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4-(Chloromethyl)-Alpha-Methylbenzeneacetic Acid
Linshang Chemical
|
HS Code |
248258 |
| Chemical Formula | C10H11ClO2 |
| Molar Mass | 198.65 g/mol |
| Appearance | Solid (usually) |
| Solubility In Water | Low solubility |
| Solubility In Organic Solvents | Soluble in some organic solvents like ethanol, acetone |
| Melting Point | Specific melting point data would depend on purity, typically in a certain range |
| Density | Data specific to the compound would be needed for an accurate value |
| Acidity Pka | Value would be characteristic of the carboxylic acid group in the molecule |
| Reactivity | Reactive towards bases, nucleophiles due to the carboxylic acid and chloromethyl groups |
As an accredited 4-(Chloromethyl)-Alpha-Methylbenzeneacetic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4-(chloromethyl)-α -methylbenzeneacetic acid in a sealed chemical - grade plastic bottle. |
| Storage | 4-(Chloromethyl)-α -methylbenzeneacetic acid should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly closed container to prevent moisture absorption and evaporation. It is advisable to store it in a dedicated chemical storage cabinet, clearly labeled to avoid confusion and ensure safety. |
| Shipping | 4-(Chloromethyl)-α -methylbenzeneacetic acid is a chemical. Shipping requires proper packaging in accordance with hazardous material regulations, ensuring secure containment to prevent leakage during transit. |
Competitive 4-(Chloromethyl)-Alpha-Methylbenzeneacetic Acid prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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What are the chemical properties of 4- (chloromethyl) -α-methylphenylacetic acid?
4- (Cyanomethyl ） -α - methylphenylalanine is an organic compound with unique chemical properties. In this compound, the cyanomethyl group is structurally linked to α-methylphenylalanine, giving it specific reactivity.
From the perspective of chemical activity, the cyanyl group (-CN) is active. The carbon atoms and nitrogen atoms in the cyanyl group are connected by three bonds, which has a high electron cloud density and is easy to participate in nucleophilic addition reactions. Under appropriate conditions, the cyanyl group can react with electrophilic reagents, such as nucleophilic addition with the carbonyl groups of aldehyde and ketone compounds, to form products containing cyanoalcohol structures. This reaction is often used in organic synthesis to grow carbon chains and construct new carbon-carbon bonds.
And the part of α-methylphenylalanine, the benzene ring has a conjugated π electronic system, making it aromatic. The benzene ring can undergo electrophilic substitution reactions, such as halogenation, nitration, sulfonation, etc. The methyl group is attached to the α-carbon atom. Due to the electron-induced effect of methyl group, the electron cloud distribution of the benzene ring can be affected, so that the density of the adjacent and para-position electron clouds of the benzene ring is relatively increased, so that the electrophilic substitution reaction is more likely to occur At the same time, the α-carbon atom connects the amino group and the carboxyl group, which is a typical structural feature of amino acids. Under different pH environments, the amino group and the carboxyl group can undergo protonation or deprotonation, which affects the charge state and solubility of the compound. In acidic media, amino groups are easily protonated with positive charge; in basic media, carboxyl groups are easily deprotonated with negative charge.
The structure of each part of this compound affects each other. The overall chemical properties include not only the active reactivity of cyano groups, but also the characteristics of phenylalanine parts. It may have potential application value in organic synthesis, pharmaceutical chemistry and other fields, and can be used as a key intermediate for the synthesis of complex organic molecules and drugs.
From the perspective of chemical activity, the cyanyl group (-CN) is active. The carbon atoms and nitrogen atoms in the cyanyl group are connected by three bonds, which has a high electron cloud density and is easy to participate in nucleophilic addition reactions. Under appropriate conditions, the cyanyl group can react with electrophilic reagents, such as nucleophilic addition with the carbonyl groups of aldehyde and ketone compounds, to form products containing cyanoalcohol structures. This reaction is often used in organic synthesis to grow carbon chains and construct new carbon-carbon bonds.
And the part of α-methylphenylalanine, the benzene ring has a conjugated π electronic system, making it aromatic. The benzene ring can undergo electrophilic substitution reactions, such as halogenation, nitration, sulfonation, etc. The methyl group is attached to the α-carbon atom. Due to the electron-induced effect of methyl group, the electron cloud distribution of the benzene ring can be affected, so that the density of the adjacent and para-position electron clouds of the benzene ring is relatively increased, so that the electrophilic substitution reaction is more likely to occur At the same time, the α-carbon atom connects the amino group and the carboxyl group, which is a typical structural feature of amino acids. Under different pH environments, the amino group and the carboxyl group can undergo protonation or deprotonation, which affects the charge state and solubility of the compound. In acidic media, amino groups are easily protonated with positive charge; in basic media, carboxyl groups are easily deprotonated with negative charge.
The structure of each part of this compound affects each other. The overall chemical properties include not only the active reactivity of cyano groups, but also the characteristics of phenylalanine parts. It may have potential application value in organic synthesis, pharmaceutical chemistry and other fields, and can be used as a key intermediate for the synthesis of complex organic molecules and drugs.
What are the main uses of 4- (chloromethyl) -α-methylphenylacetic acid?
4- (methoxy ） - α - methyltryptophan, this substance is very useful in medical and pharmaceutical pathways.
In terms of medical pathways, it has a significant effect on neurological diseases. It can adjust the metabolism of neurotransmitters, such as serotonin, dopamine, etc. In many emotional diseases, such as depression and anxiety, the neurotransmitter imbalance in the patient's body, 4- (methoxy ） - α - methyltryptophan can return it to balance, relieve the pain of the patient's mood, make it normal, and restore life and work.
In the pharmaceutical pathway, this is the key raw material for the preparation of a variety of specific drugs. By means of chemical methods, new drugs with stronger targeting and better curative effect can be made by combining with other drugs. And because of its special chemical structure, it can enhance the ability of drugs to penetrate biofilms, make the drug power reach the disease faster, and improve the efficiency of drug treatment.
Furthermore, in the process of scientific research, 4- (methoxy ） - α - methyltryptophan is also an important research object. By studying its mechanism of action and metabolic pathway, scholars can deepen their understanding of the mysteries of life, pave the foundation for the progress of medical science, and bring dawn to conquer more difficult and complicated diseases.
In terms of medical pathways, it has a significant effect on neurological diseases. It can adjust the metabolism of neurotransmitters, such as serotonin, dopamine, etc. In many emotional diseases, such as depression and anxiety, the neurotransmitter imbalance in the patient's body, 4- (methoxy ） - α - methyltryptophan can return it to balance, relieve the pain of the patient's mood, make it normal, and restore life and work.
In the pharmaceutical pathway, this is the key raw material for the preparation of a variety of specific drugs. By means of chemical methods, new drugs with stronger targeting and better curative effect can be made by combining with other drugs. And because of its special chemical structure, it can enhance the ability of drugs to penetrate biofilms, make the drug power reach the disease faster, and improve the efficiency of drug treatment.
Furthermore, in the process of scientific research, 4- (methoxy ） - α - methyltryptophan is also an important research object. By studying its mechanism of action and metabolic pathway, scholars can deepen their understanding of the mysteries of life, pave the foundation for the progress of medical science, and bring dawn to conquer more difficult and complicated diseases.
What is the synthesis method of 4- (chloromethyl) -α-methylphenylacetic acid?
To prepare 4- (methoxy) -α-methylphenylacetic acid, you can follow the following ancient method.
First take an appropriate amount of toluene, treat it with a mixed acid of sulfuric acid and nitric acid, and control the temperature to about 30 degrees to obtain p-nitrotoluene. This step is to use the nitrification of mixed acids to make the nitro group enter the parathylate of toluene.
Second time, iron powder and hydrochloric acid are used as reducing agents, p-nitrotoluene is co-heated with it, and the nitro group is then reduced to an amino group to obtain p-aminotoluene. The reduction system constructed by iron and hydrochloric acid can effectively change the nitro group to an amino group.
Then take p-aminotoluene and acylate it with acetic anhydride to obtain p-acetaminotoluene. The purpose of this acylation reaction is to protect the amino group from being unduly affected by other reagents in subsequent reactions.
4 - (methoxy) -p-acetaminotoluene is obtained by co-placing p-acetaminotoluene with iodomethane and potassium carbonate in an appropriate solvent, heating and stirring. Potassium carbonate acts as a base to promote nucleophilic substitution of iodomethane with p-acetaminotoluene, and methoxy is introduced.
Thereafter, 4- (methoxy) -p-acetaminotoluene is hydrolyzed with dilute hydrochloric acid to give 4- (methoxy) -p-aminotoluene. The dilute hydrochloric acid provides an acidic environment for the hydrolysis of amide bonds.
The diazonium salt reagent prepared by sodium nitrite and hydrochloric acid is reacted with 4- (methoxy) -p-aminotoluene at low temperature to obtain diazonium salt. Low temperature can stabilize the diazonium salt and avoid its premature decomposition.
The diazonium salt is treated with cuprous cyanide and potassium cyanide, and the Sandmeier reaction occurs. The diazonium group is replaced by a cyano group to obtain 4- (methoxy) -phenylacetonitrile. The Sandmeier reaction is a classic method for introducing cyano groups.
Finally, the hydrolysis of 4- (methoxy) -phenylacetonitrile is catalyzed by acid to obtain 4- (methoxy) -phenylacetic acid. Under appropriate conditions, methylation reagents such as iodomethane and alkali are applied to 4- (methoxy) -phenylacetic acid, and methyl is introduced at the α position to obtain 4- (methoxy ） - α - methylphenylacetic acid.
The reaction steps should follow the specifications, pay attention to temperature control, time control and reagent dosage, in order to obtain satisfactory yield and purity.
First take an appropriate amount of toluene, treat it with a mixed acid of sulfuric acid and nitric acid, and control the temperature to about 30 degrees to obtain p-nitrotoluene. This step is to use the nitrification of mixed acids to make the nitro group enter the parathylate of toluene.
Second time, iron powder and hydrochloric acid are used as reducing agents, p-nitrotoluene is co-heated with it, and the nitro group is then reduced to an amino group to obtain p-aminotoluene. The reduction system constructed by iron and hydrochloric acid can effectively change the nitro group to an amino group.
Then take p-aminotoluene and acylate it with acetic anhydride to obtain p-acetaminotoluene. The purpose of this acylation reaction is to protect the amino group from being unduly affected by other reagents in subsequent reactions.
4 - (methoxy) -p-acetaminotoluene is obtained by co-placing p-acetaminotoluene with iodomethane and potassium carbonate in an appropriate solvent, heating and stirring. Potassium carbonate acts as a base to promote nucleophilic substitution of iodomethane with p-acetaminotoluene, and methoxy is introduced.
Thereafter, 4- (methoxy) -p-acetaminotoluene is hydrolyzed with dilute hydrochloric acid to give 4- (methoxy) -p-aminotoluene. The dilute hydrochloric acid provides an acidic environment for the hydrolysis of amide bonds.
The diazonium salt reagent prepared by sodium nitrite and hydrochloric acid is reacted with 4- (methoxy) -p-aminotoluene at low temperature to obtain diazonium salt. Low temperature can stabilize the diazonium salt and avoid its premature decomposition.
The diazonium salt is treated with cuprous cyanide and potassium cyanide, and the Sandmeier reaction occurs. The diazonium group is replaced by a cyano group to obtain 4- (methoxy) -phenylacetonitrile. The Sandmeier reaction is a classic method for introducing cyano groups.
Finally, the hydrolysis of 4- (methoxy) -phenylacetonitrile is catalyzed by acid to obtain 4- (methoxy) -phenylacetic acid. Under appropriate conditions, methylation reagents such as iodomethane and alkali are applied to 4- (methoxy) -phenylacetic acid, and methyl is introduced at the α position to obtain 4- (methoxy ） - α - methylphenylacetic acid.
The reaction steps should follow the specifications, pay attention to temperature control, time control and reagent dosage, in order to obtain satisfactory yield and purity.
What are the precautions for 4- (chloromethyl) -α-methylphenylacetic acid during storage and transportation?
4 - (methoxy ） -α - methylphenylalanine, there are various matters that need to be paid attention to during storage and transportation.
The temperature and humidity of the first storage. This substance is quite sensitive to temperature and humidity, and should be stored in a cool and dry place. If the humidity is too high, it may cause it to get damp, cause hydrolysis and other changes, and damage its quality; if the temperature is too high, it may promote its decomposition and reduce its potency. Therefore, it is usually necessary to control the temperature in the [specific temperature range] and the humidity in the [specific humidity range] to ensure its stability.
The second is the tightness of the packaging. It is necessary to use packaging materials with good airtightness, such as special glass bottles or aluminum foil bags, to prevent contact with air. Some groups in this compound are easy to react with oxygen and water vapor in the air, causing it to deteriorate. The name, properties, precautions, etc. should also be clearly marked on the outside of the package for identification and use.
When transporting, caution must also be taken. A smooth transportation method should be selected to avoid severe vibration and collision, and to avoid material leakage caused by package damage. And the temperature and humidity of the transportation environment should also meet the storage requirements. Temperature-controlled transportation equipment can be used to ensure that the conditions of the whole transportation process are suitable.
In addition, during the handling process, the operator must follow strict operating procedures and wear appropriate protective equipment, such as gloves, goggles, etc. Because the substance may be irritating or toxic, if it comes into contact with the skin or into the eyes, rinse with plenty of water as soon as possible and seek medical attention as appropriate.
All of these are the key precautions for the storage and transportation of 4- (methoxy ） -α - methylphenylalanine, which should be strictly observed to ensure its quality and safety.
The temperature and humidity of the first storage. This substance is quite sensitive to temperature and humidity, and should be stored in a cool and dry place. If the humidity is too high, it may cause it to get damp, cause hydrolysis and other changes, and damage its quality; if the temperature is too high, it may promote its decomposition and reduce its potency. Therefore, it is usually necessary to control the temperature in the [specific temperature range] and the humidity in the [specific humidity range] to ensure its stability.
The second is the tightness of the packaging. It is necessary to use packaging materials with good airtightness, such as special glass bottles or aluminum foil bags, to prevent contact with air. Some groups in this compound are easy to react with oxygen and water vapor in the air, causing it to deteriorate. The name, properties, precautions, etc. should also be clearly marked on the outside of the package for identification and use.
When transporting, caution must also be taken. A smooth transportation method should be selected to avoid severe vibration and collision, and to avoid material leakage caused by package damage. And the temperature and humidity of the transportation environment should also meet the storage requirements. Temperature-controlled transportation equipment can be used to ensure that the conditions of the whole transportation process are suitable.
In addition, during the handling process, the operator must follow strict operating procedures and wear appropriate protective equipment, such as gloves, goggles, etc. Because the substance may be irritating or toxic, if it comes into contact with the skin or into the eyes, rinse with plenty of water as soon as possible and seek medical attention as appropriate.
All of these are the key precautions for the storage and transportation of 4- (methoxy ） -α - methylphenylalanine, which should be strictly observed to ensure its quality and safety.
What is the market price range for 4- (chloromethyl) -α-methylphenylacetic acid?
I look at your question, but I am inquiring about the market price range of 4- (cyanomethyl ） - α - methylphenylalanine. However, the price of these fine chemicals often varies due to factors such as quality, purity, supply and demand situation, procurement volume and channels, so it is difficult to determine the exact number.
If it is a high-purity scientific research-grade reagent used in precision experiments, because of its complicated preparation process, strict quality control, the price per gram may reach hundreds of yuan, or even thousands of yuan. The field of scientific research requires extremely high purity of reagents, and some impurities may affect the experimental results, which is expensive.
And industrial grade, for large-scale production, although the purity requirements are slightly lower, due to the large production scale, the cost may be diluted. However, the price also depends on the specific purity standard, and the price per ton may range from tens of thousands to hundreds of thousands of yuan.
If the purchase volume is huge, the merchant may give a certain discount for small profits but quick turnover; in different procurement channels, such as purchasing directly from the manufacturer or changing hands through the dealer, the price is also different. And the market supply and demand are fickle. When the supply is abundant, the price decreases, and when the demand is strong, the price rises.
In short, in order to know the exact market price range of 4- (cyanomethyl ） - α - methylphenylalanine, it is necessary to study the above factors in detail, or consult the industry merchants, distributors, in order to obtain a more accurate number.
If it is a high-purity scientific research-grade reagent used in precision experiments, because of its complicated preparation process, strict quality control, the price per gram may reach hundreds of yuan, or even thousands of yuan. The field of scientific research requires extremely high purity of reagents, and some impurities may affect the experimental results, which is expensive.
And industrial grade, for large-scale production, although the purity requirements are slightly lower, due to the large production scale, the cost may be diluted. However, the price also depends on the specific purity standard, and the price per ton may range from tens of thousands to hundreds of thousands of yuan.
If the purchase volume is huge, the merchant may give a certain discount for small profits but quick turnover; in different procurement channels, such as purchasing directly from the manufacturer or changing hands through the dealer, the price is also different. And the market supply and demand are fickle. When the supply is abundant, the price decreases, and when the demand is strong, the price rises.
In short, in order to know the exact market price range of 4- (cyanomethyl ） - α - methylphenylalanine, it is necessary to study the above factors in detail, or consult the industry merchants, distributors, in order to obtain a more accurate number.
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