting in its stability being slightly inferior to that of the analogue without nitro group. When heated or under specific conditions, the nitro group may decompose and other reactions occur, resulting in nitrogen oxides.
In addition, the solubility of 4- (chloromethyl) -1 -methyl-2 -nitrobenzene is affected by molecular polarity. The molecule has a certain polarity, and the solubility is acceptable in polar organic solvents such as acetone and dichloromethane; in water, the solubility is poor due to the weak interaction between water molecules and the organism.
In short, the chemical properties of 4- (chloromethyl) -1 -methyl-2 -nitrobenzene are determined by the interaction of its functional groups. In the field of organic synthesis, it has important applications due to its active chloromethyl and unique electron cloud distribution of benzene ring.
In terms of its reactivity, chloromethyl is active and can initiate many reactions. Due to the strong electronegativity of chlorine atoms, the carbon atoms of chloromethyl groups are positively charged and vulnerable to attack by nucleophiles. For example, under basic conditions with alcohols, nucleophilic substitution reactions can occur, and the chlorine atoms are replaced by alcoholoxy groups to form corresponding ether compounds. This reaction mechanism is that the electron-rich part of the nucleophile attacks the carbon atoms of chloromethyl groups, and the chlorine atoms leave with a pair of electrons. The electron cloud density of the benzene ring can be increased by methyl group as the donator group, but its donator effect is weak. In contrast, the nitro group is a strong electron-absorbing group, which greatly reduces the electron cloud density of the benzene ring, especially at the ortho and para-positions of the nitro group. Therefore, the electrophilic substitution reactivity of the benzene ring is reduced, and the reaction check point is mostly in the ortho and para-position of the methyl group. Due to the methyl donator, the electron cloud density of the ortho and para-position is relatively high.
In addition to its stability, due to the strong electron absorption of the nitro group, the charge distribution in the molecule is uneven, resulting in its stability being slightly inferior to that of the analogue without nitro group. When heated or under specific conditions, the nitro group may decompose and other reactions occur, resulting in nitrogen oxides.
In addition, the solubility of 4- (chloromethyl) -1 -methyl-2 -nitrobenzene is affected by molecular polarity. The molecule has a certain polarity, and the solubility is acceptable in polar organic solvents such as acetone and dichloromethane; in water, the solubility is poor due to the weak interaction between water molecules and the organism.
In short, the chemical properties of 4- (chloromethyl) -1 -methyl-2 -nitrobenzene are determined by the interaction of its functional groups. In the field of organic synthesis, it has important applications due to its active chloromethyl and unique electron cloud distribution of benzene ring.
What are the synthesis methods of 4- (chloromethyl) -1-methyl-2-nitrobenzene
There are many ways to synthesize 4- (chloromethyl) -1 -methyl-2 -nitrobenzene. First, it can be prepared from the corresponding aromatic hydrocarbons through a series of reactions such as nitrification and halogenation. First, take the appropriate aromatic hydrocarbons, treat them with nitrifying reagents under specific conditions, and introduce nitro groups. In this step, attention should be paid to the reaction temperature, reagent ratio and other factors. If the temperature is too high or the ratio is out of balance, it is easy to cause more side reactions, which affects the purity and yield of the product. After the successful introduction of nitro groups, a halogenation reaction is carried out to introduce chloromethyl into the benzene cyclomethyl group. In this halogenation process, the choice of halogenation reagents, reaction solvents and
Second, other compounds containing specific functional groups can also be used as starting materials and spliced through multi-step organic synthesis reactions. For example, select benzene derivatives with suitable substituents, first perform functional group conversion to create conditions conducive to subsequent reactions, and then gradually construct the structure of the target molecule through condensation, substitution and other reactions. This process requires fine planning of the reaction sequence, according to the activity differences of each functional group, rationally arranging each step of the reaction, and controlling the reaction conditions must be accurate, such as pH, temperature, reaction time, etc. If there is a slight difference, it may deviate from the expected reaction path and form impurities or by-products.
Furthermore, reaction strategies using transition metal catalysis can also be considered. Transition metal catalysts can effectively promote the formation of carbon-carbon and carbon-heteroatom bonds, which is quite advantageous in the synthesis of such complex benzene derivatives. In the presence of suitable ligands, the selection of appropriate transition metal catalysts and the design of reasonable reaction routes can efficiently achieve the synthesis of target molecules. However, transition metal catalysts are often expensive, and post-reaction treatment or complex separation and purification steps are involved. It is necessary to weigh the cost and benefit, and optimize the reaction process in order to achieve practicality.
Second, other compounds containing specific functional groups can also be used as starting materials and spliced through multi-step organic synthesis reactions. For example, select benzene derivatives with suitable substituents, first perform functional group conversion to create conditions conducive to subsequent reactions, and then gradually construct the structure of the target molecule through condensation, substitution and other reactions. This process requires fine planning of the reaction sequence, according to the activity differences of each functional group, rationally arranging each step of the reaction, and controlling the reaction conditions must be accurate, such as pH, temperature, reaction time, etc. If there is a slight difference, it may deviate from the expected reaction path and form impurities or by-products.
Furthermore, reaction strategies using transition metal catalysis can also be considered. Transition metal catalysts can effectively promote the formation of carbon-carbon and carbon-heteroatom bonds, which is quite advantageous in the synthesis of such complex benzene derivatives. In the presence of suitable ligands, the selection of appropriate transition metal catalysts and the design of reasonable reaction routes can efficiently achieve the synthesis of target molecules. However, transition metal catalysts are often expensive, and post-reaction treatment or complex separation and purification steps are involved. It is necessary to weigh the cost and benefit, and optimize the reaction process in order to achieve practicality.
What are the precautions for 4- (chloromethyl) -1-methyl-2-nitrobenzene during use?
4- (chloromethyl) -1-methyl-2-nitrobenzene is an important compound in organic synthesis. During use, there are several precautions that practitioners should keep in mind.
Bear the brunt of this compound, which is toxic and can cause damage to human health. Therefore, when operating, be sure to wear appropriate protective equipment, such as gloves, goggles, gas masks, etc., to prevent skin contact, inhalation or accidental ingestion. After the operation, it is also necessary to wash the exposed skin in time to prevent toxic residues.
For the second time, 4- (chloromethyl) -1-methyl-2-nitrobenzene is flammable. In the place of storage and use, keep away from fire and heat sources, and prepare fire extinguishing equipment to prevent the occurrence of fire. In case of unfortunate fire, dry powder fire extinguishers and carbon dioxide fire extinguishers should be used to put out the fire, and no water should be used.
Furthermore, the chemical activity of this compound is quite high, and it is easy to react with many substances. When using, it is necessary to carefully check its compatibility with the substances in contact to avoid dangerous chemical reactions, such as violent exothermic, gas escape, etc. When dispensing and mixing, you should operate slowly and pay close attention to the reaction situation.
In addition, because of its volatility, it is suitable to operate in a well-ventilated place or in a fume hood, so that the volatile gas can be discharged in time, reduce its concentration in the air, and reduce the harm to the human body.
And in terms of storage, it should be placed in a cool, dry and ventilated place, away from oxidants, strong alkalis and other substances to prevent deterioration and dangerous reactions. At the same time, it should be properly marked, indicating its name, nature, hazards and other key information for access and management.
In short, when using 4- (chloromethyl) -1-methyl-2-nitrobenzene, it is necessary to be careful, strictly abide by the operating procedures, and pay attention to safety protection in order to ensure the smooth operation of the experiment or production, and also protect the health of the practitioners.
Bear the brunt of this compound, which is toxic and can cause damage to human health. Therefore, when operating, be sure to wear appropriate protective equipment, such as gloves, goggles, gas masks, etc., to prevent skin contact, inhalation or accidental ingestion. After the operation, it is also necessary to wash the exposed skin in time to prevent toxic residues.
For the second time, 4- (chloromethyl) -1-methyl-2-nitrobenzene is flammable. In the place of storage and use, keep away from fire and heat sources, and prepare fire extinguishing equipment to prevent the occurrence of fire. In case of unfortunate fire, dry powder fire extinguishers and carbon dioxide fire extinguishers should be used to put out the fire, and no water should be used.
Furthermore, the chemical activity of this compound is quite high, and it is easy to react with many substances. When using, it is necessary to carefully check its compatibility with the substances in contact to avoid dangerous chemical reactions, such as violent exothermic, gas escape, etc. When dispensing and mixing, you should operate slowly and pay close attention to the reaction situation.
In addition, because of its volatility, it is suitable to operate in a well-ventilated place or in a fume hood, so that the volatile gas can be discharged in time, reduce its concentration in the air, and reduce the harm to the human body.
And in terms of storage, it should be placed in a cool, dry and ventilated place, away from oxidants, strong alkalis and other substances to prevent deterioration and dangerous reactions. At the same time, it should be properly marked, indicating its name, nature, hazards and other key information for access and management.
In short, when using 4- (chloromethyl) -1-methyl-2-nitrobenzene, it is necessary to be careful, strictly abide by the operating procedures, and pay attention to safety protection in order to ensure the smooth operation of the experiment or production, and also protect the health of the practitioners.
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