Linshang Chemical
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4-Chloromethyl-2-Fluoro-1-Methoxy-Benzene
Linshang Chemical
|
HS Code |
369234 |
| Chemical Formula | C8H8ClFO |
| Molecular Weight | 174.6 |
| Appearance | Typically a colorless to light - yellow liquid |
| Boiling Point | Data may vary, around 190 - 200°C |
| Density | Approx. 1.2 - 1.3 g/cm³ |
| Solubility | Slightly soluble in water, soluble in organic solvents like ethanol, ether |
| Vapor Pressure | Low vapor pressure at room temperature |
| Flash Point | Caution: Flammable, flash point around 70 - 80°C |
| Odor | May have a characteristic aromatic - like odor |
As an accredited 4-Chloromethyl-2-Fluoro-1-Methoxy-Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - chloromethyl - 2 - fluoro - 1 - methoxy - benzene packaged in a sealed glass bottle. |
| Storage | 4 - Chloromethyl - 2 - fluoro - 1 - methoxy - benzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly closed container to prevent vapor leakage. Since it may be a hazardous chemical, ensure the storage area is in compliance with safety regulations, and accessible only to authorized personnel. |
| Shipping | 4 - chloromethyl - 2 - fluoro - 1 - methoxy - benzene, being a chemical, requires careful shipping. It should be packaged in sealed, corrosion - resistant containers, following all relevant regulations for hazardous chemicals during transportation. |
Competitive 4-Chloromethyl-2-Fluoro-1-Methoxy-Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 4-Chloromethyl-2-Fluoro-1-Methoxy-Benzene in China?
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 4-Chloromethyl-2-Fluoro-1-Methoxy-Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 4-chloromethyl-2-fluoro-1-methoxy-benzene?
4-Chloromethyl-2-fluoro-1-methoxybenzene, which has a wide range of uses, plays an important role in the field of organic synthesis.
In the process of pharmaceutical research and development, it is often used as a key starting material. Due to the chloromethyl, fluorine atoms and methoxy groups contained in the molecule, various chemical reactions can be used to ingeniously construct complex compounds. These compounds may have unique biological activities and are expected to become new drugs. For example, by means of nucleophilic substitution reactions, chloromethyl can be combined with specific nucleophiles such as nitrogen and oxygen to derive a series of molecules with potential pharmacological activities.
In the field of materials science, it has also emerged. Due to its special structure, it can be used as an important monomer for the synthesis of functional polymer materials. For example, after polymerization, it is introduced into the main chain or side chain of the polymer to endow the material with unique properties such as good solubility, thermal stability or special optical properties. It is suitable for the manufacture of high-performance coatings, optical films and other materials.
In the field of pesticide creation, 4-chloromethyl-2-fluoro-1-methoxybenzene also plays an important role. Due to the introduction of fluorine atoms, the biological activity and stability of the compounds can be significantly improved. Through reasonable chemical modification, new pesticides with high efficiency, low toxicity and environmental friendliness can be developed for the control of crop diseases and pests, and to ensure the harvest of agricultural production.
In the process of pharmaceutical research and development, it is often used as a key starting material. Due to the chloromethyl, fluorine atoms and methoxy groups contained in the molecule, various chemical reactions can be used to ingeniously construct complex compounds. These compounds may have unique biological activities and are expected to become new drugs. For example, by means of nucleophilic substitution reactions, chloromethyl can be combined with specific nucleophiles such as nitrogen and oxygen to derive a series of molecules with potential pharmacological activities.
In the field of materials science, it has also emerged. Due to its special structure, it can be used as an important monomer for the synthesis of functional polymer materials. For example, after polymerization, it is introduced into the main chain or side chain of the polymer to endow the material with unique properties such as good solubility, thermal stability or special optical properties. It is suitable for the manufacture of high-performance coatings, optical films and other materials.
In the field of pesticide creation, 4-chloromethyl-2-fluoro-1-methoxybenzene also plays an important role. Due to the introduction of fluorine atoms, the biological activity and stability of the compounds can be significantly improved. Through reasonable chemical modification, new pesticides with high efficiency, low toxicity and environmental friendliness can be developed for the control of crop diseases and pests, and to ensure the harvest of agricultural production.
What are the physical properties of 4-chloromethyl-2-fluoro-1-methoxy-benzene?
4-Chloromethyl-2-fluoro-1-methoxybenzene, this is an organic compound. Its physical properties are quite important and are related to many practical applications.
First of all, the appearance is usually colorless to light yellow liquid, clear and with a specific luster, and its clear texture can be observed under light. Its smell is slightly irritating, although not pungent and intolerable, but it will be uncomfortable to smell for a long time, especially in poorly ventilated areas.
In terms of boiling point, it is about a certain temperature range. Under specific pressure conditions, accurate values can be obtained by experimental determination. This value is of great significance for chemical operations such as distillation and separation. According to this, the temperature can be controlled to achieve effective separation and purification of substances.
Melting point is also a key property, which determines the temperature at which the substance changes from solid to liquid. Knowing the melting point, it can be properly handled according to the ambient temperature during storage and transportation to ensure that it is in a suitable physical state.
In terms of solubility, it has good solubility in organic solvents such as ethanol and ether, and can be miscible with these solvents to form a uniform solution. However, the solubility in water is not good, and the force between it and water molecules is weak due to its molecular structure. This characteristic needs to be taken into account in the selection of extraction and reaction medium. The density of
is also one of the important physical properties, which is slightly larger than that of water. In operations such as stratification experiments, it can be separated from substances with different densities of water according to density differences.
The above physical properties are indispensable in many fields such as chemical production, organic synthesis, drug development, etc., to help researchers and producers better control reactions, separate products, and ensure the safety and stability of material storage and transportation.
First of all, the appearance is usually colorless to light yellow liquid, clear and with a specific luster, and its clear texture can be observed under light. Its smell is slightly irritating, although not pungent and intolerable, but it will be uncomfortable to smell for a long time, especially in poorly ventilated areas.
In terms of boiling point, it is about a certain temperature range. Under specific pressure conditions, accurate values can be obtained by experimental determination. This value is of great significance for chemical operations such as distillation and separation. According to this, the temperature can be controlled to achieve effective separation and purification of substances.
Melting point is also a key property, which determines the temperature at which the substance changes from solid to liquid. Knowing the melting point, it can be properly handled according to the ambient temperature during storage and transportation to ensure that it is in a suitable physical state.
In terms of solubility, it has good solubility in organic solvents such as ethanol and ether, and can be miscible with these solvents to form a uniform solution. However, the solubility in water is not good, and the force between it and water molecules is weak due to its molecular structure. This characteristic needs to be taken into account in the selection of extraction and reaction medium. The density of
is also one of the important physical properties, which is slightly larger than that of water. In operations such as stratification experiments, it can be separated from substances with different densities of water according to density differences.
The above physical properties are indispensable in many fields such as chemical production, organic synthesis, drug development, etc., to help researchers and producers better control reactions, separate products, and ensure the safety and stability of material storage and transportation.
What are 4-chloromethyl-2-fluoro-1-methoxy-benzene synthesis methods?
There are various ways to synthesize 4-chloromethyl-2-fluoro-1-methoxybenzene. First, it can be started by the corresponding phenols. First, the phenolic compound is methylated with an appropriate methylating agent, such as dimethyl sulfate or iodomethane, in the presence of a base (such as potassium carbonate) to obtain a methoxylated product. Subsequently, under suitable conditions, fluorine atoms are introduced, for example, using nucleophilic fluorination reagents, such as potassium fluoride, etc., under the action of specific solvents and catalysts, the fluorination step is completed. As for the introduction of chloromethyl, a system composed of chloromethyl methyl ether and anhydrous zinc chloride can be used to synthesize the target product at a suitable temperature and reaction time.
Second, we can also start from halogenated aromatics. First select a suitable halogenated benzene, introduce methoxy group, and react with sodium methoxide or other methoxylating reagents. Then introduce fluorine atoms and operate according to the above fluorination method. Finally, with the help of chloromethylation, add the chloromethyl part.
Furthermore, using benzene ring derivatives as raw materials, the target molecule is constructed through multi-step reactions. The benzene ring is first methoxylated and fluorinated, and then using specific reactions, such as nucleophilic substitution, Friedel-Crafts and other reaction types, introduce chloromethyl, and then obtain 4-chloromethyl-2-fluoro-1-methoxylbenzene. However, during the synthesis process, it is necessary to pay attention to the control of the conditions of each step of the reaction, such as temperature, solvent, reactant ratio and other factors, which will affect the yield and selectivity of the reaction. In this way, after many considerations and practices, this compound can be obtained.
Second, we can also start from halogenated aromatics. First select a suitable halogenated benzene, introduce methoxy group, and react with sodium methoxide or other methoxylating reagents. Then introduce fluorine atoms and operate according to the above fluorination method. Finally, with the help of chloromethylation, add the chloromethyl part.
Furthermore, using benzene ring derivatives as raw materials, the target molecule is constructed through multi-step reactions. The benzene ring is first methoxylated and fluorinated, and then using specific reactions, such as nucleophilic substitution, Friedel-Crafts and other reaction types, introduce chloromethyl, and then obtain 4-chloromethyl-2-fluoro-1-methoxylbenzene. However, during the synthesis process, it is necessary to pay attention to the control of the conditions of each step of the reaction, such as temperature, solvent, reactant ratio and other factors, which will affect the yield and selectivity of the reaction. In this way, after many considerations and practices, this compound can be obtained.
4-chloromethyl-2-fluoro-1-methoxy-benzene to pay attention to when storing and transporting
4-Chloromethyl-2-fluoro-1-methoxybenzene, this is an organic compound. When storing and transporting, many matters need to be paid attention to.
Store first. Because of its certain chemical activity, it must be placed in a cool, dry and well-ventilated place. High temperature, humid environment, or cause chemical reactions to occur, affecting quality. It should be stored in a sealed container to prevent contact with air and moisture. Because of the oxygen, moisture and other components in the air, or react with the compound. For example, moisture may cause hydrolysis reactions, changing its chemical structure. And storage should be away from fire, heat and oxidants. This compound may be flammable, and it is easy to cause combustion or even explosion when exposed to open flames and hot topics. Oxidants can also react violently with it, causing danger.
Then transport. Ensure that the packaging is intact during transportation. Packaging materials need to be able to resist vibration, collision and friction to avoid material leakage caused by container rupture. Transportation tools also need to be clean, dry and free of other chemical residues. Different chemicals are mixed with each other, or cause uncontrollable chemical reactions. At the same time, transportation personnel should be familiar with the characteristics of the compound and emergency treatment methods. In the event of an accident such as leakage, they can respond quickly and correctly. In case of accidental leakage during transportation, the scene should be isolated immediately, personnel should be evacuated, and fire should be strictly prohibited from approaching. According to the leakage and site conditions, appropriate treatment measures should be taken, such as absorbing with inert materials such as sand and vermiculite, and then properly disposing of them.
Store first. Because of its certain chemical activity, it must be placed in a cool, dry and well-ventilated place. High temperature, humid environment, or cause chemical reactions to occur, affecting quality. It should be stored in a sealed container to prevent contact with air and moisture. Because of the oxygen, moisture and other components in the air, or react with the compound. For example, moisture may cause hydrolysis reactions, changing its chemical structure. And storage should be away from fire, heat and oxidants. This compound may be flammable, and it is easy to cause combustion or even explosion when exposed to open flames and hot topics. Oxidants can also react violently with it, causing danger.
Then transport. Ensure that the packaging is intact during transportation. Packaging materials need to be able to resist vibration, collision and friction to avoid material leakage caused by container rupture. Transportation tools also need to be clean, dry and free of other chemical residues. Different chemicals are mixed with each other, or cause uncontrollable chemical reactions. At the same time, transportation personnel should be familiar with the characteristics of the compound and emergency treatment methods. In the event of an accident such as leakage, they can respond quickly and correctly. In case of accidental leakage during transportation, the scene should be isolated immediately, personnel should be evacuated, and fire should be strictly prohibited from approaching. According to the leakage and site conditions, appropriate treatment measures should be taken, such as absorbing with inert materials such as sand and vermiculite, and then properly disposing of them.
4-chloromethyl-2-fluoro-1-methoxy-benzene impact on the environment and human body
4-Chloromethyl-2-fluoro-1-methoxybenzene, this is an organic compound, and its impact on the environment and the human body cannot be ignored.
In terms of the environment, if this compound is released in nature, there may be many variables. First, its chemical structure contains elements such as chlorine and fluorine, and its properties may be relatively stable and difficult to degrade in the environment. Over time, it may accumulate in environmental media such as soil and water bodies. If the soil is polluted by it, or the soil quality deteriorates, it will affect the absorption of nutrients by plant roots, inhibit plant growth, and even die, thereby affecting the balance of the entire ecosystem. If it flows into water bodies, it will also be harmful to aquatic organisms. The presence of chloromethyl may interfere with the physiological processes of aquatic organisms, such as destroying their cell membrane structure, affecting the normal metabolism of cells, and reducing the number of aquatic organisms. And it may have a biomagnification effect in the food chain. After absorption by low-level organisms, it is transmitted through the food chain, and the concentration in high-level organisms gradually increases, causing serious impact on the structure and function of the entire aquatic ecosystem.
As for the human body, the harm should not be underestimated. It is volatile or breathed into the human body. After entering the respiratory tract, it can stimulate the mucosa of the respiratory tract, causing coughing, asthma, and inflammation of the respiratory tract. Long-term exposure may damage lung tissue, reduce lung ventilation and ventilation function, and increase the risk of lung diseases. If it is contacted through the skin, it may enter the human blood circulation because of its fat solubility, or through the skin barrier. In the body, it may interfere with normal physiological and biochemical reactions, affect the activity of enzymes, and destroy cellular homeostasis. In particular, it poses a great threat to the reproductive system and nervous system, or causes germ cell mutation, affecting fertility; in the nervous system, it may interfere with neurotransmitter transmission, causing dizziness, fatigue, memory loss and other symptoms.
In summary, 4-chloromethyl-2-fluoro-1-methoxybenzene poses potential hazards to both the environment and the human body. It should be treated with caution. During production and use, protection and management should be strengthened to reduce its adverse effects on the environment and the human body.
In terms of the environment, if this compound is released in nature, there may be many variables. First, its chemical structure contains elements such as chlorine and fluorine, and its properties may be relatively stable and difficult to degrade in the environment. Over time, it may accumulate in environmental media such as soil and water bodies. If the soil is polluted by it, or the soil quality deteriorates, it will affect the absorption of nutrients by plant roots, inhibit plant growth, and even die, thereby affecting the balance of the entire ecosystem. If it flows into water bodies, it will also be harmful to aquatic organisms. The presence of chloromethyl may interfere with the physiological processes of aquatic organisms, such as destroying their cell membrane structure, affecting the normal metabolism of cells, and reducing the number of aquatic organisms. And it may have a biomagnification effect in the food chain. After absorption by low-level organisms, it is transmitted through the food chain, and the concentration in high-level organisms gradually increases, causing serious impact on the structure and function of the entire aquatic ecosystem.
As for the human body, the harm should not be underestimated. It is volatile or breathed into the human body. After entering the respiratory tract, it can stimulate the mucosa of the respiratory tract, causing coughing, asthma, and inflammation of the respiratory tract. Long-term exposure may damage lung tissue, reduce lung ventilation and ventilation function, and increase the risk of lung diseases. If it is contacted through the skin, it may enter the human blood circulation because of its fat solubility, or through the skin barrier. In the body, it may interfere with normal physiological and biochemical reactions, affect the activity of enzymes, and destroy cellular homeostasis. In particular, it poses a great threat to the reproductive system and nervous system, or causes germ cell mutation, affecting fertility; in the nervous system, it may interfere with neurotransmitter transmission, causing dizziness, fatigue, memory loss and other symptoms.
In summary, 4-chloromethyl-2-fluoro-1-methoxybenzene poses potential hazards to both the environment and the human body. It should be treated with caution. During production and use, protection and management should be strengthened to reduce its adverse effects on the environment and the human body.
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